Form-Fill-Seal Machines
Submitted By
Roll No : DEP/11/084
Submitted To
Indian Institute of Packaging E-2, MIDC Area, Chakala, Andheri (East), Mumbai 400 093
FORM-FILL-MACHINES :
Form, fill and seal machines are packaging equipment that uses flexible, heat-sealable, plastic film to form packages that can be filled with a product and then sealed, and cut. There are many types of form, fill, and seal machines. Forming machines form packages, but do not fill or seal them. Filling machines load previously formed packages with a specific product quantity, but do not provide closing or sealing action. Seal-only equipment wraps or secures products, but does not form packages or fill them. Equipment that combines form, fill and seal functions is also available. Some devices transport the plastic film horizontally. Others transport the film vertically. Manual machines aid only in the setting or holding of products. Semiautomatic machines help with both packaging and placement, allowing a single operator to perform several activities with greater speed and accuracy. Fully automatic equipment requires limited operator intervention. Typically, operators need only replenish packaging components by loading supply hoppers or removing completed cartons. Form, fill and seal machines are used to process liquids, granules, powders, and sprays for consumer, bulk and original equipment manufacturer (OEM) supply shipments. Packaging materials include aerosol containers, bags and pouches, blister packs, bottles and jars, cartons and boxes, cans, capsules, cartridges, cases, cups and trays, drums and kegs, pallets and pails, and tubes and vials. Intermediate bulk containers (IBCs) have a capacity of not more than 3 cubic meters and are designed to be handled by form, fill and seal machines. There are several ways to close packages. Examples include caps and lids, corks, glue, heat seals, nails and staples, tapes, tucks and folds, wrappers, and tamper-resistant materials. Selecting form, fill and seal machines require an analysis of specifications, features, and applications. Typically, fully automated machines list the rate, which is usually expressed in pieces per minute. Some automated machines include an integral feeder and a computer interface that links to a control network. Others are made from stainless steel for improved corrosion resistance. Aseptic or sanitary equipment is easy to clean and designed in a manner that inhibits the growth or presence of pathogenic microrganisms. Portable machinery is lightweight or includes wheels or casters for ease of movement. In terms of applications, form, fill and seal machines are used widely in the automotive, chemical, medical, and pharmaceutical industries. They are also used to process food, beverages, cosmetics, electronics, semiconductors, stationary, tobacco, and military products. There are two basic types, horizontal and vertical. A horizontal machine forms a package, fills with product, and seals in a sequence of operations while the film is being transported in a horizontal direction. They are widely used for packaging solid foodstuffs. A vertical machine forms a tube, fills, and seals in a sequence of operations while the film is being transported vertically downwards. They are widely used for packaging foodstuffs in a liquid, powder, paste, or granule state.
1.6.1. Before any sterilization process is adopted, its suitability for the product and its efficacy in achieving the desired sterilizing conditions in all parts of each type of load pattern to be processed, shall be demonstrated by physical measurements and by biological indicators, where appropriate. 1.6.2 All the sterilization process shall be appropriately validated. The validity of the process shall be verified at regular intervals, but at least annually. Whenever significant modifications have been made to the equipment and product, records shall be maintained thereof. 1.6.3 The sterilizer shall be double ended to prevent mix-ups. 1.6.4 Periodic bio-burden monitoring of products before terminal sterilization shall be carried out and controlled to limits specified for the product in the Master Formula. 1.6.5 The use of biological indicators shall be considered as an additional method of monitoring the sterilization. These shall be stored and used according to the manufacturers instructions. Their quality shall be checked by positive controls. If biological indicators used, strict precautions shall be taken t avoid transferring microbial contamination from them. 1.6.6 There shall be clear means of differentiating sterilized and unsterilized products. Each basket, tray or other carrier of products or components shall be clearly labeled with the name of the material, its batch number, and sterilization status. Indicators shall be used, where appropriate, to indicate whether a batch (or sub-batch) has passed through the sterilization process. 1.6.7 Sterilization records shall be available for each sterilization run and may also include thermographs and sterilization monitoring strips. They shall be maintained as part of the batch release procedure. 1.7. Sterilization (by dry heat).-
1.7.1 Each heat sterilization cycle shall be recorded on a time/temperature chart of a suitable size by appropriate equipment of the required accuracy and precision. The position of temperature probes used for controlling and/or recording shall be determined during the validation and, where applicable, shall also be checked against a second independent temperature probe located in the same position. The chart shall form a part of the batch record. Container mapping may also be carried out in the case of Large Volume Parenterals. 1.7.2 Chemical or biological indicators may also be used, but shall take the place of physical validation. 1.7.3. Sufficient time shall be allowed for the load to reach the required temperature before measurement of sterilization time commences. This time shall be separately determined for each type of load to be processed. 1.7.4. After the high temperature phase of a heat sterilization cycle, precautions shall be taken against contamination of sterilized load during cooling. Any cooling fluid or gas in contact with the product shall be sterilized unless it can be shown that any leaking container would not be approved for use. Air inlet and outlets shall be provided with bacterial retaining filters.
1.7.5. The process used for sterilization by dry heat shall include aircirculation within the chamber and the maintenance of a positive pressure to prevent the entry of non-sterile air. Air inlets and outlets should be provided with micro-organism retaining filters. Where this process of sterilization by dry heat is also intended to remove pyrogens, challenge tests using endotoxins would be required as part of the validation process. 1.8. Sterilization (by moist heat).1.8.1 Both the temperature and pressure shall be used to monitor the process. Control instrumentation shall normally be independent of monitoring instrumentation and recording charts. Where automated control and monitoring systems are used for these applications, these shall be validated to ensure that critical process requirements are met. System and cycle faults shall be registered by the system and observed by the operator. The reading of the independent temperature indicator shall be routinely checked against the chart-recorder during the sterilization period. For sterilizers fitted with a drain at the bottom of the chamber, it may also be necessary to record the temperature at this position throughout the sterilization period. There shall be frequent leak tests done on the chamber during the vacuum phase of the cycle. 1.8.2 The items to be sterilized, other than products in sealed containers, shall be wrapped in a material which allows removal of air and penetration of steam but which prevents recontamination after sterilization. All parts of the load shall be in contact with the sterilizing agent at the required temperature of the required time. 1.8.3. No Large Volume Parenteral shall be subjected to steam sterilization cycle until it has been filled and sealed. 1.8.4 Care shall be taken to ensure that the steam used for sterilization is of a suitable quality and does not contain additives at a level which could cause contamination of the product or equipment. 1.9. Completion/finalisation of sterile products.1.9.1. All unit operations and processes in the manufacture of a batch shall have a minimum time specified and the shortest validated time shall be used from the start of a batch to its ultimate release for distribution. 1.9.2. Containers shall be closed by appropriately validated methods. Containers closed by fusion e.g. glass or plastic ampoules shall be subjected to 100% integrity testing. Samples of other containers shall be checked for integrity according to appropriate procedures. 1.9.3 Containers sealed under vacuum shall be tested for required vacuum conditions. 1.9.4 Filled containers parenteral products shall be inspected individually for extraneous contamination or other defects. When inspection is done visually, it shall be done under suitably controlled conditions of illumination and background. Operators doing the inspection shall pass regular eye-sight checks with spectacles, if worn, and be allowed frequent rest from inspection. Where other methods of inspection are used, the process shall be validated and the performance of the equipment checked at suitable intervals. Results shall be recorded.
Bottles/vials
Blow fill seal.
Cartons
Vertical carton board form fill seal.
Products commonly associated with form/fill/seal include: Crisps; Nuts; Sugar; Rice; Pulses; Sweets & Confectionery; Sauces & Soups; Pet Foods; Grain; Jams & Preserves; Cakes; Bread; Biscuits; Tea Bags; Condiments; Tablets, Capsules and Pills, Greetings cards; Phone cards.
Flow Wrapping
A Flow Wrapping Machine is a horizontally operated machine with the packaging material mounted above the operating level where the product is loaded horizontally with a longitudinal seal formed below the pack. Uses: solid products like biscuits, chocolate bars and phone cards.
machine. Packs are formed using flexible packaging material on one or more mandrel to form the pack which is then filled and sealed within the machine. Uses: Traditionally used for flour and sugar.
Strip Pack
Vertically operated FFS which produces strips of individually sealed packs joined together in predetermined lengths for a variety of uses including soluble medicines.
Stick Pack
Horizontally or vertically operated FFS machine forming a thin 3 sided sachet from flexible packaging materials resembling a stick or pen. Uses: sugar, tea, coffee, sauces, shampoos and toiletries.
B/F/S Process
The ASEP-TECH System automatically delivers a finished package in five steps:
Thermoplastic resin is extruded into a tubular shape called a parison. (Figure a.)
When the parison reaches the proper length, the mold is closed and the parison is cut. The bottom of the parison is pinched closed and the top is held in place. The mold is then conveyed to a position under the blowing and filling nozzle. (Figure b.)
The blow-fill nozzle is lowered into the parison until it forms a seal with the neck of the mold. The container is formed by blowing sterile filtered compressed air into the parison and expanding it against the walls of the integrally cooled mold cavity. Next, the sterile air is vented from the container and the sterile product is metered into the container through the fill nozzle, which then retracts. (Figure c.) Separate sealing molds close to form the top and hermetically seal the container. (Figure d.)
The mold opens, and the formed, filled and sealed container is conveyed out of the machine. (Figure e.)
