Anemia Makrositik (MCV > 100 fl)

Anemia defisiensi asam folat

Anemia defisiensi B12

Anemia Mikrositik (MCV < 80 fl )

Iron
Deficiency
Iron deficiency
most common
cause karena
blood loss
(women lose
additional 1 mg
daily compared
to men )
Common in
infant,
pregnant,
female, elderly
Serum iron
Serum ferritin
TIBC
% transferrin
saturation
Ada pencil cell
Anemia of
chronic disease
In patients with
chronic
disease :
cancer, chronic
infection, DM,
CAD
Decreased RBC
survival and
decreased
production EPO,

Thalassemias
Inherited
condition of
abnormal alpha
or beta Hgb
chain.

Sideroblastic
Anemia

Fe stores
trapped in RE
system, bone
marrow less
responsive to
EPO
Common in
chronic dz CAD,
DM, malignancy
Serum iron or
normal
Serum ferritin
normal or
TIBC
% transferrin
saturation
normal

In African,
Mediteranean,
South Asian
heritage