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Anti Konvulsi

Anti Konvulsi

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Dipublikasikan oleh Veliana Teta

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Published by: Veliana Teta on May 19, 2011
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04/28/2013

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DATA PENGAMATAN & PERHITUNGAN

Tabel Perhitungan Volume Dosis
Menci
t
Berat Badan
(Gram)
Volume Dosis
(mL)
1 10.2
10.220×0.5=0.23
5
2 16.5
16.520×0.5=0.41
25
3 13.9
13.920×0.5=0.34
75
Data Pengamatan
Jenis Uji Mencit
Waktu (detik)
Jumlah
Onset Kematian
Kontrol
Negatif
1 184.0 41.0 22.0
2 !".0 1.4 221.4
" 4#.! !.0 108.!
4 40.0 2.0 10.0
Jumlah !"#$ !$#% !1.#
&ata'rata ()#" ()# 1".0
Dia*e+am
Dosis ,
1 #".0 22#.0 "2".0
2 !.0 4#.0 11.0
" !4.! 4$. 10!.1
4 !0.0 80.0 1"4.0
Jumlah !"!#$ %-$#" 8.1
&ata'rata "$#" )-)#% 1$.0
Dia*e+am
Dosis ,,
1 100.0 22$.0 "28.0
2 1"0.0 41.0 1$".0
" 122.8 18!.2 "11.0
4 0.0 #8.0 12.0
Jumlah %)!#( $$)#! #4.0
&ata'rata )-#! ).#( 241.0
Jumlah Total )--)#( )!(!#) !!(#/
Jumlah &ata'rata !$-#% !-#$
P0&1,TU2342
% inhibisi onset=Waktu rata-rata onset (uji-kontrolWaktu rata-rata onset
kontrol×100%
% inhibisi onset !osis "=65.6175-#1.6275#1.6275×100%=-19.61%
% inhibisi onset !osis ""=103.205-#1.6275#1.6275×100%=26.43%
% inhibisi $aktu ke%atian=Waktu rata-rata ke%atian (uji-kontrolWaktu rata-rata
onset kontrol×100%
% inhibisi $aktu ke%atian !osis "=101.405-#1.34#1.34×100%=24.66%
% inhibisi $aktu ke%atian !osis ""=137.7#7-#1.34#1.34×100%=69.39%
4245,6,6 V4&,426
• 1,POT06,6
○ H0% Ti&a' a&a (engar)* (e+,erian o,at ter*a&a( a'ti-ita. anti'on-)l.i
○ H1% A&a (engar)* (e+,erian o,at ter*a&a( a'ti-ita. anti'on-)l.i
• T4&47 284T4
/ 0 0.0!
• P0&1,TU2342 424V4
Derajat 9ebas
!br=1
!bb=r-1=2-1
!b&=t-1=3-1=2
!b'=!bb.!b&=2.1=2
!btotal=24
!b'subsa%&lin'=!btotal-!b'-!bb-!br=24-2-2-1-1=1#
Jumlah Kuadrat
()*=+2n=22#3.9224=217341.63
(),=1001.#2-12#2.124×3-217341.63=3273.67
().=651.92-66#.12-96424×2-217341.63=3273.67
/b=326.52-325.42-262.52-405.62-412.#2-551.224-
217341.63=12690.94
()0subsa%&lin'=12-()*-/b=301#59.2-217341.63-12690.94=71557.13
Kuadrat Tengah
(),=3237.671=3237.67
().=7736.772=3#6#.3#5
()0=16#0.52=#40.25
()0subsa%&lin'=71556.631#=3975.36#
7'hitung
2hit=)3.)30=3#6#.3#5#40.25=4.603#5
7'tabel
20.052412=3.#9
T4905 424V4
6V db JK KT 7hit 7tab
&ata'rata 1 21$"41. 21$"41.
9lok 1 "2"$.$ "2"$.$
Perlakuan 2 $$".$$ "88."8! 4.0"8! ".8#
3alat 2 180.! 840.2!
3alat sub sam+ling 18 $1!!." "#$!."8
Total 24 "01!!".2
• K06,MPU542
Karena 1*it21ta, +a'a H0 &iteri+a3 4ang artin4a Ti&a' a&a (engar)* (e+,erian o,at
ter*a&a( a'ti-ita. anti'on-)l.i. 5le* 'arena it) ti&a' (erl) &ila')'an )6i lan6)t t7.t)&ent.
3ra:ik

61% % inhibisi onset dosis II=103.94 JKGsubsampling=Y2-JKR-Sb=301859.dbp=2.627581.% inhibisi onset=Waktu rata-rata onset (uji-kontrol)Waktu rata-rata onset kontrol×100% % inhibisi onset dosis I=65.6175-81.67 JKP=651.62+412.9224=217341.205-81.63=3273.3481.67 Sb=326.43% % inhibisi waktu kematian=Waktu rata-rata kematian (uji-kontrol)Waktu rata-rata onset kontrol×100% % inhibisi waktu kematian dosis I=101.39% ANALISIS VARIANS • HIPOTESIS ○ H0: Tidak ada pengaruh pemberian obat terhadap aktivitas antikonvulsi ○ H1: Ada pengaruh pemberian obat terhadap aktivitas antikonvulsi TARAF NYATA • α = 0.13 Kuadrat Tengah JKB=3237.63-12690.42+262.82+1282.787-81.94=71557.6275×100%=26.52+405.671=3237.6275×100%=-19.66% % inhibisi waktu kematian dosis II=137.05 • PERHITUNGAN ANAVA Derajat Bebas dbr=1 dbb=r-1=2-1 dbp=t-1=3-1=2 dbg=dbb.2-217341.67 .627581.52+325.63=12690.1=2 dbtotal=24 dbgsubsampling=dbtotal-dbg-dbb-dbr=24-2-2-1-1=18 Jumlah Kuadrat JKR=x2n=2283.12+96424×2-217341.34×100%=69.34×100%=24.63 JKB=1001.124×3-217341.63=3273.3481.224217341.405-81.82+551.92+668.

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