Tabel Uji Keseragaman Bobot Tablet

Formula
F1
Nomor

II
595.5
593.1
602
604.1
606.9
605.6
603.2
604.7
596.9
592.3
597.6
596.4
594.2
595.4
598
603.1
604.2
597.8
596.8
596.8
599.23

I
610
580
570
580
560
570
600
570
600
570
590
580
580
580
580
580
580
560
560
580
579

5%
min
max

29.851 29.9615
567.169 569.2685
626.871 629.1915

28.95
550.05
607.95

10%
min
max

59.702
537.318
656.722

1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
Rata2

I
594
598.3
603.5
584.7
599.4
592.2
595.6
597.6
598.8
582.6
595
608
601.1
592.6
601
604.5
598.3
602.4
595
595.8
597.02

Fa

59.923
539.307
659.153

57.9
521.1
636.9

Fb
Replikasi (mg)
II
I
II
578
618.5
610.3
578
618.6
600.7
576
626.8
607.3
584
625.1
612.4
584
624
602.8
583
626.5
605
575
606
608.3
585
624.1
609.2
580
619.6
613
575
603.6
605.1
585
618.6
616.8
575
619.6
621.3
576
623.5
610.7
576
619.3
606.1
582
620.8
622.4
588
613.4
618.1
577
617.2
599.7
584
623.9
621
583
626.1
610.4
584
616.5
607.9
580.4 619.585 610.425
RANGE
29.02 30.97925 30.52125
551.38 588.6058 579.9038
609.42 650.5643 640.9463
RANGE
58.04 61.9585 61.0425
522.36 557.6265 549.3825
638.44 681.5435 671.4675

Fab
I
614.3
588.8
582.2
591
579
586.2
603.7
593
592.2
588.4
592.1
587.5
584
587.3
591.6
591.8
596.1
581.2
580.3
583
589.685

II
591.7
614.2
616.9
589.3
597.6
589.8
595.6
589.8
586
590.3
592.3
598
581.4
594
599.7
600
590.2
596.9
583.9
598.9
594.825

29.48425 29.74125
560.2008 565.0838
619.1693 624.5663
58.9685 59.4825
530.7165 535.3425
648.6535 654.3075

Fb dalam gram
I
II
0.6185
0.6103
0.6186
0.6007
0.6268
0.6073
0.6251
0.6124
0.624
0.6028
0.6265
0.605
0.606
0.6083
0.6241
0.6092
0.6196
0.613
0.6036
0.6051
0.6186
0.6168
0.6196
0.6213
0.6235
0.6107
0.6193
0.6061
0.6208
0.6224
0.6134
0.6181
0.6172
0.5997
0.6239
0.621
0.6261
0.6104
0.6165
0.6079

Tabel Uji Kekerasan Tablet (Sudah dikonversi dari KP ke kg--> 1KP = 0,484 kg)
Formula
F1
Fa
Fb
Replikasi (kg)
Nomor
I
II
I
II
I
II
1
3.2912
2.904
3.008
3.2428
3.1944
3.1944
2
3.0976
3.008
2.904
2.904
3.63
2.904
3
2.662
2.1296
2.9524
2.6136
3.388
2.8072
4
2.7104
3.2912
2.5168
2.42
3.1944
3.0492
5
3.3396
2.662
3.2912
3.0008
3.1944
3.146
6
3.0976
2.7588
2.904
2.7104
3.2912
3.2428
7
3.7268
3.0442
2.8556
2.5652
3.146
3.146
8
3.0492
2.9624
2.904
2.952
3.2428
3.5332
9
3.3396
2.904
2.904
3.0976
3.0976
3.0492
10
2.7104
3.7752
2.662
2.7104
3.6784
3.5332
Rata2
3.10244
2.94394
2.8902
2.82168
3.30572
3.16052
rata2 replikasi
3.02319
2.85594
3.23312
Tabel Uji Kerapuhan Tablet
Formula
F1
Fa
Fb
Replikasi (gram)
Keterangan
I
II
I
II
I
II
Sebelum
5.9310
5.9479
5.7330
5.7860
6.1108
6.1257
Pengujian
Sesudah
5.6964
5.9215
5.9247
5.7445
6.0480
6.0886
Pengujian
Selisih
0.0095
0.0232
0.0366
0.0415
0.0628
0.0371
Bobot
%Kerapuhan
0.1602% 0.3901% 0.6384% 0.7172%
1.0277% 0.6056%
Rata2
0.2751%
0.6778%
0.8167%
Tabel Uji Waktu Hancur
Formula
Keterangan
Waktu
Rata2
Waktu Max

