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Atypical fibroxanthoma

(AFX)

Deba P Sarma, MD
Omaha
F 49, right chest lesion. On
immunosuppresive therapy.
CK 1/3: Negative
S-100: Negative
SMA: Negative
CD 68: Positive
Ki67: High proliferative activity
The ulcerated, raised spindle cell tumor is composed of
pleomorphic spindle cells positive for CD68, but negative for CK AE
1/3, A-100, MART-1 and SMA.

Ki 67 stain shows high proliferative activity.

AFX is considered a superficial variant of malignant fibrous


histiocytoma (MFH) with favorabe prognosis than that of a deep soft
tissue MFH.

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