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Genomes, Chromosomes, and DNA Web Quest


Topic: Genomes and Chromosomes
Go to: http://ghr.nlm.nih.gov/handbook/hgp/genome
1. What is a genome?
A organs complete set of DNA.

2. On the left hand side, click on cells and DNA. Explore this site to answer the
following questions:
a. What is a chromosome?
A DNA molecule that is packaged into thread-like structures
b. When are chromosomes visible?
When the DNA that makes up chromosomes become more tightly packed
during cell division.
c. What is a centromere?
The construction point that divides the chromosome into two sections
d. How many chromosomes do people have?
23
Go to: http://learn.genetics.utah.edu/content/begin/traits/karyotype/
3. What is a karyotype?
Someones collection of chromosome.
4. Match the chromosomes to complete the karyotype (turn on hints for help). Is the
karyotype from a male or female? How do you know?
Male, the X and Y chromosomes.
Modeling Instruction AMTA 2012

Unit 6 Growth and Reproduction

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5. Predict what would happen if a person has the incorrect number of


chromosomes. Write your prediction here.
The will have a birth defect
6. Do a quick google search to find the answer to question 5.
Missing genetic materials
As a class you determined that chromosomes must be duplicated before the cell can
divide. This process is called DNA Replication.
Topic: DNA Replication
Go to: http://www.pbs.org/wgbh/aso/tryit/dna/shockwave.html
Click: DNA replication (upper left) and then click unzip Read the script, answer the
questions below, and then, click OK.
1.

In a real cell, what does the DNA molecule do before it unzips?

The molecule unwinds from spools made from protein and then untwist.
2.

What molecules break the rungs (bases) apart?

DNA molecule is known to break the rungs apart. The bases must synthesize with the
DNA

Drag the correct bases over to synthesize the new DNA halves.
Read script, answer questions, and then click OK.
3.

How many base pairs are in the real human genome?

3 billion

Modeling Instruction AMTA 2012

Unit 6 Growth and Reproduction

Name________________________________________

Date_______

Go to: http://nobelprize.org/educational_games/medicine/dna_double_helix/
Click on Play DNA Game; Click next and reading each page, continue to click next
until you come to the game.; Click on organism #1 and match the base pairs as fast as
you can! It is hard.
Click Next and then click on each organism until you identify the one that belongs to
chromosome #1; continue playing the game with the other two chromosomes, filling in
the chart below.
Be careful, other teams may get different results.
Chromosome #
1

How many
chromosomes?
20

How many
base pairs?
2,500 million

How many
genes?
22,000

What is the
organism?
House mouse

14

22.7 million

5,300

Malaria
parasite

16

11.7 million

6,300

Bakers yeast

Topic: Mutations
Go to: http://evolution.berkeley.edu/evolibrary/article/mutations_03
Read the information and fill out the table below:
Type of mutation
Substitution

Description
Mutation that exchanges one base for
another

Effect on resulting protein


It changes a condo to a encode the same
amino acid

Insertion

Extra base pair are inserted into a


new place in the DNA

Protein is made by the gene and it may


not function properly.

Deletion

A section of DNA is lost or deleted

Frameshift

Inseryion and deletion alter a gene

deletions may remove one or a few base


pairs within a gene, while larger deletions
can remove an entire gene or several
neighboring genes
Its usually nonfunctional.

Modeling Instruction AMTA 2012

Unit 6 Growth and Reproduction