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A C TIO N P O TEN TIA L O F

H EA R T
Ayu Indraswary
3415 122 171
Pendidikan Biologi Reguler 2012

ElectricalActivity ofH eart


Atria contract as single unit followed

after brief delay by a synchronized


ventricular contraction
Action potentials of cardiac contractile
cells exhibit prolonged positive phase
(plateau) accompanied by prolonged
period of contraction
Ensures adequate ejection time
Plateau primarily due to activation of slow

L-type Ca2+ channels


Chapter 9 Cardiac Physiology
Human Physiology by Lauralee Sherwood 2007 Brooks/Cole-Thomson
Learning

ElectricalActivity ofH eart


Ca2+ entry through L-type channels in

T tubules triggers larger release of


Ca2+ from sarcoplasmic reticulum
Ca2+ induced Ca2+ release leads to cross-

bridge cycling and contraction

Chapter 9 Cardiac Physiology


Human Physiology by Lauralee Sherwood 2007 Brooks/Cole-Thomson
Learning

ExcitationContraction
Coupling in Cardiac
Contractile Cells

Chapter 9 Cardiac Physiology


Human Physiology by Lauralee Sherwood 2007 Brooks/Cole-Thomson
Learning

ElectricalActivity ofH eart


Because long refractory period

occurs in conjunction with prolonged


plateau phase, summation and
tetanus of cardiac muscle is
impossible
Ensures alternate periods of contraction

and relaxation which are essential for


pumping blood

Chapter 9 Cardiac Physiology


Human Physiology by Lauralee Sherwood 2007 Brooks/Cole-Thomson
Learning

Relationship of an
Action Potential and the
Refractory Period to the
Duration of the
Contractile Response in
Cardiac Muscle

Chapter 9 Cardiac Physiology


Human Physiology by Lauralee Sherwood 2007 Brooks/Cole-Thomson
Learning