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Alice T.

Lim
BSN IIB DRUG STUDY Aug. 9, 2010

Carbocisteine

Aflem/Aflem Forte® [cap]

MIMS Class : Cough & Cold Preparations

Indications
Cough including those associated w/ excessive & tenacious bronchial secretions as in
acute & chronic bronchitis, bronchiectasis & emphysema.

Dosage
Aflem cap 1 cap tid-qid.

Administration
Should be taken with food

Contraindications
Active ulceration.

Special Precautions
Elderly patient w/ severe resp insufficiency, asthma.

Adverse Drug Reactions


Bronchospasms, nausea, vomiting, stomatitis & rhinorrhea. Occasionally chills & fever.

ATC Classification
R05CB03 - Carbocisteine ; Belongs to the class of mucolytics. Used in the treatment of
wet cough.

Poison Schedule
Non-Rx Presentation/Packing

Form Packing/Price
Aflem/Aflem Forte capsule Aflem/Aflem Forte 500 mg x 100's (P896)

Paracetamol
Biogesic® [tab]
United Lab [ Biomedis ]
MIMS Class: Analgesics (Non-Opioid) & Antipyretics

Contents

Paracetamol
Relief of fever, minor aches & pains.
Indications
Dosage Tab Adult & childn >12 yr 1-2 tab every 4-6 hr as needed. Max: 8
tab in 24 hr.
Administration May be taken with or without food
Contraindications Anemia, cardiac & pulmonary disease. Hepatic or severe renal
disease.
Special
Pain of >5 days for children & 10 days for adults. Fever of >3 days.
Precautions
Adverse Drug Allergic skin reactions & GI disturbances.
Reactions
Drug Interactions Anticonvulsants, aspirin, INH, phenothiazines, alcohol.
Pregnancy
Category (US
FDA) Category B: Either animal-reproduction studies have not
demonstrated a foetal risk but there are no controlled studies in
pregnant women or animal-reproduction studies have shown an
adverse effect (other than a decrease in fertility) that was not
confirmed in controlled studies in women in the 1st trimester (and
there is no evidence of a risk in later trimesters).
MIMS Class Analgesics (Non-Opioid) & Antipyretics
ATC N02BE01 - Paracetamol ; Belongs to the class of anilide
Classification preparations. Used to relieve pain and fever.
Poison Schedule Non-Rx

Presentation/Packing

Form Packing/Price Photo


Biogesic 500 mg x 20's
Biogesic tablet
Biogesic 500 mg x 500's (P2.9/tab)

Amoxicillin
Bradoxil® [cap]
Singapore Pharmawealth Lifesciences [ Phil Pharmawealth ]
MIMS Class : Penicillins

Contents
Amoxicillin (cap: Treatment of infections caused by susceptible strains of gm+ve &
trihydrate, vial: gm-ve microorganisms eg actinomycosis, biliary tract, bone & joint
Na) infections, bronchitis, endocarditis, gastroenteritis, gonorrhea, mouth
Indications infections, otitis media, pneumonia, spleen disorders, typhoid &
paratyphoid fever & UTI. Lyme disease.
Dosage Cap 250-500 mg 8 hrly.
Administration May be taken with or without food (May be taken w/ meals for
better absorption & to reduce GI discomfort.).
Contraindications Hypersensitivity to penicillins.
Special History of allergy or asthma, hay fever or urticaria. Severe renal
Precautions failure.
Adverse Drug Skin rash, GI effects, pseudomembranous colitis. Reversible blood
Reactions & lymphatic reactions eg anemia, thrombocytopenia,
thrombocytopenic purpura, eosinophilia, leukopenia &
agranulocytosis.

