P. 1
Sistem Endokrin

Sistem Endokrin

|Views: 731|Likes:
Dipublikasikan oleh Hendrik_Nurfitrianto
DOWNLOAD : http://www.ziddu.com/download/12820663/SistemEndokrin.doc.html
DOWNLOAD : http://www.ziddu.com/download/12820663/SistemEndokrin.doc.html

More info:

Published by: Hendrik_Nurfitrianto on Dec 04, 2010
Hak Cipta:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as DOC, PDF, TXT or read online from Scribd
See more
See less

02/25/2013

pdf

text

SISTEM KOORDINASI : HORMON overview

S IS T E M S Y A R A F S IS T E M E N D O K R IN

k o o rd in a s i

S IS T E M R E S P IR A S I S IS T E M P E N C E R N A A N S IS T E M S IR K U L A S I S IS T E M E K S K R E S I S IS T E M G E R A K

© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

SISTEM KOORDINASI

S IS T E M S Y A R A F
- a k s i b e rs ifa t s e g e ra c o n to h : ~ d e n y u t ja n tu n g ~ k o n tra k s i o to t

S IS T E M E N D O K R IN
- a k s i le b ih la m b a t c o n to h : ~ p e rtu m b u h a n ~ p e rk e m b a n g a n n e u ro n d i s is te m s y a ra f p u s a t

- u n tu k p e n g a tu ra n c e p a t - p e n g a tu ra n ja n g k a p a n ja n g

- n e u ro n d a n s e ra b u t s y a ra f s e l-s e l k e le n ja r e n d o k rin d a n - s e k re s i n e u ro tra n s m itte r - s e k re s i h o rm o n - k o m u n ik a s i a n ta r n e u ro n- tra n s p o rt v ia s is te m s irk u la s i, m e la lu i s y n a p s is m e lib a tk a n s is te m re s e p to r

K O M U N IK A S I N E U R A L+

K O M U N IK A S I H O R M O N A L

K O M U N IK A S I N E U R O E N D O K R IN s e k re s i n e u ro h o rm o n

© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

KOMUNIKASI HUMORAL K e le n ja r E n d o k rin H u m o r (c a ira n )

H o rm o n

N e u ro h o rm o n

H o rm o n e lik e

m a s in g -m a s in g m e m ilik i fu n g s i y a n g s p e s ifik , n a m u n s a lin g b e k e rja s a m a d a la m m e n ja la n k a n fu n g s in d a n a d a s a lin g k e te rg a n tu n g a n s a tu s a m a la in M DL O E

n e u ro h o rm o n h ip o ta la m u s h o rm o n a d e n o h ip o fis e s e l/ja rin g a n /o rg a n s a s a ra n p ro d u k h o rm o n lo k a l
© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

++ e fe k +++

BERBAGAI SINYAL KIMIA ANTARSEL

© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

5 K A R A K T E R IS T IK H O R M O N :

1 . M a m p u m e n im b u lk a n e fe k y a n g s ig n ifik a n d a la m -6 - 1 -1 y a n g s a n g a t re n d a h (1 0 0 2 M ) 2 . S u k a r d iis o la s i, d iid e n tifik a s i, d a n d iu k u r s e c a ra a k 3 . U m u rn y a s a n g a t p e n d e k , d is e k re s i s e te la h a d a s ti d a n s e g e ra d iin a k tifk a n o le h e n z im y a n g k h a s 5 AKSI HORM ON: 1 . S e c a ra la n g s u n g , d a la m h itu n g a n d e tik c o n to : e p in e frin /a d re n a lin h 2 . B e k e rja la m b a t, d a la m h itu n g a n ja m - h a ri c o n to : e stro g e n h 5 E F E K Y A N G D IT IM B U L K A N H O R M O N : 1 . E fe k k in e tik M ig ra s i p ig m e n , k o n tra k s i o to t, s e k re s i k e le n ja r 2 . E fe k m e ta b o lik N u tris i, p e rtu m b u h a n , p e rk e m b a n g a n , re p ro d u k s i 3 . E fe k p e rila k u C o n to h : e s tro g e n E fe k : 1 . m e m u n c u lk a n c iri k e la m in s e k u n d e r 2 . p e ru b a h a n tin g k a h la k u 3 . k o n tra k s i o to t u te ru s (b e k e rja s a m a d e n g a n o k sito s in )

S u a tu h o rm o n d a p a t m e n im b u lk a n e fe k le b ih d a ri s a

© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

5 K LA S IFIK A S I H O R M O N : B e rd a s a rk a n k tu r k imd a ns ifa t k e la ru ta n : y a s tru ia n A . H o rm o n le m a k ru t d a la m p e la ru t le m a k - la
Prostaglandin
Hormon asam lemak Tromboksan Prostasiklin Leukotrin Hormon seks Hormon korteks adrenal

Hormon steroid

B . H o rm o n p ro te in ru t d a la m a ir - la
Hormon derivat asam amino

Epinefrin, norepinefrin
Dopamin Hormon tiroid (T4, T3) Melatonin Hormon hipotalamus (RH, IH) Hormon hipofise posterior Hormon hipofise intermedia Kalsitonin Glukagon ACTH Endorfin Timosin Lipotropin Somatostatin GH PRL Insulin TSH Gn (LH/ICSH, FSH) PTH

Hormon polipeptida

Hormon protein

Hormon glikoprotein

5 M E K A N IS M E K E R JA H O R M O N : M e lib a tk are s e p to r n : 1 . H o rm o n ste ro id se p to r d i sito so l d a n n u k le u s t re 2 . H o rm o n p ro te in se p to r d i m e m b ra n se l t re
© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

