6.5
OUTLINE
I.
Motor
Control
II.
Basal
Ganglia
System
A.
Components
B.
Nomenclature
III.
Connections
of
Basal
Ganglia
IV.
Basal
Ganglia
Feedback
Loops
V.
Basal
Ganglia
Diseases
A.
Parkinsons
Disease
B.
Chorea
Figure
1.Motor
control
system.
Alpha
motor
neurons
are
the
final
common
path
for
motor
control.
Peripheral
sensory
input
and
spinal
cord
tract
signals
that
descend
from
the
brainstem
and
cerebral
cortex
influence
the
motor
neurons.
The
cerebellum
and
basal
ganglia
contribute
to
motor
control
by
modifying
brainstem
and
cortical
activity.
Objectives:
Name
the
3
systems
involved
in
the
suprasegmental
mechanism
of
voluntary
motor
control.
Describe
the
basal
ganglia
and
its
composition
Enumerate
the
sources
of
the
afferent
fibers
to
the
basal
ganglia.
State
the
parts
of
the
basal
ganglia
where
almost
all
the
afferent
impulses
terminate
and
where
almost
all
afferent
fibers
arise.
Name
the
efferent
tracts
from
the
globuspallidus
Trace
the
different
circuitry
within
the
basal
ganglia
and
name
the
neurotransmitters
involved.
Describe
the
common
basal
ganglia
disorders
I.MOTOR
CONTROL
Evolution
of
Movement.
Movement
is
a
fundamental
and
essential
property
of
animal
life.
o In
simple,
unicellular
animals,
motion
depends
on
the
contractility
of
protoplasm
and
the
action
of
accessory
organs:
cilia,
flagella,
etc
o Rudimentary
multicellular
animals
possess
primitive
neuromuscular
mechanisms
o In
more
advanced
forms
of
animal
life,
reflexive
motion
is
based
on
the
transmission
of
impulses
from
the
receptor
through
the
afferent
neuron
and
ganglion
cell
to
motor
neurons
&
muscles
=
which
is
found
in
the
REFLEX
ARC.
Reflex
arc
is
seen
in
higher
form
of
animals
with
developed
Spinal
Cord.
Superimposed
on
these
reflex
circuits,
the
Brain
is
concerned
with
the
initiation
and
control
of
movement
and
the
integration
of
complex
motions.
Motor
system
in
humans
control
complex
neuromuscular
network.
Commands
must
be
sent
to
many
muscles,
and
many
joints
must
be
stabilized.
Group
2
|
Agulto,
Agustin
B,
Al-qaseer,
Alano,
Alastra,
Alegre,
Almario
Page 1 of 6
B.
Nomenclature
of
the
Basal
Ganglia
Page
2
of
6
Lentiform
Nucleus
o Thumb-sized mass of gray matter wedged against the internal
capsule
o Wedge-shaped mass of gray matter whose broad convex base is
directed laterally and its blade medially
o Buried deep in the white matter of the cerebral hemisphere and
o Related medially to the internal capsule which separates it from
the caudate nucleus and the thalamus
o Related laterally to a thin sheet of white matter, the external
capsule which separates it from a thin sheet of gray matter called
the the claustrum
o Divided into putamen and globus pallidus
Putamen
Larger and darker lateral portion
Has the same histological appearance as the caudate
nucleus, with numerous and densely packed small neurons
Contains granules with Ach that account for its darker color
Globus Pallidus
Lighter medial region
Contains sparsely distributed large cells and traversed by
many myelinated fibers
Paleness due to the high concentrations of myelinated
fibers
A cell sparse lamina separates the globus pallidus itself
into: external globus pallidus and internal globus pallidus
NOTES:
Almost all efferents from GB arise from GPi (w/c contain the inhibitory
neurotransmitter, GABA
GPi sends (1) Major inhibitory output from BG back to thalamus and (2)
few projections to area of midbrain to assist in postural control
Both GPe and GPi receive info from caudate and putamen
They both are in communication with subthalamic nucleus
They also provide output to substantia nigra
Posterior limb of internal capsule: separates lentiform nucleus from
thalamus
anterior limb of the internal capsule: separates lentiform from head of
caudate nucleus.
Striatum
(aka
Neostriatum,
Dorsal
Striatum)
=
Putamen
+
Caudate
o Acetylcholine
is
the
neurotransmitter
of
interneurons
o An
acetylcholinesterase
(AChE)
stains
for
the
enzyme
that
degrades
acetylcholine
(ACh).
o It
receives
major
inputs
to
the
basal
ganglia
provided
by
afferents
from
the
cerebral
cortex,
thalamus
and
substantia
nigra.