Pregnancy
Category (US
FDA) Category B: Either animal-reproduction studies have not
demonstrated a foetal risk but there are no controlled studies in
pregnant women or animal-reproduction studies have shown an
adverse effect (other than a decrease in fertility) that was not
confirmed in controlled studies in women in the 1st trimester (and
there is no evidence of a risk in later trimesters).
MIMS Class Penicillins
ATC J01CA04 - Amoxicillin; Belongs to the class of penicillins with
Classification extended spectrum. Used in the systemic treatment of infections.
Poison Schedule Rx

Presentation/Packi
ng
Packin
Form
g/Price
Brad Bradoxil
oxil 250 mg x
caps 100's
ule
Bradoxil
500 mg x
100's

Glibenclamide
Gluban® [tab]
Vendiz [ Metro Drug ]
MIMS Class : Antidiabetic Agents

Contents Glibenclamide
Indications NIDDM or type II-maturity-onset diabetes.
Dosage Initially 2.5-5 mg once daily, may be increased in increments of ≤2.5
mg at wkly intervals until diabetic control is obtained. Max: 20
mg/day.
Administration Should be taken with food
Contraindications IDDM, diabetic ketoacidosis, serious impairment of renal hepatic or
adrenocortical function, surgical operation, pregnancy.
Adverse Drug Mild GI or allergic skin reactions, reversible leukopenia &
Reactions thrombocytopenia, transient changes in liver function tests.

Drug Interactions Hypoglycemic effect may be enhanced by dicoumarol, MAOI, β-


blockers, sulfonamides, phenylbutazone, chloramphenicol,
cyclophosphamide, salicylates or diminished by adrenaline,
corticosteroids, OC or thiazide diuretics.

Pregnancy
Category (US
FDA) Category C: Either studies in animals have revealed adverse effects
on the fetus (teratogenic or embryocidal or other) and there are no
controlled studies in women or studies in women and animals are
not available. Drugs should be given only if the potential benefit
justifies the potential risk to the fetus.
MIMS Class Antidiabetic Agents
ATC A10BB01 - Glibenclamide ; Belongs to the class of sulfonamides,
Classification urea derivatives. Used in the treatment of diabetes.
Poison Schedule Rx

Presentation/Packing
Form Packing/Price
Gluban tablet Gluban 5 mg x 100's (P700)
Metformin
Insunex® [tab]

Medopharm [ NextChem ]
MIMS Class: Antidiabetic Agents

Contents Metformin HCl


Indications NIDDM; primary or secondary sulfonylurea failure, where it may
replace or be combined w/ sulfonylureas as an adjunct to therapy in
IDDM.
Dosage 1 tab bid-tid, increased up to 2-3 g daily.
Administration Should be taken with food (Take w/ or after meals.).
Contraindications Diabetic coma, severe ketoacidosis, severe renal or hepatic
insufficiency, cardiac failure, severe thyroid function impairment,
dehydration, acute or chronic alcoholism. Trauma & post-op.
Special
Hepatic & renal disease. Pregnancy.
Precautions
Adverse Drug Anorexia, nausea, vomiting.
Reactions
Pregnancy
Category (US
FDA) Category B: Either animal-reproduction studies have not
demonstrated a fetal risk but there are no controlled studies in
pregnant women or animal-reproduction studies have shown an
adverse effect (other than a decrease in fertility) that was not
confirmed in controlled studies in women in the 1st trimester (and
there is no evidence of a risk in later trimesters).
MIMS Class Antidiabetic Agents
ATC A10BA02 - Metformin ; Belongs to the class of biguanides. Used in
Classification the treatment of diabetes.
Poison Schedule Rx

Presentation/Packing
Form Packing/Price
Insunex tablet Insunex 500 mg x 100's (P350)
Aluminum Hydroxide
Kremil-S (Reformulated)® [tab]

United Lab [ Therapharma ]


