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mediCAL FEATURE:
CANNABIS & ADD/ADHD..................................
FEATURED NEWS:
COLOMBIA LEGALIZES
MEDICAL MARIJUANA.........................................

mediCAL FEATURE:
CANNABIS & PARKINSONS...............................
MEDICAL FEATURE:
CANNABIS & DIABETES........................................
MEDICAL FEATURE:
CANNABIS & ARTHRITIS......................................
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MEDICAL FEATURE:
420INSIGHT.COM
CONTRIBUTOR
In the eyes of popular culture,
cannabis consumers arent exactly
models of concentration and cognitive
performance. So when a small group
of researchers began exploring
cannabis as alternative treatment for
attention deficit disorders, there was of
course some scoffing and skepticism.
Nevertheless, with so many medical
marijuana patients swearing by its ability
to promote focus in place of prescription
stimulants, these doctors sought to take
a closer look at the scientific basis of this
counterintuitive phenomenon.
Attention deficit hyperactivity disorder,
better known as ADHD, is a controversial
diagnosis marked by distractibility,
hyperactivity, and impulsivity. Adults
are more likely to be diagnosed with
attention deficit disorder, or ADD, which
lacks this hyperactivity characteristic,
but is similar in other ways to ADHD.
More than one in 10 children in the U.S.
will be diagnosed with ADD/ADHD, a
figure that has grown exponentially in the
last 50 years. Since 1957, doctors have
been treating ADD/ADHD patients with
psychostimulants like Adderall, Ritalin,
and Concerta medications that are
molecularly indistinguishable from drugs
like methamphetamine and cocaine.
Antonio Rodriguez, diagnosed with
ADD/ADHD at age six, had been among
the masses prescribed stimulant
medications. I remember having
headaches all the time to the point
where I wasnt able to sleep, Antonio
said, adding that his appetite was also
nonexistent until treating with cannabis;

10

CANNABIS & ADD/ADHD


and not only was cannabis lifting the
stimulant side effects, it improved
Antonios ADD/ADHD symptoms.
For the first time ever, I was in the
state where I could really get my mind
together.
Having only been taught the dangers of
using cannabis, Antonio was cautious
about trying it for the first time. I got
scared about the whole addiction side
of cannabis, Antonio said. I was waiting
for the moment my body asked me for
weed, but it never happened.
For those coming from an anti-cannabis
background, explaining its therapeutic
properties to friends and family can be
difficult. This was no less true for Antonio,
despite the fact that his performance in
school had won him college acceptance
with a scholarship. The reality is, theres
far too little research on cannabis and
ADD/ADHD to know exactly how the
two interact. Still, the data and results
emerging from initial investigations show
that there is more digging to be done.
One main physiological irregularity of
ADD/ADHD is the brains shortage of
dopamine, a chemical neurotransmitter
involved in cognitive processes like
memory and attention. Medications like
Adderall and Ritalin stimulate dopamine,
thereby promoting concentration, but
come with a myriad of unpleasant side
effects and withdrawal symptoms.
Dr. David Bearman, a figurehead of
cannabis research, has studied the
relationship between the cannabinoid
system and ADHD and discovered
potential
therapeutic
value
as
cannabinoids interact with the brains

dopamine management systems.


Cannabis appears to treat ADD and
ADHD by increasing the availability of
dopamine, Dr. Bearman wrote. This
then has the same effect but is a different
mechanism of action than stimulants like
Ritalin (methylphenidate) and dexedrine
amphetamine, which act by binding to
the dopamine and interfering with the
metabolic breakdown of dopamine.
Put simply, the compounds found in
cannabis, called cannabinoids, could
potentially correct the dopamine
deficiency observed in ADD/ADHD
patients if dosed appropriately and
administered safely. Even in its raw form,
cannabis is able to provide the mental
slowdown necessary for concentration
in many patients. Boring and arduous
tasks become more manageable, and
mood swings tend to level out. But why?
The most accepted theory about ADHD
rests on the fact that about 70 percent
of the brains function is to regulate input
to the other 30 percent, Dr. Bearman
says. Basically the brain is overwhelmed
with too much information coming too
fast. In ADHD, the brain is cluttered with
and too aware of all the nuances of a
persons daily experience.
While most medical professionals agree
that anecdotal evidence is not sufficient
in recommending cannabis for ADD/
ADHD, researchers are optimistic about
the potential cannabis is demonstrating.
When political blockades let up and
further research resumes, it could be
that cannabinoid therapy provides a
frontier for safer, more effective ADD/
ADHD medication.

11

12

medible NEWS:

COLOMBIA LEGALIZES

MEDICAL MARIJUANA

B. LE GRAND
EDITOR-IN-CHIEF
Bogota (AFP) - Colombian President
Juan Manuel Santos signed a decree
last month legalizing and regulating
medical marijuana, the latest softening
of the countrys hardline tactics in the
war on drugs.
In a nationally televised address, Santos
announced it would be fully legal to grow,
process, import and export cannabis
and its derivatives for medicinal and
scientific use.
This decree allows licenses to be
granted for the possession of seeds,
cannabis plants and marijuana. It places
Colombia in the group of countries that
are at the forefront... in the use of natural
resources to fight disease, Santos said
from his presidential palace.
He added in his statement that the
measure does not go against our
international commitments on drug
control.
Colombias government has long been
an ally of the United States in fighting
international drug trafficking, using its
military and billions of US dollars to try
to shed its title as the worlds biggest
cocaine producer.
But Colombia has shown signs of easing
its hardline stance in recent months.
Santoss announcement follows a
recent decision to stop aerially spraying
the herbicide glyphosate on fields of
coca, the raw ingredient for cocaine.
The World Health Organization warned
in April 2015 that the chemical, sold by
16

US biotech company Monsanto under


the brand name Roundup, is probably
carcinogenic.

pot, and Mexico will open a national


debate in January 2016 on overhauling
its prohibitionist marijuana laws.

Santos also announced in September


that Colombia would begin giving land to
farmers who stop growing coca.

Colombia decriminalized possession of


up to 20 grams of marijuana in 2012,
and it is legal to grow up to 20 cannabis
plants in the country. But consuming it
in public and selling it are illegal.

Prior to now, medical marijuana had


fallen into a legal gray area in Colombia.
It was authorized under a 1986 law,
but the lack of regulation prevented
production on a national level.
The manufacture, export, sale, and
medical and scientific use of this and
other substances have been permitted
for several decades in Colombia.
However, they were never regulated.
That is what we are doing today, Santos
said.
Under the new regulation decree,
growers will apply for licenses from the
National Narcotics Council, while those
seeking to manufacture cannabis-based
medicine will apply for permits from the
health ministry. The health ministry will
also grant permits to export such drugs
to countries where they are legal.
Our goal is for patients to be able
to access medications made in
Colombia that are safe, high-quality
and accessible. It is also an opportunity
to promote scientific research in our
country, Santos said.
The push to legalize marijuana
appears to be gaining momentum in
Latin America, for both medical and
recreational use.
Uruguay legalized the production, sale
and use of marijuana in 2013, Chiles
Congress is debating a bill to legalize

Medical marijuana is already used in


Colombia on a small scale. For example,
some epileptics use cannabis extract
to control their seizures. But health
professionals and pharmaceutical
companies say the new decree will
make it much easier to buy, sell and
manufacture cannabis medicines.
Illegal drugs have given rise to horrific
violence by drug cartels in Colombia,
and have fueled a five-decade conflict
between leftist guerrillas and the
Colombian
government
that
is
responsible for the deaths of more than
220,000 people.
Colombia has received $9 billion in
US funding since 1999 under Plan
Colombia, a military and economic
cooperation program aimed at
combating drug trafficking.
However, it still remains a top producer
of illegal drugs, particularly cocaine.
Colombias cocaine production surged
by 52 percent last year, to 442 tons,
according to the United Nations.
It is yet to be seen if legalizing the use
of medical marijuana in Colombia is
a precursor to the legalization and
recreational use of other drugs, but its
a step in the right direction for scientific
research regarding cannabis.
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MEDICAL CORNER:

CANNABIS & PARKINSONS

420INSIGHT.COM
CONTRIBUTOR

chemicals) found in cannabis, are


known to control spasms, reduce
inflammation, and prevent further
Parkinsons Disease (PD) is a motor neurological damage.
system disorder classified as a
progressive neurological disease According to one study, smoking
which occurs when neurons in the cannabis
significantly
reduced
basal ganglia degenerate, causing the tremors associated with PD,
a shortage of dopamine production. improved sleep, and reduced pain
This results in the impairments in patient participants. In the sames
in movement associated with the study, no significant adverse effects
disease. Parkinsons typically affects were observed. This suggests that
men over 60, but as Michael J. cannabis might have a place in the
Fox has unfortunately proven can therapeutic armamentarium of PD. It
afflict significantly younger adults.
demonstrates that although the best
neuroprotective treatments for PD
Historically, cannabis has been used are not known, the endocannabinoid
to treat PD as far back as the 19th system may be the most promising
Century, despite the fact that doctors target for further studies and
were unaware of cannabinoids research.
and no clinical studies had been
conducted. Patients with a variety of This is all perfectly logical when one
similar neurological disorders, such considers that research reveals
as multiple sclerosis, dystonia, and that PD sufferers show naturally
epilepsy have been found to gain elevated levels of endocannabinoids,
significant benefit from the use of chemicals produced by the body
cannabis.
that help maintain a healthy nervous
system among many other
Can the same be said of Parkinsons? functions.
The Research

24

In fact, the cannabinoids found in


cannabis mimic endocannabinoids
While the cause of Parkinsons and can be thought of as a supplement
remains unknown, it is tied to the to the effort of a PD patients body
untimely death of specialized cells to fight the disease. One study found
in the brain that produce dopamine that some Parkinsons patients
and results in a lack of coordination, showed endocannabinoid levels that
poor motor function, and difficulty were twice that of non-PD sufferers.
walking.
While more research is needed,
this suggests that cannabinoids,
The primary symptoms of Parkinsons whether derived externally from
Disease include:
cannabis or internally from ones
endocannabinoid system, have true
Tremors
therapeutic value in the treatment of
Rigidity
PD.
Bradykinesia (very slow physical
movements)
Because cannabis has been found
Impaired balance coordination
to effectively treat other neurological
Sleep disturbance
diseases, it makes sense that it
Neuropathic pain
might also be an effective treatment
for tremors and other motor
Cannabis has been found to treat impairments. In addition to treating
not only the shaking and rigidity the symptoms of Parkinsons,
that accompany Parkinsons, but cannabis is also believed to be an
also the depression that typically effective treatment for the disease
results. Tetrahydrocannabinol (THC) itself. The cannabinoids found in
and Cannabidiol (CBD), the primary marijuana that impersonate the
cannabinoids (active therapeutic bodys endocannabinoid system are

highly regarded for their antioxidant


and neuroprotective properties,
which scientists believe may have
a direct application in slowing the
progression of Parkinsons.
Because it provides relief for not only
multiple symptoms of Parkinsons,
but also the core disease itself,
many doctors and researchers are
optimistic about the role of cannabis
in the treatment of PD. Recent
research also reveals that sufferers
have gained more relief after having
used cannabis to treat their disorder
for at least two months. This has lead
researchers to conclude that it is
very unlikely that [their improvement]
could be attributed to a placebo
reaction.
According to Paul Armentano at
NORML, most patients afflicted
with Parkinsons are unaware that
marijuana can ease their symptoms
and slow the progress of the disease.
Despite this, those who have selfmedicated with cannabis label it one
of the most effective alternative
treatments available.
Survey data published in the journal
Evidence-Based Complimentary and
Alternative Medicine indicates that
cannabis is especially good at dealing
with pain, anxiety, tremors, and nonmotor symptoms. It also reportedly
relieves symptoms like nausea and
vomiting caused from taking major
pharmaceutical medications.
Strains reported to be especially
effective for Parkinsons include:
Deadhead OG
Bubba Kush
Flo
Hashberry
Recon
Amnesia Haze
Although varieties high in CBD are
often recommended for their ability
to decrease pain and allow patients
to sleep, strains high in THC have also
been found to deliver therapeutic
benefits, especially the treatment of
anxiety and depression.
25

