EFFECT OF MYCOTOXIN IN

ANIMAL HEALTH &

PRODUCTION
ITS
PREVENTION AND
TREATMENT
Dr.Kedar Karki
 MYCOTOXI COSIS

• MANIFESTATION OF
MYCOTOXIN POISONING

• ACUTE CAUSE OF POOR

ANIMAL PERFORMENCE.
CHRONIC SUBCLINICAL MYCO
TOXIN
• INCREASED DISEASE
SUSCEPTABILITY
• POORPERMENCE
• DIRECT EFFECTION ANIMAL
• INDIRECT EFFECT OF
IMMUNE SYSTEM.
 CONT.

• MOLD AND MYCOTOXIN

• WIDELY DISTRIBUTED IN NATURE.

• SUFFICIENT ORGANIC MATTER.

• WATER, TEMPERATURE TO
REPRODUCE.
 CONTD:
• LARGE VOLUME OF FEED STUFF
STORED
• CONSIDEREBLE OPPERTUNITY FOR
FUNGAL GROWTH.
• FUNGUS CAN PRODUCE MYCOTOXIN
WHEN IN UNDER STREESS.
• MYCOTOXIN INGESTED IN LARGE
VOLUME SINGLE DOSE.
 CONTD:

• SMALL QUANTITY OVER

LONG PERIOS.
• ADVERS EFFECT ON
• PRODUCTIVE CAPACITY
• REPRODUCTIVE EFFECIENCY
• HEALTH OF ANIMAL
 IS THERE A PROBLEM ?
• DIFFICULT TO MAKE
DIAGNOSIS OF MYCOTOXI
COSIS.
• SEVERAL GENERAL SYMPTOMS.
• SYMPTOMATIC TO OTHER
PROBLEM.
 CONTD.
• CONSUMPTION OF LESS DRY
MATTER
• SYMPTOM OF AFLATIOOXIN OR
OTHER MYCOTOXIN.
• MORE INTAKE THAN PRODUCTION
WARRANTS
• INDICATES
 CONTE.
• DON DIXYNIVALENOL OR
ZERALENONE.
• HIGH INCIDENCE OF DIGESTIVE
UPSET.
• DIARRHEA, IMPACTIONS.
RUMENSTASIS.
• LOT OF MUCUS IN DUNG.
• SYMPTOMATIC OF ALL MYCOTOXIN.
 CONTE..
• HIGH INCIDENCE OF DISEASE
ASSOCIATED
• DEPRESSED IMMUNE SYSTEMS. Eg.
H.S.
• TISSUE EDEMA GENERELIZED.
• BRISKET AND HOCK AREAS.
• SWOLLING AND SLOUGHING OF
SKIN
• TAIL, ABOVE CORONET. EAR TIPS,
NOZZLE
• INDICATES MYCOTOXIN
ASSOCIATED WITH
• MYCOTOXIN WITH FUSARIUMTYPE.
• HIGH RESORPTION RATE

• SHORT HEATS

• NYMPHOMANIA

• INDICATE ZERALENONE
CONTAMINATION
• GENERAL UNTHRIFTYNESS
APPEARENCE.

• LOWER MILK PRODUCTION

• ROUGH HAIR COAT

• SAD APPEARENCE
• SLIGHTLY ARCH BACK
• DONOT RESPONDS TO RATIONAL
TREATMENT
• SUGGESTIVE OF POOR MANAGEMENT
• GENERAL CONSIDERATION
• FOR FUNGUS GROWTH TO OCCURE.
• FOURCONDITION MUST EXISTS.
• AN ADEQUATE FOOD SOURCE.
• TEMP BETWEEN 31-34o c
• FUNGUS PRODUCES MYCOTOXIN.
• IN RESPONSE TO STRESS.
• FUNGUS DONOT BE ABLE TO
PRODUCE MYCOTOXIN.
• SUBJECTEDTO FREEZING
TEMPERATUE.
• MOISTURE DEPRIVATION.
• MYCOTOXIN PROBLEM MORE
PRONOUNCED.
• CROPS GROWING UNDER COOL
MOIST CONDITION.
• UNDER DROUGHT STRESSED
CONDITION.
• DIRECT PROPOTION TO DURATION
OF STRESS.
• 400 MYCOTOXIN BUT
UNIDENTIFIED.
• PURE MYCOTOXIN LITTLE IMPACT.
• CONJUGATION OF GROOP OF
MYCOTOXIN.
• DEVASTATING EFFECT. ON
• HEALTH AND PRODUCTIVITY.
 SYMPTOMS
• POOR MILK PRODUCTION.

• POOR FEED CONSUMPTION.

• POOR VODY CONDITION.

• DIARRHEA.
• QUANTITIS OF MUCOUS IN
DUNG

• ANESTRUS
• POOR REPROSUCTIVE
PERFORMENCE
• ABORTION
• DRYING ND SLOUGHING OF TAIL AT
MANE REGEION.
• SWELLING, CRACKING,SLOUGH OF
KIN OBOVE HOOF
• DRYING, SLOUGHINY CURLING OF
EARTIPS.
• DRYING AND LOUGHING OF
MUZZOL.
• HIGH DISEASE INCIDENCE

• GENERAL LETHARGY.

