DAFTAR ISI

ABSTRAK ...............................................................................................
PERNYATAAN PERSETUJUAN ........................................................
KATA PENGANTAR ...........................................................................
DAFTAR ISI ...........................................................................................
DAFTAR GAMBAR...............................................................................
DAFTAR TABEL ...................................................................................
DAFTAR ISTILAH ................................................................................
BAB I
PENDAHULUAN
1.1. Latar
Belakang

BAB II

Halaman
i
ii
iv
vi
viii
ix
x
1

..............................................................
1.2. Permasalahan ..........................................................

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1.3. Tujuan .....................................................................

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1.4. Manfaat ...................................................................

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PERAN RESVERATROL SEBAGAI ANTIOKSIDAN
PADA PENYAKIT KARDIOVASKULAR DITINJAU
DARI KEDOKTERAN
1. Penyakit

Kardiovaskular

Penyakit

10

Kardiovaskular ....................................
3. Aterosklerosis ....................................................

11

...........
4. Resveratrol .........................................................

17

...............................................
2. Gejala

...........
BAB III

PERAN RESVERATROL SEBAGAI ANTIOKSIDAN

PADA PENYAKIT KARDIOVASKULAR DITINJAU
DARI ISLAM
1. Pandangan

Islam

Resveratrol .........
6

Terhadap

Senyawa

26

2. Penyakit Kardiovaskular Menurut Pandangan

33

Islam ....
3. Pandangan Islam Tentang Peran Resveratrol
Terhadap
BAB IV

Penyakit

38

Kardiovaskular ...............................................
KAITAN PANDANGAN ANTARA KEDOKTERAN
DAN ISLAM TENTANG PERAN RESVERATROL
SEBAGAI ANTIOKSIDAN PADA PENYAKIT

44

KARDIOVASKULAR DITINJAU DARI

BAB V

KEDOKTERAN DAN ISLAM ...........................................

SIMPULAN DAN SARAN
1. Simpulan ............................................................

46

...........
2. Saran ..................................................................

47

...........
DAFTAR PUSTAKA .............................................................................

49

DAFTAR GAMBAR

Gambar 2.1
Gambar 2.2
Gambar 2.3

Halaman
Proses patogenesis pembentkan Aterosklerosis ................
13
Perkembangan aterosklerosis ............................................
15
Struktur kimia trans- dan cis- Resveratrol (3, 4, 518

Gambar 2.4
Gambar 2.5

trihydroxy-trans-stilbene) ..................................................
Efek resveratrol pada jalur transduksi sinyal intrasel ........
Jalur metabolisme lipid di regulasi oleh resveratrol

18
19

Gambar 2.6
Gambar 2.7

..........
Efek Resveratrol pada jalur sel dan proses metabolik ......
Dampak oksidatif stress pada metabolisme lemak ...........

20
25

DAFTAR TABEL

Tabel 2.1
Tabel 2.2
Tabel 2.3

Halaman
Faktor resiko penyakit jantung ............................................
10
Fase pembentukan aterosklerosis ........................................
12
Efek kardioprotektif resveratrol ...........................................
18

DAFTAR ISTILAH

ABC
ABCA1
ABCG1
Akt
AMPK
AP-1
eNOS
ERK
HDL
HIF-1
IFN
IKK
LDL
LOX-1
LXRs
MAPKs
NF-B
ox-LDL
PI3K
PJK
:
PKC
PPAR
PPAR
ROS
SIRT1
SMC
STAT3
TNF
WHO

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ATP binding cassette

ATP binding cassette A1
ATP binding cassette G1
Protein kinase B
AMP-activated protein kinase
Activator protein-1
Endotel nitric oxide synthase
Extracellular-signal-regulated kinase
High Density Lipoprotein
Hypoxia induceible factor-1
Interferon
IKB kinase
Low Density Lipoprotein
ox-LDL reseptor-1
Liver X receptors
Mitogen-activated protein kinase
Nuclear factor-kappaB
Oxidized Low Density Lipoprotein
Phosphatidylinositol-3 kinase
Penyakit Jantung Koroner

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Protein kinase C
Peroxisome proliferator-activated receptor
Peroxisome proliferator-activated receptor
Reactive oxygen species
Silent Information Regulator 1
Smooth muscle cell
Signal transducer and activator of transcription 3
Tumor Necrosis Factor
World Health Organization

10