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PATHOPHYSIOLOGY

RISK FACTORS
Precipitating factors:
Fever, Nausea, Vomiting, bleeding
Virus goesFactors:
Predisposing into the circulation
Modifiable: Age, Environment,
geography
Non-modifiable:gender

Bite of an aedes aegypti mosquito carrying a virus and incubates for 6-7 weeks

Virus goes into the May reduced


circulation platelets or an
increase in blood
hematocrit

Causes viremia which


Infects cells &
explains appearance of
generate cellular
generalized flushing
response

Enters bone marrow and


arrest the maturation of
megakaryocutes

Initiates destruction of the


platelet

Skin petechiae, epistaxis, Increase potential for


Hematochezia hemorrhage
Stimulates intense inflammatory response

Release of exogenous pyrogens The body releases anti-


inflammatory mediators
(Histatin, Kinins)

Increase WBC
(Neutrophils & A sign of
Macrophages) infection Vascular response

Redness and heat


Release of
endogenous
pyrogens

Dizziness, nausea and


vomiting, abdominal
pain, Circulatory
FEVER Collapse Shock

Muscle Blood vessels contract to


contract to prevent body heat loss DEATH
produce
additional heat

Shivering and chills

Dengue Hemorrhagic Fever