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29

MEDICAL CORNER:
DR. NICOLA DAVIES
CONTRIBUTOR (420INSIGHT.COM)
In the U.S., over 29.1 million people are currently
diagnosed with diabetes. This is almost 10
percent of the population. Furthermore, two
out of three of these people will die from the
condition or the many complications that arise
from it. This has prompted researchers to
look into how medical marijuana can help treat
diabetes and its associated complications.
Type 1 diabetes, often termed juvenile
diabetes, is a genetic disorder where the
pancreas doesnt produce enough insulin
a hormone that allows the body to process
the sugars from carbohydrates. Sufferers of
Type 1 diabetes often take multiple injections
of insulin each day. On the other hand, Type 2
diabetes (also known as adult onset diabetes)
is a disorder where the body doesnt process
insulin properly, often signaling the pancreas
to make more insulin than required. This is the
most common type of diabetes.
Medical marijuana has been the focus of
several studies examining potential diabetes
treatment. One such study, published in
the American Journal of Medicine, found
that active users of marijuana had a more
productive carbohydrate metabolism than
people who didnt use marijuana.1 Murray
Mittleman, Associate Professor of Medicine
at Harvard and author of the study, said,
[Marijuana users] fasting insulin levels were
lower, and they appeared to be less resistant to
the insulin produced by their body to maintain a
normal blood-sugar level.
The study comprised over 4,657 men and
women participating in the National Health
and Nutrition Examination Survey between
2005 and 2010 48 percent had smoked
marijuana at least once and 12 percent were
current cannabis smokers. The researchers
controlled for other factors that might impact
diabetes risk, such as gender, income, alcohol
use, cigarette smoking and physical activity.
Even after these adjustments, the current
marijuana users showed fasting insulin levels
thatwere16percentlowerthanthoseofformer
users or those who had never used the drug.
These findings are applicable to both types of
diabetes. In Type 1 diabetes, a lower fasting
level might eliminate the need for an insulin
injection at that time. While injections wouldnt
be completely eliminated, it could decrease the
number needed per day. For those with Type
2 diabetes, being less resistant to the insulin
could help control the advancing of the disease
by improving the bodys ability to manage sugar
levels naturally.

30

Some of the complications that can


arise from Type 1 and Type 2 diabetes
are neuropathy, glaucoma, high blood

CANNABIS & DIABETES


pressure, and peripheral vascular disease.
Medical marijuana has been studied to
see its effects on each of these conditions.
Neuropathy, a nerve damage contracted from
certain diseases or disorders, is found in 60 to
70 percent of all people with diabetes. More
specifically, there are four types of diabetesrelated neuropathy: peripheral (located in the
hands, arms, legs and feet), autonomic (which
affects the nerves that control blood glucose
levels, blood pressure, and the heart), focal
(specific nerve damage to the head, torso, and
leg), and proximal (sometimes called diabetic
amyotrophy and usually centralized on one side
of the body in the hips, thighs, and buttocks).
Several studies have shown vaporized cannabis
to reduce pain and slow the advancing nerve
damage of all four types of neuropathy. In some
types, there was more than a 30 percent
improvement without any significant impact on
daily functioning or cognitive abilities.
Glaucoma is another complication that can
arise with diabetes. The general term for
glaucoma-related complications is retinopathy.
People who have diabetes are 40 percent
more likely to contract glaucoma than people
without the disease. Glaucoma occurs when
pressure builds inside the eye, eventually
cutting off blood flow and damaging the
optic nerve. Vision is gradually lost due to the
continued pressure and nerve damage.
Medical marijuana is already being
recommended for glaucoma sufferers, as it
can directly reduce the inflammation caused
by the nerve damage and increased blood flow.
However, since the relief is only temporary,
some doctors believe that people need to
partake every 2 or 3 hours (around the
clock) to maintain a consistent eye pressure.
This could lead to other health complications,
making doctors more hesitant to recommend
it. There is also a fear that glaucoma sufferers,
without first consulting a doctor, might choose
to self-medicate due to the belief that it cant
hurt. Marijuana does help ease the pain, but
glaucoma is a progressive disease with no
cure. Without a doctors supervision, those
who choose to self-medicate can harm the
results of tests that could detect or track the
progression of the disease.
High blood pressure is often a complication
of Type 2 diabetes and, although medical
marijuana does lower blood pressure, it also
briefly elevates heart rate after smoking. As a
result, marijuana isnt recommended for those
with pre-existing heart conditions. However,
studies have shown that prolonged marijuana
users have a tolerance for these side-effects
and have suffered no adverse effects of the
briefly quickened heart rates.
Peripheral vascular disease is caused by

atherosclerosis the process in which fatty


material builds up inside the arteries over
time. This fatty material hardens as it mixes
with calcium, scar tissue, and other materials,
creating plaque on the arterial walls. This
plaque can inhibit or completely block blood
flow through the arteries. People with high
blood sugar levels caused by diabetes can
have narrow, weak blood vessels, in addition to
accelerated fat levels in the blood, and higher
blood pressure which dramatically affects the
rate of developing atherosclerosis. All of this
exponentially increases the chance of angina,
heart attacks, and strokes.
Medical marijuana isnt recommended for
sufferers of peripheral vascular disease.
Although studies have shown that medical
marijuana can significantly decrease angina,
it can also cause acute coronary events. The
increased heart rate, combined with the
combustion inhalation of smoke, is thought to
be one of the main reasons for the possible
coronary complications and the lack of doctor
recommendation. This has begun a debate of
the use of synthetic cannabinoids, like Sativex
and Marinol, versus hemp oil and vaporized
medical marijuana.
Having
received
Drug
Enforcement
Administration approval of both synthetics,
Sativex is approved by several countries as
a treatment for pain and nausea of cancer
patients. Marinol has been approved by the U.S.
FoodandDrugAdministrationasananti-nausea
solution for people with AIDS. Both synthetics
have more severe side-effects than medical
marijuana; thus, controversy exists about
whether their use is as effective as vaporized
medical marijuana or hemp oil. Neither Sativex
nor Marinol have been studied for peripheral
vascular disease or diabetes control.
There are many unknowns about the effects
of medical marijuana for diabetes prevention
and control, and studies are becoming
harder to fund as the controversy of legality
in the U.S. continues. With mid-term elections
approaching, politicians seem to be wary
of openly supporting legalized marijuana or
studies for its various capabilities. However,
research has already shown medical
marijuana to be effective in treating not only
diabetes, but also some, if not all, of its possible
complications.
References
Penner, E.A. et al. (2013). The Impact of Marijuana Use on
Glucose, Insulin, and Insulin Resistance among US Adults. The
American Journal of Medicine, Volume 126 , Issue 7 , 583
589.
Ellis R.J., et al. (2009). Smoked medicinal cannabis for
neuropathic pain in HIV: a randomized, crossover clinical
trial. Neuropsychopharmacol 2009; 34(3): 672-80.
Dr. Nicola Davies is a psychologist and writer with a passion
for writing on psychology and health-related matters. You can
follow her on Twitter (@healthpsychuk) or sign up to her free
blog: http://healthpsychologyconsultancy.wordpress.com/

31

34

35

MEDICAL CORNER:

STUDY SAYS CANNABIS

TREATS RHEUMATOID ARTHRITIS

420INSIGHT.COM
CONTRIBUTOR

flowers are used to make the marijuana


drugcontain up to 35 percent (E)-BCP.

shows that the anti-inflammatory effects are


mediated via the CB2 receptor, Gertsch said.

A new study published by the National Institute of Health has found that cannabinoid
receptoractivationsomethingdonenaturally
by cannabis may provide a treatment
for rheumatoid arthritis. Rheumatoid
arthritis is a long-term disease that causes
inflammation of the joints and tissues.

But even after decades of cannabis


research, scientists hadnt previously known
that the compound had anti-inflammatory
properties. This is because the focus was
on the classical cannabinoids [rather than (E)BCP], said lead study author Jrg Gertsch
of the Swiss Federal Institute of Technology.

Drug Building Block?

Recent
studies
have
suggested
immunomodulatory and anti-inflammatory
effects of cannabinoid receptor 2 (CB2R)
activation, states the studys abstract.
Despite these recent studies, researchers
say that the connection between these
cannabinoid receptors and rheumatoid
arthritis has been much less observed,
leading them to conduct this study. According
to their researchers, data suggests that
CB2R may be a potential therapeutic target
of RA [rheumatoid arthritis].

Lone Receptor

The study will appear in the Oxford journal


Rheumatology. and was conducted by
researchers at Changhai Hospital, the
Second Military Medical University and
Shanghai Guanghua Hospital, all in China.

36

Marijuana supporters have long argued


that the plants active ingredients, known
as cannabinoids, are safe and effective
treatments for pain, nausea, and other
ailments. The most active cannabinoid
delta-9-tetrahydrocannabinol, or THCis
known to have anti-inflammatory properties.
But it is also responsible for the plants
psychotropic effects. Now researchers
say that another cannabinoid, called betacaryophyllene, or (E)-BCP, helps combat
inflammation without affecting the brain.
(E)-BCP is already part of many peoples
daily diets, the researchers note. Foods
that are particularly high in the compound
include black pepper, oregano, basil, lime,
cinnamon, carrots, and celery. Essential oils
from cannabis plantswhose leaves and

Cannabinoids in marijuana are known to


primarily affect two of the many molecular
receptors in the human body. The CB1
receptor is found in the brain and central
nervous system and is responsible for the
high people experience when they smoke pot.
The other receptor, called CB2, is found in
tissues in the rest of the body and triggers
a cascade of biochemical reactions that can
help combat inflammation. Our interest is
to exploit the pharmacological nature of the
CB2 receptor, because it does not have
psychotropic side effects, Gertsch explained
in an email.
Targeting the CB2 receptor could be a
therapeutic strategy to prevent or treat
diseases like Crohns disease [inflammation
of the intestinal tract], liver cirrhosis,
osteoarthritis, and atherosclerosis. THC
activates both receptors, so it wont alleviate
inflammation without also making people
high. But (E)-BCP affects only the CB2
receptor, according to the new study, which
appears in todays issue of the Proceedings
of the National Academy of Sciences. As part
of their research, the scientists engineered a
strain of mice that lacked the CB2 receptor.
The team then fed the modified mice and
normal mice a diet rich in (E)-BCP. When
the scientists induced inflammation with
chemicals, normal mice experienced an
anti-inflammatory effect while the genetically
engineered mice did not. This experiment