F1

I
85

Fa
II
41

63
85

Fb
Replikasi (detik)
II
I
43.9
60

I
43.2
43.55
43.9

II
63
61.5
63

0,484 kg)
Fab

g)
I
II
2.9524
3.0492
2.662
3.2912
3.0976
2.9524
3.008
2.5652
2.8072
2.8556
2.5168
2.7104
2.662
2.8072
2.9524
2.904
2.904
3.4364
2.7104
2.5652
2.82728 2.91368
2.87048
Fab

am)
I

II

5.8959

5.9247

5.8360

5.8792

0.0599

0.0455

1.0160% 0.7680%
0.8920%

Fab

tik)
I
68

II
80
74
80

X1(Amilum)
+
+

X2(Mg Stearat)
+
+

X12
+
+

y=3,2256+-0,022X1-0,326X2-0,046X1X2
Mg Stearat
2
0.45 23.6104911
0.5 23.1941964
0.55 22.7779018
0.6 22.3616071
0.65 21.9453125
0.7 21.5290179
0.75 21.1127232
0.8 20.6964286
0.85 20.2801339
0.9 19.8638393
0.95 19.4475446
1
19.03125
1.05 18.6149554
1.1 18.1986607
1.15 17.7823661

Faktor A
Faktor B
-1
-1
1
-1
-1
1
1
1
Jumlah
Efek Uji

2.5
12.44977679
12.03348214
11.6171875
11.20089286
10.78459821
10.36830357
9.952008929
9.535714286
9.119419643
8.703125
8.286830357
7.870535714
7.454241071
7.037946429
6.621651786

2.8
5.75334821
5.33705357
4.92075893
4.50446429
4.08816964
3.671875
3.25558036
2.83928571
2.42299107
2.00669643
1.59040179
1.17410714
0.7578125
0.34151786
-0.0747768

Kekerasan
y=2,80575+1,8125x10^-3X1+0,259X2-0,01225x1x2
Mg Stearat
3
0.95 3.84771987
1 5.02969918
1.05 6.21167848
1.1 7.39365779
1.15 8.5756371
1.2 9.7576164
1.25 10.9395957
1.3 12.121575
1.35 13.3035543
1.4 14.4855336
1.45 15.6675129
1.5 16.8494922
1.55 18.0314715
1.6 19.2134509
1.65 20.3954302

4
-91.95607396
-90.77409465
-89.59211535
-88.41013604
-87.22815674
-86.04617743
-84.86419812
-83.68221882
-82.50023951
-81.3182602
-80.1362809
-78.95430159
-77.77232228
-76.59034298
-75.40836367

Faktor AB
1
-1
-1
1

Kekerasan
3.02319
2.85594
3.23312
2.87048

Persamaan ini tar diubah ke X1

5
-187.75987
-186.57789
-185.39591
-184.21393
-183.03195
-181.84997
-180.66799
-179.48601
-178.30403
-177.12205
-175.94007
-174.7581
-173.57612
-172.39414
-171.21216

2.9
3.5212054
3.1049107
2.6886161
2.2723214
1.8560268
1.4397321
1.0234375
0.6071429
0.1908482
-0.225446
-0.641741
-1.058036
-1.47433
-1.890625
-2.30692

-0.010438
0.24675
6
-283.5637
-282.3817
-281.1997
-280.0177
-278.8357
-277.6538
-276.4718
-275.2898
-274.1078
-272.9258
-271.7439
-270.5619
-269.3799
-268.1979
-267.016

Kekerasan Tablet (

Mg Stearat (G)

Formula
1
A
B
AB

1
0.95
0.9
0.85
0.8
0.75
0.7
0.65
0.6
0.55
0.5

MG stearat 0,5 - 1
Amilum 2 - 10

5
Amilum (gram)

Kerapuhan
y=-0,4498+0,0457x1+0,624x2-0,0205x1x2
Mg Stearat
0.95
1
1.05
1.1
1.15
1.2
1.25
1.3
1.35
1.4
1.45
1.5
1.55
1.6
1.65

0.3
7.002976
5.805556
4.608135
3.410714
2.213294
1.015873
-0.18155
-1.37897
-2.57639
-3.77381
-4.97123
-6.16865
-7.36607
-8.56349
-9.76091

21.5774095
22.7593888
23.9413681
25.1233474
26.3053267
27.487306
28.6692853
29.8512646

-74.22638436
-73.04440506
-71.86242575
-70.68044645
-69.49846714
-68.31648783
-67.13450853
-65.95252922

-170.03018
-168.8482
-167.66622
-166.48424
-165.30226
-164.12028
-162.9383
-161.75632

-265.834
-264.652
-263.47
-262.288
-261.1061
-259.9241
-258.7421
-257.5601

1.7
1.75
1.8
1.85
1.9
1.95
2
2.05

Mg Stearat(gram)

