Drug Supplied Induction Onset/pk/Dur Other

Amidate Etomidate 2 mg/ml 0.1-.04 mg/kg .5-103-10 Myoclonis/pain on injection/cardiac stable/Adrenal

suppression
Ketamine Kerolar 10 mg/ml 0.5 -2 mg/kg .505-15 Halluinations/ C.O.,HR, Salivate
Methohexital Brevital 10 mg/ml 1-1.5 mg/kg .75305-10 Pain on injection/epileptic Foci/no liver failure
Propofol Diprvan 10 mg/ml 1.5-2.5 mg/kg .7515-10 Pain on injection/Don’t give if egg allergy
Thiopental Pentothal 20 mg/kg 3-5 mg/kg 15.65-15 No in asthma/may shiver on emergence/+ Histamine
Midazolam Versed 1 mg/ml .02-.04mg/kg .5-1415-18 Resp. Depressant/Renal elimination

Succinycholine Anectine 20 mg/ml 1.5 mg/kg .5-114-6 Ultrashort Elim. Plasma Pseudocholinesterrae
Mivacurium Mivacron 2 mg/ml .15-.2 mg/kg 1.51-26-16 Short Met plasma cholinesterase, Histamine release
Atracurium Tracrium 10 mg/ml .3-.5 mg/kg M=0.2 mg 23-520-35 Intermediate Hoffman Elimination/ Mod. Histamine
Vecuronium Norcuron 10 mg .08-.1 mg/kg M=.05 mg 23-525-30 Intermediate Renal-Hepatic Elimination/  Histamine
Rocuronium Zemuron 10 mg/ml .6-1.2 mg/kg M=0.1 mg 1.51-315-150 Intermediate Renal-Hepatic Elimination/  Histamine
Cisatracurium Nimbex 2 mg/ml .15-0.2 mg/kg M=0.03 1.51-26-16 Intermediate Hoffman Elimination/  Histamine
Pancuronium Pavulon 1-2 mg/ml .04-0.1 mg/kg M=0.05 1-33-540-65 Long use peds vent , HR/ Histamine
Doxacurium Nuromax 1mg/ml .05-.08 mg/kg M=0.05 23-930-60 Long Renal Elimination
Pipecuronium Arduan 10 mg .07-.085 mg/kg 23-545-120 Long Renal Elimination/  Histamine

Alfentanil Alfental (600) 500 g/ml 50-300 g/kg 1-21-210-15 Renal Elim./Poss tigh chest-least potent
Fentanyl Sublimaze (15) 50 g/ml 2-20 g/kg .55-1530-60 Poss. Tight chest/Hepatic Pulmonary Elim.
Sufentanil Sufenta (1) 50 g/ml .6-4 g/kg 1-33-520-45 Hepatic Elim./Poss tight chest-most potent
Remifentanil Ultiva (30) 1-2 mg 0.5-1 g/kg/min 11-23-6 Esterase elim./Poss tight chest
Normeperidine metabolite-seizure/ MAOI/ Cross placenta/similar to atropine  HR. Tx shaking, incompatible
Meperidine Demerol 10mg/ml IV: 1mg/kg 51 hr2-4 hrs w/barbiturates

Ketorolac Toradol 30mg/ml IV: 30mg /IM: 60 mg 3060-1204-6 hrs Bleeding/Inhibit cyclooxygenase/No parturient,ulcers,CHF,./asthama

Morphine (100) 10mg/ml 0.1 mg/kg 15-202-7 hrs For PAIN, N&V/most allergies: histamine release
Hydromorphone Dilauded 2mg/ml IV: 0.01-0.04 mg/kg 10-15 | 15-30 | 2-3hrs Hepatic elim./N&V/Histamine reslease/antitussive

Ephedrine 50 mg/ml 2.5-10mgPed .1mg/kg 02-510-60 4cc NS 10mg/cc*   uterine Bld flow
1,1 stimulation*Mix
Phenylephrine/Neosynephrine 10mg/ml IV:40-100 g 0115-20 1 stimulation *Dilute to 40 g/ml
Epinephrine1:1000(.01mg/ml)(20kg=.2cc) 1:10,000(.1mg/ml)(20kg=2) Infusion:2-20 g/min .5310 direct  than  StimulationC.O.,H.R.,Contractility
Dopamine Intropin 200-400mg/5ml amp Infusion:2-20 g/min 2-42-1010-20  &  Adrenergic
Dobutamine Dobutrex 250mg/20ml vial Infusion:2-20 g/min 1-21-1040 Selective B1 agonist/+ Inotrope