B/F/S Machines
Model 603 | Model 624 | Model 628 | Model 640
ASEP-TECH Blow/Fill/Seal machines are designed and manufactured by Weiler Engineering, Inc. in Elgin, Illinois. Our team is dedicated to the highest performance standards in the design and development of Blow/Fill/Seal packaging systems. This unique combination of world-class engineering, leading-edge automation and process design, assures years of reliable, high
quality production. Blow-fill-seal technology, originally developed in Europe in the 1930s and introduced in the US in the 1960s, has emerged as a preferred method for aseptic packaging of pharmaceutical and healthcare products due to unrivalled flexibility in container design, overall product quality, product output and low oprational costs. The Weiler design incorporates the multi-step process of blow moulding, aseptic filling and hermetic sealing of liquid products in one sequential operation on a compact, automated machine frame with fill volumes ranging from 0.1 millilitre (ml) to 1,000ml. A variety of polymers may be used in the process, low and high-density polyethylene and polypropylene being the most popular. The innate ability to form the container/closure during the actual aseptic packaging process allows for custom design of the container to meet the specific needs of the application. This flexibility not only improves container ease of use, but provides a means of interfacing with many of todays emerging drug delivery technologies, most notably in the field of respiratory therapy. Recent advancements in machine design allow for insertion of pre-moulded, pre-sterilised components to be moulded into the container creating additional design options to create multi-use and injectable product containers. Furthermore, the blow-fill-seal process flow is normally impacted by only two raw materials, product and polymer, that are each processed inline, thereby making the process amenable to large uninterrupted batch sizes, some in excess of 500,000 units, and fill durations of up to 120 hours. The net effect is routinely an increase in production efficiency and a subsequent decrease in operational costs for the user. Blow-fill-seal systems represent a niche market within the larger form-fill-seal marketplace for pharmaceutical packaging equipment. The blow-fillseal process is a robust, advanced aseptic processing technology, recognised by worldwide regulatory authorities for its inherent operational advantages over conventional aseptic production. Blow-fill-seal systems offer a unique combination of flexibility in packaging design, low operating cost and a high degree of sterility assurance. The machines require aminimum number of operating personnel and have a relatively small space requirement.
Applications
The ability to provide sterile liquid products that meet corporate, scientific, regulatory and end-user requirements can be a demanding task in today's environment. Through your implementation of ASEP-TECH Blow/Fill/Seal technology, these application challenges can be met by the creative container and closure designs available with each system. Several machine models are available to choose from, designed to manufacture containers ranging in size from 0.2mL to 1000mL at production rates of up to 15,000 units per hour, depending on container configuration.
Small Volume Parenterals (SVPs) Large Volume Parenterals (LVPs) Ophthalmic's Respiratory therapy Other applications New concepts
The feeding of material and cutting of the pouch can be determined either by pouch length, or indexing to an eyespot, which is detected by a visual sensor. While single web systems are popular for food applications, the dual web four side seal system is often popular for IVD and Medical device products. Closely related is the horizontal form-fill-seal machine, which is generally uses more floor space than a vertical system. Modern advancements in pouch forming technology have allowed for smaller and smaller Vertical pouch forming systems.
PLEASE CONTINUE HERE FOR MORE INFORMATION ABOUT FORM-FILL-SEAL MACHINES HORIZONTAL FORM FILL SEAL 02, Singapore 368359. +65 67414077 www.clearpack.com
An Introduction to HORIZONTAL FORM FILL SEAL MACHINES www.clearpack.com 1 MACHINESA Clearpack White Paper 134 Joo Seng Road, #04-02, Singapore Introduction Horizontal Form Fill Seal Machine: Flexible packaging has changed in great manner in the past point that today, the pack presentation cannot any longer be a simple package but a real packaging solution with real shape and function benefits which will set the difference between a well presented and innovative product and the rest. Horizontal Form Fill Seal Machine is an intermittent system. Here the pouch is sealed on three sides and later filled on the 4 using this principle: Strong seal integrity Capability to fill from 1cc to 3500cc
Possibility to do different pack styles in sachet and stand up pouch. Flexibility is the main aspect, as using the same machine. It is possible to make a wide range of different pack presentations with maximum efficiency and keeping high seal integrity. 02, Singapore 368359. +65 67414077 www.clearpack.com Horizontal Form Fill Seal Machine: Flexible packaging has changed in great manner in the past few years, to the point that today, the pack presentation cannot any longer be a simple package but a real packaging solution with real shape and function benefits which will set the difference between a well presented and innovative product and the Horizontal Form Fill Seal Machine is an intermittent system. Here the pouch is sealed on three sides and later filled on the 4th side. Following are the benefits
Capability to fill from 1cc to 3500cc to do different pack styles in sachet and stand up pouch. Flexibility is the main aspect, as using the same machine. It is possible to make a wide range of different pack presentations with maximum efficiency and keeping high seal integrity. www.clearpack.com 2 few years, to the point that today, the pack presentation cannot any longer be a simple package but a real packaging solution with real shape and function benefits which will set the difference between a well presented and innovative product and the Horizontal Form Fill Seal Machine is an intermittent system. Here the pouch is side. Following are the benefits to do different pack styles in sachet and stand up pouch. Flexibility is the main aspect, as using the same machine. It is possible to
make a wide range of different pack presentations with maximum efficiency A Clearpack White Paper 134 Joo Seng Road, #04-02, Singapore Basic Operating Principle Horizontal Form Fill Seal Machine has a reel unwinder on which the film is mounted. This film is released from the unwinder. It passes through a forming plough and is further sealed at the will cut the pouch vertically at the right time controlled by the photocell. The pouch opening device opens t top stretching mechanism stretches the pouch to make a clean to 02, Singapore 368359. +65 67414077 www.clearpack.com Basic Operating Principle: Horizontal Form Fill Seal Machine has a reel unwinder on which the film is mounted. This film is released from the unwinder. It passes through a
forming plough and is further sealed at the bottom and 2 sides. The scissors will cut the pouch vertically at the right time controlled by the photocell. The pouch opening device opens the pouch and brings it to the filling station. The top stretching mechanism stretches the pouch to make a clean top seal. www.clearpack.com 3 Horizontal Form Fill Seal Machine has a reel unwinder on which the film is mounted. This film is released from the unwinder. It passes through a bottom and 2 sides. The scissors will cut the pouch vertically at the right time controlled by the photocell. The e pouch and brings it to the filling station. The p seal.A Clearpack White Paper 134 Joo Seng Road, #04-02, Singapore HFFS - Machine Layout: How to select the right machine: We need to consider the following basic points when selecting the machine
1. Nature of the Product 2. Product Dimensions 3. Pouch Material 4. Pouch Dimension/Size 5. Pouch Style 6. Speed Required 7. Hourly output of the product to be packed 8. Filling Temperature 02, Singapore 368359. +65 67414077 www.clearpack.com How to select the right machine: We need to consider the following basic points when selecting the machine Pouch Dimension/Size Hourly output of the product to be packed www.clearpack.com 4 We need to consider the following basic points when selecting the machineA Clearpack White Paper 134 Joo Seng Road, #04-02, Singapore Pouch Styles Horizontal Form Fill Seal Machine: Stand up pouch Variants:
Stand up pouches are made on HFFS machine using a film or a laminate. Stand up pouches gives the packaging an aesthetic appeal. There are other features which are added to stand up pouches like a spout, zip or a straw. Spouted pouches are either top spout or edge spout depending on the requirement. Spouted pouches are used for products which are free flowing liquids and pastes. Zipper pouches are used when the pouc reclosed after the required amount of product has been used so that the product remains fresh for a longer duration or retains certain properties like aroma in coffee. Straw pack is also another application wherein the straw is already made available within the pouch. The best application is in beverage. Stand up pouches offers these variations and also gives the pouch shelf appeal and becoming a sales agent
Stand Up Pouch
Top Spout
02, Singapore 368359. +65 67414077 www.clearpack.com Horizontal Form Fill Seal Machine: Variants: Stand up pouches are made on HFFS machine using a film or a laminate. Stand up pouches gives the packaging an aesthetic appeal. There are other added to stand up pouches like a spout, zip or a straw. Spouted pouches are either top spout or edge spout depending on the requirement. Spouted pouches are used for products which are free flowing liquids and pastes. Zipper pouches are used when the pouch needs to be reclosed after the required amount of product has been used so that the product remains fresh for a longer duration or retains certain properties like aroma in coffee. Straw pack is also another application wherein the straw is
vailable within the pouch. The best application is in beverage. Stand up pouches offers these variations and also gives the pouch shelf appeal and becoming a sales agent. Top Spout Edge Spout Zipper Pouch
www.clearpack.com 5 Stand up pouches are made on HFFS machine using a film or a laminate. Stand up pouches gives the packaging an aesthetic appeal. There are other added to stand up pouches like a spout, zip or a straw. Spouted pouches are either top spout or edge spout depending on the requirement. Spouted pouches are used for products which are free flowing h needs to be reclosed after the required amount of product has been used so that the product remains fresh for a longer duration or retains certain properties like
aroma in coffee. Straw pack is also another application wherein the straw is vailable within the pouch. The best application is in beverage. Stand up pouches offers these variations and also gives the pouch shelf appeal Straw Pack A Clearpack White Paper 134 Joo Seng Road, #04-02, Singapore Pouch Styles Horizontal Variety of products can be filled in these pouches. This pouch style is economical and is used for filling of: Powder (Pharmaceutical, Energy Drink, Liquids (Shampoo, Gel, Creams and Sauce) Tablets Pouches can be made with certain features like Hole Punch, and Free Shape on the horizontal form fill seal machine. This gives the pouch a value added feature. With the help of Hole Punch and Euro Hole feature, the
pouch can be displayed in an effective way. The customized Free Shape given to the pouch makes it more attracti and increases the selling ability of the product by giving it a shelf appeal. 3 Side Seal Hole pouch 02, Singapore 368359. +65 67414077 www.clearpack.com orizontal Form Fill Seal Machine: Variety of products can be filled in these pouches. This pouch style is
B/F/S Process
The ASEP-TECH System automatically delivers a finished package in five steps: Thermoplastic resin is extruded into a tubular shape called a parison. (Figure a.)
