Z I N C - G LY C I N E C O M P L E X

(SKINCARE )

(FACE)
( M E TA L LOT H I O N E I N E I N D U C E R )

(NO ANIMAL
TESTING)

A N T I - A G E I N G L I G H T E N I N G

The mineral and synthetic Zinc-Glycine Complex uses the Metallothioneine inductive ability of Zinc
and the ligand properties of Glycine for skin penetration.

This complex reduces the intracellular oxidative stress

and synergistically potentiates a lightening effect through two metabolic pathways.

Reduces Intracellular Oxidative stress

Suppresses Melanocyte Stimulating Factors

Inhibits Tyrosinase activity

INCI: ZINC GLYCINATE

CAS number : 14281-83-5 / Einecs : 238-173-1

IN USE CONCENTRATION: 0,5 to 1%

 METALLOTHIONEINE INDUCTION resistance against oxidative stress
uvb-induced intracellular
** peroxidation (HaCaT keratinocytes)
25.0

1.6
**

A ratio of fluorescence of control cells

20.0 1.4

MT (mg/mg protein) 1.2

15.0
1.0

0.8
10.0
0.6

0.4
5.0

0.2

0 0.0
Cont. ZnCl210µM) 1 10 100 Cont ZnCl2 10 M Zn(Gly)2 10 M
Zn(Gly)2

Conc.(µM) Without UVB irradiation 5 mJ/cm2 UVB irradiation

10µM Zn(Gly)2 = 2ppm Zn(Gly)2 10µM Zn(Gly)2 = 2ppm Zn(Gly)2

MELANOCYTE GROWTH: -10% with 20 ppm Zn(Gly) 2

TYROSINASE ACTIVITY: -40% with 0,02 ppm Zn(Gly) 2

E V A L U AT I O N
ON 3D
SKIN MODEL

UVB-irradiation (control) 100µM Zn(Gly) 2 100µM ZnSO 4

Skin Lightening Cream

INGREDIENTS INCI %
Cyclopentasiloxane ; PEG-10
NIKKOMULESE WO 2,70
Dimethicone ; Disteardimonium Hectorite
DC 345 Cyclomethicone 6,00
DM 350 Dimethicone 2,00
A TRIFAT S -308 Triethylhexanoin 3,00
CIO Cetyl Ethylhexanoate 4,00
MACADAMIA NUT OIL Macadamia Ternifolia Seed Oil 2,00
Phenoxyethanol ; Methylparaben ; Ethylparaben ;
DECABEN C 0,60
Butylparaben ; Isobutylparaben
B PLASTIC POWDER CS 400 HDI / PPG / Polycaprolactone Crosspolymer ; Silica 2,00
BUTYLENE GLYCOL Butylene Glycol 7,00
GLYCERIN Glycerin 7,00
TRISODIUM CITRATE Trisodium Citrate 1,50
C
CITRIC ACID Citric Acid 0,70
ZINC - GLYCINE COMPLEX Zinc Glycinate 1,00
WATER Water 60,50

M A N U FA C T U R E P R O C E S S :
1 Disperse A (check no blocks of Nikkomulese WO).
2 While dispersing, add B.
3 Mix all ingredients of C and add it gradually.