12/4/15 6:27 PM

Background: High grade serous ovarian cancer is characterised by high

initial response to chemotherapy but poor outcome in the long term due to
acquired resistance. One of the main genetic features of this disease is TP53
mutation. The majority of TP53 mutated tumors harbor missense mutations
in this gene, correlated with p53 accumulation. TP53 null tumors constitute a
specific subgroup characterised by nonsense, frameshift or splice-site
mutations associated to complete absence of p53 expression. Different
studies show that this kind of tumors may have a worse prognosis than
other TP53 mutated HGSC.

12/4/15 6:27 PM

12/4/15 6:27 PM