When the parison reaches the proper length, the mold is closed and the parison is cut. The bottom of the parison is pinched closed and the top is held in place. The mold is then conveyed to a position under the blowing and filling nozzle. (Figure b.)
The blow-fill nozzle is lowered into the parison until it forms a seal with the neck of the mold. The container is formed by blowing sterile filtered compressed air into the parison and expanding it against the walls of the integrally cooled mold cavity. Next, the sterile air is vented from the container and the sterile product is metered into the container through the fill nozzle, which then retracts. (Figure c.)
Separate sealing molds close to form the top and hermetically seal the container. (Figure d.)
The mold opens, and the formed, filled and sealed container is conveyed out of the machine. (Figure e.)
B/F/S Machines
Model 603 | Model 624 | Model 628 | Model 640
ASEP-TECH Blow/Fill/Seal machines are designed and manufactured by Weiler Engineering, Inc. in Elgin, Illinois. Our team is dedicated to the highest performance standards in the design and development of Blow/Fill/Seal packaging systems. This unique combination of world-class engineering, leading-edge automation and process design, assures years of reliable, high quality production.
Applications
The ability to provide sterile liquid products that meet corporate, scientific, regulatory and end-user requirements can be a demanding task in today's environment. Through your implementation of ASEP-TECH Blow/Fill/Seal technology, these application challenges can be met by the creative container and closure designs available with each system. Several machine models are available to choose from, designed to manufacture containers ranging in size from 0.2mL to 1000mL at production rates of up to 15,000 units per hour, depending on container configuration.
Small Volume Parenterals (SVPs) Large Volume Parenterals (LVPs) Ophthalmic's Respiratory therapy Other applications New concepts
Sacmi sinergies for Innovative Technology ISA Integrated Sleeve Applicator Since the the beginning Sacmi Imola Group welcomed with great interest the idea of a Sleeve Applicator (ISA) developped recently by Sacmi Labelling to be Integrated with Benco Pack FFS machines and after numerous laboratory tests what seemed to be just a dream was transformed into reality so that it is now possible to adapt to labelling a wide range of containers of different shapes directly thermoformed by a FFS machine. In a unique structure, the filled and sealed container is individually treated in a series of closed chambers, where a jet of steam, with variable duration, but always less than 0.6 seconds, causes the sleeve label shrinking onto the container.
An innovative technique allows reducing steam consumption up to 10 times versus the traditional heat-shrinkage tunnels thanks to the elimination of the pre-heating phase and also steam is not pointlessly consumed when the machine is in standby. As far as material is concerned, ISA uses sleeve labels made of different types of material: OPS, PET and PVC manufactured by a wide-range of suppliers on the international and local markets, among which customers can choose the most suitable and convenient for the their needs. ISA ADVANTAGES Packaging appeal: brighter printing and transparent colours and higher graphic resolution Cup shapes: suitable for a wide range of body shape System integrated in the FFS machine Steam consumptions: up to 10 times lower than the traditional shrinking tunnel Suitable for hot filling and for fully aseptic machine
(isotonic drnks, juices, UHT dairy desserts) Decoration on multipacks without format change. Machine output from 6.000 to 36.000 cup/h FORM-FILL-SEAL MACHINES
Description Definition Importance Scope and use of areas Types of machines Objectives
Form and seal packaging machines use heat-sealable, flexible plastic, packaging film to form a package; the package is then filled, heat-sealed, and cut off. There are two basic types, horizontal and vertical. A horizontal machine forms a package, fills with product, and seals in a sequence of operations while the film is being transported in a horizontal direction. They are widely used for packaging solid foodstuffs. A vertical machine forms a tube, fills, and seals in a sequence of operations while the film is being transported vertically downwards. They are widely used for packaging foodstuffs in a liquid, powder, paste, or granule state.
microrganisms. Portable machinery is lightweight or includes wheels or casters for ease of movement. In terms of applications, form, fill and seal machines are used widely in the automotive, chemical, medical, and pharmaceutical industries. They are also used to process food, beverages, cosmetics, electronics, semiconductors, stationary, tobacco, and military products.
[SCHEDULE M] [See Rules 71, 74, 76 and 78] GOOD MANUFACTURING PRACTICES AND REQUIREMENTS OF PREMISES, PLANT AND EQUIPMENT FOR PHARMACEUTICAL PRODUCTS.
10. Form-Fill-Seal Technology or Blow, Fill-Seal Technology. 10.1 Form-Fill-Seal units are specially built automated machines in which through one continuous operation, containers are formed from thermoplastic granules, filled and then sealed. Blow, fill-seal units are machines in which containers are moulded / blown (pre-formed) in separate clean rooms, by noncontinuous operations. Note: (i) These shall be installed in at least Grade C environment. (ii) These shall comply with the limits as recommended in Table at Item 4.2. 4.2 There shall be a written environmental monitoring program and microbiological results shall be recorded. Recommended limits for microbiological monitoring of clean areas in operation are as given in the table below: TABLE RECOMMENDED LIMITS FOR MICROBIOLOGICAL MONITORING OF CLEAN AREAS IN OPERATION Grade Air sample Settle plates (dia. 90mm. Contact plates (dia. Glove points Cfu/m 2
Cfu/2 hrs. 55mm) cfu per plate (five fingers) cfu per glove A <1 <1 <1 <1 B 10 5 5 5 C 100 50 25 -D 500 100 50 -Notes: (a) These are average values. (b) Individual settle plates may be exposed for not less than two hours in Grade B, C and D areas and for not less than thirty minutes in Grade A area. 10.2. Form-Fill-Seal/Blow, Fill-Seal machines used for the manufacture of products for terminal sterilization shall be installed in at least Grade C environment and the filling zone within the machine shall fulfill Grade A requirements. 10.3. Terminally sterilized products. 10.3.1. Preparation of primary packaging material such as glass bottles, ampoules and rubber stoppers shall be done in at least Grade D environment. Where there is unusual risk to the product from microbial contamination, the above operation shall be done in Grade C environment. All the process used for component preparation shall be validated. 10.3.2. Filling of products requiring terminal sterilization shall be done under Grade A environment with a Grade C background. 10.4 Preparation of solutions, which are to be sterilized by filtration, shall be done in Grade C environment, and if not to be filtered, the preparation of materials and products shall be in a Grade A environment with Grade B in background. 10.5 Filtration (membrane).(i) Solutions for Large Volume Parenterals shall be filtered through a non-fibre releasing, sterilizing grade cartridge/membrane filter of nominal pore size of 0.22 for aseptic filling whereas 0.45 porosity shall be used for terminally sterilized products. (ii) A second filtration using another 0.22 sterilizing grade cartridge / membrane filter shall be performed immediately prior to filling. Process specifications shall indicate the maximum time during which a filtration system may be used with a view to precluding microbial build-up to levels that may affect the microbiological quality of the Large Volume Parenterals. (iii) The integrity of the sterilized filter shall be verified and confirmed immediately after use by an appropriate method such as Bubble Point, Diffusive Flow or Pressure Hold Test. 10.6 Sterilization (Autoclaving).10.6.1. Before any sterilization process is adopted, its suitability for the product and its efficacy in achieving the desired sterilizing conditions in all parts of each type of load pattern to be processed, shall be demonstrated by physical measurements and by biological indicators, where appropriate. 10.6.2 All the sterilization process shall be appropriately validated. The validity of the process shall be verified at regular intervals, but at least annually. Whenever significant modifications have been made to the equipment and product, records shall be maintained thereof. 10.6.3 The sterilizer shall be double ended to prevent mix-ups.
10.6.4 Periodic bio-burden monitoring of products before terminal sterilization shall be carried out and controlled to limits specified for the product in the Master Formula. 10.6.5 The use of biological indicators shall be considered as an additional method of monitoring the sterilization. These shall be stored and used according to the manufacturers instructions. Their quality shall be checked by positive controls. If biological indicators used, strict precautions shall be taken t avoid transferring microbial contamination from them. 10.6.6 There shall be clear means of differentiating sterilized and unsterilized products. Each basket, tray or other carrier of products or components shall be clearly labeled with the name of the material, its batch number, and sterilization status. Indicators shall be used, where appropriate, to indicate whether a batch (or sub-batch) has passed through the sterilization process. 10.6.7 Sterilization records shall be available for each sterilization run and may also include thermographs and sterilization monitoring strips. They shall be maintained as part of the batch release procedure. 10.7. Sterilization (by dry heat).10.7.1 Each heat sterilization cycle shall be recorded on a time/temperature chart of a suitable size by appropriate equipment of the required accuracy and precision. The position of temperature probes used for controlling and/or recording shall be determined during the validation and, where applicable, shall also be checked against a second independent temperature probe located in the same position. The chart shall form a part of the batch record. Container mapping may also be carried out in the case of Large Volume Parenterals. 10.7.2 Chemical or biological indicators may also be used, but shall take the place of physical validation. 10.7.3. Sufficient time shall be allowed for the load to reach the required temperature before measurement of sterilization time commences. This time shall be separately determined for each type of load to be processed. 10.7.4. After the high temperature phase of a heat sterilization cycle, precautions shall be taken against contamination of sterilized load during cooling. Any cooling fluid or gas in contact with the product shall be sterilized unless it can be shown that any leaking container would not be approved for use. Air inlet and outlets shall be provided with bacterial retaining filters. 10.7.5. The process used for sterilization by dry heat shall include aircirculation within the chamber and the maintenance of a positive pressure to prevent the entry of non-sterile air. Air inlets and outlets should be provided with micro-organism retaining filters. Where this process of sterilization by dry heat is also intended to remove pyrogens, challenge tests using endotoxins would be required as part of the validation process. 10.8. Sterilization (by moist heat).10.8.1 Both the temperature and pressure shall be used to monitor the process. Control instrumentation shall normally be independent of monitoring instrumentation and recording charts. Where automated control and monitoring systems are used for these applications, these shall be validated to ensure that critical process requirements are met. System and cycle faults shall be registered by the system and observed by the operator. The reading of the independent temperature indicator shall be routinely checked against the chart-recorder during the sterilization period. For sterilizers fitted with a drain at the bottom of the chamber, it may also be necessary to record the temperature at this position throughout the sterilization period. There shall be frequent leak tests done on the chamber during the vacuum phase of the cycle. 10.8.2 The items to be sterilized, other than products in sealed containers, shall be wrapped in a material which allows removal of air and penetration of steam but which prevents re-contamination after sterilization. All parts of the load shall be in contact with the sterilizing agent at the required temperature of the required time. 10.8.3. No Large Volume Parenteral shall be subjected to steam sterilization cycle until it has been filled and sealed.
