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Artificial Sweeteners From The Merck Index (1989) (Naturally-occurring sweeteners are shaded)

Marketing Formula MW x Discoverer IUPAC nam e, and other Structure


Name(s)/ (g/mol)
sw eeter or Patent scientifically accepted nam es
Common than Ow ner
Name(s) sugar (year)

Table sugar, C1 2 H2 2 O1 1 342.3 1 — Sucrose


can e su gar, (This sugar Saccharose
b e e t suga r occurs in $-D-Fructofuranoysyl-"-D-glycopyranoside
nature)

Fruit Sugar C6 H1 2 O6 180.2 2 — Fructose


Fru ctoste ril (This sugar Levulose
La e v ora l occurs in $-D-Fructose
Le vu g en
nature) D-Fructose
La e v osa n

Saccharine1 C7 H5 NO3 S 183.2 500 Remsen & 1,2-benzisothiazol-3(2H)-one 1,1-dioxide


G lu s id e (metallic, Fahlberg (1879) benzosulfinide
G lu cid bitter ortho-sulfobenzoic acid imide
G aran tose
aftertaste)
S ac cha rino l
S acch arin ose
S ac cha ro l
S axin
S yko se
H e rm e se ta s

Cyclamate C6 H1 2 NSO3 Na 202.1 30 du Pont Sodium Cyclamate


Assugrin Chemicals Sodium cyclohexylsulfamate
Sucrosa (1942)

NutraSweet C1 4 H1 8 N2 O5 294.3 160 Searle Aspartame


Canderel Pharmaceuticals N-L-"-aspartyl-L-phenylalanine-1-methyl ester
Equal (1970)
Sanecta
Tri-Sweet

Monellin (Protein ~10,700 3000 Inglett (1969) Monellin Extracted from the Serendipity Plant,
chain of 91 and is thought to have more than 1 such
amino acids) protein from that plant.

Thaumatin (Protein ~22,000 100,000 van der Wel, Thaumatin Extracted from a West African licorice
chain of 207 (Licorice and Loeve Talin plant, and there is thought to 5 types of
amino acids) aftertaste) (1972) Thaumatin proteins in existence, with 2
of them predominating. Sweetness is
lost if protein denatures (heat, pH).
Tertiary structure of protein is important
in sweetness.
1
Saccharine “may reasonably be anticipated to be a carcinogen” Fourth Annual Report on Carcinogens (1985) p 179

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