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9/4/2015

Arctigeninprotectsfocalcerebralischemiareperfusionratsthroughinhibitingneuroinflammation.PubMedNCBI

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BiolPharmBull.201235(11):20049.Epub2012Aug22.

Arctigeninprotectsfocalcerebralischemiareperfusionratsthrough
inhibitingneuroinflammation.
FanT1,JiangWL,ZhuJ,FengZhangY.

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Abstract
Strokeisthethirdleadingcauseofdeathinindustrializedcountriesandthemostimportantcause
ofacquiredadultdisability.Manyevidencessuggestthatinflammationaccountsforthe
progressionofcerebralischemicinjury.Arctigenin,aphenylpropanoiddibenzylbutyrolactone
ligninisolatedfromcertainplants,hasshownantiinflammatoryactivityagainstdiabetesand
Alzheimer'sdisease.Inthisstudy,wetestedwhetherarctigenincanprotectmiddlecerebral
arteryoccluded(MCAO)rats.MaleSpragueDawleyratswerepretreatedwitharctigeninor
vehiclefor7dbeforebeingsubjectedtotransientocclusionofmiddlecerebralarteryand
reperfusion.Ratswereevaluatedat24hafterMCAOforneurologicaldeficitscoring.
Furthermore,themechanismoftheantiinflammatoryeffectofarctigeninwasinvestigatedwitha
focusoninflammatorycells,proinflammatorycytokines,andtranscriptionalfactors.Arctigenin
significantlyreducedcerebralinfarctionandimprovedneurologicaloutcome.Arctigenin
suppressedtheactivationofmicrogliaanddecreasedtheexpressionofinterleukin(IL)1and
tumornecrosisfactor(TNF).Theseresultsrevealedthatarctigeninhasapromisingtherapeutic
effectinischemicstroketreatmentthroughanantiinflammatorymechanism.
PMID:22972486[PubMedindexedforMEDLINE]

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http://www.ncbi.nlm.nih.gov/pubmed/22972486

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9/4/2015

Arctigeninprotectsfocalcerebralischemiareperfusionratsthroughinhibitingneuroinflammation.PubMedNCBI

http://www.ncbi.nlm.nih.gov/pubmed/22972486

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