Rx 1: _________________

Container: 25 g J&J Sifter top container

Label: External
BUD: Maximum 3-month beyond-use date is used. The beyond-use date will
be limited further if 25% times the Nystatin product expiration date is less
than 3 months.

Ingredients (w/
original amount)
Nystatin
Zinc oxide
Talc
Starch
Calcium carbonate

Amount Used

Therapeutic Use

2.0
5.0
5.0
5.0
5.0

Antifungal
Astringent/Adsorbent
Vehicle/Adsorbent
Vehicle/adsorbent
Astringent/Adsorbent

g
g
g
g
g

Compounding Procedure:
1. Weigh 2 g of Nystatin Topical Powder USP 100,000 units/g, and 5 g
each of zinc oxide, talc, starch, and calcium carbonate.
2. Mix the adsorbent powders together (for approximately 2 minutes) by
tumbling in a 1-gallon zipper-closure bag.
3. Place the Nystatin Topical Powder in a mortar and, using geometric
dilution, add the combined adsorbent powders to the Nystatin Topical
Powder with trituration to obtain a homogenous powder mix.
4. Weigh the sifter-top preparation container.
5. Using a powder funnel, transfer the powder to the container and
reweigh to determine the final weight of powder.
6. Label appropriately (RED) and dispense.
Note: Compatibility and Stability
The adsorbent powders zinc oxide, talc, starch, and calcium carbonate
are compatible and stable in powder form. Nystatin has questionable
stability, even in dry powder form. Both Chemical Stability of Pharmaceuticals
and Trissels Stability of Compounded Formulations report that Nystatin
degrades when exposed to heat, light, oxygen, and moisture.
Calculations:
Nystatin Concentration:
If the prescription order is interpreted as Nystatin Topical Powder USP, which
is 100,000 units/g:
(100,000 units)/(g Nystatin powder)(2g Nystatin powder)/(22g
powder)=9090.91units/(g powder)
If the prescription order is interpreted as Nystatin USP, apply the units-permilligram equivalence printed on the bottle of nystatin powder that will be
used (a value that varies with the manufacturer and lot number), in this case
6,050 units/mg
6050units/(mg powder)(2000mg Nystatin powder)/(22g
powder)=550000units/(g powder)

Zinc oxide, Starch & Calcium carbonate Concentration:

(5g ingredient)/(22g powder)100%=22.73%
Talc Concentration:
(mg Nystatin)/(4400 units)200000units=45.45mg
2g Nystatin-0.045g Nystatin=1.955g Talc
5g+1.955g=6.955g
6.955g/22g100%=31.61%
Amount of each ingredients:
20g/4=5g
(1 part Nystatin)/(10 parts other powders)=(x g Nystatin)/(20 g powder)
x=2g Nystatin powder
Label Directions:
Apply to area with each diaper change.
Rx 3: _________________
Container: Glassine paper, paper envelope
Label: Internal
BUD: 25% of the remaining beyod use date of the manufactured tablet

Ingredients (w/
original amount)
Digoxin

Amount Used

Therapeutic Use

200 mcg/papertab

Anti-arrythmia / For
heart failure

Compounding Procedure:
1. Weigh tablet
2. Compute how many tablets are needed for the Rx
3. Crush and weigh, get specified amount of powder for each papertab
4. Fold papertab and put on the paper envelope. No need for double
wrapping.
Calculations:
Digoxin Concentration:
200mcg/papertab
Amount of ingredient:
(weight of tablet)/250mcg200mcg5=weight of total tablet powder
(130mg5)-weight of total tablet powder=weight of total lactose
Label Directions:
One paper once a day.

Rx 2: _________________
Container: 30ml narrow amber bottle
Label: Internal
BUD:
Ingredients (w/
original amount)
Potassium bromide
(2.67g)
Syrup of orange
( 4mL)
Water qs ad
(60mL)

Amount Used

Therapeutic Use

1.335 g

Sedative-hypnotic

2 mL

flavorant

30 mL

vehicle

Compounding Procedure:
1. Dissolve potassium bromide in water.
2. Add orange syrup.
3. Filter.
4. Add enough water to volume.
Calculations:
Potassium bromide

2.67 g
60 mL

xg
30 mL

X = 1.335 g
Syrup of orange

4 mL
60 mL

x mL
60 mL

X= 2mL
Label Directions:
Take one tablespoon three times a day
Patient counseling:
Rx 4: _________________
Container: 30ml narrow amber bottle
Label: External
BUD: of 30 days or duration of therapy w/c ever is less.
Ingredients (w/
Amount Used
original amount)
Zephiran
(1:750)
*Zephiran: Benzalkonium chloride solution
Compounding Procedure:

