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  • Single Oral Dose Pharmacokinetics of Decursin, Decursinol Angelate, and Decursinol in Rats

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    Domitian Pasca
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    Single Oral Dose Pharmacokinetics of Decursin, Decursinol Angelate, And Decursinol in Rats

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    Single Oral Dose Pharmacokinetics of Decursin, Decursinol Angelate, And Decursinol in Rats

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    Single Oral Dose Pharmacokinetics of Decursin, Decursinol Angelate, And Decursinol in Rats

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    4 tayangan2 halaman

    Single Oral Dose Pharmacokinetics of Decursin, Decursinol Angelate, and Decursinol in Rats

    Diunggah oleh

    Domitian Pasca
    Single Oral Dose Pharmacokinetics of Decursin, Decursinol Angelate, And Decursinol in Rats

    Hak Cipta:

    © All Rights Reserved
    Unduh sebagai PDF, TXT atau baca online dari Scribd
    Tandai sebagai konten tidak pantas
    dari 2

    9/4/2015

    Singleoraldosepharmacokineticsofdecursin,decursinolangelate,anddecursinolinrats.PubMedNCBI

    PubMed

    Abstract

    Fulltextlinks

    PlantaMed.2013Mar79(34):27580.doi:10.1055/s00321328202.Epub2013Jan30.

    Singleoraldosepharmacokineticsofdecursin,decursinolangelate,and
    decursinolinrats.
    LiL1,ZhangJ,XingC,KimSH,LJ.

    Authorinformation
    Abstract
    Decursinanddecursinolangelatearethemajorcomponentsinthealcoholicextractoftherootof
    AngelicagigasNakai.Ourpreviousworkconvincinglydemonstratedthatbothdecursinand
    decursinolangelatewererapidlyconvertedtodecursinolinmiceafteradministrationbyeither
    oralgavageori.p.injection.Inthecurrentstudy,wecomparedforthefirsttimetheplasma
    profilesofdecursinol,whenequalmolesofdecursin/decursinolangelateordecursinolwere
    giventoratsbyoralgavage,andinvestigatedtheeffectofdifferentformulasandotherchemicals
    inAngelicagigasextractonthebioavailabilityofdecursinol.Ourresultsshowthatgavageof
    decursinolledtoafasterattainmentofplasmadecursinolpeak(Tmax~0.7h)andmuchhigher
    peaklevelsthananequalmolaramountadministeredasdecursin/decursinolangelatemixtureor
    asAngelicagigasethanolextract,resultingin23foldhigherbioavailabilityasestimatedbythe
    areaunderthecurveoftherespectiveregimens(65012vs.27033hng/mLfordecursinoland
    decursin/decursinolangelatetreatmentgroups,respectively).Comparedtoaformulabasedon
    ethanolPEG400Tween80,carboxylmethylcellulosewasalessoptimizedvehicle.Inaddition,
    wedetectedpeaklevelsofdecursinanddecursinolangelateintheplasmaofratsadministered
    withdecursin/decursinolangelateorAngelicagigasextractinthenMrange(Tmax~0.5h)witha
    newlyestablishedsensitiveUHPLCMS/MSmethod.Furthermore,ourdatasupporttheliver,
    insteadofintestine,asamajororgansitewheredecursinanddecursinolangelatewere
    hydrolyzedtodecursinolwithaS9microsomalinvitrometabolismassay.Takentogether,our
    studyprovidedimportantPK,LCMS/MSmethodology,formulationandmetabolisminsightsina
    rodentmodelfortherationaldesignofinvivoefficacystudiesofthecorrespondingchemicalsin
    thefuture.
    GeorgThiemeVerlagKGStuttgartNewYork.
    PMID:23364885[PubMedindexedforMEDLINE]

    PublicationTypes,MeSHTerms,Substances,GrantSupport
    LinkOutmoreresources

    http://www.ncbi.nlm.nih.gov/pubmed/23364885

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    9/4/2015

    Singleoraldosepharmacokineticsofdecursin,decursinolangelate,anddecursinolinrats.PubMedNCBI

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