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Predisposing Precipitating

Age Environment

Geographical Are – tropical Immunocompromised


islands in the Pacific
Sweaty Skin
Rainy Seasons
Bite from Aedis aegypti (Dengue
Virus Carrier) in the skin as the Redness and
portal of entry itchiness in the area

Dengue Virus will be inoculated in


the circulation (Incubation Period
of 3-14 days)
Virus stimulates WBC
including B lymphocytes

Immunoglobulin Macrophages Neutrophils


s

Phagocytocis

Enters to Enters to the


Binding
the Spleen bone marrow
because
and Liver
of Fc
receptor
Replicates in the
cells

Recognition of dengue
viral antigen on infected
monocyte
Release of inflammatory
response such as cytokines
and vaso active agents
such as interleukins.
Stimulates WBC and
Pyrogen Release
Fever
Virus Targets Liver and spleen DengueCellular
Fever direct destruction and
parenchymal cells where Syndromeinfection of red bone marrow Decreased
infection produces Apoptosis precursor cells as well as Platelet
Complications:
immunological
Intense shortened platelet
bleeding
Increase number and size of
Pulmonary Edema
the pores in the capillaries
Shock
Hepatospleenomegaly which leads to a leakage of
Thrombocytopenia Petechial
Very low blood
Pleural
fluid from the blood to the
pressure Rash
Effusion
interstitial
Liverfluid (capillary
cirrhosis
Dengue Abdominal
Abdominal Pain Hemoptysis Dengue Ascites
Death
leakage)
Distention