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Cell membrane and

Transport Across Membrane
Mitra Handini

Functions of Cell Membrane

Shape
Barrier
Exchange
Intercellular communication

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Structure
Lipid bilayer
Protein
Integral protein (transmembrane)
Peripheral protein

Cholesterol
Fluidity
Structural integrity and flexible (ability to change shape)

Fluid mosaic model

Mosaic pattern of protein embedded in lipid bilayer

Carbohydrate
self-recognition processes and cells interactions

Structure

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Membrane Transport

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Diffusion

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Transport through channel

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Highly selective

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Carrier-Mediated Transport
Slower than movement through channel
(5000 particles vs 5 million ions/second)
Specificity
Saturation
Competition
2 different substances compete for one transport protein

Saturation

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Facilitated diffusion of glucose into cells

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Primary Active Trasport

Uphill movement
(against concentration
gradient)
ATP is required

Primary active transport : Na-K pump

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Na-K pump step by step

Secondary Active Transport

Cotransport
Na-Glucose
Na-Amino acid

Countertransport
Na-Ca
Na-H

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Primary and Secondary Transport

Contransport

Countertransport

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Vesicular Transport

Endocytosis
3 types:
Pinocytosis
Phagocytosis
Receptor-mediated endocytosis

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Endocytosis & exocytosis

Receptor-mediated endocytosis and exocytosis

Epithelial transport
Paracellular
Transcellular

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Transepithelial transport

Transepithelial transport of glucose

Trancytosis

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Osmosis

Osmotic pressure

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Osmotic pressure of the cytosol = interstitial fluid

Thank You

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