Stephen Safe, director of the Texas A&M


Universitys Center for Environmental and
Genetic Medicine, said he is impressed by
the teams results both in mouse cells and in
live mice. They did a good study, said Safe,
who was not involved in the research.
He also noted that a lot of other studies have
been finding that fat-soluble chemicals from
plants activate many receptors in the body.
A lot of these [come from plants that] have
been used in traditional medicine, he said.
This is another example of thatbut a bit of
a sexy one. In this case, he noted, Gertschs
team has identified some petty good
activators of the CB2 receptor. Can they be
further developed and modified into better
anti-inflammatory drugs? he asked. Maybe.
[(E)-BCP] could be a new model [compound]
for drug design.
MedlinePlus, the National Library of
Medicines online Medical Encyclopedia,
stated as of May 15, 2006:
Arthritis is inflammation of one or more
joints, which results in pain, swelling, and
limited movement.
Osteoarthritis is a common type of arthritis
characterized by a gradual loss of cartilage
from the joints. Although osteoarthritis can
affect almost any joint, it most often affects
the hands, knees, hips, and spine. Common
symptoms include pain, stiffness, some loss
of joint motion, and changes in the shape of
affected joints.
Rheumatoid arthritis is a chronic
autoimmune disease, mainly characterized
by inflammation of the lining, or synovium,
of the joints. It can lead to long-term joint
damage, resulting in chronic pain, loss of
function and disability
37

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CUMULUS CANDIES
BEST WASHINGTON EDIBLE

YUMMI KARMA
BEST SAUCE LINE
BEST SAVORY EDIBLE
BEST GLYCERIN INFUSED EDIBLE

MADE IN POTLAND
BEST OREGON EDIBLE

38

SENSI PRODUCTS
BEST SLEEP AID

GREEN TICKET BAKERY


INCREDIBLES
BEST HASH INFUSED EDIBLE
BEST MILK CHOCOLATE
BEST SATIVA EDIBLE
WHOLE PLANT CBD: BEST EDIBLE

MISS MARY JANES


EDIBLES
BEST BROWNIE
PEOPLES CHOICE: EDIBLE

EDIBLES R US
BEST BEEF JERKY
BEST SALAD DRESSING
39

LAZY MAES
EDIBLES
BEST COOKIE

CHOICE REMEDY
BEST COCONUT OIL EDIBLE

SOMETHING EDIBLE, LLC


BEST CHOCOLATE TRUFFLE

GETRITE MEDS
BEST GUMMY
CANDY
KOZY HOUSE
SNACKS
BEST NUTS
STONED OVEN
BEST PIZZA

MADAME MUNCHIE
BEST GOURMET
INFUSIONS
BEST CAKE POP

GARDEN OF
WEEDEN
BEST DRIED FRUIT

SNOWPUFFS
MICROWAVE
POPCORN
MOST INNOVATIVE

ANGELS HOMEMADE
MEDIBLE EDIBLES
BEST RAW EDIBLE
REMEDY PLUS
BEST CO2
INFUSED EDIBLE

40

TO WHOM IT MAY
CHOCOLATES
BEST PACKAGING
BEST LOW DOSE EDIBLE

MONA LISA EDIBLES BY


THE HIPPIE LOUNGE
BEST VEGGIE OIL EDIBLE
JULIES NATURAL
EDIBLES
BEST GRANOLA

HEAVENLY SWEET
MEDIBLES
BEST SUGAR-FREE

AUNTIE EMS
EDIBLE COMPANY
BEST CAKE/CUPCAKE
SO KIND
BEST CANNA
BUTTER EDIBLE

AVEDICA
NUTRACEUTICALS, INC.
BEST VEGAN

LEKAS CANDYS
BEST HYBRID
EDIBLE

THE 420 KITCHEN


BEST HARD CANDY

HEALTHY HIGH
BEST ICE CREAM

STOKES CONFECTIONS
BEST MINT

TROKIE
BEST LOZENGE

MONDO, CO.
BEST BACON
MOTHER
NATURES REMEDY
CANNATELLA
BEST SPREAD

TRANSCENDENTAL
MINTS
BEST TAFFY

LEAF OF LOLLIES
BEST BRITTLE

THE MUFFIN MAN


BEST GLUTEN-FREE

DISCREET CAPS
BEST CAPSULE

CA HAPPY ROOTS
BEST CARAMEL
JILLY JANES
TRIPLE7BAKERY
BEST CEREAL BAR

STRICTLY EDIBLES
BEST DOUGHNUTS
HIGHEST POTENCY

JOLLY MEDS
BEST HONEY

VARAVO
BEST WHITE CHOCOLATE

MOONMANS
MISTRESS
BEST HEALTHY EDIBLE

VEDA BALM
WHOLE PLANT CBD:
BEST TOPICAL

INCREDIMEDS BY
THE GREEN CROSS
BEST CHOCOLATE BAR

CBD ZONE
HEMP CBD:
BEST EDIBLE

INFUSED
EDIBLES
BEST TAKE-N-BAKE
CBD ZONE
HEMP CBD:
BEST PET LINE

GEMM FARMS
HEMP CBD:
BEST TOPICAL

GEMM FARMS
BEST SYRUP
41

ZEN POTION
BEST TEA

TRIKOM TREATS
BEST COCONUT OIL

HOUSE OF JANE
BEST COCOA

SPRIG
BEST SODA

CHEF NUHA
BEST OLIVE OIL

JAYDENS JUICE
PEOPLES CHOICE:
WHOLE PLANT CBD

PC EXTRACTS
PIRATE GOLD
NUGGETS
BEST CAVIAR

BUTTER BABY
BEST CANNABUTTER

MARQAHA
BEST TINCTURE

GANJA GRINDZ
COFFEE COMPANY
BEST COFFEE

EARTH RESEARCH LABS


HEMP CBD: BEST TINCTURE

AQUABLITZED
BEST WATER

TREAT WELL
WHOLE PLANT CBD:
BEST PET LINE

APOTHECANNA
BEST TOPICAL
BEST LOTION

MARYS MEDICINALS
BEST TRANSDERMAL
PATCH
42

ALTERED STATES
BY DANK
GRASSHOPPER
BEST CO2
CONCENTRATE

CARE BY DESIGN
WHOLE PLANT CBD:
BEST TINCTURE

MARYS MEDICINALS
BEST LIP BALM
PEOPLES CHOICE:
TOPICALS

INCREDIBLE MEDIBLES
BEST BATH BOMB
PURE ORGANICS
VAPES: BEST INDICA
KUSHY VAPES
VAPES: BEST
DISPOSABLE

CORNERSTONE
RESEARCH
COLLECTIVE
BEST WHOLE
PLANT CBD
CONCENTRATE

FORIA
BEST FEMALE
LUBRICANT

LOVE & LIGHT


BAKERYS
DRAGON BALM
BEST SALVE

ZASP
BEST JUICE
DANK TANK
VAPES: BEST HEMP CBD

BETTER BRANDS
BEST SKIN
CARE LINE

MACKENZIES
MEDICINALS
BEST TOPICAL
TINCTURE

DANK TANK
VAPES: BEST PORTABLE
VAPORIZER

CANNAVEST
PEPLES CHOICE:
BEST HEMP CBD

DANK TANK
VAPES: BEST
HYBRID

VARAVO
VAPES: BEST SATIVA ABSOLUTEXTRACTS
VAPES: BEST FLAVOR
VAPES: HIGHEST
PEOPLES CHOICE: VAPE
POTENCY

43

MEXICO ISSUES FIRST PERMIT

world news:

TO GROW AND USE MARIJUANA

B. LE GRAND
EDITOR-IN-CHIEF
MEXICO CITY -- The Mexican
government granted the first
permits to allow growing and
the possession of marijuana for
personal use last month.
The
governments
medical
protection agency said the permits
will apply only to the four plaintiffs
who won a November 2015
Supreme Court ruling.

RAW

TYPE OF EDIBLES: Cake Pops, Truffles, Brownie


Bites, Whoopie Pies, Cookies

TYPE OF EDIBLES: Olive Oil, Caramel Popcorn,


Brownies, Cookies, Crispy Treats, Cheez Its,
Pretzels, Empanadas RAW
STRAIN USED: Indica, Sativa ,Hybrid

YUMMI KARMA

TYPE OF EDIBLES: Sauces, Salad Dressings,


RAWTopicals
Infused Potato Chips, Body Butter,
STRAIN USED: Indica

STRAIN USED: Indica, CBD, Hybrid or Mix

EDIBLES MADE WITH: All Natural Extra


Virgin Canna Olive Oil

EDIBLES MADE WITH: CO2 Extract

TESTS FOR POTENCY: Yes

EDIBLES MADE WITH: Canna Olive Oil,


Alochol Based Tincture, Co2 Concentrate

TESTS FOR POTENCY: Yes

DOSAGE AVAILABLE: Varies per Product

TESTS FOR POTENCY: Yes

DOSAGES AVAILABLE: Varies per Product

NUTRITIONAL FACTS AVAILABLE: Yes

DOSAGES AVAILABLE: 50mg-200mg

MOST POPULAR IN: Southern California

MOST POPULAR IN: Southern California

AVAILABLE IN: California

www.MissMaryJanesEdibles.com
Facebook.com/Miss-Mary-Janes-Edibles
Twitter.com/MaryJaneBakes
Instagram.com/MissMaryJanesEdibles

www.GBMagooch.com
Twitter.com/GBMaGooch
Instagram.com/GoodiesbyMagooch

www.YummiKarma.com
Twitter.com/YummiKarma
Facebook.com/YummiKarma
Instagram.com/YummiKarma

E D I B L E S

x NON-GMO
CBD

The court ruled that growing and


consuming marijuana is covered
The permits do not allow the sale under the right of free development
or distribution of marijuana. The of personality.
courts ruling does not imply a
general legalization. But if the court President Enrique Pena Nieto has
rules the same way on five similar repeatedly stated that he opposes
petitions, it would then establish the legalization of marijuana, as do a
precedent to change the law and majority of Mexicans surveyed in
recent polls.
allow general recreational use.

GOODIES BY MAGOOCH

GMO

Dozens of people have since filed


similar appeals to get such permits.

C A

miSS MARY JANES

The permits wont allow smoking


marijuana in the presence of
children or anyone who hasnt given
consent.

45
45

x NON-GMO
CBD

HEAVENLY SWEET

JILLY janes

Something chocolate

zasp CO.