MIMS Class : Antacids, Antireflux Agents & Antiulcerants

Contents Al(OH)3 178 mg, Mg(OH)2 233 mg, simethicone 30 mg


Indications Symptomatic relief of hyperacidity associated w/ peptic ulcer,
gastritis, esophagitis & dyspepsia. Supplement to H2-blockers or
proton pump inhibitors for rapid relief of ulcer symptoms.
Antiflatulent to alleviate the symptoms of gassiness, including post-
op gas pain, associated w/ hyperacidity.
Dosage Adult 1-2 tab 1 hr after each meal and at bedtime.
Administration Should be taken on an empty stomach (Take 1 hr after each meal &
at bedtime. Break/ chew before swallowing.).
Contraindications Patients with renal failure. Partial intestinal obstruction, appendicitis,
fecal impaction, gastric outlet obstruction & constipation. Phosphate
depletion, low serum phosphate & osteomalacia.
Special Risk of Al accumulation & toxicity w/ advanced renal failure.
Precautions Prolonged use of Al-containing antacids in patients w/ renal failure
may result in or worsen dialysis osteomalacia.
Adverse Drug Diarrhea or constipation may occur to patients taking antacids
Reactions containing Mg & Al. The following occur rarely: Due to Al(OH)3:
Proximal myopathy; encephalopathy & dementia may occur in
patient w/ renal failure; intestinal obstruction; fecal impaction;
osteomalacia.

Drug Interactions Alkalinization of gastric content decreases the bioavailability of Fe,


ketoconazole & tetracyclines. The absorption of tetracyclines is
further reduced by its chelation with Al & Mg ions.
MIMS Class Antacids, Antireflux Agents & Antiulcerants
ATC A02AF02 - Ordinary salt combinations and antiflatulents ; Belongs
Classification to the class of antacids with antiflatulents.
Poison Schedule Non-Rx
Presentation/Packing
Form Packing/Price
Kremil-S (Reformulated) 8's (P33.2)
Kremil-S (Reformulated) Kremil-S (Reformulated) 100's (P415)
tablet Kremil-S (Reformulated) 500's (P2075)
Kremil-S (Reformulated) (P4.15/tab)
Loperamide
Diatabs (Reformulated)® [cap]

United Lab [ Biomedis ]


MIMS Class : Antidiarrheals

Contents Loperamide HCl


Indications Symptomatic control of acute & chronic diarrhea. Ileostomy.
Dosage Adult Acute diarrhea 2 cap followed by 1 cap after each unformed
stool. Do not use for >5 days. Chronic diarrhea 2 cap then adjust
dose until 1-2 solid stools/day are obtained. Max: 16 mg/day.
Administration May be taken with or without food
Contraindications Constipation. Acute ulcerative colitis, pseudomembranous colitis,
acute dysentery.
Special Hepatic dysfunction, persistent diarrhea, patients receiving anti-
Precautions infectives. Childn <12 yr. Pregnancy & lactation.
Adverse Drug Constipation, nausea, vomiting, tiredness, drowsiness or dizziness,
Reactions dry mouth.

Pregnancy
Category (US
FDA) Category B: Either animal-reproduction studies have not
demonstrated a foetal risk but there are no controlled studies in
pregnant women or animal-reproduction studies have shown an
adverse effect (other than a decrease in fertility) that was not
confirmed in controlled studies in women in the 1st trimester (and
there is no evidence of a risk in later trimesters).
MIMS Class Antidiarrheals
ATC A07DA03 - Loperamide ; Belongs to the class of antipropulsives.
Classification Used in the treatment of diarrhea.
Poison Schedule Non-Rx
Presentation/Packing
Form Packing/Price
Diatabs (Reformulated) 2 mg x 8's (P54)
Diatabs (Reformulated) Diatabs (Reformulated) 2 mg x 100's (P675)
capsule Diatabs (Reformulated) 2 mg x 500's (P3375)
Diatabs (Reformulated) 2 mg (P6.75/cap)
Diclofenac Sodium
Difenax® [tab]
GXI [ Metro Drug ]
MIMS Class : Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Contents Diclofenac Na
Indications Inflammatory & degenerative forms of rheumatism, ankylosing
spondylitis, osteoarthritis & spondylarthritis. Painful post-traumatic
& post-op inflammation & swelling.
Dosage 50 mg bid.
Overdosage View Difenax overdosage for action to be taken in the event of an
overdose.
Administration Should be taken with food (Take immediately after meals.).
Contraindications Peptic ulcer.
Special Close monitoring necessary in patient w/ GI disorders. Severe
Precautions impairment of hepatic function.
Adverse Drug Epigastric pain, nausea, vomiting, diarrhea, headache & dizziness,
Reactions rashes or skin eruptions.