10.8.4 Care shall be taken to ensure that the steam used for sterilization is of a suitable quality and does not contain additives at a level which could cause contamination of the product or equipment. 10.9. Completion/finalisation of sterile products.10.9.1. All unit operations and processes in the manufacture of a batch shall have a minimum time specified and the shortest validated time shall be used from the start of a batch to its ultimate release for distribution. 10.9.2. Containers shall be closed by appropriately validated methods. Containers closed by fusion e.g. glass or plastic ampoules shall be subjected to 100% integrity testing. Samples of other containers shall be checked for integrity according to appropriate procedures. 10.9.3 Containers sealed under vacuum shall be tested for required vacuum conditions. 10.9.4 Filled containers parenteral products shall be inspected individually for extraneous contamination or other defects. When inspection is done visually, it shall be done under suitably controlled conditions of illumination and background. Operators doing the inspection shall pass regular eye-sight checks with spectacles, if worn, and be allowed frequent rest from inspection. Where other methods of inspection are used, the process shall be validated and the performance of the equipment checked at suitable intervals. Results shall be recorded.
http://www.ppma.co.uk/form-fillseal/modified-atmospherepackaging.htm
Form Fill Seal
Form Fill Seal (FFS) machines are packaging machines that form fill and seal a package on the same machine. The main types are vertical form fill seal (VFFS) and horizontal form fill seal (HFFS) machines a term often used in the market place to cover horizontal versions of flow-wrappers, sachet machines, blister pack machines, four side seal machines and thermoform fill and seal machines.; in both cases packaging material is fed off a roll, shaped, and sealed. The bags/packs are then filled, sealed and separated.
Today many FFS systems are highly sophisticated featuring computer interfaces and control networks. Greater speed and versatility are the major benefits of FFS systems for user companies. For example snack producers demand systems that have the versatility to provide fast changeover between many different packaging formats to meet growing demand for single serve packs. Here VERTICAL FFS is capable of creating virtually any size or shape ranging from the standard pillow pack to bags sealed on all four sides. The multiplicity of FFS machines employ a wide range of material types and are used across numerous markets including food, drinks, cosmetics, electronics, stationary, tobacco, chemical, medical, and pharmaceuticals. Form fill seal machines are often divided into the types of packs they produce: Bags and Pillow packs flow-wrapper; lower reel flow-wrapper; vertical form fill and seal; stickpack machines; mandrel form fill seal. Bottles/vials blow fill seal. Cartons vertical carton board form fill seal. Pots trays and blisters cold form fill seal; thermoform fill seal; blister form fill seal. Sachets and Envelopes edge seal machine; horizontal form fill seal; vertical sachet form fill seal. Sacks and Bags tubular sack form fill seal and vertical form fill seal. However, each type is introduced individually on the following pages to ensure that browsers are able to access information on easily. Products commonly associated with form/fill/seal include: Crisps; Nuts; Sugar; Rice; Pulses; Sweets & Confectionery; Sauces & Soups; Pet Foods; Grain; Jams & Preserves; Cakes; Bread; Biscuits; Tea Bags; Condiments; Tablets, Capsules and Pills, Greetings cards; Phone cards.
Common Terminology
Horizontal product infeed mechanism Film unwind mechanism Film folding box Longitudinal seal mechanism Transverse seal mechanism Transverse cutting mechanism Discharge conveyor Film forming tube Automatic filling device Film transport mechanism Mandrel Mandrel bag forming mechanism Bag fold and seal Bag seal Multihead weigher
hopper augur filler Bag Bag-in-Box Block bottom bag Deformable material Film reel Film web Flexible packaging material Lay flat tube Paper/foil laminate Pre-made bag Pre-made sack Sachet Pouch Side seam seal Thermoformable material Longitudinal seal Magazin
Flow Wrapping
A Flow Wrapping Machine is a horizontally operated machine with the packaging material mounted above the operating level where the product is loaded horizontally with a longitudinal seal formed below the pack. Uses: solid products like biscuits, chocolate bars and phone cards. Lower Reel Flow Wrapping As above, except the packaging material is mounted below the operating level and the longitudinal seal is on top. Uses: delicate products like vegetables and airline cutlery.
Uses: The well-known Tetra Pak carton for milks and juices is a variant of a carton VFFS pack. Mandrel Flexible Package Form Fill and Seal Machine A packaging machine which forms packs from a reel of flexible material, on one or a number of mandrels, before filling the packs with product and sealing their tops within the machine. Packs are formed using flexible packaging material on one or more mandrel to form the pack which is then filled and sealed within the machine. Uses: Traditionally used for flour and sugar.
Strip Pack
Vertically operated FFS which produces strips of individually sealed packs joined together in predetermined lengths for a variety of uses including soluble medicines.
Stick Pack
Horizontally or vertically operated FFS machine forming a thin 3 sided sachet from flexible packaging materials resembling a stick or pen. Uses: sugar, tea, coffee, sauces, shampoos and toiletries.
Dry Products
These are fully automatic FFS machines, controlled by Electro-Mechanical & equipped with Man Machine Interface, for easy and user friendly operations. The FFS machines for Dry products aids in packing Detergent Powder, Pan-masala, Henna, Talcum powder, ORS, Namkeen, Peanuts, Tea, Coffee, Sugar Salt. etc.
SPECIFICATION:-
This machine can automatically measure, convey and feed, fill and form bags. It also performs date code printing, bag sealing and cutting. It has a servo-motor control bag pulling system, high precision fiber optic photo sensor control, plc control system, selected electrical and pneumatic components from a reliable international manufacturer, preloaded operation menu on 5. 7" touch screen and can easily set and change the packing parameter. It displays daily production output and self-diagnoses machine error. PID temperature controller monitors heat sealing temperature to +I - 1c. Automatic edge position control assures consistent film alignment during production to produce uniform bag quality.
Mechanism Filling Range Feeding System Pouch Size Sealing Packing Material Contact Parts Temperature Controller Power Supply Machine Weight
Electro-Mechanical 2 gms. to 200 gms. (Different Models) One line adjustable disc with telescopic volumetric cup filler Length : 45mm to 200mm Appx. Width : 20mm to 150mm Appx. Central Seal, 3 Side Seal, 4 Side Seal Any Continuous Heat Sealable Laminate in roll form with eye marks. SS 202 Digital or Blind (as per Customer requirement) 1/2 HP, 220V, Single Phase, 50hz 250 Kgs. Appx.
Salient Features
Compact, Automatic, and Robust Machine. Entire Contact Parts are Fabricated of Stainless Steel. Easy operation, High Productivity, and Low Maintenance. Fast Change over to new Pouch Size and Different Filling Volume. Photoelectric Mark Registration system for Precision Cutting and Sealing of Sachet / Pouches. Machine. Mounted on Wheels for Easy Movement. Finest Quality Components and Excellent Workmanship.
A brief outline of a typical Form-Fill-Seal process to which this guide applies is as follows: (a) A Form-Fill-Seal unit is specially built equipment which in one continuous operation forms containers from a thermoplastic granulate, and then fills and seals them. Originally developed for other purposes, they have for some years been suitably adapted and available for use in the manufacture of pharmaceutical products, specifically sterile products. (b) Bulk solution prepared under "microbiologically clean" or aseptic conditions (as appropriate) is delivered to the machine through a bacteria-retaining filter. Pipework, filter housings and machine parts in contact with the product are steam sterilized in place, where practicable. (c) Filtered compressed air and granules of a plastic material conforming to a pre-determined specification and known to be compatible with the product to be filled (usually polyethylene, poly-propylene or polyethylene / polypropylene co-polymers) are supplied to the machine. (d) Within the machine, the plastic granules are extruded downwards under pressure (up to 350 bar) as a hot hollow mouldable plastics tube (or "parison") or tubes. As a result of the high pressure extrusion process, the parison reaches a temperature of 170o - 230o C. The configuration and internal integrity of the parison is maintained by an internal downward flow of filtered air under pressure. (e) The two halves of a mould close around the parison and seal the base. Simultaneously, the top of the parison is cut free by a hot knife-edge. The plastics material is now formed into a container(s) as determined by the design of the mould by vacuum and/or sterile air pressure. (f) The container(s) is/are immediately filled with a metered volume of the solution, displacing the sterile air. Both the air and the solution are filtered through bacteria retaining filters immediately before entry into the forming, or formed container(s). (g) When the required volume is filled into the container(s) the filling unit is raised and the containers are sealed automatically. The mould then opens, releasing a package formed, filled and sealed all in the one continuous, automatic, cycle which takes a matter of seconds. Meanwhile, parison-extrusion continues, and the cycle repeats. The filled and sealed units usually require "cropping" off excess plastic.
