Drug Information Center RVS/SVCOP Query on: 17.08.

2015
Chittoor 517127 A.P

Answered on: 17.08.2015

Query: Treatment of streptococcal induced endocarditis?

Query from : Hari mam
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Name: 12GT1T0026

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Dept. of Pharmacy Practice, RVS Hospital, RVS Nagar, Chittoor (dt)

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Drug Information Center RVS/SVCOP Query on: 17.08.2015

Chittoor 517127 A.P

Answered on: 17.08.2015

Answer:
Treatment of Endocarditis Caused by Penicillin-Sensitive Streptococci:
ANTIBIOTIC
Penicillin G
Ceftriaxone
Ceftriaxone plus gentamicin

DOSAGE REGIMEN
DURATION (Weeks)
12-18 MU IV q24h
4
2g IV q24h
4
2g IV q24h
2
1mg/kg IV q8h
Vancomycin
1g IV q12h.c
4
The penicillins, often in combination with gentamicin, remain the cornerstones of
therapy for endocarditis caused by penicillin-susceptible streptococci. For penicillin-allergic
patients, vancomycin is substituted. IV ceftriaxone, given once daily for 4 weeks, is another
option, and even a 2-week course in combination with gentamicin.

Treatment of Endocarditis Caused by Penicillin-Insensitive Streptococci:

ANTIBIOTIC
Penicillin G or ceftriaxone plus
gentamicin

Vancomycin

DOSAGE REGIMEN
4 MU IV q4h

DURATION (Weeks)
4-6

2g IV q24h

4-6

1mg/kg IV/IM q8h

1g IV q12h

2
4-6

penicillin-insensitive streptococci, the penicillin dosage is higher and duration of therapy

is 2 weeks. Gentamicin is given for the first 2 weeks; both penicillin and gentamicin are given
for 6 weeks. Patients who are penicillin-allergic, should receive vancomycin.

ANSWERED BY: GOWTHAMI.V

REFERENCE: www.clevelandclinicmeded.com

Dept. of Pharmacy Practice, RVS Hospital, RVS Nagar, Chittoor (dt)

E-mail:
Phone:.
Disclaimer: This is a confidential message, please discard or return it if you
are not the intended recipient. It is highly advisable to refer other standard
drug information resources for more complete or specific answers.

Drug Information Center RVS/SVCOP Query on: 17.08.2015

Chittoor 517127 A.P

Answered on: 17.08.2015

Dept. of Pharmacy Practice, RVS Hospital, RVS Nagar, Chittoor (dt)

E-mail:
Phone:.
Disclaimer: This is a confidential message, please discard or return it if you
are not the intended recipient. It is highly advisable to refer other standard
drug information resources for more complete or specific answers.