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  • Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance

    Diunggah oleh

    Domitian Pasca
    8 tayangan2 halaman
    Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance

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    Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance

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    8 tayangan2 halaman

    Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance

    Diunggah oleh

    Domitian Pasca
    Arctigenin Efficiently Enhanced Sedentary Mice Treadmill Endurance

    Hak Cipta:

    © All Rights Reserved
    Unduh sebagai PDF, TXT atau baca online dari Scribd
    Tandai sebagai konten tidak pantas
    dari 2

    9/4/2015

    Arctigeninefficientlyenhancedsedentarymicetreadmillendurance.PubMedNCBI

    PubMed

    Abstract

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    PLoSOne.20116(8):e24224.doi:10.1371/journal.pone.0024224.Epub2011Aug26.

    Arctigeninefficientlyenhancedsedentarymicetreadmillendurance.
    TangX1,ZhuangJ,ChenJ,YuL,HuL,JiangH,ShenX.

    Authorinformation
    Abstract
    Physicalinactivityisconsideredasoneofthepotentialriskfactorsforthedevelopmentoftype2
    diabetesandothermetabolicdiseases,whileenduranceexercisetrainingcouldenhancefat
    oxidationthatisassociatedwithinsulinsensitivityimprovementinobesity.AMPactivatedprotein
    kinase(AMPK)asanenergysensorplayspivotalrolesintheregulationofenergyhomeostasis,
    anditsactivationcouldimproveglucoseuptake,promotemitochondrialbiogenesisandincrease
    glycolysis.RecentresearchhasevensuggestedthatAMPKactivationcontributedtoendurance
    enhancementwithoutexercise.Herewereportthatthenaturalproductarctigeninfromthe
    traditionalherbArctiumlappaL.(Compositae)stronglyincreasedAMPKphosphorylationand
    subsequentlyupregulateditsdownstreampathwayinbothH9C2andC2C12cells.Itwas
    discoveredthatarctigeninphosphorylatedAMPKviacalmodulindependentproteinkinase
    kinase(CaMKK)andserine/threoninekinase11(LKB1)dependentpathways.Micetreadmill
    basedinvivoassayfurtherindicatedthatadministrationofarctigeninimprovedefficientlymice
    enduranceasreflectedbytheincreasedfatiguetimeanddistance,andpotentlyenhanced
    mitochondrialbiogenesisandfattyacidoxidation(FAO)relatedgenesexpressioninmuscle
    tissues.Ourresultsthussuggestedthatarctigeninmightbeusedasapotentialleadcompound
    forthediscoveryoftheagentswithmimicexercisetrainingeffectstotreatmetabolicdiseases.
    PMID:21887385[PubMedindexedforMEDLINE] PMCID:PMC3162610

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    http://www.ncbi.nlm.nih.gov/pubmed/21887385

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    9/4/2015

    Arctigeninefficientlyenhancedsedentarymicetreadmillendurance.PubMedNCBI

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