(h) In versions of these machines adapted for aseptic manufacture, the cycle is conducted automatically within the machine's own internal sterile air flushed environment (or "air shower"). The machines can also be used to fill suspensions, ointments, creams, and liquids other than aqueous solutions, although with such products it is not always possible to employ the final aseptic product filtration prior to filling. (i) A "multiblock" version of the machine permits the formation of a number (or set) of containers at each pass from the parison by one mould. When used for aseptic manufacturing, the cycle is conducted automatically within the machines own internal sterile air flushed environment (or air shower). The range, accuracy, reproducibility and response time of all controlling and recording instruments associated with the FFS machine and all supporting equipment, must be adequate to ensure that defined process conditions will be consistent during routine production. All instruments must be calibrated before any meaningful operational qualification can be performed. Written calibration procedures should specify the methods to be used for each instrument. Recalibration should be carried out after any maintenance, and all records maintained. New machine specs should state requirements for: Materials of construction for all components, particularly all contact parts, such as machine pipe work; internal components of purchased fittings like automatic valves including elastomeric and mechanical seals; pipeline joint seals; welding materials; filters and filter housings including casing and substrate layers of cartridges, as well as the main medium and all elastomeric seals; and polymer extrusion equipment. Pipe work configuration, with attention to sterile fluid pathways for example, the elimination of deadlegs; position of thermocouples (as installed configuration, verified against the original design configuration and confirmed by temperature mapping is typically part of the validation protocol); and filter housing design. Porosity of the product and air filters. The validation data from the filter manufacturers should be available. Mold design, considering fill volume range, wall thickness, opening characteristics and ease of use, shape and other aesthetic considerations. If FFS machines are used for the manufacture of non-sterile products, FDAs current Good Manufacturing Practices (cGMP) requirements should be followed. When used to manufacture products intended for subsequent sterilization, these machines may be installed within an environment that would normally be considered appropriate for the manufacture and filling of terminally sterilized products. If the machines are to be used for the aseptic filling of sterile products they are usually provided with a localized environment at the point of fill with Grade A air. The Installation Qualification process for any FFS system should confirm and certify that the room conforms to the specified Environmental Standard. A new cleanroom installation should include: room air filter integrity tests; determination of air velocity at the face of each air inlet filter; room air change rate; air particle counts, both viable and non-viable, in the rest condition; room pressure differentials; and lighting, heating and humidity readings.
Blow-Fill-Seal Technology
Blow-Fill-Seal technology refers to the manufacturing technique used to produce small, (0.1mL) and large volume, (500mL +) liquid filled containers. Blow-Fill-Seal technology was originally developed in Europe in the 1930s and was introduced in the United States in the 1960s, but over the last 20 years it has become more prevalent within the pharmaceutical industry, and it is now widely considered to be the superior form of aseptic processing by various medicine regulatory agencies including the U.S. Food and Drug Administration (FDA) in the packaging of pharmaceutical and healthcare products.
The basic concept of blow fill seal (BFS) is that a container is formed, filled, and sealed in a continuous process without human intervention, in a sterile enclosed area inside a machine. Thus this technology can be used to Aseptically Manufacture sterile pharmaceutical liquid dosage forms. The process is multi-stepped, firstly pharmaceutical-grade plastic resin is vertically heat extruded through a circular throat, to form a hanging tube called the Parison. This extruded tube is then enclosed within a two-part mould, and the tube is cut above the mould. The mould is transferred to the filling zone, or sterile filling space where filling needles mandrels are lowered and used to inflate the plastic to form the container within the mould. Following the formation of the container, the mandrel is used to fill the container with liquid, following filling the mandrels are retracted and a secondary top mould seals the container. All actions take place inside a sterile shrouded chamber inside the machine. The product is then discharged to a non-sterile area for labelling, packaging and distribution. Blow fill seal technology reduces personnel intervention making it a more robust method for the aseptic preparation of sterile pharmaceuticals. BFS is used for the filling of vials for parenteral preparations and infusions, optphalmic products and inhalation products for example Respules (TM). Generally the plastic containers are made up of polyethylene and polypropylene. Polypropylene is more commonly used to form containers which are further sterilised by autoclaving as Polypropylene has greater thermostability. The versatility of the FFS technology is particularly demonstrated in the field of easy-to-use pre-portioned consumer products. The practical and consumer-friendly FFS technology offer interesting applications that enable sales figures to be increased for both newly created products and established branded products.
Effectiveness
The following effective quality can be maintained in form fill seal technique:
Output performance High operating comfort Remote diagnosis and tele-service via an internet link HMI (Human Machine Interface) Operational data collection Automatic station positioning Dosing units with optimum filling accuracy From hygienic to fully aseptic configurations
Flexibility
Customer- and product-specific design, adjusted to the product and production requirements Many different packs/moulds/designs are possible Size configuration in keeping with the production capacity required Flexible control concepts and integration with customer-specific systems All common packaging materials that are suitable for heat-sealing can be processed
Cost reduction
for the same cup capacity, the most economic use of raw materials,for the same production, the most economic solution in terms of personnel, power consumption and maintenance
for the same volume of production, lower cost of raw material storage (pre-formed containers can use more than 6 times the space needed for materials on reels).
Flexibility The combination of several functions on one machine provides the opportunity to have unique container shapes and product formats with rapid change-overs in volumes and cutting in singles or multi-packs. Marketing The in-mould labeling facility provides the means to decorate the product and promote brand identification, as well as displaying nutritional and other information. The paper also adds rigidity to the side-wall of the cup, guaranteeing a reduction of 10 to 20% in the thickness of the plastic. Hygiene Thermoforming temperatures, in the range of 140 to 160C, destroy much of any bacteria on the packaging materials. A range of hygiene options enable an FFS machine to be built to suit our products and environment. General Technical Advantages
Customer- and product-specific design in line with product and production requirements. Many cup designs are possible. Size configuration in keeping with the production capacity required. Flexible control concepts and integration with customer-specific systems. All common packaging materials can be processed.
Prospective Validation applies to new processes and new equipment, where studies are conducted and evaluated, and the overall process/equipment system is confirmed as validated before the commencement of routine production. Concurrent Validation applies to existing processes and equipment. It consists of studies conducted during normal routine production and can only be considered acceptable for processes which have a manufacturing and test history indicating consistent quality production. Although lack of suitable records relating to the Qualification phases may not necessarily compromise concurrent validation of some other processes, evidence of proper machine installation is particularly important in the context of F-F-S. Concluding Note on Validation Terminology. While there is considerable variation in the understanding and use of the various terms discussed above, there is general agreement that the critical validation concepts are the following: 1. The overall process is understood. 2. Equipment is appropriately specified and designed. 3. Equipment is properly installed and maintained and is demonstrably operating as specified and designed. 4. The process is validated to ensure that it does achieve the desired and intended result.
3. Personnel
Documented evidence of the relevant experience and training of all personnel involved in validation studies should be maintained.Appropriately qualified personnel should ensure that the protocol and the testing methodology are based on sound scientific and engineering principles and that all studies are properly evaluated and certified.All personnel conducting tests and measurements should be trained and experienced in the use of the equipment and measuring devices. Engineering/mechanical personnel should be fully trained and competent in the operation and maintenance of the F-F-S machines and any subsidiary equipment. They should also have basic training in GMP requirements applicable to sterile production, such as gowning and manipulations.
1 Machine pipework. 2 Internal components of purchased fittings e.g. automatic valves, including elastomeric and mechanical seals. 3 Pipeline joint seals. 4 Welding materials, particularly if any modifications to the manufacturer's specifications are required. 5 Filters and filter housings, including casing and substrate layers of cartridges, as well as the main medium and all elastomeric seals. 6 Polymer extrusion equipment. (b) Pipework configuration, with attention to sterile fluid pathways, for example; 1 Elimination of "deadlegs". 2 Position of thermocouples ("as installed" configuration, verified against the original design configuration - to be confirmed by temperature mapping as part of validation protocol). 3 Design of filter housings. (c) Porosity both of product and air filters. The validation data from the filter manufacturers should be available. (d) Design of moulds, considering fill volume range plus ullage, wall thickness, opening characteristics and ease of use, as well as overall shape and other aesthetic considerations.
6. Equipment Qualification
6.1 Prior to the commencement of any Process Validation studies it is necessary to demonstrate and certify that the F-F-S Machine and any supporting/subsidiary equipment, sub-systems and services are properly installed and functioning in accordance with their basic design parameters. 6.2 For new equipment, qualification begins with the establishment of design, purchase and installation requirements. 6.2.1 These requirements should be specified in writing and should include those matters relevant to the FF-S machine itself, in addition to design specifications for ancillary equipment, where relevant. 6.2.2 These design and installation requirements must be specific to the type and model of the equipment required. 6.3 Installation Qualification of new equipment should be based on written procedures and the results documented. 6.3.1 These written procedures should ensure that the pre-defined construction and installation requirements are confirmed as being met, during the actual installation process. 6.3.2 All key installation parameters should be recorded, and certified as conforming to the predetermined requirements prior to operational qualification of the equipment. 6.4 For existing equipment, installation qualification may consist of defining existing equipment design and installation parameters from records and from direct assessment. 6.4.1 This equipment should then be evaluated for its ability to meet the defined process specifications and for the determination of any mechanical upgrading or procedural modifications needed to meet process requirements.