GMO

TYPE OF EDIBLES: Peanut Budders, Chill Pills,


Slam cakes, Caramel Chocolate Bombs,
Smorezzz, Nuggets, CBD Soda
STRAIN USED: Sativa, Indica, Hybrid, CBD
EDIBLES MADE WITH: CannaButter,
Other Extract, Kief Extract
TESTS FOR POTENCY: Yes
DOSAGE AVAILABLE: Varies by Product
NUTRITIONAL FACTS AVAILABLE: Yes

MOST POPULAR IN: California

varavo

CBD
TYPE OF EDIBLES: Strain Specific Baked Goods,
Cupcakes, Brownies, Crispy Treats, Hilbilly Hash
Tea, Cookies, Granola,
RAW Peanut Butter Cups RAW
STRAIN USED: Sativa, Indica,
Hybrid, CBD
RAW
EDIBLES MADE WITH: Canna Coconut Oil
Alcohol & Glycerin Based Tinctures, Hash Infusion
TESTS FOR POTENCY: Yes
DOSAGES AVAILABLE: 16mg - 648mg
NUTRITIONAL FACTS AVAILABLE: Yes

MOST POPULAR IN: California


www.GreenTicketBakery.com
Facebook.com/GreenTicketBakery
Twitter.com/GreenTicketBky
Instagram.com/GreenTicketBakery_

infusions

TYPE OF EDIBLES: 125+ variety of Gourmet


edibles: brownies, lemon bars, cereals, ice
creams, Potsicles, Squookies, Munchies, frozenRAW
pizzas, crispy bars, butter and spreads, sugar- RAW
RAW
free and gluten-free options.
STRAIN USED: Hybrid Strain or Mix

STRAIN USED: Indica, Sativa, Hybrid, CBD


EDIBLES MADE WITH: C02 Concentrate
TESTS FOR POTENCY: Yes

TEST FOR POTENCY: Yes


DOSAGE AVAILABLE: 200mg - 700mg

DOSAGES AVAILABLE: Varies by Product

NUTRITIONAL FACTS AVAILABLE: Yes

MOST POPULAR IN: Southern California

MOST POPULAR IN: California

www.Varavo.com

infusions215@gmail.com

TYPE OF EDIBLES: Cereal Bars

TYPE OF EDIBLES: Chocolate truffles, bars and


confections with each box inspired by music

TYPE OF EDIBLES: Cannabis Infused Drinks

STRAIN USED: Hybrid Strain or Mix

RAW
STRAIN USED: Hybrid or
Mix

STRAIN USED: Indica, Sativa, Hybrid, CBD

EDIBLES MADE WITH: CO2 Extract

EDIBLES MADE WITH: CannaButter

EDIBLES MADE WITH: C02 Extract, Other

TESTS FOR POTENCY: Yes

TESTS FOR POTENCY: Yes

TESTS FOR POTENCY: Yes

DOSAGE AVAILABLE: 37mg THC - 588mg THC


NUTRITIONAL FACTS AVAILABLE: Yes

DOSAGES AVAILABLE: 50mg,180mg,


360mg, 777mg

TESTS FOR POTENCY: Yes


DOSAGE AVAILABLE: 20mg/piece, 80mg/box
NUTRITIONAL FACTS AVAILABLE: Yes

NUTRITIONAL FACTS AVAILABLE: Yes

MOST POPULAR IN: Northern California

MOST POPULAR IN: Northern California

MOST POPULAR IN: California

MOST POPULAR IN: California

jillyjanestriple7bakery@gmail.com
Facebook.com/jillyjanestriple7bakery
Instagram.com/jillyjanestriple7bakery

www.heavenlysweetmedibles.com
Twitter.com/heavenlysweetmedibles
Instagram.com/heavenlysweetmedibles

strictly edibles

care by design

DOSAGE AVAILABLE: Varies by Product

www.ZaspCo.com
Instagram.com/Zasp.Co
Facebook.com/ZaspCo
Twitter.com/ZaspCo

www.Something-Chocolate.com
Twitter: @SomethingChoco
Facebook: Something Chocolate
Instagram: @SomethingChoco

EDIBLES R US

MADAME MUNCHIE

x N0N-GMO

GMO

x NON-GMO

STRAIN USED: OG, Sour Diesel, Jack Herer


EDIBLES MADE WITH: CannaButter,
Canna Coconut Oil, Alochol Based
Tincture, BHO Extraction

x NON-GMO

GMO

EDIBLES MADE WITH: Canna Butter, THC


Vegetable OilCanna Coconut Milk, Other Extract

GMO

TYPE OF EDIBLES: Brownies, Hard Candies,


Caramels, Cake Pops, THC Capsules, etc.

RAW

x NON-GMO

GMO

x NON-GMO

GMO

CBD
TYPE OF EDIBLES:

RAW

1) CBD-rich Oral mouth sprays in CBD:


RAW

THC ratios of 1:1, 2:1, 4:1, 8:1, and 18:1


2) CBD:THC 2:1 disposable vape cartridge
3) CBD-rich Concentrated Oil Extract with
applicator in 18:1
and 4:1 CBD:THC
4) CBD-rich 4:1 honey straws

EDIBLES MADE WITH: Coconut oil,


Cannabis Oil
TESTS FOR POTENCY: Yes
AVAILABLE IN: California & Oregon
CBD.org
Facebook.com/CareByDesign
Instagram.com/CareByDesign
Twitter.com/CareByDesign

TYPE OF EDIBLES: Cookies, Brownies, Stuffed


Brownies, Crispy RAW
Treats, Truffles, Peanut Butter
Cups, Snack Cakes, Mini Donuts

RAW

RAW

STRAIN USED: Hybrid or Mix


EDIBLES MADE WITH: CannaButter
TESTS FOR POTENCY: Yes
DOSAGES AVAILABLE: 100 mg - 1500 mg THC
NUTRITIONAL FACTS AVAILABLE: Yes

MOST POPULAR IN: Northern California


www.strictlyediblescollection.com
Twitter.com/strictlyedibles
Facebook.com/strictlyedibles
Instagram.com/strictlyedibles

TYPE OF EDIBLES: Artisanal Cannabis Macarons


STRAIN USED: Hybrid
EDIBLES MADE WITH: Clarified Cannabutter
TEST FOR POTENCY: Yes

RAW

DOSAGE AVAILABLE: 20mg per macaron 100mg per box of 5


NUTRITIONAL FACTS AVAILABLE: Yes
MOST POPULAR IN: California
www.MadameMunchie.com
Facebook.com/MadameMunchieEdibles
Instagram.com/MadameMunchie

E D I B L E S

E D I B L E S

www.LazyMaesEdibles.com
Facebook.com/LazyMaes
Twitter.com/LazyMaes
Instagram.com/LazyMaesEdibles

TYPE OF EDIBLES: Chocolate Chunks


and Vape Cartridges

46

green ticket bakery

C A L I F O R N I A

C A L I F O R N I A

lazy maes edibles

TYPE OF EDIBLES: Gourmet Edibles,


Granola, Peanut Butter, Ranch Dressing,
Ketchup, BBQ Sauce, Hot Sauce, Chicken
& Waffles available at Ktown Collective
STRAIN USED: Hybrid Strain or Mix
EDIBLES MADE WITH: Cannabis Flowers
TESTS FOR POTENCY: Yes
DOSAGES: Varies by Product
NUTRITIONAL FACTS AVAILABLE: Yes
AVAILABLE IN: California

www.EdiblesRUs.org

47

BUTTER BABY

MOONMANS MISTRESS

THE 420 KITCHEN

x NON-GMO

GMO

TYPE OF EDIBLES: cookie, brownie,cakes, crispy,


gummy bears, fruit rolls, candy, popcorn, pixie
sticks, beef jerky

RAW GMO
x

RAW

CBD

NON-GMO
RAW

TYPE OF EDIBLES: High Potency Fruit Chews

TYPE OF EDIBLES: 20+ Baked Treats!!


Pastries Cookies Breads Brownies,
Cannabis Infused Coconut Oil

STRAIN USED: Indica, Sativa, Hybrid

STRAIN USED: Hybrid Strain or Mix

TYPE OF EDIBLES: Canna Butter,Brownies,


cookies,cakes

TYPE OF EDIBLES: Baked Goods, Cookies,


Mini Cakes

STRAIN USED: Indica Strain, Hybrid Strain or Mix


EDIBLES MADE WITH: Canna Coconut Oil

STRAIN USED: Hybrid Strain or Mix RAW


EDIBLES MADE WITH: Canna Coconut Oil

TESTS FOR POTENCY: Yes

TESTS FOR POTENCY: Yes

TESTS FOR POTENCY: Yes

EDIBLES MADE WITH: CO2 Extract

DOSAGE AVAILABLE: 20mg

DOSAGE AVAILABLE: Varies per Product

DOSAGE AVAILABLE: 20mg

TESTS FOR POTENCY: Yes

DOSAGE AVAILABLE: 60mg, 80mg, 200mg

DOSAGE AVAILABLE: 100mg - 110mg

NUTRITIONAL FACTS AVAILABLE: Yes

NUTRITIONAL FACTS AVAILABLE: Yes

NUTRITIONAL FACTS AVAILABLE: Yes

DOSAGES AVAILABLE: Varies per Product

NUTRITIONAL FACTS AVAILABLE: Yes

NUTRITIONAL FACTS AVAILABLE: Yes

MOST POPULAR IN: California

MOST POPULAR IN: California

MOST POPULAR IN: Northern California

MOST POPULAR IN: Southern California

MOST POPULAR IN: Southern California

MOST POPULAR IN: Southern California

STRAIN USED: Indica, Sativa

RAW

EDIBLES MADE WITH: Alochol Based Tincture,


Glycerin Based Tincture, BHO Extraction

sexy eds

Igotbutterbaby.com
Twitter: Igotbutterbaby
Instagram: Igotbutterbaby
Facebook.com: Butter Baby

INFUSED EDIBLES

STRAIN USED: Indica, Sativa, Hybrid or Mix

www.MoonmansMistress.com
Twitter.com/Moon_mans
Facebook.com/ MoonmansMistress
Instagram.com/MoonmansMistress

stokes CONFECTIONS

EDIBLES MADE WITH: Canna Oil

RAW

TESTS FOR POTENCY: Yes

RAW

www.TrikomTreats.com
Facebook.com/trikomtreats
Twitter.com/trikomtreats
Instagram.com/trikom_treats

jolly meds

remedy plus

CBD
x NON-GMO

x N0N-GMO

GMO

GMO

CBD

TYPE OF EDIBLES: Gluten Free, Grain Free,


Starch Free, Organic,
RAWPaleo, Raw, Vegan,
Healthy Gourmet Edibles

TYPE OF EDIBLES: Sour Candy, fruits, nuts,


trail mix, brownie mix, cake mix, sugar-free,
RAW
gluten-free

TYPE OF EDIBLES: 5mg Sugar Free Micros (pack

STRAIN USED: Hybrid Strain or Mix

STRAIN USED:
Indica, Sativa ,Hybrid, CBD
RAW

STRAIN USED: Indica, Sativa ,Hybrid, CBD

EDIBLES MADE WITH: Other Extract

EDIBLES MADE WITH: Different


concentrates used for different products

EDIBLES MADE WITH: Ethanol, Other Extract

EDIBLES MADE WITH: Co2 Oil

TEST FOR POTENCY: Yes

TESTS FOR POTENCY: Yes


DOSAGES AVAILABLE: 50mg per 4
(200mg Total)

TESTS FOR POTENCY: Yes

TEST FOR POTENCY: Yes

DOSAGES AVAILABLE: Varies by Product

DOSAGE AVAILABLE: 150mg & 300mg

DOSAGE AVAILABLE: 5mg Mircros


& 20mg Truffles

NUTRITIONAL FACTS AVAILABLE: Yes

NUTRITIONAL FACTS AVAILABLE: Yes

NUTRITIONAL FACTS AVAILABLE: Yes

MOST POPULAR IN: California

POPULAR IN: California

POPULAR IN: California

Instagram.com/sexy_eds

www.InfusedEdible.org
Instagram.com/InfusedEdible

www.getstokes.com
Twitter.com/GetStokes215
Instagram: @getstokes215
Facebook: Stokes-Confections

x NON-GMO

GMO

TYPE OF EDIBLES: Baked goods, cookies,


cupcakes, brownies

of 20 or 50). 20mg Gluten-Free Truffles. Filled with


delicious ganaches, caramel, and peanut butter.