Therapeutic Use
Topical antiseptic/ antiinfective

1. Get the amount (mL) of Zephiran solution specified depending on

the stock solution that is available.
Calculations:
Zephiran
1g
750mL

= x
30mL

X= 0.04g
-then ratio and proportion, use available stock solution.
Label Directions:
As directed
Patient counseling:
Zephiran solution
Generic name: Benzalkonium chloride
This medication is used to clean wounds to prevent further infection. It
is also used to clean unbroken skin prior to surgery. It is also used as a
disinfectant in surgery, ophthalmology and in general practice.
Pour adequate amount of Zephiran onto a cotton or gauze sponges.
Apply to wound.
Applicators of this medication should be separated and dipped in
Zephiran solution immediately before use.
This medication should not be used in occlusive dressing and casts.
Adverse drug reactions: Hypersensitivity
Zephiran solution is inactivated by soaps and detergents, thorough
rinsing is necessary prior to its application.
Store medication at room temperature.
Diluent: Sterile water for injection
If benzalkonium chloride aqueous solution, in dilutions stronger than
1:3 000 enters the eyes, they should be immediately and repeatedly
rinsed with water. Prompt medical attention is necessary.
On accidental ingestion: Administer several glasses of a mild soap
solution, milk or egg whites beaten in water. Follow by gastric lavage
with a mild soap solution. Avoid alcohol as it promotes absorption.
Rx 5: Propranolol HCl 4mg/mL
Container: 30mL wide mouth amber
Label: Internal (white)
Auxiliary: Shake well before use
BUD: 14 days in 5C
Ingredients (w/ original
amount)
Propranolol
Acacia
Water

Amount Used

Therapeutic Use

120mg
600mg
q.s. ad to 30ml

antihypertensive
Suspending agent
vehicle

Compounding Procedure:
1. Weigh and pulverize the Propranolol HCl tablet
2. Prepare mucilage by using 2% acacia and water
3. Mix by portion the propranolol and mucilage
4. Add water to make 30ml
Calculations:
Dosage Form: Suspension
Amount of Propranolol:
4mg:1ml= x: 30ml
x=120mg Propranolol
Availability of Propranolol:
10 mg or 40 mg tablet
Number of tablets to be used:
120mg/10mg= 12 tablets(10mg)
or
120mg/40mg= 4 tablets (40mg)
Amount of suspending agent available in the lab (Acacia):
2% acacia
2g: 100ml= x: 30ml
x= 0.6g or 600mg acacia
Label Directions:
Take one milliliter oral three times a day.
Notes:
You should not use this medication if you are allergic to propranolol, if you
have asthma, a slow heart rate, or a serious heart condition such as "sick
sinus syndrome" or "AV block" (unless you have a pacemaker).
If you need surgery, tell the surgeon ahead of time that you are using
propranolol. You may need to stop using the medicine for a short time.
Do not skip doses or stop using propranolol without first talking to your
doctor. You may need to use less and less before you stop the medication
completely. Do not double the doses if skipped take missed dose once
remembered.
C.I. May experience insomnia, fatigue and depression. Avoid drinking alcohol.
It may increase your blood levels of propranolol. Drug interaction: digoxin,
OHA, epinephrine, clonidine
Propranolol is only part of a complete program of treatment for hypertension
that may also include diet, exercise, and weight control. Follow your diet,
medication, and exercise routines very closely if you are being treated for
hypertension.

If you are being treated for high blood pressure, keep using this medication
even if you feel well. High blood pressure often has no symptoms. You may
need to use blood pressure medication for the rest of your life
Prescription no. 7: Phenolated Calamine Topical Suspension
External/ Topical
Beyond use date: 30 days
Indication: Use to relieve pain and itching from sunburns, rashes, and
insect bites.
Container: 30 ml narrow mouth amber bottle;
Auxiliary labels: For external use only and shake well before use
Description of the finished product: Pink suspension with a
viscosity that is similar to a thick syrup. The preparation is easily
dispersed with shaking.
Ingredients w/ original
amount

Amount Used

Therapeutic Use

Phenol ( 0.6g)

0.3 g

Calamine (3.0 ml)

1.5 ml

Clear liquid; Antiseptic,

Disinfectant,
Preservative
Pink powder; Insoluble in
water and ethanol. Acts
as protectant, astringent
and antiseptic,
antipruritic

Zinc oxide (6.0 g)

6.0 g

Glycerin (3.0 ml)

1.5 ml

Purified water qs ad
60.0 ml

Dispense 30 ml

White powder; Insoluble

in water and ethanol.
Acts as protectant,
astringent, antibacterial,
antifungal, and
antipruritic
Clear viscous liquid and
miscible in water;
Humectant,
Preservative, Emollient
Vehicle

Compounding Procedures:
1. Weigh the ingredients.
2. Triturate zinc oxide in a mortar and add a small amount of calamine
lotion. Triturate into a smooth paste.
3. Add phenol and remaining calamine lotion in portion with trituration
to obtain a uniform, pourable suspension.
4. Add water to come up with 30 ml.
5. Pour the suspension in an amber bottle.