Atropine 0.4 mg/ml or 1mg/ml 7-10mcg/kg w/Enlon 121-4 hrs Min. dose 0.1 mg/kg; Cross B.B.B./tertiary ammonium
Glycopyrrolate Robinul 0.2 mg/ml .05-.01mg/kg 452-7 hrs  Cross B.B.B./  secretions/quaternary ammonium
Scopalomine .3,.4,1mg/ml 0.2-1 mg(usually IM) 5-10/20-60/2 hrs Best  secretions, amnesia,sedation,  C.O.,closed-angle glaucoma

Neostigmine Prostigmine 1mg/ml 0.05 mg/kg 3-5min7min1-2hrs Max dose 5 mg /Cholinergic syndrome/ HR Glyco.2mg
Physostigmine Antilirium 1mg/ml .01-.03mg/kg 45-10.5-5 Cross B.B.B.(tertiary amine), Do NOT use asthma
Edrophonium Enlon 10mg/ml 0.5-1 mg/kg 30-60s1min60min Max dose 40mg,.014mg atropine (plus already atropine in)
Muscarinic effects: HR,bronchoconstrict salivation, BP Miosis, intestinal spasm
.
Flumazenil Romazivcon .1mg/ml .2mg over 15 sec. 1-36-1045-90 Benzodiazepine antagonist/repeat
.2mg q min(Max 3mg/hr)
Naloxone Narcan .4mg/ml 0.4-2 mg( postop.1-.2mg) 1-25-151-2 hrs (Mu) Reversal of opioids/.4-1.2(1-3cc for shockC.O.,MABP)

Hydralazine Apresoline 20mg/ml 5-40 mg 5-202-24 hrs Arteriole vasodilator/  HR,C.O.,SVR

Labetalol Trandate 5mg/ml 0.25 mg/kg 1-25-152-4 hrs 12Blockade ratio 1:7,  HR  give slow
Esmolol Brevibloc 10mg/ml .2-.5 mg/kg (25-100mg) 1-2510-20 Cardioselective Blocks 1/ 2 at high dose,ultra short B1agonist, give>1st block

Ondansetron Zofran 2mg/ml 4mg Peds:.15mg/kg 302hrs4-24hrs 5-HT3 antagonist/give slow to prevent headache
Droperidol Inapsine 2.5mg/ml PONV .625-2.5mg 1-2302-4hrs Paradoxical reaction/ BP/  dopamine in CNS
Dexamethasone Decadron 4 mg/ml Peds: .5mg/kg <1| 12-24hrs | 36-54 hrs  inflammation, immune

Gas MAC B/G O/G VP Met Advantages: Disadvantages

Isoflurane Forane 1.15%; .5%-70% N2O 1.4 99 238 <1% A: Stable,  Met, Ok CBF(ICP) D: Pungent ordor,B/PHR/steal
Sevoflurane Ultane 2%; .7%-70% N2O .6 50 160 2-5% A:odor(peds), Rapid, Ok CBF(ICP) D: $, Rx w/ Co2 cmpd A, FreeF
Deslurane Suprane 6%; 2-3%-70% N2O .42 18.7 664 <1% A: Stable, soluble, Rapid, Ok ICP/CBF D: Sp Vap.,  odor, COCO2
Enflurane Ethrane 1.6% .5%-70% N2O 1.9 99 175 2-4 % A:$, Stable D: Cause EEG/Seizures,  Bld sugar, ICP
Nitrous Oxide 105 .47 1.4 38,770 Post op nausea, 35X more diffusible
Halothane Fluothane .75; .29 %-70% N2O 2.4 225 243 12-25% Possible Hepatic Toxicity

Drug 5feet T-10 T-8 T-6 DOA +/- 6 in

Tetracaine 1% (10mg/cc)/2hr w/ epi 4-6 10mg(1cc) 12 mg(1.2) 14mg(1.4) 90-120 2
Bupivacaine .75% (7.5mg/cc) 7.5mg(1cc) 9mg(1.2) 10.5mg(1.4) 90-120 1.5
Lidocaine 5% (50mg/cc) 50mg(1cc) 60mg(1.2) 70mg(1.4) 30-90 10
Mivacron 1.4 Vecuronium
mg 0.7 mg
Rocuronium Nimbex 0.7
3 mg mg
Estimating Blood Volumes: Obese: 55ml/kg Female:65ml/kg Male:75ml/kg Children 1-2yrs 80ml/kg Infants:
85ml/kg Neonate 90ml/kg