Inh|b|t|on of

prote|n synthes|s
1 Charged L8nA carrylng amlno
acld 8 blnds Lo Lhe accepLor slLe
on Lhe 70s rlbosomes
2 1ranspepLldaLlon Lhe pepLldyl
L8nA aL Lhe donor slLe wlLh
amlno acld chaln Lo amlno acld
8
3 1he uncharged L8nA lefL aL Lhe
donor slLe ls released
4 1ranslocaLlon Lhe new 8 amlno
acld chaln wlLh lL's L8nA shlfLs
Lo Lhe pepLldyl
3 Chloramphenlcol and
macrolldes blnd Lo Lhe 30s
subunlL and block
LranspepLldaLlon
6 1eLracycllnes blnd Lo Lhe 30s
subunlL and prevenL blbdlng of
Lhe lncomlng charged L8nA
unlL(sLep 1)
2
1
4
3
chloramphenlcol
macrolldes
Amlno
acld +
charged
L8nA
LeLracycllne
AccepLor slLe
uncharged L8nA
epLldyl
donor slLe
W Amlnoglycoslde
lock formaLlon of Lhe lnlLlaLlon complex
Mlscodlng of amlno aclds ln Lhe emerglng pepLlde
chaln due Lo mlsreadlng of Lhe m8nA
lock of LranslocaLlon on m8nA