Calculations:
Calamine:
3.0 ml = x
60.0 ml 30 ml
x= 1.5 ml
Same calculation in other ingredients

Patient counseling:
Good afternoon Maam, Im _______ and Im the pharmacist in charge of
your prescription. May I have 5 minutes of your time to talk about your
prescription? Are you Evangeline Natividad?
Is Dr. Gabriel Macapagal the one prescribed your prescription? Are you
taking any medications or vitamins right now? Do you have allergies?
(Recap)
Your prescription says to dispense 30 ml Phenolated Calamine Topical
Suspension to be applied to the affected areas at bedtime. This medication is
used to relieve pain and itching from sunburns, rashes, and insect bites. In
applying this medication, pour adequate amount on the affected areas at bed
time. There are no side effects in using this medication. Remember to store
it at room temperature and avoid exposure to sunlight. This is good for only
30 days. Is everything clear or do you want me to repeat? Can you repeat
the instructions that Ive mentioned? Heres written information about your
medication. If you have any questions, dont hesitate to come back or call
our pharmacy. Thank you Maam for your time and have a nice day!
Rx 6: _________________
Container: 30mL narrow amber bottle
Label: External
BUD: 30 days
Ingredients (w/
original amount)
Sodium bicarbonate
Glycerol
Water, q.s.ad

Amount Used

Therapeutic Use

500mg
3.0ml
10.0ml

Ceruminolytic
Thickening agent
vehicle

Compounding Procedure:
1. Dissolve sodium bicarbonate in water. (1:12)
2. Add glycerol.
3. Add enough water to make 10mL
Calculations:
N/A
Label Directions:
Instill one drop to both ears.
Rx 8: _________________

Container: 30mL narrow amber bottle

Label: External
BUD: 30 days
Ingredients (w/
original amount)
Potassium
permanganate
Water

Amount Used

Therapeutic Use

0.06g

Antiseptic, Antiinfective
vehicle

To make 30mL

Compounding Procedure:
1. Dissolve potassium permanganate in water. (1:12)
Calculations:
0.2g : 100mL = x : 30mL
X = 0.06g
Label Directions:
Apply to affected area three times a day.
Rx 9: Calcium Carbonate Suspension
Container: 30ml wide-mouth amber bottle
Label: Internal, Shake well
BUD: 1 month
Ingredients (w/
original amount)
Chalk (2g)
Tragacanth (200mg)

Amount Used

Pharmaceutic Use

600mg
60mg

Conc. Cinnamon Water

(0.4ml)
Syrup (10ml)

0.12mL

Antacid
Binder/Suspending
Agent
flavor/carminative

Purified water (100ml)

30mL

3mL

sweetener /Increases
viscosity
solvent/vehicle

Compounding Procedure:
1. Weigh chalk and tragacanth. Lightly mix in a mortar and pestle.
2. Add the syrup and mix to make a paste.
3. Gradually add the concentrated cinnamon water.
4. Rinse the mortar with of the needed amount of Purified water.
5. Complete to 30mL volume of water.
6. Seal the bottle and shake the suspension well.
Calculations:
Chalk: (2000mg*30mL)/100mL = 600mg
Tragacanth: (200mg*30mL)/100mL = 60mg
Conc. Cinnamon Water: (0.4mL*30)/100mL = 0.12mL
Syrup: (10mL*30mL)/100mL = 3mL
Label Directions:
Use as directed.

Notes:
Chalk is practically insoluble in water and is an indiffusible solid which
requires a suspending agent (Tragacanth, for this prep).
Reference: Pharmaceutical Practice (5th Edition) edited by Judith A Rees, Ian
Smith, Jennie Watson
Prescription # 10
Mineral Oil Emulsion
White Label
30 mL Wide mouth Amber bottle
Shake well Label
INGREDIENT
Mineral Oil
Acacia
Syrup
Vanillin
Purified water, to
make

AMOUNT
15mL
3.75 g
3mL
1.2 mg
30mL

Sig. Take one (1) tablespoonful four times daily; after meals and before
bedtime
Notes:
PROCEDURE
1. Prepare the primary nucleus with a ratio of 4:2:1
2. Mix oil with acacia and add purified water
3. Slowly add the other ingredients with triturationn with vanillin
dissolved in alcohol.
BEYOND USE DATE
14 days