Potassium Insulin Regulation

Yunita Wannur Azah

Postgraduate Biomedical Science

Faculty Of Medicine
University Sumatera Utara
2016

Potassium is important why?

Potassium is a mineral that is essential for the function
of all our cells, tissues and organs in our body.

Substances associated with the electrical charges in the

body, along with sodium, chloride, calcium and
magnesium.
Potassium also helps muscle contraction, fluid balance
and maintain the heart rate.
Cogswell et al, Sodium and Potassium Intake Among US Adult, 2012, 96(3):647-57

Potassium Function
Some hormonal factors may play a role in potassium
homeostasis hormones including insulin
Participates in many metabolic processes, e.g. regulation
of protein and glycogen synthesis

Maintance osmotic and acid base balance between intra

and extra cell
Maintain resting membrane potential (RMP) of cellular
membrane
Cogswell et al, Sodium and Potassium Intake Among US Adult, 2012, 96(3):647-57

Insulin Secretion by Cell Pancreatic

Insulin secretion by cells depend by three
main factors:
Blood glucose levels
ATP-sensitive K channels
Voltage-sensitive Calcium

Nepton S, Beta Cell Function and Failure, Type 1 Diabetic ,2013

In the resting cell with normal

ATP levels, potassium diffuses
follow concentration gradients
through the canal Potassium_ATP
If the glucose level increases,
increased production of ATP, ATP
will close the potassium channels,
which causes cell depolarization
Frances M. Ashcroft, The Journal of Clinical Investigation, Volume 115, Number 8 August 2005

Beta Cell Biology Consorium,2004

Frances M. Ashcroft, The Journal of Clinical Investigation, Volume 115, Number 8 August 2005

Disfunction of insulin regulation

due to mutation

Frances M. Ashcroft, The Journal of Clinical Investigation, Volume 115, Number 8 August 2005