EDIBLES MADE WITH: Canna Coconut Oil


TESTS FOR POTENCY: Yes

KushyPunch.com
Instagram.com/KushyPunch
Facebook.com/KushyPunch
Twitter.com/Kushypunch

www.the420kitchen.com

dhamma edibles

RAW

RAW

RAW

STRAIN USED: Hybrid or Mix

RAW
RAW RAW

RAW

RAW

TYPE OF EDIBLES: Medicate Lozenges,


RAW

TYPE OF EDIBLES: Gummy Candy, South of the


border Candies, Medicated Powdered Drink
STRAIN USED: Hybrid

RAW

RAWHard Candies and Syrups


RAW
RAW
STRAIN USED: Indica, Sativa, Hybrid, CBD
EDIBLES MADE WITH: Bud & Trim

EDIBLES MADE WITH: THC Oil Tincture

TESTS FOR POTENCY: Yes

TESTS FOR POTENCY: Yes

DOSAGES AVAILABLE: Varies by Product

NUTRITIONAL FACTS AVAILABLE: Yes

DOSAGES AVAILABLE: 150mg, 300mg

NUTRITIONAL FACTS AVAILABLE: Yes

MOST POPULAR IN: California

MOST POPULAR IN: California

MOST POPULAR IN: California

jake@dhammaca.com
Instagram: @Dhammaedibles

E D I B L E S

E D I B L E S

www.strangetherapysolutions.com
Instagram: @strange710

TYPE OF EDIBLES: Cookies,


RAWfudge, hard candies,
jollies, suckers,
sugar
RAW free hard candies

CBD

48

trikom treats

Kushy PUnch

C A L I F O R N I A

C A L I F O R N I A

GETRITE MEDIBLES

CustomerService.RemedyPlus@gmail.com
Instagram.com/RemedyPlus
Twitter.com/RemedyPlusCandy

www.JollyMeds.com
Facebook.com/Jolly.Lolly
Twitter.com/JollyMeds
Instagram.com/JollysWizard

49

CBD

x NON-GMO

GMO

TYPE OF EDIBLES: Pizza & Ice Cream


STRAINS USED: Indica Strain, Strain or Mix
EDIBLES MADE WITH: Other extract
TESTS FOR POTENCY: Yes

TYPE OF EDIBLES: Chocolate Caramels

RAW

STRAIN USED: Sativa, Indica, Hybrid, CBD


EDIBLES MADE WITH: Canna Oil

RAW

TESTS FOR POTENCY: Yes

TYPE OF EDIBLES: Chocolate, Gummies,


MiniBrownie Bites, Breakfast Bars,
Hard Candy, Capsules, CannaButter,
Peanut Butter and LiquidRAW
Caramel RAW
STRAIN USED: Hybrid, Sativa, Indica,
CBD or Mix
EDIBLES MADE WITH: Hash Oil
TESTS FOR POTENCY: Yes

DOSAGES AVAILABLE: Varies per product

DOSAGES AVAILABLE: 100mg in 4 - 25mg


doses and 200mg in 4 - 50mg doses

NUTRITIONAL FACTS AVAILABLE: Yes

NUTRITIONAL FACTS AVAILABLE: Yes

NUTRITIONAL FACTS AVAILABLE: Yes

MOST POPULAR IN: Southern California

MOST POPULAR IN: California

MOST POPULAR IN: California

www.SensiProducts.com
Facebook.com/SensiProducts
Info@SensiHerbalCare.com

c a

CANNATOPICS

t o p i c a l s

TYPE OF PRODUCT: Pain Salve,


Massage Oil, Sport Massage Oil,
Body Lotion, Hash Bath, Lip Balm,
Skin Products, Topical Tincture,
First Aid Ointment

APOTHECANNA

xRAW
NON-GMO

GMO

CBD

DOSAGES: Varies per Product

.DankGrasshopper.com
Facebook.com/DankGrasshopper
Twitter.com/DankGrasshopper
IG: @DankGrasshopperMedibles

mary janes

TYPE OF PRODUCT: All Natural


Cannabis Infused Pain Salve
& Topical Products
STRAIN USED: Hybrid, CBD
MADE WITH: Canna Grapeseed Oil
RECOMMENDED FOR: Physical Pain,
Arthritis, Skin conditions like Psoriasis
or Eczema, Carpal Tunnel, Tendonitis,
rashes, burns or scrapes

STRAIN USED: Hybrid

TYPE OF PRODUCT: Topicals

MADE WITH: Canna Olive Oil

STRAIN USED: CBD Strain,RAW


Hybrid Strain/Mix

TEST FOR POTENCY: Yes

MADE WITH: Hash Oil

DOSAGES AVAILABLE: Varies per Product

TEST FOR POTENCY: Yes

NUTRITIONAL FACTS AVAILABLE: Yes

ADDITIONAL INFORMATION: 1:1 THC:CBD

salve, lip balm, topical tincture, hemp


bath, massage oil, topical tincture

MOST POPULAR IN: California

MOST POPULAR IN: California

AVAILABLE IN: Colorado & California

www.CannaTopics.com
Facebook.com/CannaTopics
Instagram.com/CannaTopics
Twitter.com/CannaTopics

www.apothecanna.com
Twitter.com/apothecanna
Instagram: @apothecanna
Facebook.com/apothecanna

RAW
PRODUCTS: 0.5oz, 1oz, 2oz, 4oz

MaryJanesMedicinals.com
Twitter.com/ MaryJanes.Medicinals
Facebook.com/MaryJanes.Medicinals

22k vape pens

K
T

pure vape

absolute xtracts

O - K

TYPE OF VAPORIZER: Auto Draw


T

x NON-GMO
CBD

O - K

GMO

CARTRIDGE SOLD SEPARATE: Yes


DISPOSABLE CARTRIDGE: Yes

O - K

RAW

TYPE OF VAPORIZER: Portable


Vape Pen, with Cartridges
CARTRIDGE SOLD SEPARATE: Yes
DISPOSABLE CARTRIDGE: Yes
STRAIN USED: Hybrid, Indica, Sativa
MADE WITH: Concentrate
TESTS FOR POTENCY: Yes
DOSAGES: 74% THC, 500mg
MOST POPULAR IN: California
TwentyTwoKPens@gmail.com
Instagram.com/twenty_two_k_

cbd zone

TYPE OF VAPORIZER: Personal Vaporizer Pen


with Pre-Filled Cartridge
CARTRIDGE SOLD SEPARATE: Yes
DISPOSABLE CARTRIDGE: Yes
STRAIN USED: Sativa, Indica,
Hybrid - Strain Strain Specific

STRAIN USED: Hybrid, Indica, Sativa,


RAW
Strain Specific (Grape Stomper,
Blackberry
Kush, Cherry Pie, OG Kush, Sour Diesel,
Green Dragon, Girl Scout Cookie,
Chem Dawg, Blue Dream, Blue Jay Way)
THREADING: Yes
HEAT SETTINGS: Yes

MADE WITH: Co2 Oil

MADE WITH: Concentrate

TESTS FOR POTENCY: Yes

TESTS FOR POTENCY: Yes

DOSAGES AVAILABLE: 500mg, 1,000mg

DOSAGES AVAILABLE: 500mg THC

AVAILABLE IN: California

AVAILABLE IN: California & Oregon

Instagram.com/purevape55

bluebird botanicals

www.AbsoluteXtracts.com
Instagram.com/AbsoluteXtracts
Facebook.com/AbsoluteXtracts
Twitter.com/AbsoluteExtracts

CANNAVEST

RAW

RAW

x NON-GMO
CBD

GMO

TYPES OF EDIBLES: CBD Oils, Caps

TYPES OF EDIBLES: CBD Oils, Tinctures

TYPES OF EDIBLES: CBD Oils, Caps RAW

STRAIN USED: CBD

STRAIN USED: CBD

STRAIN USED: Sativa, Indica, CBD, Hybrid

MADE WITH: Other Extract

MADE WITH: Other Extract

MADE WITH: Other Extract

TESTS FOR POTENCY: Yes

TESTS FOR POTENCY: Yes

TESTS FOR POTENCY: Yes

DOSAGES: Varies by Product

DOSAGES: Varies by Product

DOSAGES: Varies by Product

AVAILABLE: Nationwide

AVAILABLE: Nationwide

AVAILABLE: Nationwide

www.cbdzone.com

www.bluebird-botanicals.com

www.CannaVest.com
Twitter.com/CannaVestCorp
Facebook.com/CannaVest
Inststagram.com/CannaVest_

c a Va p e s / o i l s ca Hemp

E D I B L E S

x NON-GMO

GMO

stonedoven.blogspot.com
Facebook: Stoned Oven Pizza

50

dank grasshopper

sensi chews

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C a E D I B L E S
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C A

stoned oven pizza

RAW

51

52

www.kushism.com
Instagram: @kushismvannuys
Facebook.com/kushism
Twitter: @KushismVanNuys

Total Herbal Consultation


3 SoCal Locations Open Daily:
5985 Topanga Canyon #B,
Woodland Hills, CA, 9am-6:30pm,
19825 Ventura Blvd., 10am-4:30pm,
4942 Vineland Ave. 9am-7:30pm,
Phone: (818) 888.7162
About: At Total Herbal Consultation,
our licensed physicians are dedicated
to spending time with you to evaluate
your medical history and perform a
comprehensive physical exam. Our
consulting services are provided in
compliance with prop.215 and sb420,
health and safety code section11362.5.
Our physician and his team are more
than qualified to provide the highest
quality MMJ recommendations for you.
Specials: $10 OFF patient coupons
available, Veterans receive $10 OFF
Cost: Renewal - $50, New Patients - $70
North Hollywood Location - $40, $60
www.DR420.com

Shop Name: Green Soldiers Healers


Location: LOS ANGELES COUNTY
DELIVERY SERVICE ONLY
Phone Number: (310) 500-7419
Hours: 9am - 8pm Daily
DISCOUNT FOR VETERANS
Menu Includes:
Flowers
Edibles
Drinks
Topicals
Tinctures
Concentrates
Pre-Rolls
Pet Products
www.greensoldhere.com
Instagram: @gshdelivery
Facebook.comGreen Soldiers Healers
Twitter: @gshdelivery

COAST TO COAST

Shop Name: Coast to Coast Collective


Address: 7127 Canoga Ave,
Canoga Park, CA 91303
Phone Number: (818) 712-0535
Hours: 10am - 8pm Daily
Menu Includes:
Flowers
Edibles
Drinks
Topicals
Tinctures
Concentrates
Website: www.c2cmeds.com
IG: @coast2coastcollective
FB:/CoastToCoastCollective
Twitter: @c2cMeds

AMEC 420

ECMM

American Medical Evaluation Centers


Address: 20830 S. Vermont Ave.