• INDICATES EITHER POOR VET.

OR MANAGER.
• ACCUMULATE IN LIVER.
• LIVER TOXICOSIS.
• INCREASE LIVER ENZYMES.
• SGOT (SERUM GLUTAMIC ACIL
OXALTE TRANSAMINASE).

• LDH (LACTICDEHYDROGENASE).
• INCREASD SERUMCHOLESTROL
LEVEL

• DECREASED WHITE CELL COUNT.

• ELASTIN – ELASTASE

• COLAGENE – COLA GENASE.

• HEPATIC CARCINOMA

• SPLEENO MEGALY.

• LUNG EMPHYSOEMA.

• TOXIC TO RUMEN BACTARIA.

• MALABSORPTION OF NUTRIENT.

• EXCESSIVE MUCOUS PRODUCTION.

• TISSUE EROSION.

• HEMORHAGE
• TISSUE NECROSIS
• INITIAL IWCREASE OF LYMHOCYTE,
NUTRPHIL, MONOCYTE
• AFTER THIRD WEEK LYMHICTE TEND TO
DECLINE
• OTHER TWO CELL CONTINEW TO
INCREASE
• INDICATE THE CHRONICITY OF DISEASE.
 TESTING:
• ALL FEED CONTAINS SOME MYCOTOXINS.

• NATURAL SITUATION

• 5 PPB OF ZEAR LENONE WHY TO WORRY

• 50 PPB – 100 PPB IS DANGEROUS.

 SAMPLING OF FEED AND
FORAGE:
• FROM BEGINNING

• MIDDLE

• END

• ABSENCE OF ONE MYCOTOXIN DOSE NOT

MEAN

• ABSENCE O ALL MYCOTOXIN.

 KNOWN MYCOTOXIN:
AFLATOXIN

• DECREASED APPETITE.

• DECREA SED PRODUCTION.

• WIEGHT LOSS.

• HIGH LIVER ENZYMES.

• LOSS OF LIVER FUNCTION.

• ULTIMATELY DEATH:
 DEOXYNIVANOLENOL (DON):
• mycotxin OF FUSARIUM.

• MARKER MYCOTOXIN.
 ZEARALENONE:
• ESTERO GENIC ACTIVITY

• TWINE OF FUSARIUM.

• LOWERED MILK PRODUCTION

• ABORTION
 CONTE..
• SHORT HEAT CYCLE.

• NYMPHO MANIA.
 T2 TOXIN
(TRICHOTHECENES):
• secondary mycotoxinOF FUSARIUM.

• LOWER MILK PRODUCTION

• DIARRHEA.
• HEMORRHAGIC BOWEL

• STERLITY

• IMMUNE FUNCTION SEVERELY

DEPESSED

• ACUTE DEATH.
 FUMOSINE.
• LIVER KIDNEY DAMAGE.

• DECREASED IMMUNE SYSTEM.

• CARCINO GENIC FOR SWINE HORSE.

 ORCHATOXIN:
• Mycotoxins of ASPERGILLUS
OCHCEUS.

• CONTROLLED STUDY IN ANIMAL

LACKING ?
 DIAGNOSIS:
• CULTURE IN

• PDS. NOBUL, SABRODS DEXTROS

AGAR

• SEROLOY. DOUBLE IMMUNE ASSAY

KITS
 MYCOTOXIN IS THE PROBLE
WHAT IS THE SOLUTION ?
• SaiLAGE TREAT WITH PROPIONIC
ACID.

• USE MYCOTOXIN BINDER

• IF NOT HERE IS ANTIDEGNALA

LIQUOR.
 SUPPLIMENT VIT. A AND E

• IMMUNO MODULATOR, ADATOGEN,

LIVERTONIC IMMUNI STIMULENTS.
CLINICAL IEATURE OF FUSRIUM MYCOTOXICOSIS IN BUFFALO
OBSERVATION OF FORAGE
AND FODDER FOR
FUSARIUM INFECTION
FUSARIUM INFECTION A NEW PROBLEM IN OUR FOOD BASKET
 ANTI DEGNALA LIQUOR
WHAT IS ITS PROPERTIES ?

• ALTERATIVE

• TONIC

• SKIN AND NERVINE TONIC

 ANTI DEGNALA LIQUOR
• HAEMATINIC.

• STOMACHIC.

• ANTHELMINTIC (FOR CERTAIN

PROTOZOA).
 ANTI DEGNALA LIQUOR
• CAUSTIC.

• PARACITICIDE.

• REDUCES OXIDATION.

• ACCELARATE FAT DEPOSITION.

• HELP TO REMOVE MYCOTXIN BY

DIURATION.
 THANKS TO
ALL PARTICIPANTS
SHARE WITH ME YOUR IDEA.
THE END