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HLA-DR3,HLA-DR2,

Kadar EstrogenHLA-B8,HLA-B7,HLA-DQA0102
& progesterone yang
HLA-A2
tinggi
Kadar prolaktin yg ting

Kadar anti-DNA titer


Rasio
CD4/CD8
Jumlah
B-Cell yg meninggalkan sumsum t
Jumlah self-reaktif limfosit

Mempercepat autoimun d

Faktor Lingkungan

Paparan Radiasi UVB berulang

Rokok

Lipogenic aromaticT amine


Infeksi -virus (Sindbis, rubella, cytomegalovirus)
Cell DNA hipometilantion

Memindahkan
autoantigen mediator
(Ro/SS-A, related
Release berlebihan
imun autoantigen, La/SS-B, calretikulin) didalam epidermal keratinosit ke permukaan sel

Induced realese CCL27

Aktivasi T-Cell, IFN-, serta produksi DCs

Keratinosit Apoptosis
Induced ekspresi cell surface (Ro/SS-A)

Virus-induced apoptosis

Keratinosit Apoptosis

Gambar 2 Bagan Patofisiologi CDLE

Drug