6.4.2 Any modification should be documented as having been performed in accordance with predetermined requirements, and certified as rendering the equipment suitable for Process Validation Studies. 6.5 The Installation Qualification phase should be designed to ensure that the specified construction and installation requirements are met, including correct provision of, and connection to, all services, powersupplies, drainage systems and all ancillary equipment and instruments. In addition it should also cover all basic functional checks, including: 6.5.1 Operation of all electric motors, pumps etc. (e.g. extruder drive motor, hydraulic vacuum pumps). 6.5.2 Operation of all automatic valves, switches etc. 6.5.3 Operation of automatic systems for each of the pre-defined stages of production. This includes all computerized process control systems associated with the operation of the machine. 6.5.4 Operation of steam traps. 6.5.5 Operation of extruder heaters. 6.5.6 Operation and designation of thermocouples. 6.5.7 Setting and operation of alarm systems. (e.g. Air shower filter blockage, filter damaged switches). 6.5.8 Operation of hydraulic system. (e.g. Mould carriage, mould closing systems). 6.5.9 Positioning of main and head moulds (in relation to each other and to the platen). 6.5.10 Operation of the extruder including position of die and pin. 6.5.11 Fixing of timer settings for each stage of the process. 6.6 Operational Qualification consists of checking the equipment (as installed) over its defined operating range in order to verify that it will perform consistently with the pre-determined limits. 6.6.1 Three or more test-runs should be performed in order to demonstrate through documented, certified evidence that:
operational parameters are maintained as pre-set for each test-run; all controls, alarms, indicators, and sensing, monitoring and recording devices function correctly; written procedures accurately reflect equipment operation. the equipment/pipe-line sterilization process (including steam supply temperature and pressure, temperature mapping for "cold point" determinations; the overall profile of the sterilization cycle should be monitored in order to minimize the use of excessive heating and/or time at elevated temperature to bring the coldest part to the required temperature); fluid and air flows, including mould coolant temperature and flow-rate and air supply pressure for each function; timer settings for each stage of the process; flushing and cleaning of all product and other fluid pathways (in respect of each product manufactured); the filter drying process; extrusion of polymer and formation of product units to the required specification (e.g. appearance, size, shape, wall thickness, fill volume, opening characteristics etc.; conformance to the
6.6.2 Functions requiring attention in the specific context of F-F-S technology include:
specifications should be assessed for each change in variable such as mould shape and size, type of polymer, product formulation, product filter etc.);
filter testing - to cover the testing of all filters, and to include the establishment of filter test frequency for routine production.
6.7 Equipment must be certified as operationally qualified before any subsequent studies can be considered valid.
10. Incubation
Incubation of medium-filled units should take at least 14 days and may be at room temperature for 14 days or may be at room temperature for the first 7 days, with the final 1 to 7 days at 30oC to 35oC. Alternate suitable incubation schedules may be used as determined by the pharmacy to ensure enough growth of any potential contaminating micro-organisms to be visually detectable.
11. Revalidation
Following initial aseptic process validation, media-fills should be repeated to an extent, and at a frequency, which will depend on an occurrence of events or changes which may bear upon the potential microbial hazard to the process and product. Significant modifications to equipment or facilities, changes in personnel, undesirable trends in environmental monitoring results, and sterility test failures may all indicate an immediate need to repeat a full process validation protocol (minimum of 3 consecutive successful media-fill runs). During this time, the machine in question is taken out of service until any problems have been resolved, and the results of the three media-fills have been evaluated and found acceptable. In the absence of any significant changes, or of any other events giving cause for concern, then a minimum re-test frequency should be twice per year per machine, or where the machines are operated on a continuous 24-hour operation basis, once per shift per year, that is, 3 times per year.
12. Documentation
A comprehensive outline of the protocol followed in the whole validation of the process should be prepared. The overview should indicate the steps performed, in proper sequence, and should encompass: a. the approach taken; b. justification of the approach based on the product factors; c. summation of any modifications to the equipment required; and d. any modifications to the protocol resulting from the study. Expert Evaluation An evaluation of the entire study against the protocol requirements as outlined above should be prepared and the conclusions drawn at each stage stated. The final conclusions should reflect whether the protocol requirements were met. The evaluation should include an assessment of the ability of the planned maintenance programs for the FF-S machine and ancillary equipment and instrumentation to maintain the validated conditions. In addition, all process monitoring and control procedures required to routinely ensure that the validated conditions are maintained should be reported. The evaluation should be signed by duly authorized officers of the organization who were members of the team establishing the protocol, and who have appropriate expertise in the area assigned to. Overall approval of the study should be authorized by the head of the validation team and the head of the Quality Control Department.
http://catalogs.indiamart.com/products/form-fill-seal-machines.html
Horizontal Form Fill Seal Machine For Soap (Finseal-11S) We are one of the leading manufacturers of horizontal form fill seal machine, automatic form fill seal machine that offers a good mix of precision, reliability and repeatability with low maintenance, FINSEAL 11 SOAP gives cost effective packaging solution. Built to the highest standards, FINSEAL 11 SOAP maximizes process productivity for those companies seeking long term performance.
Horizontal Highlights * * * * * * Specially Link Two designed Form for wrapping soap machine packs also an Fill toilet to be inserted integral soap and Seal (Regular and guest Machine size)
can
Principle of Soaps are placed on flat belt conveyor, either by link up conveyor (not more...
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Fully Automatic Vertical Form-Fill-Seal Machine for Packing Tablet (Model No. ARP-157) Application: The Machine operates on the principle filling of volumetric dish counting system. It is suitable for automatic packaging of medicine & food stuff products such as Sugar Coat Tablet, Medicine Tablet, Chocolate Pill, Round Sugar Ball etc.
Sealing 3 Packing 100mm 200mm (Enlarged Packing Depending Speed 20 (Depending on on flow side sealing type specific 22 rate & can gravity / 4 Type side Size 280mm 400mm be Range of sealing / (film (film made material pouches volume to / of PET/POLY, the upon be centre : sealing : length) width) order) : packed : min. product) : PET/FOIL/
Packing All heat sealable POLY MET, PET/POLY/CPP/OPP etc. more... Mumbai
Material laminate
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Automatic
Machine
Center
Seal more...
Noida
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Automatic Collar Type Form Fill Seal Machine With Auger Filler Model No. BE/CF/500 Application: Flour, Spices, Milk Powder, Cocoa, Packaging Range: 200
Coffee
(Auger Powder, -
Besan,
Faridabad
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Form Fill Seal Machines We offer quality range of single track form fill machines and form fill seal machines (FFS) which is manufactured using latest technology and is used to fill the bags and pouches. In this machine, the bag length is adjusted by the photocell that traces the film mark. Our machines are renowned for their compactness, simplicity in operation and low maintenance features.
The * * * * * * * * Besides specifications of Auger 3 Length Film Power Aluminum, the of Size Packing Consumption Packing PE, PP above said bag Width Motor & features, film BOPP we 40 40 Speed HP, side mm. mm. 40 220 used V in as attachments Code to to our machine are: filler sealing 140 mm 100 mm bags/min Single Phase roll supporting film which include: Imprinter Pump
also Electronic
Harshika Industries
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Pick and Fill Sealing Machine Intermediate Motion Rotary machine * Conveyor magazine for up * Transfer to * Pouch opening by filtered * Pouch forming * 1st filling station to fill the product * 2nd filling station to fill the product by valve * Pouch * 1st * 2nd * Cooler of seal imprint acting emboss * Discharge Futures: * Servo with * Quick change over * No pouch * Positive Technical Model P F S - 8 more... Coimbatore
with to before by and valve piston, and if 8 2000 compressed station pouches Grippers air filling piston necessary stretching. Sealing Sealing time Conveyor
coding
same
P or cutoff
L bag , failure
C size of nozzles
10
or No
Specification:
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* Vertical Form Fill Seal Machine fitted with auger filler machine * Micro Processor based Machine * Electro-Pneumatically controlled * Setting on HMI keypad * Pillow (Centre) Sealed Pouches * Positive Film unwinding * Online Tracking * Online Batch Coding & photo-mark position adjustment * User Friendly Features * No fill no pouch Logic * Auto Diagnostic Mode Applications Milk powder, Wheat Flour, Instant Food Mixes , Spices, Coffee Powder, Detergents, Pesticides, Fertilizers, Chemicals and other powders more...
Mumbai
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Bag Filling Machines We offer Bag Filling Machine which are used feed the quantity of material, which is to be bagged through the keyboard of controller. We also supply automatic pouch packing machines. These are widely used for various applications like Rice, Sugar, Dal, Cattle Feed, Chemicals, Minerals and Fertilizers. The salient features are as follows: * Rugged * Accurate * User friendly Specifications: M/C Capacity[kg] 0-10, 0-25, 0-50, 0-100 Resolution 5gm Accuracy 20gms Speed 5-6 bags/min Optional Printer interface/PC interface. Features Cumulative totalizer batch totalizer To set target No. of bags to be filled. Air supply 6 bar filtered regulator air supply more... Bengaluru
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Automatic Form Fill Seal Machine As the name suggests our range of automatic form fill seal machine are fully automated machineries. These automatic form fill seal machine have widespread application which has been divided into two broad categories namely powder and granules. This specific packaging machine is utilized in the packaging of powders, granules, tablets, pan masala, tobacco, tea coffee, detergents, spices, khaini and other granules in small quantities between 5 gm to 30 gm. Certain specific features of these machines are: * Photocell control system * Provision for belt conveyor attachment * Screw jack type adjustable disc * Provided with double die roller drive The specifications for powder and granules used for filing and packaging are: * Size of the machine: 762x610x1800 mm (LxWxH) * Net Weight: 350 kg * Gross Weight: 450 kg In order to work on heavy packaging, we have introduced a new model which is used for packing of namkeens, pulses, rice, sugar and more...