Drug Interactions May increase plasma levels of warfarin, lithium, methotrexate,


digoxin.

Pregnancy
Category (US
FDA) Category B: Either animal-reproduction studies have not
demonstrated a foetal risk but there are no controlled studies in
pregnant women or animal-reproduction studies have shown an
adverse effect (other than a decrease in fertility) that was not
confirmed in controlled studies in women in the 1st trimester (and
there is no evidence of a risk in later trimesters).
in 3rd trimester or near delivery.

Category D: There is positive evidence of human foetal risk, but the


benefits from use in pregnant women may be acceptable despite the
risk (e.g., if the drug is needed in a life-threatening situation or for a
serious disease for which safer drugs cannot be used or are
ineffective).
Storage View Difenax storage conditions for details to ensure optimal shelf-
life.
Description View Difenax description for details of the chemical structure and
excipients (inactive components).
Mechanism of View Difenax mechanism of action for pharmacodynamics and
Action pharmacokinetics details.
MIMS Class Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
ATC M01AB05 - Diclofenac ; Belongs to the class of acetic acid
Classification derivatives and related substances of non-steroidal antiinflammatory
and antirheumatic products.
Poison Schedule Rx
Presentation/Packing
Form Packing/Price Photo
Difenax tablet Difenax 50 mg x 100's (P5.57/tab)

Mefenamic Acid
Mefenax® [susp]

One Pharma [ One Pharma ]


MIMS Class : Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Contents Mefenamic acid


Indications Headache, muscular & traumatic pain; post-op, post-extraction &
postpartum pain; relief of primary dysmenorrhea.
Dosage Susp 25 mg/kg body wt daily in 3 divided doses. Treatment should
not exceed 7 days.
Administration Should be taken with food (Take immediately after meals.).
Contraindications Ulceration or inflammation of GIT.
Special
Renal or liver impairment.
Precautions
Adverse Drug GI irritation, diarrhea (high doses/long-term therapy), skin rash.
Reactions Rarely, thrombocytopenia & reversible hemolytic anemia.

Side Effects Side effects are few and mild at the recommended dosage for
analgesic use and are readily detected and easily controlled when
encountered with high dosage and long-term use. Gastric irritation is
infrequent and may be minimized by taking Mefenax with meals.

Diarrhea has been observed when mefenamic acid was given in


higher than recommended doses and/or long-term continuous
therapy. Skin rash has occurred but disappeared upon withdrawal of
medication. Rarely, thrombocytopenia and reversible hemolytic
anemia have been reported with mefenamic acid.
Drug Interactions May enhance effects of coumarin anticoagulants.

Pregnancy
Category (US
FDA) Category C: Either studies in animals have revealed adverse effects
on the foetus (teratogenic or embryocidal or other) and there are no
controlled studies in women or studies in women and animals are
not available. Drugs should be given only if the potential benefit
justifies the potential risk to the foetus.
in 3rd trimester or near delivery.

Category D: There is positive evidence of human foetal risk, but the


benefits from use in pregnant women may be acceptable despite the
risk (e.g., if the drug is needed in a life-threatening situation or for a
serious disease for which safer drugs cannot be used or are
ineffective).
Storage View Mefenax storage conditions for details to ensure optimal shelf-
life.
Mechanism of View Mefenax mechanism of action for pharmacodynamics and
Action pharmacokinetics details.
MIMS Class Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
ATC M01AG01 - Mefenamic acid ; Belongs to the class of non-steroidal
Classification antiinflammatory and antirheumatic products, fenamates.
Poison Schedule Rx

