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  • Toxicologie Clinica: Diagnosticul Intoxicatiilor Acute

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    Alexandra Tudorache
    25 tayangan3 halaman
    1. The document discusses various symptoms that can indicate acute intoxication, including changes in mental status, vital signs like blood pressure and heart rate, neurological symptoms, and effects on organs like the liver and kidneys. 2. It outlines several specific conditions related to acute intoxication, such as hypotension, cardiac arrhythmias, convulsions, and various types of toxic neuropathies. 3. It also lists many compounds that can cause different toxic effects, including medications, industrial chemicals, and recreational drugs, as well as the mechanisms by which some of these compounds may cause hypotension, arrhythmias, convulsions or other symptoms.

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    1. The document discusses various symptoms that can indicate acute intoxication, including changes in mental status, vital signs like blood pressure and heart rate, neurological symptoms, and effects on organs like the liver and kidneys. 2. It outlines several specific conditions related to acute intoxication, such as hypotension, cardiac arrhythmias, convulsions, and various types of toxic neuropathies. 3. It also lists many compounds that can cause different toxic effects, including medications, industrial chemicals, and recreational drugs, as well as the mechanisms by which some of these compounds may cause hypotension, arrhythmias, convulsions or other symptoms.

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    © All Rights Reserved
    Unduh sebagai DOCX, PDF, TXT atau baca online dari Scribd
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    25 tayangan3 halaman

    Toxicologie Clinica: Diagnosticul Intoxicatiilor Acute

    Diunggah oleh

    Alexandra Tudorache
    1. The document discusses various symptoms that can indicate acute intoxication, including changes in mental status, vital signs like blood pressure and heart rate, neurological symptoms, and effects on organs like the liver and kidneys. 2. It outlines several specific conditions related to acute intoxication, such as hypotension, cardiac arrhythmias, convulsions, and various types of toxic neuropathies. 3. It also lists many compounds that can cause different toxic effects, including medications, industrial chemicals, and recreational drugs, as well as the mechanisms by which some of these compounds may cause hypotension, arrhythmias, convulsions or other symptoms.

    Hak Cipta:

    © All Rights Reserved
    Unduh sebagai DOCX, PDF, TXT atau baca online dari Scribd
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    Toxicologie clinica

    DIAGNOSTICUL INTOXICATIILOR ACUTE

    ISTORIC:

    Expunerea unde, cand, de ce , cat ?


    Martori ai evenimentului; container
    Simptome-dupa ingestie pana la prezentarea la spital; ex: voma, dispnee, tuse, modificari de
    constienta, convulsii
    Ce terapie s-a efectuat
    EXAMEN FIZIC
    Alterarea statusului mental, parametri
    Simptomatologia relevanta toxidroame
    Alte simptome fizice
    Come toxice particularitati

    DIAGNOSTICUL DE LABORATOR

    Simptome relevante pt. dg. Toxicologic


    1.
    2.
    3.
    4.
    5.
    6.
    7.
    8.
    9.
    10.
    11.
    12.
    13.
    14.
    15.
    16.
    17.
    18.
    19.
    20.
    21.
    22.
    23.

    Hiper termie
    Hipotermia
    Hipotensiune
    Hipertensiunea
    Bradicardia
    Tahicardia
    Delir, psihoza
    Coma
    Convulsii
    Mioza
    Midriaza
    Nistagmus
    Nevrita optica
    Hemoragie retiniana
    Oftalmoplegia
    Piele: cianoza, eritem, diaforeza, acnee, piele uscata
    Tulburari de gust si miros
    Rabdomioliza
    Simpt. Musculare
    Neuropatie periferica
    Hepatotoxicitate
    Nefrotoxicitate
    Simpt. Pulmonare

    1. HIPOTENSIUNEA
    Asociata sau nu cu hipoperfuzie tisulara
    deprimarea constientei
    vasoconstrictie periferica
    acidoza metabolica
    oligurie
    Mecanismele hipoperfuziei

    presarcina: nitriti, nitrati


    hipovolemie: metale grele, colchicina, intox alimen
    postsarcina
    contractilitatea: clonidina, barbiturice,
    alte hipnotice, narcotice, antidepresive triciclice

    60/min
    frecventa cardiaca debit cardiac
    150/min
    Disritmii: solventi, fenol, fluoroacetat
    Tulburari de conducere: dinitrofenol, as, p, op, carbamati, li, co, cn, h2s, cloralhidrat,
    antidep.triciclice, chinidin, fenotiazine, succinilcolina, cocaina, digitalice, -blocante, teofilina,
    hidantoina, verapamil
    2.ARITMIA CARDIACA DE ORIGINE TOXICA
    Antid. Triciclice
    Chinina
    Fenotiazine
    Clorochin
    Monoxid carbon
    Cloralhidrat
    Cianuri
    Fenol
    Cocaina
    Arsenic
    Digitalice
    Dinitrofenol
    Calciu blocante
    Fluoroacetat
    blocante
    Succinilcolina
    Clonidina
    Etanol
    3.COMPUSI CONVULSIVANTI
    Ag contrast iodati
    Ac. Nalidixic
    Organofosforice
    Stricnina
    Antihistaminice
    Antidepresive
    Antipsihotice
    Ag hipoglicemianti
    Oxigen hiperbar
    Izoniazida
    Cocaina
    Co, pb, li
    4.NEUROPATII TOXICE
    Neuropatie senzoriala
    etionamida
    Parestezii
    streptomicin
    acid nalidixic

    Neuropatie mixta (s-m)


    izoniazida
    etambutol
    Predominant motor
    sulfamide
    Nevrita optica
    metanol, arsenic organic, etambutol, hin, pb, sulfamide

    5.Compusi miotici

    A. CENTRAL LOCUS COERULEUS- scade tonus simpatic central


    1. agonisti :
    CLONIDINA
    2. receptori opiacei: MORFINA, HEROINA
    3. coma profunda: DEPRIMANTE, BARBITURICE, BENZODIAZEPINE, ETANOL
    4. hemoragia pontina

    B. EFECTE PE REC. PERIFERICI


    5. blocare:
    PRAZOSIN, FENOTIAZINE
    6. anticolinesterazice: CARBAMATI, OF, FENCICLIDINA
    7. stimulare muscarinica: AMANITA MUSCARIA

    C . EFECTE GANGLIONARE
    8. stimulare nicotinica: NICOTINA
    D. EFECTE LOCALE: PILOCARPINA
    MIOTICE
    DIVERSE: BROMURA
    Cai rezistente la agresiunea toxico-metabolica
    Conservarea raspunsului foto-motor (diagnostic diferential cu coma structurala)
    Exceptie: anticolinergice, glutetimida
    6.Midriaza medicamentoasa anticolinergice:

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