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tramadol pain drug

Author Wednesday, December 8, 2010 4:13 PM   Tramadol Pain Drug

Tramadol has been used as an analgesic since the late 1970s, and became
one of the most popular analgesics of its class in Germany. International
interest for the drug has been renewed when it was discovered that tramadol
not only acts like opioids, but also inhibits serotonin and noradrenaline
reuptake.

tramadol pain drug

Author Wednesday, December 8, 2010 4:13 PM  

The Unique Pain Medication

By Yury Bayarski

Tramadol has been used as an analgesic since the late

1970s, and became one of the most popular analgesics
of its class in Germany. International interest for the
drug has been renewed when it was discovered that
tramadol not only acts like opioids, but also inhibits
serotonin and noradrenaline reuptake.

Mechanism of action

Tramadol is a unique medication. Its mode of action and safety profile distinguishes it from other opioids.
It is classified as an atypical centrally acting analgesic, and has opioid and non-opioid properties.
Tramadol is a synthetic analogue of codeine that has weak opioid agonist properties. It also inhibits the
neuronal reuptake of norepinephrine and serotonin as do the antidepressant drugs

Tramadol has strong structural similarities to the antidepressant venlafaxine. Because of its similarities to
venlafaxine, tramadol may possibly exert a degree of antidepressant effect in certain patients,
particularly those with chronic pain.

Side effects

Tramadol is generally well tolerated, the most common side effects being nausea and vomiting. In
contrast to agents such as morphine and pethidine, respiratory depression rarely occurs during tramadol
treatment at equipotent doses. But large doses of tramadol may increase the respiratory effects of other
drugs. It is also associated with a low incidence of cardiac depression and significantly less dizziness and
drowsiness than morphine.

Finally, dependence and abuse potential is relatively low because it has only a weak opioid effect. The
low abuse potential of tramadol has been demonstrated by postmarketing surveillance data.

Tramadol appears to carry the same risk of urinary disorders (difficulty in micturition, urinary retention)
as other opiates.