Presentation/Packing
Form Packing/Price
Mefenax suspension Mefenax 50 mg/5 mL x 60 mL (P80)

Ascorbic Acid
Ceelin® [syr]

Pediatrica [ United Lab ]


MIMS Class : Vitamins & Minerals (Pediatric)
Contents Ascorbic acid
Indications Prevention & treatment of vit C deficiency.
Dosage Syr Childn 7-12 yr 5-10 mL (1-2 tsp), 2-6 yr 5 mL (1 tsp). To be
taken once daily for supplementation, bid-qid for therapeutic use.
Administration May be taken with or without food
Adverse Drug Nausea, abdominal cramps, diarrhea, nose bleeds.
Reactions
Drug Avoid in phenylketonurics as tab contains phenylalanine.
Interactions
MIMS Class Vitamins & Minerals (Pediatric)
ATC A11GA01 - Ascorbic acid (vit C) ; Belongs to the class of ascorbic
Classification acid (vitamin C). Used as dietary supplements.
Poison Schedule Non-Rx

Presentation/Packing
Form Packing/Price
Ceelin 100 mg/5 mL x 60 mL (P54.5)
Ceelin 100 mg/5 mL x 120 mL (P116)
Ceelin syrup
Ceelin 100 mg/5 mL x 250 mL (P196.75)
Ceelin 100 mg/5 mL x 500 mL (P323.25)

Multivitamins
K-A Plus Multivitamins®
[cap]

Diamond Lab [ Tobie


Pharma ]
MIMS Class : Vitamins &/or Minerals

Contents Vit A 4,000 iu, vit B2 2 mg, vit B1 2 mg, vit B6 1 mg, vit B12 1 mcg, vit
C 60 mg, vit D 400 iu, vit E 10 mg, nicotinamide 15 mg, Ca
pantothenate 10 mg, rutin 20 mg, Ca phosphate dibasic 307.5 mg,
standardized Korean ginseng 40 mg, Ca fluoride 0.5 mg, cupric
sulfate 2.8 mg, K sulfate 18 mg, manganese sulfate 2.8 mg, Zn sulfate
2.8 mg, Fe sulfate 30 mg, deanol 26 mg, inositol 25 mg, choline Cl 25
mg, linoleic acid 25 mg, Mg sulfate 50 mg, lysine HCl 25 mg
Indications Prevents & treats nutritional vit & mineral deficiencies, increases
body resistance against diseases & overcomes undue fatigue & stress.
Provides nutritional supplement for metabolic build up & conditions
as in athletic exertions. Restores energy & vigor for physical activities
& improves mental capacity for work.
Dosage 1-2 cap daily.
Administration May be taken with or without food (May be taken w/ meals for better
absorption or if GI discomfort occurs.).
Storage Store at a temperature not exceeding 30°C.
Description Each capsule contains the following: Retinol acetate (vitamin A) 4000
IU, riboflavin (vitamin B2) 2 mg, thiamine mononitrate (vitamin B1)
2 mg, pyridoxine hydrochloride (vitamin B6) 1 mg, cyanocobalamin
(vitamin B12) 1 mcg, ascorbic acid (vitamin C) 60 mg, ergocalciferol
(vitamin D) 400 IU, L-tocopherol (vitamin E) 10 mg, nicotinamide 15
mg, calcium pantothenate 10 mg, rutin 20 mg, dibasic calcium
phosphate 307.5 mg, Standardized Korean ginseng (made from roots
of the best quality genuine Panax ginseng) 40 mg, calcium fluoride
0.5 mg, cupric sulfate 2.8 mg, potassium sulfate 18 mg, manganese
sulfate 2.8 mg, zinc sulfate 2.8 mg, ferrous sulfate (equivalent to 7.2
mg elemental iron) 30 mg, deanol 26 mg, inositol 25 mg, choline
chloride 25 mg, linoleic acid 25 mg, magnesium sulfate 50 mg and
lysine hydrochloride 25 mg.

