DAFTAR ISI

Halaman Judul...............................................................................................i
Lembar Pengesahan.....................................................................................ii
Kata Pengantar..............................................................................................iii
Abstrak.......................................................................................................... v
Abstract......................................................................................................... vi
Daftar Isi........................................................................................................ vii
Daftar Gambar...xii
Daftar Tabel...................................................................................................xiii
Daftar Lampiran.xiv

BAB 1 PENDAHULUAN............................................................................... 1
1.1
1.2
1.3
1.4

Latar Belakang................................................................................... 1
Rumusan Masalah............................................................................. 3
Tujuan Penelitian................................................................................ 3
1.3.1 Tujuan Penelitian umum............................................................ 3
1.3.2 Tujuan Penelitian Khusus.......................................................... 4
Manfaat Penelitian............................................................................. 4
1.4.1 Manfaat Akademis..................................................................... 4
1.4.2 Manfaat Praktis ........................................................................ 4

BAB 2 TINJAUAN PUSTAKA....................................................................... 5

2.1

Kacang Kedelai..................................................................................
2.1.1 Pendahuluan..........................................................................
2.1.2 Taksonomi..............................................................................
2.1.3
Kandungan Kedelai ............................................................

2.2

Susu Kedelai...................................................................................... 9

2.3

Fitoestrogen dan Isoflavon................................................................... 10

2.3.1
2.3.2

5
5
7
8

Fitoestrogen............................................................................ 10
Isoflavon................................................................................. 11

2.4

Sistem Endokrin................................................................................. 13

2.5

Endocrine Disrupter............................................................................ 14

2.6

Apoptosis sel...................................................................................... 15
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2.7

Testosterone....................................................................................... 16

2.8

Vesika Seminalis................................................................................ 16

2.9

Pengaruh fitoestrogen pada sistem reproduksi pria........................... 19

BAB 3 KERANGKA KONSEP DAN HIPOTESIS PENELITIAN.................... 21

3.1 Kerangka Konsep.......................................................................................... 21
3.2
Uraian Konsep................................................................................... 22
3.3
Hipotesis Penelitian............................................................................ 23
BAB 4 METODE PENELITIAN...................................................................... 24
4.1 Desain Penelitian............................................................................... 24
4.2 Populasi dan Sampel Penelitian......................................................... 24
4.2.1 Populasi..................................................................................... 24
4.2.2 Sampel...................................................................................... 24
4.2.3 Perkiraan Banyak Sampel......................................................... 24
4.2.4 Karakteristik Sampel.................................................................. 25
4.3 Identifikasi Variabel............................................................................ 25
4.3.1 Variabel Tergantung................................................................ 25
4.3.2 Variabel Bebas....................................................................... 25
4.4 Lokasi dan Waktu Penelitian.............................................................. 25
4.4.1 Lokasi Penelitian.................................................................... 25
4.4.2 Waktu Penelitian.................................................................... 25
4.5 Alat dan Bahan................................................................................... 25
4.5.1. Susu Kedelai.......................................................................... 25
4.5.2. Persiapan Diet Normal........................................................... 26
4.5.3. Pembedahan dan Persiapan Slide Histopatologis.................. 26
4.5.4. Pemeliharaan Tikus................................................................ 26
4.6 Definisi Operasional........................................................................... 26
4.7 Prosedur Penelitian............................................................................ 26
4.7.1 Persiapan Susu Kedelai......................................................... 26
4.7.2 Persiapan Tikus Wistar .......................................................... 27
4.7.3 Pemberian Susu Kedelai ....................................................... 27
4.7.4 Pembedahan Tikus WIstar..................................................... 28
4.7.5 Persiapan Slide Histopatologis Tikus ..................................... 28
4.7.6 Penilaian Slide Histopatologis Vesika Seminalis.................... 29
4.8 Pengolahan dan Analisis Data........................................................... 29
4.9 Alur Penelitian.................................................................................... 30
BAB 5 HASIL PENELITIAN DAN ANALISIS DATA...................................... 32
5.1
Hasil Penelitian.................................................................................. 32
5.2
Analisis Data...................................................................................... 33
5.2.1 Uji Asumsi Data......................................................................... 34
5.2.1.1 Uji Normalitas Data........................................................ 34

5.2.1.2 Uji Homogenitas Data.................................................... 35

5.2.2 Uji ANOVA................................................................................. 35
5.2.3 Uji Post Hoc Tukey.................................................................... 35
5.2.4 Uji Korelasi Pearson dan Regresi Linier.................................... 36

BAB 6 PEMBAHASAN................................................................................. 37

BAB 7 Kesimpulan dan Saran..................................................................... 39

7.1 Kesimpulan........................................................................................ 39
7.2 Saran................................................................................................. 39
Daftar Pustaka.............................................................................................. 40
Lampiran...................................................................................................... 42
Pernyataan Keaslian Tulisan....................................................................... 48

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DAFTAR GAMBAR

Gambar 2.1

Tanaman Kedelai dan Biji Kedelai...............................................6

Gambar 2.2

Kedelai........................................................................................7

Gambar 2.3

Histologis Vesika Seminalis .......................................................18

Gambar 2.4

Vesika Seminalis.........................................................................18

Gambar 2.5

Organ Reproduksi Pria................................................................19

Gambar 3.1

Kerangka Konsep....................................................................... 21

Gambar 5.1

Gambar Histopatologi Kontrol......................................................32

Gambar 5.2

Gambar Histopatologi P1.............................................................33

Gambar 5.3

Gambar Histopatologi P2.............................................................33

Gambar 5.4

Gambar Histopatologi P3.............................................................34

Gambar 5.5

Grafik Rata-rata Perbandingan Jumlah sel Nukleus Abnormal dan

Normal Vesika Seminalis.............................................................35

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DAFTAR TABEL

Tabel 2.1

Komposisi Kedelai per 100 gram bahan...................................... 8

Tabel 5.1

Rata-rata Perbandingan Jumlah sel Nukleus Abormal dan Normal

Vesika Seminalis.........................................................................33

Tabel 5.2

Data Hasil Transformasi Log 10..................................................34

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DAFTAR LAMPIRAN

Lampiran 1

Hasil Uji Asumsi Data..................................................................42

Lampiran 2

Hasil Uji Parametrik.....................................................................43

Lampiran 3

Hasil Uji Korelasi dan Regresi.....................................................44

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