organisms we
line up the sequences and look for
similarities or
differences and of course bonding regions,
and what
we see is that we're really all genetic
relatives.
One interesting example of these relations
can be
seen by examining an enzyme class called
kinases.
When we compare these kinases
in humans to drosophila or fly families we
see
that some kinase proteins are only found
in humans.
Well it's quite interesting as we see that
many more kinases are shared with flies.
More so than are human specific.
And what that demonstrates is a level of
homology or
similarity between humans and the
seemingly unrelated organism, the fly.
Flies can give us a lot of insight about
the human
genome and the human condition.
We can look at
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and see that there are hundreds of
disease associated genes that have already
been identified
and a lot of these disease causing genes
have been identified, that have been
identified in
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also cause similar diseases in humans.
Some examples are, cancer and tinman gene
I discussed earlier.
And diseases like Parkinson's and
Huntington's can
be studied using flies as a model system.
So, insects are great for studying human
diseases and its progression because
they're inexpensive,
easy to rear, quick to grow, they
have relatively small genomes and minimal
ethical implications.
That means we can use flies
to develop.
And test drugs which could possibly treat
or cure human diseases.
We can make fly genes non-functional and
absorb
the phenotype, like what we saw with
knock-out mice.
One way we can do that is to remove or
disrupt
the gene's functions by using a technique
called RNAi or RNA interference.
Flies have less than 15,000 genes compared
to our
22,500 genes and their genome is very well
annotated.
There's a lot of data and analyses that
are available about flies.
They're also
significantly similar to humans and we've
examined or reported a lot
of conserved biochemical pathways in flies
that are also seen in humans.
There are Drosophila homologs for 60% of
the genes involved in human cancers.
One example is p53, the tumor suppressor
gene,
which is implicated in a host of human
cancers.
Beyond cancer, we can use model organisms
to research where and when developmental
genes are expressed, and how these genes
influence one another.
This study is called developmental
genetics, and what we see is that
mRNA and proteins affect development based
on their concentration and location within
cells.
And in early embryonic development, the
body, the
major axes, the number and orientation of
segments
in a body, are determined, as well as
the identity of each segment, by proteins
and mRNA.
There's polarity,
a dorsal back region, a ventral front
region.
There's a head, anterior region and a
posterior hind region.
And a cascade of genes regulates and
establishes this polarity or identity
of the body parts, and in humans we call
those homeotic genes.
This tells your body where the head should
be, where your arms should
be, where the legs develop, and what
structures are on the face, for example.
These genes, again, are the major
regulators in development
that allow you to form properly.
In mammals, they're called hox genes.
Interesting, we even have hox genes that
are no longer functional.
And sometimes we see the expression of
such
hox genes, and we call that an atavism.
That's the reappearance of an ancestral
condition.
The same gene can be fully functional
on another organism but isn't functional
on us.
For example, the gene for tail formation,