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13/05/2016

NewcastleHospitalsNewcastleexpertsdemonstratereversalofdiabetesthroughweightloss

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01.12.2015

Newcastleexpertsdemonstratereversalofdiabetesthroughweightloss
AteamfromNewcastlehasshownthatType2Diabetesiscausedbyfataccumulatinginthepancreasandthatlosinglessthanonegramofthatfatthroughweightloss
reversesthediabetes.
AffectingtwoandahalfmillionpeopleintheUKandontheincreaseType2diabetesisalongtermconditioncausedbytoomuchglucose,atypeofsugar,intheblood.
TheresearchledbyProfessorRoyTaylor,aConsultantPhysicianspecialisinginDiabetesattheNewcastleHospitalsandProfessorofMedicineandMetabolismatNewcastle
UniversityaspartoftheNewcastleAcademicHealthPartners ,isbeingpublishedonlinetodayinDiabetesCare.HeissimultaneouslypresentingthefindingsattheWorld
DiabetesConferenceinVancouver.

ProfessorRoyTaylor,ConsultantPhysicianspecialisinginDiabetesandProfessorofMedicineandMetabolismatNewcastleUniversity

Bariatricsurgery
Inatrial,18peoplewithType2diabetesand9peoplewhodidnothavediabetesweremeasuredforweight,fatlevelsinthepancreasandinsulinresponsebeforeandafter
bariatricsurgery.ThepatientswithType2diabeteshadbeendiagnosedforanaverageof6.9years,andallforlessthan15years.
ThepeoplewithType2diabeteswerefoundtohaveincreasedlevelsoffatinthepancreas.
Theparticipantsinthestudyhadallbeenselectedtohavegastricbypasssurgeryforobesityandweremeasuredbeforetheoperationthenagaineightweekslater.Afterthe
operation,thosewithType2diabeteswereimmediatelytakenofftheirmedication.
Bothgroupslostthesameamountofweight,around13%oftheirinitialbodyweight.Critically,thepooloffatinthepancreasdidnotchangeinthenondiabeticsbutdecreased
toanormallevelinthosewithType2diabetes.

ThisshowsthattheexcessfatinthediabeticpancreasisspecifictoType2diabetesandimportantinpreventinginsulinbeingmadeasnormal.Whenthatexcessfatis
removed,insulinsecretionincreasestonormallevels.Inotherwords,theywerediabetesfree.
Drainexcessfatoutofthepancreas
ProfessorTaylorsaid:ForpeoplewithType2diabetes,losingweightallowsthemtodrainexcessfatoutofthepancreasandallowsfunctiontoreturntonormal.
Soifyouaskhowmuchweightyouneedtolosetomakeyourdiabetesgoaway,theanswerisonegram!Butthatgramneedstobefatfromthepancreas.Atpresenttheonly
waywehavetoachievethisisbycalorierestrictionbyanymeanswhetherbydietoranoperation.
InpatientswhohadstartedwithType2diabetes,fatlevelsinthepancreas(pancreatictriglyceride)decreasedby1.2%overthe8weeks.Veryexactmethodswereneededto
beabletomeasurethisandanewmethodusingaspecialMRIscanwasdeveloped.WithanaveragepancreasforapersonwithType2diabeteshavingavolumeof50ml,
thisistheequivalentofaround0.6gramsoffat.
However,thepatientswhohadneverhaddiabetessawnochangeintheleveloffatintheirpancreasdemonstratingthattheincreaseinfatinthepancreasisspecificto
peoplewhodevelopType2diabetes.Importantly,individualsvaryinhowmuchfattheycantolerateinthepancreasbeforeType2diabetesoccurs.
TransformingthethinkingonType2diabetes
Traditionally,Type2diabeteshasbeenthoughtofasaprogressivecondition,controlledbydietinitiallythentablets,butwhichmayeventuallyrequireinsulininjections.
Itaffects9%oftheglobalpopulationandwasonceknownasadultonsetdiabetesbutisnowfoundinyoungadultsandchildren.Itcausestoomuchglucoseintheblooddue
tothepancreasnotproducingenoughinsulinahormonewhichbreaksdownglucoseintoenergyinthecellstogetherwithinsulinresistance,aconditioninwhichthebody
respondspoorlytoinsulin.
PreviousworkbyProfessorTaylorandhisteamhighlightedtheimportanceofweightlossthroughdietinreversingType2Diabetes.Thisworkin2011transformedthethinking

http://www.newcastlehospitals.org.uk/news/newsitem21490.aspx

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13/05/2016

NewcastleHospitalsNewcastleexpertsdemonstratereversalofdiabetesthroughweightloss

indiabetesasitwasthefirsttimethatithadbeendemonstratedthatdietcouldremovefatcloggingupthepancreasallowingnormalinsulinsecretiontoberestored.
ProfessorTayloradds:ThisnewresearchdemonstratesthatthechangeinleveloffatinthepancreasisrelatedtothepresenceofType2diabetesinapatient.Thedecrease
inpancreasfatisnotsimplyrelatedtotheweightlossitself.Itisnotsomethingthatmighthappentoanyonewhetherornottheyhaddiabetes.ItisspecifictoType2diabetes.
Whatisinterestingisthatregardlessofyourpresentbodyweightandhowyouloseweight,thecriticalfactorinreversingyourType2diabetesislosingthat1gramoffatfrom
thepancreas.
NewcastleAcademicHealthPartners isacollaborationinvolvingNewcastleUniversity,NewcastleuponTyneHospitalsNHSFoundationTrustandNorthumberland,Tyne
andWearNHSFoundationTrust.Thispartnershipharnessesworldclassexpertisetoensurepatientsbenefitsoonerfromnewtreatments,diagnosticsandprevention
strategies.

ENDS
Informationonthedietthatcanreversediabetesandaninformationsheetformedicalteamscanbefoundhere:
http://www.ncl.ac.uk/magres/research/diabetes/reversal.htm
http://www.ncl.ac.uk/icm/people/profile/roy.taylor
http://www.ncl.ac.uk/press/news/2015/10/type2diabetes/ .
ProfessorRoyTaylor,NewcastleUniversityisinVancouverfortheconference.Hecanbereachedbyemailpleasecontactvia:press.office@ncl.ac.uk

http://www.newcastlehospitals.org.uk/news/newsitem21490.aspx

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