1.7
1.75
1.8
1.85
1.9
1.95
2
2.05

-10.9583
-12.1558
-13.3532
-14.5506
-15.748
-16.9454
-18.1429
-19.3403

2
1.9
1.8
1.7
1.6
1.5
1.4
1.3
1.2
1.1
1
4

Wkt Hncr
85
43.9
63
80

Faktor Kekerasan
Faktor Waktu Hancur
A*kekerasan B*kekerasan AB*kekerasan A*WKt Hncr B*Wkt Hncr
-3.02319
-3.02319
3.02319
-85
-85
2.85594
-2.85594
-2.85594
43.9
-43.9
-3.23312
3.23312
-3.23312
-63
63
2.87048
2.87048
2.87048
80
80
-0.52989
0.22447
-0.19539
-24.1
14.1
-0.264945
0.112235 -0.097695
-12.05
7.05

Kerapuhan(%)
0.2751
0.6778
0.8167
0.892

CONTOH

Counter Post Waktu Hancur Tablet, Kekerasan Tablet

x adalah faktor pertama --> Amilum
y adalah faktor kedua --> Mg stearat

Kekerasan Tablet (kg)

Pengaruh Faktor terhadap Level dan termasuk Counter

Super impose adalah irisan dari counter post-counter p
MG stearat 0,5 - 1
Amilum 2 - 10
2,5 kg
2,8 kg
2,9 kg

4498+0,0457x1+0,624x2-0,0205x1x2
0.4
10.97123
9.77381
8.576389
7.378968
6.181548
4.984127
3.786706
2.589286
1.391865
0.194444
-1.00298
-2.2004
-3.39782
-4.59524
-5.79266

10

0.0252
0.6035
0.5
14.93948413
13.74206349
12.54464286
11.34722222
10.14980159
8.952380952
7.754960317
6.557539683
5.360119048
4.162698413
2.965277778
1.767857143
0.570436508
-0.626984127
-1.824404762

0.6
18.9077381
17.71031746
16.51289683
15.31547619
14.11805556
12.92063492
11.72321429
10.52579365
9.328373016
8.130952381
6.933531746
5.736111111
4.538690476
3.341269841
2.143849206

0.7
22.8759921
21.6785714
20.4811508
19.2837302
18.0863095
16.8888889
15.6914683
14.4940476
13.296627
12.0992063
10.9017857
9.70436508
8.50694444
7.30952381
6.11210317

Mg Stearat(gram)

5
6
7
Amilum (gram)

2
1.9
1.8
1.7
1.6
1.5
1.4
1.3
1.2
1.1
1
4

-6.99008
-8.1875
-9.38492
-10.5823
-11.7798
-12.9772
-14.1746
-15.372

-3.021825397 0.946428571 4.91468254

-4.219246032 -0.25099206 3.7172619
-5.416666667
-1.4484127 2.51984127
-6.614087302 -2.64583333 1.32242063
-7.811507937 -3.84325397
0.125
-9.008928571
-5.0406746 -1.0724206
-10.20634921 -6.23809524 -2.2698413
-11.40376984 -7.43551587 -3.4672619

Kerapuhan Tablet (%)

0.3%
0.4%
0.5
0.6

0.7
6

10

12

14

Amilum (gram)

16

18

20

Faktor Waktu Hancur

Faktor Kerapuhan
AB*Wkt Hncr A*Kerapuhan B*Kerapuhan AB*Kerapuhan
85
-0.2751
-0.2751
0.2751
-43.9
0.6778
-0.6778
-0.6778
-63
-0.8167
0.8167
-0.8167
80
0.892
0.892
0.892
58.1
0.478
0.7558
-0.3274
29.05
0.239
0.3779
-0.1637

Post Waktu Hancur Tablet, Kekerasan Tablet

h Faktor terhadap Level dan termasuk Counter plot bisa memenuhi standar syarat persamaan
pose adalah irisan dari counter post-counter post(dibuat kalau ada lebih dari 1 yang memenuhi syarat)

Waktu Hancur
y=131,8-6,2x1-36,525x2+3,63125x1x2

Super imposed 2 faktor

0.3%
0.4%
0.5
0.6
0.7
40 detik

50 detik
60 detik
70 detik
80 detik
6

10

12

14

Amilum (gram)

16

18

20

Mg Stearat
0.95
1
1.05
1.1
1.15
1.2
1.25
1.3
1.35
1.4
1.45
1.5
1.55
1.6
1.65

Mg Stearat(gram)

1.7
1.75
1.8
1.85
1.9
1.95
2
2.05

2
1.9
1.8
1.7
1.6
1.5
1.4
1.3
1.2
1.1
1
4

Waktu Hancur
y=131,8-6,2x1-36,525x2+3,63125x1x2
40
23.57212263
22.93185401
22.2915854
21.65131679
21.01104818
20.37077956
19.73051095
19.09024234
18.44997372
17.80970511
17.1694365
16.52916788
15.88889927
15.24863066
14.60836204