Faridabad
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Form Fill and Sealing Machines We are catering a wide assortment of vertical form fill machines for weighing, filling and sealing of various products into laminated and PP films. We use our machines for weighing, filling and sealing a wide variety of products including granules, powders, masala, spices, food products, sugar, salt, detergent powder, liquids like oil, shampoo. These form fill machines and sealing machines are fully-automatic provided with intermittent motion mechanism to manage diverse laminated films like polyester, BOPP, Polyethylene, aluminium foil. These are extensively used for packing powder, sugar, liquid, jam, granules, salt and foods.
Salient * * * * * * * * * more... Pondicherry Power Front Filling The Easy User range: Improved machine change friendly Programmable 5 is over Consumption: side gms draw controlled for vertical Batch 3 web to down fully different and cutting 1000 through pack cross Features: KW alignment gms assembly PLC sizes sealers mechanism
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Vertical Form Fill Seal Machine With Auger Filler We offer Vertical Form Fill Seal Machine With Auger Filler. Auger Filler is used for packing sticky products such as coffee powder, masala/spice powder, milk powder, besan, chemicals etc. Sealing Packing Packing * * Packing * * 100 100 40 100 Size(model to Range Size(model to 280 to390mm(Film SP100) 350mm(Pouch to520mm(Film Type -10gm -Center to SP40) mm(Pouch 5 Seal Kg length), Width) length), Width)
Packing depend Power 5kw Compressed Optional Nitrogen Laminated Unique * PLC (Programmable * Optional more... Mumbai Film
60 /product Phase 10
-Laminated
Polyester
film,
Film,
BOPP/Laminated
BOPP
Film
Features: Logic Controller)from world named GE Faunc.HME from GE Faunc 4 line X 16 cha. HMI
About Us
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Automatic Form Fill Seal Mechanical Type Machine A vertical form fill sealing machine for producing centre seal. Three side seal / four side sealed sachets for handling all types of powders, granules, oils, pastes and pickles.
Packing Applications * * * granules masalas, paste sugar, tea, rice, pulses, turmeric, asafoetida, snuff, oil cosmetic cream, jam grains, jelly, powder coconut pickles oil, with coffee, shampoo, small detergent, syrup pieces material : any laminated polythene poly, metal poly & aluminium poly etc
Technical * * * * more... power speed range power : : supply 1800-2400 5-25 : consumption pkts / grns 230 hr ; v : (depending 5-25-50-100gms single 1 on ;
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FFS With Cup Filler We are instrumental in designing and manufacturing FFS cup filler automatic pouch packing machines that are used for filling cups for packaging purposes. These machines are available for our clients in the capacity range of 300 cups per hour to 12000 cups per hour and are appreciated by our clients for the following:
* Pneumatic cup falling * Provided with Coding device * Double Sealing Feature for Better Sealing * Stainless steel * In compliance with Sanitation * Integrated with Waste Film Collection * Independent Control on Each * Fully Automatic Working (with PLC * Equipped with Touch-Sensing Screen for Maximum Operation * Equipped with a Three-Color Warning Light for Clear Warning in Case Of * Fully Automatic Operations for Fast and High more... design (optional) Quality construction Standards Device Mold control) Convenience Malfunction Production
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Liquid
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Center Filler Flap Type Candy Forming Machine is suitable for forming almost all type, sizes and shapes of Candies. Spaceilly for Liquid Center Filled candies. It can produce up to 1500 Kg Candies /Per Shift depending on size, shape, weight and Liquid filling of candy. only candies are delivered to conveyor because it has O Pesentage scrap on this machine. more...
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Form Fill Seal Machine (FFSM) Hi-Tech present Automatic Form Fill Seal Machine Model No-FFS-50-H. We manufacture automatic form-fill-seal machines which have the following unique features- Salient Features Ideal for all types of powders, liquid, paste, granules, etc. Maximum filling range from1gms to 1kg (with different filling systems and machines) Suitable for 3side/ 4side/ center seal of pouches High performance filling systems attached like auger, cups, liquid pistons, weighers, etc. Available in single/ double/ multiple heads High sealing capability with mechanical/ pneumatic system On line coding attachments (e.g. contact, Inkjet) Maximumoutput:25-100pouches/min more...
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Automatic Form, Fill & Seal (AFFS) Machines to Pack Liquid Items Application
To Pack Liquid Items & Fitted With Steam Jacketed Hopper. Drive of machine is
:Electro-mechanical.
Main Types:* Automatic Form, Fill & Seal (AFFS) machine to pack liquids eg. shampoo, liquid detergent, engine oil, 2T oil, sewing machine oil, flavoured drink, liquor, edible oil etc. * Automatic Form, Fill & Seal (AFFS) machine fitted with Steam Jacketed hopper to heat & pack viscous liquids eg. tomato sauce, tomato puree, honey, gam, pure ghee etc. Range of packing capacities of different AFFS (liquid) Machines :* 1 ml to 10ml * 10ml to 50ml * 50ml to 100ml * 100ml to 200ml Pouch Size :* Minimum: Length 45mmx Width 20mm * Maximum: Length 240mm x Width 150mm Popular Models :* EC 3SS model to make 3 side sealed pouches. * EC 4SS model to make 4 side sealed pouches. Packing Film :* Laminated more...
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Automatic FFS Machine SA-052 Manufacturer, exporter and supplier of Automatic FFS Machine SA-052. follows: more...
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Rahul Packaging,
Faridabad Faridabad
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Multihead Weigher Fully automatic pneumatic operated vertical form fill & seal collar type machine to pack 'Un even easy to break Products' such as Vegetable chips, Corn flakes, Biscuits, Wafers, & other granulated grocery essential commodities etc in any heat sealable center seal pillow laminated poly pouches vise-a-vise polyester/BOPP/polyethylene/AI-foil etc. With electronic load cell based combination Multihead Weighers weigh metric filling station. Machine supported on heavy duty angular steel structure wrapped with Stainless steel cabinet all contact parts, hopper etc are made out of stainless steel.
Application : ldeal to suit to pack free flow easy to break crispy crunchy products Vegetable chips, Corn flakes, Biscuits, Wafers, granules products like grains, rice, wheat, pulses, sugar, coffee beans, dust tea, nuts, agriculture seeds Candies, Confectionery, Dried Fruits & other essential commodities etc. Optional Attachments : 8 to 14 station combinationmore...
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Filling
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Automatic Form Fill Seal Machine We manufacture a wide range of Automatic Form Fill Seal machines that are fabricated as per international quality norms. We use fine grade raw material in manufacturing process. Our product in this range is available in model no. PBP-10 and it is used in packing of following products:
* * * * * * * * * * * * * Dhana Mehandhi Snuff Pan Detergent Powders Granules powder Seeds Tea Tablets Coffee Spices powder masala Gutkha dal powder
Supari Salt Sugar pack powder Neel Namkeen Bhujiya (Rehydration) powder powder specifications: types
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We
Small FFS Machine Quick Packing Machine are the Manufacturers and Exporters range Turmeric Chilli Cumin Coriander Fennel 6.Dry Tea Mango Powder Powder Powder Powder Powder /Aamchur Masala
Small
FFS
Quick
Packing
Machine * * * * * * *
Powder Packing
Packing
* * * * * * more...
Powder Masala
Masala
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Fully Automatic Paste Machine These machines are specially designed for packing of viscous material such as gel, chayavanprash, distemper, cream, balms, lotion and more. The top loading of these machines are made of stainless steel material and hence are highly durable. The machine is provided with external battery back up for emergency filling. Our machines provide accurate amount of fill and can be outfitted to a piston paste to offer different fill capacity according to the need of the industry. Automatic paste fillers automatically index containers below the paste filling nozzles and trigger paste filling operation without any required operator input.
FEATURES * Can fill cream * Output upto * No container, * Tail * Fill quantity can * Power consumption * Easy change over from one size to other size. more... of 4400 No cutting be fill accurately 3 various viscosities. jars/hr. device. arrangment. varied. H.P.
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Foam Fill And Sealing Machine We are engaged in manufacturing Automatic Motorized Foam Fill & Sealing Machine. These Foam Fill & sealing machines are extremely easy to use and have long lasting hassle free performance. They are made of excellent base materials that provide them durability.
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Liquid / Powder Filling Machine The semi-automatic machines are perfectly suitable in liquid filling applications. Depending on design type the machines can be used for filling of watery, foaming, very viscous products or even products containing small pieces. These extremely sturdy machines (stainless steel versions available) offer a filling range from 5 ml up to 10000 ml.
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Automatic Vertical Form Seal Machines We are engaged in manufacturing a wide range of Automatic Vertical Form Seal Machines that is fabricated as per international quality norms. These are manufactured using fine grade raw material that is procured from reliable vendors. Our range of machines is extensively used for packing pepsi ice candy, sauces, honey and lime paste in LD film pouch.
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Automatic
Fill
Seal
Machine more...
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Augar Filler Form We provide a range of augar fillar form fill seal machines, which are manufactured using advanced technology and are compliance with the set industrial standards. These are highly demanded in various industries, owing to their features of sturdy construction, accurate dimension and better durability standards. more...
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F.F.S Machine We offer to our clients F.F.S machine as per clients requirements. This machine is specially designed to pack free flow Powder And Granual with very high precision setting of quality. It is fully mechanical model for pouch packing of free flow Powder nad Granual. more...
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Flowwrap Twin Roll Machine Flow wrap Twin Roll machines offered by us are horizontal form, fill seal machines that are precision designed to suit requirements of various products spread over diverse industries. These machines occupy less space and are also very easy to operate. Further, these are versatile enough to adapt to different products, shapes as well as wrapping material.more...