H O R M O N S T E R O ID

¾ B e ra s a l d a ri b a h a n d a s a r k o le s te ro l, s u a tu m o le k u l k o m y a n g te rd iri d a ri 4 c in c in lo p e n ta n a p e rh id ro fe n a n tre n Š s ik
C A B D

¾ F u n g s i: m e m a c u p e rk e m b a n g a n c iri k e la m in s e k u n d e r A N A B O L IC S T E R O ID :

- S e n y a w a s in te tis m e n y e ru p a i a n d ro g e n (te s to s te ro n ) - D u lu b ia s a d ig u n a k a n o le h a tle t u n tu k m e m p e rin d a h d a m e m p e rb e s a r o to t s e rta m e n a m b a h k e k u a ta n fis ik - E fe k s a m p in g : k e ru s a k a n h e p a r, p e n y a k it ja n tu n g , g a n g p s ik o lo g is , m e n y e b a b k a n k a n k e r H O R M O N P R O T E IN

¾ M e n g a n d u n g s a tu a ta u le b ih g u g u s a s a m a m in o , s a tu a le b ih ra n ta i p e p tid a ¾ H o rm o n g lik o p ro te h o rm o n p ro te in y a n g m e n g a n d u n g Š in g u g u s k a rb o h id ra t (c o n to h : h o rm o n h ip o fis e a n te rio r) ¾ F u n g s i: b e rm a c a m -m a c a m , m u la i d a ri y a n g s p e s ifik h a n u n tu k s a tu ja rin g a n ta rg e t s a ja h in g g a y a n g m e m p e n g a ru h s e lu ru h tu b u h s e c a ra u m u m (ta rg e t s a n g a t lu a s ).

SISTEM PATOLOGI :
- Penyebab? - Kelebihan sekresi? - Kekurangan sekresi?
© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

RESEPTOR INTRASEL

How steroid hormones work Steroid hormones are lipid soluble and thus readily pass through the plasma membrane of cells into the cytoplasma. There they bind to specific receptor proteins, forming a complex that enters the nucleus and binds to specific regulatory sites of chromosomes. The binding activates the regulated by genes the site and thus results in the production of specific proteins.

C o n to h : A ld o s te ro n

© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

RESEPTOR MEMBRAN
How peptide hormones work (1) The peptide hormone binds with its membran receptor. (2) The hormone-receptor combination triggers a series of biochemical reactions that produces the second messenger. (3) The second messenger triggers a series of reactions that lead to altered cell functions.

How second messengers work (1) Peptide hormones bind to specific receptor sites on the surface of target cells. (2) The hormone-receptor complex activates adenylate cyclase. (3) Adenylate cyclase converts ATP into cyclic AMP (cAMP) in the cell cytoplasm. cAMP acts as second messenger and activates enzymes called protein kinases. (4) Protein kinases catalyze a wide variety of actions. (5) Depending on the nature of the first messenger, a variety of altered cell functions may result. Because of the presence of second messenger, the effect on the cell is greatly amplified.

© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

BERBAGAI MACAM RESEPTOR MEMBRAN

1. Reseptor yang secara langsung mengontrol kanal membran

2. Reseptor yang mengaktivasi proteinG dan membuka kanal Ca2+

3. Reseptor yang mengaktivasi protein G dan meningkatkan sintesis second messenger

© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

4. Reseptor yang mengaktivasi protein G dan meningkatkan sintesis mediator intrasel

5. Reseptor yang secara langsung mensisntesis mediator intrasel
© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

6. Reseptor yang memfosforilasi protein intrasel

SINTESIS HORMON

Bahan dasar Biosintesis

HORMON PROTEIN Dari sintesis protein

HORMON STEROID Simpanan kolesterol (ester)

mRNA t RER t badan Golgi Lipid droplet t mitokondria t t vesikula/granula sekresi t SER t ? t sirkulasi eksositosist sirkulasi Hormon bebas (hidrofilik) Disimpan dalam vesikula/ granula sekresi (inaktif), diaktivasi oleh stimulus, disekresikan secukupnya Hormon diikat protein transpor (globulin, albumin) Disintesis segera saat dibutuhkan, sisa diinaktivasi oleh enzimt diekskresikan

Transportasi Penyimpanan

© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

5 SEKRESI HO RM O N: P e n g a tu ra n s e k re s i h o rm o n d a p a t d ila k u k a n o le h : 1 . K o m p o n e n n o n h o rm o n a l 2 . S is te m s y a ra f 3 . H o rm o n 5 R E G U LA S I H O R M O N : M e k a n is muem p a n b a lik p o s itif u m p a n b a lik n e g a tif dan y a n g m e lib a tk a n :
siste m sya ra f a k s is h ip o ta la m o -h ip o fis e o s k e le n ja r e n d o k rin p ro d u k se l-se l ta rg e t

h o m e o s ta s is

© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

M ODEL KOM UNIKASI HORM ONAL

PENGATURAN SEKRESI HORMON 1 . P e n g a tu ra n o le h k o m p o n e n n o n h o rm o n a l

© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

2 . P e n g a tu ra n s e k re s i h o rm o n o le h s is te m s y a ra f

3 . P e n g a tu ra n s e k re s i h o rm o n o le h h o rm o n

© 2005 Laksmindra Fitria ( fitonline2000@ yahoo.com )

You're Reading a Free Preview

Mengunduh
scribd
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->