OVERVIEW

CELLULAR AND
MOLECULAR
NUTRITION
DEPARTEMEN GIZI MASYARAKAT
FEMA IPB

WHY CELLULAR AND MOLECULAR

NUTRITION?

DEFINITION
Science concerned with the effect of nutrients and

foods/food components on whole body physiology

and health status at a molecular and cellular level.
molecular mechanisms underlying human health
and disease offers a great potential for promoting
health, and lowering mortality and morbidity, and
includes the science of nutrigenomics
(Norheim et al. 2012).

MOLECULAR AND CELLULLAR EFFECT OF

VIT E
Angelo Azzis group (1991) first described nonantioxidant, cell signaling

functions for vitamin E, demonstrating that vitamin E regulate protein

kinase C activity in smooth muscle cells.
At the transcriptional level, vitamin E modulates the expression of the
hepatic a-tocopherol transfer protein (TTP)
as well as the expression collagenase gene and a-tropomyosin gene
a tocopherol-dependent transcription factor (tocopherol associated
protein,TAP) has been discovered.
In cultured cells, t vitamin E inhibits inflammation, cell adhesion, platelet
aggregation, and smooth muscle cell proliferation.

 Rimbach et al. (2005).

DIET - PHENOTYPE

EXPERIMENTAL VS NON-EXPERIMENTAL STUDIES

DESKRIPSI MK GIZI SELLULER DAN

MOLEKULER
Membahas sel sebagai unit fungsional terkecil tubuh

manusia, komunikasi inter dan antar sel, regulasi hormon

dan enzim, mekanisme transpor, metabolisme di tingkat
seluler, replikasi, transkripsi serta ekspresi gen yang
dipengaruhi oleh peran molekul zat gizi.
Mata kuliah ini juga membahas teknik penelitian dan
prinsip pengukuran di tingkat seluler dan molekuler
beserta contoh aplikasinya.

PUSTAKA
Norheim et al. 2012. Review: Molecular Nutrition ResearchThe

Modern Way Of Performing Nutritional Science. Nutrients : 2012 (4),

1898-1944; doi:10.3390/nu4121898.
Advanced Nutrition and Human Metabolism, fourth Edition,

Gropper/Smith/Groff, Thompson-Wadsworth, 2005.

Understanding Nutrition, Ninth Edition, Whitney/Rolfes, Wadsworth,

2002