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Pneumatic Form Fill Seal Machine We produce a premium quality pneumatically operated vertical form fill seal machine to our customers. Our machines are appreciated for the features such as perfect finishing, high efficiency, sturdy construction and others. The features and specifications are given below:
MODEL * * * * * * * * Activate Intermittent Photocell Telescopic Auger Weigh Suitable Automatic to pack Granules, Temperature Free Eye-Mark in NO. pneumatic Type Registration Adjustable Filler Filler Controlling Flowing Powder FPM-2201: technology Sealing System Disc attachable Attachable System Pack
in
Heavy
* more...
P.L.C.
Control
Panel
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Center
We are also serving our valued clients with F.F.S. Center Seal Pneumatic Machine which are fully automatic and popular for their durability and sturdy construction. These machines are made according the international standard of quality. We can also customized these machines as per the requirement of the clients. The * * * * Highly features effective for Available Robust lubricant Easy of Oil, Milk, at and Wine these Edible to competitive sturdy Oil, machines Water and Milk are: Products operate prices construction
Specifications: Packing Heat Roll Max. more... Sealable 425 mm, Laminated Min. 120 Material Films Width mm
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Automatic Crown Capper for Glass Bottle Suitable to seal crown corks on glass bottles of soda, wine, soya milk, tomato ketchup and aerated water. The bottle gets conveyed, the crown cork gets automatically placed and sealed.
Capacity : Bottle Capacity Dimensions (mm) Weight : 700 kg more... 2000-2400 : : bottles 250 1000 x / 700 per 1250 x hour ml 1850
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Offering
Form
Seal
Machines
of
high
quality.
V. S. International Faridabad
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Automatic Form Fill Seal Machine (Collar Type) with Electronic Weighmetric Filling System
This machine is used for packing of granular, powder and freeflowing products in a wide range of consumer packs with weigh-metricfilling system in center sealed pouches, ensuring high speed andless change-over time. Application All products as sugar, coffee, tea, namkeen, snacks, dry fruits,nuts, rice, cereals, corn flakes, cashew nuts, pulses, candy,spices, milk powder, detergent powder, pesticides etc. Salient Features * Microprocessor based state of art technology. * Automatic length control, through eye mark sensor. Sensingadjustable to accommodate a variety of color schemes of pouches. * Digital display for weight setting * Vibratory feeder for feeding the material with bulk and finemode option * PLC controlled system * Automatic totalizer. * Option for 4-line ink coding system for printing mfg.,expiry date etc. * Option for inert gas flushing in the pouch. * Option for batch cutting and individual pouch more...
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Pneumatic Volumetric Cups FFS Machine The machine operate on the Principle of Volumetric Cups with a provision of volume adjustment. On Volumetric Form Fill and Sealing Machine are ideal for filling dry, free flowing products like Detergent Powders, Sugar, Salt, Tea, Namkin, (depend on grain size) Whole Spices, Rice, Pulses, Supari, Mukhwas, Dhana dal, Tobacco, Gutkha & any type of Granuals more...
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This
Automated Form Fill Seal Machine(Model No. MPS-03) machine is used for special type of liquid
like
chutney,
squash,
shaving
cream,
concentrated
l;iquid.
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Features: Vertical form fill & seal machine for producing the center sealed handing all type of free flowing & non flowing product. Very easy adjustment machine. All part in contact with product are manufacturing in stainless steel . Accurate sealing die temperature control and fully controllable die pressure. more...
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Soap Packaging Machine - EP 01 S (Logex) We are one of the prominent names in manufacturing of Horizontal Form Fill Seal Machine for Soap - EP 01 S (Logex). These are manufactured by using high grade technology in order to ensure less faults and errors. Raw materials availed from trustworthy vendors are used in manufacturing process to maintain quality standard. If we talk about its mechanism, they work both manually and mechanically and the soaps are kept in flat belt conveyor. After that these soaps are shifted to infeed lug conveyors and they are moved to wrapping film and they form a folder. The lower parts are made with rollers and the soaps are differentiated with cutting knives and cross seals. To cover or laminate these products we are using materials which can resist against high temperature. Availability of PLC, effective wrapping, great speed, easily fitted to plodder, rapid size change and worth packings are some high lights which help us to gain maximum satisfaction level of customers. more...
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Granule Packaging Machine We are known as one of the leading manufacturers, exporters and suppliers of Granule Packaging Machines. These machines are capable of filling different types of granules. The capacity of machine for filling starts from 10 gm to 10 kg and goes on to higher volume also. These machines are designed in a way that multi dose can also be done. These are specially designed using volumetric cup filling technology that enables these machines in performing well in their application areas with minor maintenance. Clients can avail these machines in both standards form auto line with 1 and 2 heads. more...
Sigma
Automation Ahmedabad
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Automatic Form Fill Seal Machine We put forth Automatic Form Fill Seal Machines that are completely automated. Our machines find application in sealing powders as well as granules. With this specific packaging machine, we are able to provide efficient packaging of powders, granules, tablets, pan masala, tobacco, tea coffee, detergents, spices and khaini in small quantities between 5 gm to 30 gm. more...
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Form Fill Seal Machine Owing to our team of efficient professionals, we have been able to manufacture Form Fill Seal Machine. These are designed using high grade raw material such as stainless steel, aluminum, gun metal and mild steel brass to ensure long functional life and fine performance. Our range is widely used in variety of applications and can be customized as per the clients specifications. more...
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Form Fill Seal Machines With the assistance of our professionals, we are offering Form Fill Seal Machines. We make use of high quality stainless steel procured from leading market vendors. Our products are widely used to pack powders, granules, nuts, rice, snack food pulses, tobacco and liquid material like tea, shampoo, oil & many other items. A digital temperature control mechanism is used by these for sealing the bottles. Additionally, compressed air is used for batch cutting and stamp foil coding. more...
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We
are
manufacturers,
exporters
and
suppliers
of
automatic
auger
type
FFS
machine.
Features: * * * * * * * automatic, Compact and Robust Simple operation and low All contact parts are made of Stainless steel This machine is equipped with the drive with the latest addition for speed Photoelectric mark registration system for precise cutting and sealing of the sachet Custom made to suit specific Top quality components and best Fully machine. maintenance 316 adjustment. / pouches. requirement. workmanship.
Specifications: Electrical Motor H.P. Single Phase , Motor 2 H.P. Single Phase Mechanism Clutch & Break Gear Box , Clutch & Break Controller, Heater: 150W 2pic 300W 2pic Filling System Weigh Filler. more...
Ahmedabad
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Vertical Form Fill Seal Machine Vertical form fill seal machines available at For-Bro Engineers are high speed packaging machines, which are designed for packing of different types of products. Convenient conveyor for product feeding and centralized control panel for operation convenience is used in the machines. Our Vertical form fill seal machines are user friendly and film rolls can be easily changed.
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Pneumatic Collar Type Machines With Cup Filler The automatic FFS Machine Pneumatically operated Machines are meant to produce center sealed pouches from a roll of any heat sealable packing material in printed or unprinted heat sealable laminate to pack various products such as tea, rice, salt, sugar, grains, coffee, spices, chips, snack, dry fruits, confectioneries, pesticides, detergent, pharmaceuticals. etc. We supply variety of automatic ffs machine, forming machine, form fill machine, fill machine, form fill seal machine, ffs equipment, filling machine, ffs packaging machine, automatic machine etc.
Fillers This * * * * more... automatic ffs machine can be synchronized easily Volumetric Volumetric Electronic Load Conveyor any of the following fillers Cup Auger Cell to pack solid products: Filler Filler Weigher Belt
Sharp
Engineers Faridabad
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Automatic Form Fill Seal Machines We are offering automatic form fill seal machines to our clients. These fully automatic machines are used to pack a wide range of powders and granules powders & Granules such as tea, coffee, tobacco, spices, rice, pulses, hina powder, milk powder, nuts, dry fruits, wheat flour, besan, maida, namkeens and snack food. These machines are available with optional attachments and optional filling systems. Following are the specifications of our machine: * All Contact Parts are made of stainless steel & teflon * Sealing Type: Centre Seal (intermittent type) * Packing Range: 10gmsto2kgs * (Depends upon product characteristics) * Packing size: 60 300 mm (Pouch length) * 120500 mm (Film width) * Packing Speed: 20-45 Pouches/min * (Depends upon weight & filling system) * Power Required: 220 VAC Single Phase, 50 Hz, 3 Kw * Compressed air required: 4Kg/Cm2 Optional Attachments: more...
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Fully Automatic Form Fill And Seal Machine The Fully Automatic Form Fill And Seal Machine can be used for packing wide range of products like paste, liquid,powder and granules. Apart from this it can also be used to pack products with suitable dozing system like jam, ketchup, tobacco, pan masala shampoo, ball bearings, sugar, skimmed milk powder, and namkeen. this fully automatic form fill & seal machine is operator friendly. The machine requires low maintenance, since it is small, elegant and can be installed anywhere. Moreover, the machine is portable with its castor wheels. Apart, from all it require single phase electrical supply. All part of the machine is made from food grade stainless steel ss-304/ss-316 following are the features of the machines: * it has a sophisticated photo registration control system which automatically correct the * the sophisticated photo registration control system can automatically adjust and correct the repetition ofmore...
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Automatic Vertical Form Fill And Seal Machines We are engaged in providing our customers with a wide range of Automatic Vertical Form Fill and Seal Machines. The fully automatic machines have been designed to provide highest efficiency and quicker functioning. These are ideal to be utilized for packaging of various types of products across the industries. The various technical specifications of the automatic vertical form fill and seal machines are as follows: more...
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