K-A Plus contains an effective combination of the necessary vitamins


and minerals plus the revitalizing properties of Korean ginseng.

K-A Plus is designed to ensure optimum energy build up during


everyday activities and stresses.

K-A Plus incorporates the most essential vitamin and mineral


supplement necessary to stimulate appetite, correct vitamin
deficiencies, restore physical stamina, maintain and improve physical
and mental development. It also helps increase body resistance against
infections and other stress-oriented conditions.
MIMS Class Vitamins &/or Minerals
ATC A11AA03 - Multivitamins and other minerals, incl. combinations ;
Classification Belongs to the class of multivitamins with minerals. Used as dietary
supplements.
Poison Schedule Non-Rx
Presentation/Packing
Form Packing/Price Photo
K-A Plus Multivitamins K-A Plus Multivitamins 30's (P240)
capsule K-A Plus Multivitamins 100's (P800)

Ampicillin
Ampico® [vial]

Sel-J Pharma [ Sel-J Pharma / Plethico ]


MIMS Class : Penicillins

Contents Ampicillin
Indications Vial: Adults: 250 mg every 6 hrs IM or IV. Children: 50 mg/kg/day,
IM or IV in divided doses every 6 or 8 hrs.

Infections of the Genitourinary Tract: Adults: 500 mg every 6 hrs IM


or IV.

Larger doses may be required for severe infections.

Children: 100 mg/kg/day in divided doses every 6 hrs.

Infections of the GIT: Adults: 500 mg every 6 hrs IM or IV.

Children: 100 mg/kg/day IM or IV in divided doses every 6 hrs.


Dosage Infections of the ear, nose, throat & lower resp tract due to
staphylococci & upper & lower resp tract infections due to H
influenzae Adult 250 mg 6 hrly. Childn 50 mg/kg/day in divided
doses 6-8 hrly. GUT infections Adult 500 mg 6 hrly. Childn 100
mg/kg/day in divided doses 6 hrly. Uncomplicated urethritis due to
N gonorrhea Adult 3.5 g single dose administered simultaneously +
1 g probenecid. GIT infections Adult 500 mg 6 hrly. Childn 100
mg/kg/day in divided doses 6 hrly. Childn >20 kg Adult dose.
Overdosage In case of overdosage, discontinue, treat symptomatically and
institute supportive measures as required. In patients with function
impairment, ampicillin-class antibiotics can be removed by
hemodialysis but not by dialysis.
Contraindications Allergy to penicillins.
Warnings Serious and occasionally fatal hypersensitivity (anaphylactoid)
reactions have been reported in patients on penicillin therapy.
Although anaphylaxis is more frequent following parenteral therapy,
it has occurred in patients on oral penicillins. These reactions are
more apt to occur in individuals with a history of sensitivity to
multiple allergens. There have been reports of individuals with a
history of penicillin hypersensitivity who experienced severe
reactions when treated with cephalosporins. Before therapy with a
penicillin, careful inquiry should be made concerning previous
hypersensitivity reactions to penicillins, cephalosporins and other
allergens. If an allergic reaction occurs, the drug should be
discontinued and the appropriate therapy should be instituted.
Serious anaphylactoid reactions require immediate emergency
treatment with epinephrine. Oxygen, IV steroids and airway
management, including intubation, should also be administered as
indicated.
Special
Discontinue in case of superinfection. Prolonged therapy.
Precautions
Adverse Drug Glossitis, stomatitis, black, hairy tongue, nausea, vomiting,
Reactions enterocolitis, pseudomembranous colitis & diarrhea. Erythematous
maculopapular rash, urticaria, erythema multiforme & anaphylaxis.
Moderate rise in SGOT. Anemia, thrombocytopenia,
thrombocytopenic purpura, eosinophilia, leukopenia &
agranulocytosis. Urticaria, other skin rashes.