Torrance, CA 90502
Phone: (310) 320.4420
Hours: Monday-Saturday 1pm-7pm

Closed Sundays
About: American Medical is the specialty
medical marijuana office in the Southbay
area since 2010. Our center has
physicians specialized in various fields
and trained to expertly evaluate patients
for medical marijuana. Patients look to us
for medical guidance and legal defense.
Our doctors, recognized as experts in the
field of medical marijuana by the California
District Attorneys office.
Specials: Veterans get recommendations
for $25 with valid documentation
Cost: Renewal - $40, New Patients - $60

ECMM
Address: 13347 W Washington Blvd,

Ste A, Culver City, CA 90066
Phone: (424) 835-4137
Hours: Sun.-Mon. 10:00am-6:00pm

Tues.-Sat. 9:30am-7:30pm
About: At ECMM, our purpose is to
provide our patients the medical marijuana
verification they need. Our medical
marijuana evaluation center is doctorowned and -operated, allowing us to give
you the thorough evaluation required for a
legitimate medical marijuana card. Started
in 2009, our medical clinic is run by a group
of CA licensed holistic and alternative
medicine physicians that believe in the
scientific evidence for the use of medical
marijuana. We take legal compliance very
seriously in order to ensure your continued
access to the treatment you require and
our knowledgeable staff will be happy to
answer any questions you may have about
our services. Come visit our cannabis
evaluation clinic to get a legitimate, safe
medical marijuana evaluation in Venice.
Cost/Specials: Call for More Information

www.Amec420.com

www.ECMMvenice.com
www.facebook.com/ecmm
www.instagram.com/ecmmvenice
www.twitter.com/ecmmvenice

c a 4 2 0 d O C s

c a 4 2 0 d O C s

THC DOCTORS

Shop Name: Kushism


Address: 7555 Woodley Ave,
Lake Balboa, CA 91406
Phone Number: (818) 994-3446
Hours: 10am - 8pm Daily
Menu Includes:
Flowers
Edibles
Drinks
Topicals
Tinctures
Concentrates
Clones
Pre-Rolls
Seeds
Tinctures
Wax

GREEN SOLDIERS HEALERS

CA collectives

CA collectives

kushism

C O LO R A D O
55

meDIBLE rECIPES:

Tokin Texas Toast Apple Bake


Ingredients

Instructions

Stoney GourmetMac N Cheese


Ingredients:

1/2 cup melted cannabutter


1 cup packed light brown sugar
1 whole loaf fresh (not frozen) Texas Toast bread
4 large eggs
3/4 cup whole milk
3/4 cup apple butter
1 tsp vanilla extract
2 granny smith apples
(or apples of your choosing, peeled and diced
2 tbsp light brown sugar mixed with 3 tsp cinnamon
Powdered sugar for sprinkling
Maple syrup for serving

4 cups (1 quart) heavy cream


3 tbsp. fresh Rosemary, chopped
2 tsp salt
2 tsp of cracked pepper
1/2 lb Applewood smoked bacon,
diced & drained
1 lb of penne pasta.
6 oz Gruyre, Mozzarella, Aged White
Cheddar & Habanero Cheddar for heat
1/2 cup cannabutter
Instructions:

In a bowl, mix the melted cannabutter and brown sugar, stir until well mixed. Grease a 9x13 pan and pour melted half the
cannabutter in pan evenly. In a bowl, beat together milk, eggs, apple butter and vanilla - set aside. Layer a single layer of Texas
toast bread in pan. Evenly distribute 1 cup of the egg mixture over bread, use spatula to ensure even soaking. Sprinkle brown
sugar/cinnamon mixture evenly. Then pour diced apples evenly over top the bread. Repeat with second layer of bread, melted
cannabutter, egg mixture and remaining brown sugar/cinnamon mixture. Cover tightly and chill in fridge overnight. Preheat oven
to 350F with rack in center of oven. Bake covered for 30 minutes. Uncover and bake another 10-15 minutes or until golden
brown. Let cool for 5 minutes, serve warm.

Balsamic-Blazed Baked Salmon

Cook pasta according to package


directions, then drain, reserve 3 tsp pasta
water for flavor Pre-heat oven to 350
degrees. Add heavy cream and Rosemary
into pan and bring to a simmer. Add salt
and pepper while it simmers. Bring to a
boil until reduced to half. Add bacon. In a
bowl mix cooked with cannabutter. Once
melted place the pasta in cream mixture.
Add cheeses and stir till fully melted. Place
in oven until top layer of cheese is golden
brown. Garnish with chopped chives. Enjoy.

Instructions:

Preheat oven to 400 degrees F. Line a


baking sheet with aluminum foil and spray
with nonstick cooking spray. Coat a small
saucepan with olive oil. Cook garlic on
medium heat until you can smell it. Mix
in white wine, cannabis honey, balsamic
vinegar, mustard and salt & pepper.
Simmer uncovered for 3 minutes until
slightly thickened. Place salmon baking
sheet and brush with Balsamic glaze and
sprinkle with oregano. Bake for 10 - 14
minutes or until flesh flakes easily with fork.
Brush fish with remaining glaze and serve.

Ingredients:

6 (5 oz) Salmon fillets


4 cloves garlic, diced
1 tbsp white wine
1 tbsp cannabis honey
1/3 cup Balsamic vinegar
4 tsp Dijon mustard
1 tbsp fresh oregano
1/2 tbsp olive oil
salt & pepper to taste

Infused Arugula, Watermelon & Feta Salad


Ingredients:

1 half small seedless watermelon, cubed


6 cups baby arugula, washed & spun dry
12 oz Feta cheese
1/4 cup red onion, thinly sliced
1/3 cup Goodies by Magooch canna olive oil
1 tbsp honey
1/3 cup Balsamic vinegar
1/2 tsp salt
1/2 tsp pepper
2 tbsp fresh mint, julienned
56

Instructions:

Wash and spin dry arugula,


set aside. In a small bowl
mix canna olive oil, Balsamic,
honey, salt and pepper until
fully mixed. Add onions,
watermelon, feta and spinach.
Pour dressing mixture over
salad and garnish with mint.
57

SCIENCE CORNER: TERPENES FOUND IN CANNABIS


420INSIGHT.COM
CONTRIBUTOR
Over 120 different types of
Terpenes, in varying amounts,
have been identified in cannabis
depending on the individual strain.
The reason for the familiar odor and
even the taste (which can vary from
plant to plant just like the scent),
are the plants terpenes. Terpenes
are a group of organic compounds
found in many plants and even
some insects. Terpenes become
Terpenoids when altered through a
process of drying, curing, or chemical
extraction. Terpenes like Limonene
can be steam distilled from the skin
of citrus fruits. Each plants unique
terpene content affects not only the
aroma and flavor, but the medicinal
qualities as well.

Linalool: (also found in lavender)


relieves anxiety and stress, is a
strong anticonvulsant and is said
to amplify serotonin receptor
transmission as well as having
antidepressant
effects;
also
reportedly effective topically to heal
tissue with reduced scarring.
Limonene: (also found in citrus,
juniper,
peppermint,
oranges,
tangerines) with an aroma of
oranges and citrus, this terpene can
aid with anxiety, depression, gastric
reflux, and heartburn issues. Even
more surprising Limonene may
even possess anti tumor properties
while benefiting the immune system.

Beta-Caryophyllene: (also found


in cloves, black pepper) is gastroprotective, treats ulcers, has
anti-inflammatory properties and
Terpenes are also found in more; said to be especially effective
vegetables, fruits, spices, herbs, because of its ability to bind to CB2
and other plants and are used in receptors.
perfumes, essential oils, aroma
therapy, to flavor food, and more. In combination with THC, CBD, and
Terpenes are a common ingredient other cannabinoids, these natural
in our diets and are safe to consume, compounds are responsible for
according to the FDA. While some the varying strain specific effects
are unique to cannabis, most of the cannabis can have on the individual.
terpenes are the same as those Some terpenes enhance the potency
found in other plants and can deliver of the THC, while others serve to
similar effects when consumed or counteract the psychoactive effect
otherwise enjoyed through aromatic of that same cannabinoid. Certain
means. There are many, but these terpenes act to facilitate the binding
are a few of the most common of cannabinoids to receptors or
found in cannabis:
allow the cannabinoids (like CBD)
to deliver a more complete effect.
Alpha-Pinene: (also found in pine, It is slowly becoming possible
rosemary, dill) found in pine trees to map the terpene content in
and orange peels this can have a plant, thus making it easier to
beneficial health effects ranging choose a strain specifically for the
from anti-inflammatory properties, effects desired by the patient. In
help with memory tasks, and acts the future, strain enthusiasts (think
as a bronchiodilator.
wine connoisseurs of the cannabis
world) suggest that proper testing
B-Myrcene: (also found in mango, could ensure patients get exactly
lemongrass, hops) this can provide the strains (specific combination of
pain relief in addition to anti- terpenes and cannabinoids) which
inflammatory properties, possible they need for whatever it is they
anti-tumor properties, help with are treating. We know now, its not
muscle spasms, and insomnia. just a matter of Indica vs. Sativa or
High levels contribute, along with hybrid (though for now this is often
the cannabinoid CBN, to the couch the most readily available indicator
lock effect.
of a strains potential effects), but a
58

whole range of differences between.


The ability to map the specifics of the
strains down to the individual terpene
is still in the beginning stages, some
labs only offering limited terpene
testing and others not really testing
for this compound yet at all. Certain
strains have been identified and
mapped for terpene content which
can be found online, but the problem
comes in knowing if the plant you
have is not only the same strain,
but has the same terpene content
as the one tested. Terpene content
is as much determined by sun, time
of day harvested, and soil content,
as by the strain type of the seed
planted.
While there isnt nearly enough
testing for these compounds
available, what is known is the
synergistic
quality
of
these
compounds when utilized together
in whole plant form. THC or CBD
alone is not enough to get the full
benefits of this amazingly diverse
plant. Terpenes and cannabinoids
combine to lend a full spectrum of
results for each patient, making a
compelling argument for utilizing the
medicine in whole plant form, rather
than those extracts sold as THC or
CBD alone. It is no wonder terpenes
are getting so much attention, it
important to understand what they
are when treating with cannabis as
medicine.
Terpenes have been taken to the
next level, cannabis concentrate
extract artists have found a
solventless way to reintroduce
terpenes like Limonene and Pinene
into their concentrates adding a
very special citrus or piney taste
and smell. This is how many of them
are winning awards at High Times
Cups and Secret Cups making their
product stand out among all other
entries. The terpenes listed as ones
found in cannabis as well as other
plants in nature are entirely legal
by themselves. You can even get
terpenes from Florida oranges to
add to your concentrates!
59

x NON-GMO

GMO

TYPE OF EDIBLES: Chocolate


Bars, Gummies, Capsules, Shatter
STRAIN USED: Hybrid
EDIBLES MADE WITH: Hash Oil
TESTS FOR POTENCY: Yes
DOSAGES: Varies by Product
MEDICAL & RECREATIONAL
www.iloveincredibles.com
Twitter.com/IncrediblesMMJ
Instagram.com/ IncrediblesMMJ

cbd zone

TYPE OF EDIBLES: Elixirs, Chocolates, Mints,


Tinctures, Topicals, Scrips, Vape Products
STRAIN USED: Hybrid or Mix
EDIBLES MADE WITH: Glycerin
Based Tincture, Co2 Concentrate
TESTS FOR POTENCY: Yes
DOSAGES: Varies by Product
NUTRITIONAL FACTS AVAILABLE: Yes
MEDICAL & RECREATIONAL
www.DixieElixirs.com
Twitter.com/DixieElixirs
Facebook.com/DixieElixirs

bluebird botanicals

TYPE OF EDIBLES: Granola Bar, Roasted


Seed Mix, Fresh Granola, Nutty Bite,
RAW Oil
CannaButter, CannaCoconut
STRAIN USED: Indica, Sativa,
Hybrid
RAW
MADE WITH: Canna Coco-Oil, CannaButter
TESTS FOR POTENCY: Yes
DOSAGE AVAILABLE: Rec: 10MG per
serving, Med: 30MG per serving
NUTRITIONAL FACTS AVAILABLE: Yes