50
19.67918
19.03891
18.39864
17.75837
17.1181
16.47784
15.83757
15.1973
14.55703
13.91676
13.27649
12.63622
11.99596
11.35569
10.71542

-2.56875
-32.8938
60
15.78623
15.14597
14.5057
13.86543
13.22516
12.58489
11.94462
11.30435
10.66409
10.02382
9.383548
8.74328
8.103011
7.462743
6.822474

70
11.89329
11.25302
10.61275
9.972485
9.332216
8.691947
8.051679
7.41141
6.771142
6.130873
5.490604
4.850336
4.210067
3.569799
2.92953

80
8.000346
7.360078
6.719809
6.079541
5.439272
4.799003
4.158735
3.518466
2.878198
2.237929
1.59766
0.957392
0.317123
-0.32315
-0.96341

13.96809343
13.32782482
12.6875562
12.04728759
11.40701898
10.76675036
10.12648175
9.486213139

10.07515
9.434881
8.794612
8.154344
7.514075
6.873806
6.233538
5.593269

6.182205
5.541937
4.901668
4.2614
3.621131
2.980862
2.340594
1.700325

2.289261
1.648993
1.008724
0.368455
-0.27181
-0.91208
-1.55235
-2.19262

-1.60368
-2.24395
-2.88422
-3.52449
-4.16476
-4.80503
-5.44529
-6.08556

Waktu Hancur (detik)

40 detik
50 detik
60 detik
70 detik
80 detik

10

12
14
16
Amilum (gram)

18

20

LR Mg Stearat
3.02
2.86

LT Mg Stearat
3.23
2.87

Kerapuhan Tablet
Level Mg Stearat
1
2

LR Amilum
0.2751
0.8167

LT Amilum
0.6778
0.892

Level Amilum
4
20

LR Mg Stearat
0.2751
0.6778

LT Mg Stearat
0.8167
0.892

Waktu Hancur
Level Mg Stearat
1
2
Level Amilum
4
20

3.15
3.05
2.95

2.85
1

1.2

1.4
1.6
Mg Stearat (gram)

Pengaruh Bahan Penghancur Terha

Kekerasan Tablet

3.25
3.2

LR Amilum
85
63
LR Mg Stearat
85
43.9

LT Amilum
43.9
80
LT Mg Stearat
63
80

Kekrasan Tablet (kg)

Level Amilum
4
20

Pengaruh Bahan Pelicin Terhadap

Kekerasan Tablet
3.25

LT Amilum
2.86
2.87
Kekerasan Tablet (kg)

Kekerasan tablet
1 = amilum
2 = Mg Stearat
Level Mg Stearat
LR Amilum
1
3.02
2
3.23

3.15
3.1

3.05
3
2.95
2.9
2.85
4

10

12

14

Amilum (gram)

Dibuat sekitar 6 kurva + superimposenya

Analisis
(irisannya_
Kekerasan
Kerapuhan
Waktu Hancur

Pengaruh Bahan Pelicin Terhadap

Kerapuhan Tablet

Level Rendah Amilum

Level Tinggi Amilum

1.6
Mg Stearat (gram)

1.8

Kerapuhan Tablet (gram)

uh Bahan Pelicin Terhadap

Kekerasan Tablet
1
0.9
0.8
0.7
0.6
0.5
0.4
0.3
0.2
1

aruh Bahan Penghancur Terhadap

Kekerasan Tablet

1.2

1.4
1.6
Mg Stearat (gram)

1.8

Pengaruh Bahan Penghancur Terhadap

Kerapuhan Tablet

Level Rendah Mg Stearat

Level Tinggi Mg Stearat

14
Amilum (gram)

16

18

20

Kerapuhan Tablet (gram)

1
0.9
0.8
0.7
0.6
0.5
0.4
0.3
0.2
4

10

12
14
Amilum (gram)

16

18

Bahan Pelicin Terhadap

apuhan Tablet

Level Tinggi Amilum

90
WAktu Hancur (detik)

Level Rendah Amilum

80
70
Level Rendah Amilum

60

Level Tinggi Amilum

50
40

an Penghancur Terhadap
apuhan Tablet

Level Tinggi Mg Stearat

20

1.2

1.4
1.6
Mg Stearat (gram)

1.8

Pengaruh Bahan Penghancur Terhadap

Waktu Hancur Tablet

90
Waktu Hancur (detik)

Level Rendah Mg Stearat

18

Pengaruh Bahan Pelicin Terhadap Waktu

Hancur TAblet

80
70
Level Rendah Mg Stearat

60

Lever Tinggi Mg Stearat

50
40
4

10
12
14
Amilum (gram)

16

18

20

cin Terhadap Waktu

Level Rendah Amilum

Level Tinggi Amilum

hancur Terhadap

Level Rendah Mg Stearat

Lever Tinggi Mg Stearat