Drug Interactions Allopurinol. Bacteriostatic antibiotics eg chloramphenicol,


erythromycin, sulfonamide & tetracycline. OCs. Probenecid.
Pregnancy
Category (US
FDA) Category B: Either animal-reproduction studies have not
demonstrated a foetal risk but there are no controlled studies in
pregnant women or animal-reproduction studies have shown an
adverse effect (other than a decrease in fertility) that was not
confirmed in controlled studies in women in the 1st trimester (and
there is no evidence of a risk in later trimesters).
Storage Store at a temperature not exceeding 30°C. Protect from direct
sunlight.

Shelf-Life: Vial: 24 months.


Description Each capsule contains ampicillin trihydrate equivalent to ampicillin
anhydrous 500 mg. Each 250- 500- and 1-g vial contains ampicillin
sodium 250- 500- and 1-g respectively.

Ampicillin is a semisynthetic penicillin derived from the basic


penicillin nucleus, 6-amino-penicillanic acid.
Mechanism of Antibacterial.
Action
Pharmacology: Ampicillin is similar to benzyl penicillin in its
bacterial action against sensitive organisms during the stage of
active multiplication. It acts through the inhibition of biosynthesis of
cell wall mucopeptide. Ampicillin differs in vitro spectrum. It exerts
high in vitro activity against many strains of Haemophilus
influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria
catarrhalis, Escherichia coli, Proteus mirabilis, Bacteroides
funduliformis, Salmonella and Shigella organisms. In vitro studies
have also demonstrated the sensitivity of many strains of the
following gram-positive bacteria; α-hemolytic streptococci,
Diplococcus pneumoniae, nonpenicillinase-producing staphylococci,
Bacillus anthracis, and most strains of enterococci and clostridia.
Ampicillin generally provides less in vitro activity than penicillin G
does against gram-positive bacteria. Because it does not resist
destruction by penicillinase, it is not effective against penicillin-
producing bacteria, particularly resistant staphylococci. All strains of
Pseudomonas and most strains of Klebsiella and Aerobacter
organisms are resistant.

Pharmacokinetics: Ampicillin is acid stable and therefore well


absorbed. Food, however, retards absorption.

Blood serum levels of approximately 2 mcg/mL are attained within


1-2 hrs following a 250 mg oral dose given to fasting adults.
Detectable amounts persist for about 6 hrs.

Ampicillin diffuses readily into all body tissues and fluids with the
exception of brain and spinal fluid except when meninges are
inflamed. Higher serum levels are obtained following IM injection.
Most of the ampicillin is excreted unchanged in the urine and this
excretion can be delayed by concurrent administration of
probenecid. The active form appears in the bile in higher
concentrations than those found in the serum. Ampicillin is 1 of the
least serum bound of all the penicillins; averaging about 20%
compared to approximately 60-90% for other penicillins.
MIMS Class Penicillins
ATC J01CA01 - Ampicillin ; Belongs to the class of penicillins with
Classification extended spectrum. Used in the systemic treatment of infections.
Poison Schedule Rx
Presentation/Packing
Form Packing/Price
Ampico 1 g x 10's
Ampico vial Ampico 250 mg x 10's
Ampico 500 mg x 10's
Ferrous Sulfate
Brisofer® [cap]

Brymar Pharma [ Brymar Pharma ]


MIMS Class : Vitamins & Minerals (Pre & Post Natal) / Antianemics

Contents Fe sulfate
Indications Iron deficiency.
Dosage 1 cap daily.
Administration Should be taken with food (Take after meals.).
Special
Administration w/ food. Gastric irritation.
Precautions
Adverse Drug Black stools.
Reactions
Drug Tetracycline, antacids.
Interactions
MIMS Class Vitamins & Minerals (Pre & Post Natal) / Antianemics
ATC B03AA07 - Ferrous sulfate; Belongs to the class of oral iron bivalent
Classification preparations. Used in the treatment of anemia.
Poison Schedule Non-Rx

Presentation/Packing
Form Packing/Price
Brisofer capsule Brisofer 250 mg x 100's

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