2015-11-22

Cell Biology
Lecture 223.20: Endocytosis and Exocytosis

Endocytosis

2015-11-22

Endocytosis-green arrows
Two Types (based on size)
pinocytosis (cellular drinking) < 150 nm; all cell
phagocytosis (cellular eating) > 250 nm; phagocytic cells
receptor mediated

Pathways to Lysosomes

2015-11-22

Phagocytosis

Phagocytosis

2015-11-22

Pathways to Lysosomes

Endocytosis

2015-11-22

Endocytosis: Receptor-mediated

Endocytosis: Receptor-mediated

Selective process
Mediated by clathrin
and transmembrane
receptor on cell surface

2015-11-22

Endocytosis - sorting in the endosome

Examples
Recycling - LDL receptor
Degradation - EGF receptor
Transcytosis - antibodies

Endocytosis -Sorting

2015-11-22

Endocytosis - sorting in the endosome

Examples
Recycling - LDL receptor
Degradation - EGF receptor
Transcytosis - antibodies

Sorting in Trans-Golgi Network

2015-11-22

Signal-mediated delivery to lysosomes

Lysosomal proteins are modified further in the Golgi

2015-11-22

Sorting in the Golgi- Lysosome Delivery

Sorting - Lysosome Delivery

2015-11-22

Exocytosis - Regulated Secretion

Exocytosis - Constitutive Secretion

10

2015-11-22

Exocytosis - Constitutive Secretion

Exocytosis - Regulated vs. Constitutive Secretion

11

2015-11-22

end

12