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MEKANISME HEMOSTASIS

MEKANISME HEMOSTASIS

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Published by: Sukhrian Muhda on Apr 01, 2011
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05/09/2013

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MEKANISME HEMOSTASIS

SUB BAG. HEMATO-ONKOLOGI ANAK FK USU

ADA 5 KOMPONEN:
1. KOMP.JARINGAN: - JAR.LONGGAR PERDARAHAN BANYAK 2. KOMP.PEMBULUH DARAH: - VASOKONSTRIKSI - FAKTOR PENARIK TROMBOSIT

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3. KOMP.TROMBOSIT:

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- MENJAGA INTEGRITAS PEMB.DARAH - MEMBENTUK GUMPALAN - CLUMPING 4. KOMP.PEMBEKUAN: - MENGUBAH GUMPALAN TROMBOSIT MASSA YG KOMPAK - MENGHASILKAN BEKUAN DI DLM PEMB.DARAH BESAR - REAKSI KASKADE

3 5. KOMP.FIBRINOLISIS - TERDAPAT FAKTOR-FAKTOR INAKTIF, AKTIF, AKTIFATOR & INHIBITOR - DIAKTIFKAN OLEH LATIHAN BERAT, ANOKSIA, KETEGANGAN (STRESS) DAN SUNTIKAN ADRENALIN

NORMAL HAEMOSTASIS
VESSEL INJURY COLLAGEN EXPOSURE

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TISSUE TROMBOPLASTIN F. XII

PLATELET RELEASE REACTION PLATELET SEROTONIN FACTORS VACOKONSTRICTION REDUCED BLOOD FLOW TROMBOXANE A2, ADP PLATELET AGGREGATION THROMBIN PRIMARY HAEMOSTATIC PLUG PLATELET FUSION STABLE HEMOSTATIC PLUG FIBRIN BLOOD COAGULATION

TF ‡ VII VESSEL INJURY TF ‡ VII a IX XIa

CONTACT

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XI

TFPI VIIIa ‡ IX a V Xa ‡ Va THROMBIN FIBRINOGEN PROTHOMBRIN XIII XIIIa STABLE FIBRIN FIBRIN POLYMER FIBRIN MONOMER FIBRINOPEPTIDES A+B

PHOSPHOLIPID SURFACE

COAGULATION FACTOR DEFICIENCIES
1. COMMON INHERITED DEFICIENCIES - F. VIII ( CLASSICAL HEMOPHILIA; HEMOPHILIA A ) - vWF ( VON WILLEBRAND DISEASE ) - F.IX ( CHRISTMAS DISEASE; HEMOPHILIA B ) - F. XI

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2. UNCOMMON INHERITED DEFICIENCIES - FIBRINOGEN & DYSFIBRINOGEN - PROTHROMBRIN (F.II) & DYSPROTHOMBRIN - F. V ( PARAHEMOPHILIA ) - F. VII - F. X - F.XII - F.XIII - COMBINED DEFICIENCIES - OTHER

3. ACQUIRED DEFICIENCIES - VIT. K - CONSUMPTION COAGULOPATHY - PARENCHYMAL LIVER DISEASE - CONGENITAL HEART DISEASE - CARDIOPULMONARY BYPASS - RENAL DISEASE - ACQUIRED INHIBITORS ( CIRCULATING ANTICOAGULANTS ) - OTHER

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4. NEONATAL DEFICIENCIES - HEMORRHAGIC DISEASE OF THE NEWBORN - INHERITED DEFICIENCIES - ACQUIRED DEFICIENCIES

PENILAIAN KLINIK:
LARGE ECCHYMOSIS HEMATOMA HEMARTHROSIS

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PTT-PROLONGED NORMAL

PTPTT-NORMAL PT- PROLONGED

PTT-PROLONGED PT-PROLONGED

PTT-NORMAL PT-NORMAL

F.VII DEF. HEMOPHILIAS vWD CIRCULATING ANTICOAGULANT HEPARIN

TT-PROLONGED TT-NORMAL

F.XII DEF. E2 NTIPLASMIN LIVER DIS. DEF. VIT.K DEF. AFIBRINOGENEMIA WARFARIN F.II,V,X DYSFIBRINOGENEMIA DEF. DIC DIC LIVER DISEASE HEPARIN (EARLY) CIRCULATING ANTICOAGULANT DYSPROTHOMBINEMIA

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