MEDICAL & RECREATIONAL


juliesnaturaledibles.com
Twitter.com/juliesnatural
Facebook.com/JuliesNaturalEdibles
Instagram.com/JuliesNaturalEdibles

CANNAVEST

RAW

x NON-GMO
CBD

GMO

TYPES OF EDIBLES: CBD Oils, Caps

TYPES OF EDIBLES: CBD Oils, Tinctures

TYPES OF EDIBLES: CBD Oils, Caps RAW

STRAIN USED: CBD

STRAIN USED: CBD

STRAIN USED: Sativa, Indica, CBD, Hybrid

MADE WITH: Other Extract

MADE WITH: Other Extract

MADE WITH: Other Extract

TESTS FOR POTENCY: Yes

TESTS FOR POTENCY: Yes

TESTS FOR POTENCY: Yes

DOSAGES: Varies by Product

DOSAGES: Varies by Product

DOSAGES: Varies by Product

AVAILABLE: Nationwide

AVAILABLE: Nationwide

AVAILABLE: Nationwide

www.cbdzone.com

www.bluebird-botanicals.com

www.CannaVest.com
Twitter.com/CannaVestCorp
Facebook.com/CannaVest
Inststagram.com/CannaVest_

cO Hemp

cO Hemp

t o p i c a l s

60

bears, dried pasta and chocolate


bars. This super strong probiotic
bacteria can survive the initial
thermal manufacturing process
used to make the food product,
Most probiotic products begin the journey from consumption to
with fresh foods that require the intestinal tract and reproduce
refrigeration. Probiotic foods like effectively enough to provide the gut
yogurt and kefir have a short health benefits. The bacterium is
shelf life and any thermal process called Bacillus coagulans and it has
involved usually ends up killing the FDA GRAS (generally recognized as
probiotic bacteria before they are safe) status and are supported by
even consumed. For this reason numerous third party clinical studies.
there are very few probiotic or There are several companies out
fermented foods in the marijuana there that sell their proprietary
food space. Most dispensaries strains and these companies often
dont have refrigeration to store exhibit at trade shows like Supply
these products and marijuana Side (www.supplyside.com) and IFT
infused food companies dont have (www.ift.org).
the safety experience to make
and sell potentially hazardous Marijuana food products already
foods that contain dairy or require provide recreational consumers
refrigeration for safety. Thus the and medical patients with a smoke
marijuana market has so far not free delivery method of THC. These
been able to provide probiotic foods food products can now provide even
to consumers.
more healthy benefits by adding
in shelf stable probiotics that can
Lately there have been a slew of withstand processing conditions.
products on the market that are
_____________________________
shelf stable and also contain live
and active probiotics that are more
resilient than before, can withstand Rachel Zemser is a certified food
a thermal process and survive scientist. To learn more about her
in shelf stable foods like gummy visit: theintrepidculinologist.com

c a

What do kombucha, pickles, yogurt,


sauerkraut and kimchi all have in
common? They all are considered
to be probiotic foodfoods that
contain live and active bacteria
cultures that are good for you and
help maintain a healthy digestive
and immune system. Probiotic or
fermented foods are fresh foods
that have been inoculated with
yeast and lactobacillus bacteria that
break down the carbohydrates in
the system and convert it into acid
and gas. The acid provides the tangy
flavor that you find in many fermented
foods and gas provides the bubbles
found in fermented beverages. The
living bacteria in these products
populates the gut and intestines and
provide health benefits in numerous
ways like reducing abdominal pain,
inhibiting bad pathogenic bacteria
and enhancing the utilization of
consumed nutrients like protein.
The strength of ones immune
system is based on the balance
of good to bad bacteria. Probiotic
good bacteria help support this
balance enhance your bodys
natural defenses. Everyone agrees
that probiotics are good and having

functional ingredients like probiotics


listed on your food product label
provides a competitive advantage in
the food and beverage marketplace.

JULIES NATURAL EDIBLES

E D I B L E S

RACHEL ZEMSER
STAFF EDITOR

E D I B L E S

Going With Your Gut- Incorporating Probiotics


Into Your Shelf Stable Food Products

DIXIE BRANDS

C O

PROBIOTICS

C O

FOOD SCIENCE:

incredibles

RAW

61

O R E G O N

64

65

MEDICAL FEATURE:
420INSIGHT.COM
CONTRIBUTOR
Considering treating your migraine or
headache disorder with medical cannabis?
Its a complicated topic with a variety of
perspectives, so Ive tried to distill some of the
most important information below. I hope its
a helpful guide.
Marijuanas Efficacy for Migraine or
Headache Disorders
Because laws make research of medical
marijuana very difficult, there have been
no blinded studies on its use for migraine
or headache disorders. Anything you learn
about it for migraine or headache is based
on anecdote (or extrapolated from a small
amount of research on rats). Ive asked
multiple headache specialists for opinions
and have been told repeatedly that patients
are pretty much evenly split between those
who get relief and those who feel worse after
using it. My discussions with patients are
along those same lines. Its strongest track
record is with treating nausea, which can be
as debilitating as the pain for some of us.
Efficacy of Different Strains

Certified Child
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Packaging

Budtainers

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The Right Packaging Choice


for Edibles & Flowers

There are hundreds (may be even thousands)


of different cannabis strains, all cultivated to
have different effects and address different
symptoms. If the marijuana that your brothers
friends cousin got for you didnt help (or made
you feel worse), a different strain may still be
effective. You can look up many of the strains
on the internet by condition or symptom that
they treat, including migraine, nausea, anxiety
and insomnia. Leafly.com displays the most
commonly reported adverse effects of each
strain. Not all of these strains will be available
at your local dispensary, but dispensary
employees can give you recommendations
for which might be most useful for you.

CANNABIS & MIGRAINES


Rebound Headache Risk
A couple headache specialists have told me
that they dont know for sure, but believe
that marijuana has a similar risk for rebound
(medication overuse) headaches as opioids
do. Its best to follow the same rules for opioids
(no more than 10 a month) and use as little
as possible each time.
How Much to Use
There are no set guidelines for how much to
use, though starting with a very small amount
is probably wise. Watch your symptoms
carefully to see if you feel better, worse or
about the same, then decide if you want to try
more. If you smoke (or eat) too much, theres
a chance youre not actually treating the
migraine or headache, but getting so stoned
that you dont notice it very much. That may
be what youre going for, but remember that
the more you use could increase your risk of
rebound headaches.
Smoking/Vaporizing vs. Eating
The two main ways to use medical cannabis
are to smoke it or to eat it. The differences
are akin to those of oral triptans vs. injected
triptans.
Smoking gets the cannabis into your system
the fastest and you can quickly see if you need
more. Smoking anything can be harmful,
although a recent large-scale study found
cannabis to cause less lung damage than
tobacco. (Using a vaporizer has similar
advantages to smoking, but is thought to
be less potentially damaging to the lungs.
Vaporizers are expensive, so you may not
want to invest in one until you discover if
marijuana is even helpful for you.)
If you eat marijuana, it will take longer to
take effect and your digestive tract may not
process a second dose in time for it to be

effective. Gastric stasis (delayed emptying of


the stomach, which is a migraine symptom)
could also mean that you dont absorb as
much as you need when you need it. And, of
course, if you vomit during your migraines, you
may not absorb much at all.
A friend who was using Marinol (prescription
THC capsules) for chemo-induced nausea
told me its effects were highly variable.
Sometimes it did nothing, other times it helped
tremendously. It depended on how how long
it had been since shed last eaten and how
effectively her digestive tract processed the
drug that day.
Depression and Cannabis
Although depression is one of the many
conditions that cannabis is purported to treat,
some research indicates that people who use
marijuana are more likely to be depressed
than those who dont. However, this could
be coincidence rather than causation. As
the Mayo Clinic says, Marijuana use and
depression accompany each other more
often than you might expect by chance, but
theres no clear evidence that marijuana
directly causes depression.
Legality
Different states have different laws and
restrictions governing the use of medical
cannabis. Even if it is legal in your state, the
regulations may make it undesirable. (In
Arizona, for example, employers can check a
database of all registered medical marijuana
users if youre not OK with your employer
knowing that, you probably dont want to get
registered.) In your research, check both
official statutes and news articles. The official
statutes provide the legal framework, while
the news stories tell you how the law is being
implemented. Whatever the laws, its better
to investigate exactly what issues you might
encounter rather than stumbling into a mess.

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hank@hankink.com

66

5 0 3 . 8 0 6 . 6 0 67

67

68

69

70

In every cell there is a family of


interconvertible
sphingolipids
that
specifically manage the life and death
of that cell. This profile of factors is
called the Sphingolipid Rheostat.
If endogenous ceramide(a signaling
metabolite of sphingosine-1-phosphate)
is high, then cell death (apoptosis) is
imminent. If ceramide is low, the cell is
strong in its vitality.

The cancer cell dies, not because of


cytotoxic chemicals, but because of
a tiny little shift in the mitochondria.
Within most cells there is a cell nucleus,
numerous mitochondria (hundreds to
thousands), and various other organelles
in the cytoplasm. The purpose of the
mitochondria is to produce energy
(ATP) for cell use. As ceramide starts to
accumulate, turning up the Sphingolipid
Rheostat, it increases the mitochondrial
membrane pore permeability to
cytochrome c, a critical protein in energy
synthesis. Cytochrome c is pushed out
of the mitochondria, killing the source of
energy for the cell.
Ceramide also causes genotoxic stress
in the cancer cell nucleus generating
a protein called p53, whose job it is
to disrupt calcium metabolism in the
mitochondria. If this werent enough,
ceramide disrupts the cellular lysosome,
the cells digestive system that provides
nutrients for all cell functions. Ceramide,
and other sphingolipids, actively inhibit
pro-survival pathways in the cell leaving
no possibility at all of cancer cell survival.
The key to this process is the
accumulation of ceramide in the system.
This means taking therapeutic amounts
of CBD and THC, steadily, over a period
of time, keeping metabolic pressure on
this cancer cell death pathway.
How did this pathway come to be? Why
is it that the body can take a simple
plant enzyme and use it for profound
healing in many different physiological
72

