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9/4/2015

AntithromboticandantiallergicactivitiesofrhaponticinfromRheiRhizomaareactivatedbyhumanintestinalbacteria.PubMedNCBI

PubMed

Abstract
ArchPharmRes.2002Aug25(4):52833.

AntithromboticandantiallergicactivitiesofrhaponticinfromRhei
Rhizomaareactivatedbyhumanintestinalbacteria.
ParkEK1,ChooMK,YoonHK,KimDH.

Authorinformation
Abstract
ToevaluatetheantithromboticandantiallergicpropertiesofrhaponticinextractedfromRhei
Rhizoma,theinvitroandexvivoinhibitoryactivitiesofrhaponticinanditsmetabolite,
rhapontigenin,weremeasured.ThesecompoundsinhibitedinvitroADPandcollageninduced
plateletaggregation.Rhapontigeninwasmorepotent,withIC50valuesof4and70microg/ml,
respectively.InexvivoADPandcollageninducedratplateletaggregation,thesecompounds
alsoexhibitedapotentinhibitoryeffect.Theantiplateletaggregationeffectsofrhaponticinand
rhapontigeninweremorepotentthanthoseofaspirin.Rhapontigeninshowedsignificant
protectionfromdeathduetopulmonarythrombosisinmice.Rhapontigeninalsoshowedthe
strongestinhibitoryactivityagainstbetahexosaminidasereleaseinducedbyDNPBSA.These
compoundsinhibitedPCAreactioninmice.Rhapontigeninintraperitoneallyadministeredshowed
thestrongestinhibitoryactivityandsignificantlyinhibitedPCAatdosesof25and50mg/kg,with
inhibitoryactivitiesof48and85%,respectively.Theinhibitoryactivityoforallyadministered
rhaponticinwasstrongerthanthatofintraperitoneallyadministeredrhaponticin.Theseresults
suggestthatrhaponticin,intherhizomeofRheiRhizoma,isaprodrugthathasextensive
antiallergicandantithromboticproperties.
PMID:12214867[PubMedindexedforMEDLINE]

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http://www.ncbi.nlm.nih.gov/pubmed/12214867

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9/4/2015

AntithromboticandantiallergicactivitiesofrhaponticinfromRheiRhizomaareactivatedbyhumanintestinalbacteria.PubMedNCBI

http://www.ncbi.nlm.nih.gov/pubmed/12214867

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