Pathogenesis:

Kwashiorkor:
• Normal energy intake, Lack of protein
• Edema:1970.decrease oncotic pressure,
– Recent> Increase Renin activity,N a and fluid retention.
• Amino aciduria due to proximal tubular dysfunction
• Failure of adaptation
• .Hepatomegaly due to fatty infiltration from
lipogenesis of excess CHO
• - Biochemical and haematological changes
Causes:
Social.ecomomic.poverity.ignorance.maternal
malnutrtion.enviromental.
Kwashiorkor:
• Insufficient intake of protein of good biological value.
• Impaired absorption of protein e.g. chronic diarrhoea.
• Abnormal losses of protein e.g.
severe nephrosis . Severe or prolonged infection
• Failure of protein synthesis e.g.
chronic liver diseases.