systems? This endocannabinoid system


exists in all animal life, just waiting for its
matched exocannabinoid activator. This
is interesting. Our own endocannabinoid
system covers all cells and nerves; it is
the messenger of information flowing
between our immune system and the
central nervous system (CNS). It is
responsible for neuroprotection, and
micro-manages the immune system.
This is the primary control system that
maintains homeostasis; our well being.
Just out of curiosity, how does the
work get done at the cellular level,
and where does the body make the
endocannabinoids? Here we see that
endocannabinoids have their origin in
nerve cells right at the synapse. When
the body is compromised through
illness or injury it calls insistently to the
endocannabinoid system and directs
the immune system to bring healing.
If these homeostatic systems are
weakened, it should be no surprise that
exocannabinoids are therapeutic. It
helps the body in the most natural way
possible.
To see how this works we visualize the
cannabinoid as a three dimensional
molecule, where one part of the
molecule is configured to fit the nerve or
immune cell receptor site just like a key
in a lock. There are at least two types of
cannabinoid receptor sites, CB1 (CNS)
and CB2 (immune). In general CB1
activates the CNS messaging system,
and CB2 activates the immune system,
but its much more complex than this.
Both THC and anandamide activate
both receptor sites. Other cannabinoids
activate one or the other receptor
sites. Among the strains of Cannabis, C.
sativa tends toward the CB1 receptor,
and C. indica tends toward CB2. So
sativa is more neuroactive, and indica
is more immunoactive. Another factor
here is that sativa is dominated by THC
cannabinoids, and indica is predominately
CBD (cannabidiol).
It is known that THC and CBD are
biomimetic to anandamide, that is, the
body can use both interchangeably.
Thus, when stress, injury, or illness
demand more from endogenous
anandamide than can be produced by
the body, its mimetic exocannabinoids
are activated. If the stress is transitory,
then the treatment can be transitory.
If the demand is sustained, such as in
cancer, then treatment needs to provide
sustained pressure of the modulating
agent on the homeostatic systems.
Typically CBD gravitates to the densely
packed CB2 receptors in the spleen,
home to the bodys immune system. From

there, immune cells seek out and destroy


cancer cells. Interestingly, it has been
shown that THC and CBD cannabinoids
have the ability to kill cancer cells
directly without going through immune
intermediaries. THC and CBD hijack
the lipoxygenase pathway to directly
inhibit tumor growth. As a side note, it
has been discovered that CBD inhibits
anandamide reuptake. Here we see
that cannabidiol helps the body preserve
its own natural endocannabinoid by
inhibiting the enzyme that breaks down
anandamide.

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7014509_origThis brief survey touches


lightly on a few essential concepts.
Mostly I would like to leave you with an
appreciation that nature has designed
the perfect medicine that fits exactly with
our own immune system of receptors
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Bibliography
1. http://cancerres.aacrjournals.org/content/65/5/1635.
abstract
Sami Sarfaraz, Farrukh Afaq, Vaqar M. Adhami, and Hasan
Mukhtar + Author Affiliations. Department of Dermatology,
University of Wisconsin, Madison, Wisconsin

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2. http://www.ncbi.nlm.nih.gov/sites/pubmed
J Neuroimmunol. 2007 Mar;184(1-2):127-35. Epub 2006 Dec
28.
Immune control by endocannabinoids new mechanisms of
neuroprotection? Ullrich O,Merker K, Timm J, Tauber S. Institute
of Immunology, Medical Faculty, Otto-von-Guericke-University
Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
oliver.ullrich@medizine.uni-magdeburg.de

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CBD.org
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GEMM FARMS

3. http://en.wikipedia.org/wiki/Endocannabinoid_system
Endocannabinoid synthesis & release.
4. http://en.wikipedia.org/wiki/Cannabinoids
Cannabinoid receptor type 1.
5.
http://www3.interscience.wiley.com/
journal/121381780/abstract?CRETRY=1&SRETRY=0
Journal of Neurochemistry, Volume 104 Issue 4, Pages 1091
1100 Published Online: 18 Aug 2008
6.
http://leavesofgrass.info/info/Non-PsychoactiveCannabinoids.pdf
Non-psychotropic plant cannabinoids: new therapeutic
opportunities from an ancient herb.
Angelo A. Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di
Marzo, and Raphael Mechoulam. Department of Experimental
Pharmacology, University of Naples Federico II, Naples, Italy.
Institute of Biomolecular Chemistry, National Research
Council, Pozzuoli (NA), Italy. Department of Medicinal Chemistry
and Natural Products, Hebrew University Medical Faculty,
Jerusalem, Israel, Endocannabinoid Research Group, Italy
7. http://sciencenews.org/view/feature/id/59872/title/
Not_just_a_high
Scientists test medicinal marijuana against MS, inflammation
and cancer
By Nathan Seppa June 19th, 2010; Vol.177 #13 (p. 16)
8.
http://www.ncbi.nlm.nih.gov/pmc/articles/
PMC1766198/
NIH Public Access:
A house divided: ceramide, sphingosine, and sphingosine-1phosphate in programmed cell death
Tarek A. Taha, Thomas D. Mullen, and Lina M. Obeid
Division of General Internal Medicine, Ralph H. Johnson Veterans
Administration Hospital, Charleston, South Carolina 29401; and
Department of Medicine, Medical University of South Carolina,
Charleston, South Carolina 29425
Corresponding author: Lina M. Obeid, M.D., Department of
Medicine, Medical University of South Carolina, 114 Doughty
St., P.O.Box 250779, Charleston, South Carolina 29425. E-mail:
obeidl@musc.edu
9. Yap WN, Chang PN, Han HY, et al. (December 2008).
Gamma-tocotrienol suppresses prostate cancer cell
proliferation and invasion through multiple-signalling pathways.
British Journal of Cancer 99 (11): 183241.doi:10.1038/
sj.bjc.6604763. PMID 19002171.
10.Ellagitannin-rich pomegranate extract inhibits angiogenesis
in prostate cancer in vitro and in vivo. Int J Oncol. 2008
Feb;32(2):475-80.
Sartippour MR, Seeram NP, Rao JY, Moro A, Harris DM,
Henning SM, Firouzi A, Rettig MB,Aronson WJ, Pantuck AJ,
Heber D.
Center for Human Nutrition, Los Angeles, CA 90095-1742,
USA.

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Very simply, when THC connects to the


CB1 or CB2 cannabinoid receptor site
on the cancer cell, it causes an increase
in ceramide synthesis which drives
cell death. A normal healthy cell does
not produce ceramide in the presence
of THC, thus is not affected by the
cannabinoid.

TO KILL CANCER CELLS

care by design

ANGELS MEDIBLES

E D I B L E

420INSIGHT.COM
CONTRIBUTOR
First lets look at what keeps cancer cells
alive, then we will come back and examine
how the cannabinoids CBD (cannabidiol)
and THC (tetrahydrocannabinol) unravels
cancers aliveness.

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Untitled-2 1

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76

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A biochemist, Raphael Mechoulam


was born in 1930 in Sofia, Bulgaria,
where his father was a physician in

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Va p e s

In the film it shows us that through


Dr. Mechoulams research and
documentation
the
remarkable
success of cannabis therapy. With so
much convincing data it paved the way
for the health officials in Israel to propose
the worlds largest state-sponsored
medical cannabis program. At this
time Doctor Raphael Mechoulam is
heralded as The Grandfather of
Cannabis Research.

cannabis. We know that many films


and documentaries have messages,
but Zach Klein had a quest and goal
to demystify the use of cannabis within
the human body and share what was
being done in Israel with the world.
His heartfelt storytelling interjected
with, cartoon, amination, sweet quirky
love story of Mechoulam and his wife
Dahlia, brings a lifelong passion to the
audience with purpose and meaning.
Part of the film takes place in the
Following World War II, the Mechoulams simple, homey Jerusalem apartment
immigrated to Israel. After a stint as where the Mechoulams reside since
a land surveyor, Mechoulam spent 1966, as well as the infamous lab
three years in the Israeli Army, at Hebrew University, where the
which had him doing research on discoveries took place at. Impromptu
insecticides. He received his doctoral rides in his seemly gas efferent car to
degree from Hebrew University on and from work, and at a meeting of
the topic of natural products related to the International Canabinoid Research
biological problems. After doing post- Society transcend the film to a down
doctoral research at the Rockefeller to earth presentation that is to some
Institute in New York, Mechoulam earth shattering!
took a position at the Weizmann
Institute in Rehovot, which is where To some reading this review, I could be
he and Gaoni (another important preaching to the choir and to others this
scientist) isolated the compounds could be pushing their buttons. So for
in hashish. Mechoulam joined the myself and cohorts from the pulpits, we
Hebrew University faculty in 1966. may be feeling the rejoicing coming to
the surface as the light at the end of the
In how he first decided to focus on tunnel of prohibition is near. The birth
cannabis research, it seems it was a of awareness that was kept quiet for
chance of convenience. Mechoulam too long as those suffered unmercifully
was directed to choose a topic not maybe coming to an end with The
already being pursued by any major Scientist. Many of us know the true
research groups and at that time benefits as well as the possibilities for
no one wanted to tackle the benefits the future and if you have the chance
of cannabis. He first identified the to view the film please take the time to
chemical structure of CBD and THC watch and hopefully share with others
(cannabidiol and tetrahydrocannabinol) the truth and message.
in 1963 and 1964, respectively.
The next monumental break-through This is documentary filmmaking to be
came in 1988 where The Scientist inspired by, congratulations to Zach
found that the human brains and Klein, Klinik Productions and to Dr.
bodies have specific receptors for Raphael Mechoulam for a story well
cannabis molecules. Amazing that our told. If you have the opportunity view this
bodies have the capabilities to make film may the visuals of cinema continue
our own cannabis internally! The next to expand your horizons in mind, heart
step was to begin the connection for and spirit.
human-generated cannabis molecules, __
and in 1992 the first was revealed:
anandamide, regulator of the immune Keiko Beatie is a Cannabis Holistic
and nervous systems.
Health Practitioner, Producer, Director
and Chef. She works with Hemp Radio
This is a major film to come out that and is the o-Founder of the US Weed
has the possibilities to transform Channel.
the general publics perception of

wa

Dr. Mechoulans spirit and humanistic


personality comes across within the
film while staying on the path of factual
data and unrelenting focus of the true
benefits of cannabis and the effect
in the human body. In the 1960s
Raphael was led by a passion to
continue for half a century experiments
and breakdowns of the compounds
that make up the endocannabinoid
elements of the cannabis plant. We
learn was it respected centuries ago
as a medicinal relief, only to have it be
revolted within the past century time
line. Those of us have experienced,
that the plant would be vilified in most
every nation on earth, starting in the
1930s, only now to finally start to be
recognized once again as having active
compounds that would be revered as
true icon of medicine in this present day.

private practice and also head of the


Jewish Hospital. Raphael was a child
during the war and when anti-Jewish
laws were enacted and the family
moved to a series of small villages
where a doctor was needed and
respected. The family did eventually
find themselves in a concentration
camp and were released after young
Mechoulam father assisted in saving
people from a fire within the camp.

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Siddhitonics

E D I B L E S

KEIKO BEATIE
STAFF EDITOR
Recently in Las Vegas, Nevada at the
informative Marijuana Daily Business
Show, the new film The Scientist,
directed by Zack Klein and produced
by Klein and Klinik Productions was
premiered. The dynamic documentary
shares the story of Doctor Raphael
Mechoulam and his decades of
research on cannabis and its healing
properties. I was fortunate to view the
film and then meet and spend time with
the director, Zack Klein and his journey
on creating this fascinating and inspiring
film. The Scientist brings to the
forefront the first factual knowledge of
scientific aspects of endocannabinoids,
cannabis and medical science.

wa

CANNABIS FILM REVIEW:

THE SCIENTIST THE DOCTOR


RAPHAEL MECHOULAM STORY

StatelyDuckApothecary.com

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