Ingredient Name
A
1.
15.00
2.
Menthol, USP
7.00
3.
Carbopol
0.30
4.
Ethanol
15.0
5.
Propylene Glycol
20.0
6.
Hydroxypropyl Cellulose
Klucel HXF
0.60
7.
Ethanol
20.0
8.
Purified Water
21.50
9.
0.40
Lavender Fragrance
0.20
10.
Product Properties
%w/w
971P NF Polymer
Appearance
Clear gel
pH
6.5
Viscosity (cP)**
8,900
Stability
- Stable for a minimum of 3 months when stored under
the following ICH conditions:
Long term (25 2C / 60 5% relative humidity)
Accelerated (40 2C / 75 5% relative humidity)
Procedure
1. Dissolve menthol in the methyl salicylate. Add in Carbopol 971P NF polymer and disperse.
Add ethanol and propylene glycol and mix well. Keep the solution covered during mixing to
prevent solvent evaporation (Part A).
2. Disperse the hydroxypropyl cellulose in ethanol using a homogenizer. Add the purified water and
homogenize to obtain a clear, viscous solution (Part B).
3. Add Part B ingredients to Part A ingredients and mix thoroughly.
4. Slowly add the 20% 2-amino-2-methyl-1-propanol solution while mixing. Add fragrance and mix to
obtain a clear, viscous gel (Part C).
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