o Receives
excitatory
input
from
neurons
in
all
areas
of
the
isocortex,
causing
excitation
w
ith
GABA
as
the
neurotrans
mitter
o Stimulation
of
cerebral
cortical
neurons
evoke
sequences
of
excitatory(fromglutamatergiccorticalefferents),followedby
inhibitory
postsynaptic
potentials
(from
GABA-ergic
interneurons
in
striatum)
o Projections
have
a
topographic
organization
that
is
continued
by
neurons
that
project
from
the
substantia
nigra
pars
reticulate
and
to
the
internal
and
external
globus
pallidus
o Neurons
from
the
striatum
to
the
external
pallidum
provide
inhibition
using
GABA
and
encephalin
o Neurons
from
striatum
to
the
internal
pallidum
also
inhibit
using
GABA
and
Substance
P
Projection
Areas
Putamen
Areas
4,
6
(lateral
and
medial)
and
3,1,2
Caudate
nucleus
Frontal
eye
fields
and
association
areas
of
the
frontal
and
parietal
lobes
Amygdaloid
Nucleus
o Situated in the temporal close to the uncus
o Considered part of the limbic system
o Influences the bodys response to environmental changes
Claustrum
o Thin sheet of gray matter that is separated from the lateral
surface of the lentiform nucleus by the external capsule
o Lateral to the claustrum is the subcortical white matter of the
insula
o Function is still unknown
NON-TELENCEPHALIC
NUCLEUS:
Subthalamic
Nuclei
o part
of
diencephalon
o largest
nuclear
mass
in
the
subthalamus
o Shape
of
a
biconvex
lens
between
thalamus
&
tegmentum,
just
rostral
to
midbrain
o Has important connections with corpus striatum; as a result
needed for the integration of smooth movements of different
parts of the body
o Disorders:
Ballism/Hemiballism
o Main
mass
of
midbrain
between
cerebral
peduncles
and
cerebral
aqueducts
o Functionally
closely
related
to
the
activities
of
the
basal
nuclei
o Neurons
are
glutaminergic
and
excitatory
o Have
many
connections
to
the
globus
pallidus
and
substantia
nigra
Substantia
Nigra
o Non-telencephalic
nucleus
=
lies
in
upper
midbrain;
between
the
cerebral
peduncle
&
tegmentum
o The nucleus is composed of medium-size multipolar neurons
that possess inclusion granules of melanin pigment within their
cytoplasm
o In
a
brain
specimen,
SN
neurons
appear
brownish-black
due
to
neuromelanin
o The
SN
neurons
are
dopaminergic
and
inhibitory
(
+
;
-
)
o It is concerned with muscle tone and is connected to the cerebral
cortex, spinal cord, hypothalamus, and basal nuclei
o Neuromelanin gives its color: black substance
o Have many connections to the corpus striatum
o It has 2 superior and 2 inferior colliculi
o 2
parts
of
the
Substantia
Nigra
Page
3
of
6
Figure
7.
Some
of
the
major
connections
between
the
cerebral
cortex,
the
basal
nuclei,
the
thalamic
nuclei,
the
brainstem,
and
the
spinal
cord.
Figure
8.
Basal
nuclei
pathways
showing
the
known
neurotransmitters.
ALMOST
all
impulses
terminate
in
the
Striatum
are
excitatory
Interneurons
within
the
striatum
are
excitatory
and
use
Ach.
Page
4
of
6
IV.
BASAL
GANGLIA
FEEDBACK
LOOPS
1. Cortico
+
striato
pallido
thalamo
+
cortical
pathway
o It
is
the
long
loop
o From
cortex
to
striatum,
and
thalamus
to
cortex,
it
is
excitatory
o From
striatum
to
globus
pallidus,
and
pallidus
to
thalamus,
it
is
inhibitory
2. Direct
loop
(nigrostriatal
fibers)
o Cortico
+
striato
pallido/snr
thalamo
+
cortical
pathway
o D1
receptors
on
striatum
are
stimulated,
which
are
excitatory
o Cortex
striatum
SNr-SNc
striatum(D1)
G
pallidus
thalamus
back
to
cortex
Page
5
of
6
B.
Chorea
A
form
of
striatal
disorder
Exhibits
involuntary,
quick,
jerky,
irregular
nonrepetitive
movements.
Ex:
swift
grimaces
and
sudden
movements
of
limbs
and
head.
May
affect
limbs
(refers
more
to
distal
movements),
face,
tongue
Huntingtons
disease
hereditary,
defect
on
chromosome
4
(protein
huntingtin).
o Degeneration
of
neurons
of
caudate
nucleus
o Disease
is
characterized
by
chorea
and
progressive
dementia
Sydenhams
Chorea
aka
St.
Vitus
Dance
o Disease
of
childhood
o Associated
with
rheumatic
fever
(streptococcal
antigens
have
same
membrane
proteins
of
striatal
neurons)
o Choreic
movements
o Disease
is
transient
and
with
full
recovery
Athetosis
o Characterized
by
slow
writhing
worm-like
involuntary
movement
of
extremities,
trunk,
and
neck
o Involves
the
cerebral
cortex
and
the
basal
ganglia
o Ex:
TICS,
Tourettessyndrom
o Aka
choreoathetosis
Dystonia
o Fixed
posture
or
sustained
postural
contraction
of
limb,
neck
and
facial
muscles
o Most
commonly
secondary
to
cerebral
palsy
Ballism
or
Hemiballismus
o Involuntary
flailing
movements
of
arm/s
and
leg/s
o Caused
by
damage
(i.e.
stroke)
of
opposite
subthalamic
nucleus.
Group
2
|
Agustin
B,
Al-Qaseer,
Alegre,
Almario,
Almazan,
Almodiente,
Altabano,
Alvarez
Page 6 of 6