A branch of biology that deals with the study of functions of living matter Oral physiology is the study of the functions of the mouth and associated structures
Guiding food intake Preparing food for swallowing and digestion Human trait Requires complicated control of many oral, pharyngeal and laryngeal structures More evident in animals
Speech production
Lubrication Calcification - calculus Mastication - occlusion Neuromuscular control of muscle movements Protection from tissue damage
Knowledge of normal functions of the mouth leads to Explanation of orofacial dysfunction, therefore Suggesting better methods for diagnosis & treatment Practical example of how knowledge of oral physiology has an impact on industry & marketing
Pain
Dentistry owes its very beginning to the quest for pain relief Classical foundations of dental profession
Pain
A subjective symptom A reaction elicited by a stimulus May involve a tissue damage Provides a warning to seek treatment Acute vs chronic Spontaneous vs. provoked Continuous vs. intermittent Recurrent periodic Localized spreading migrating - referred
Pain
Definition
A complex series of phenomena Unpleasant emotional & sensory experiences associated with actual or potential tissue damage Abnormal affective state aroused by the pathological activity of a specific sensory system
Pain
Pain is not simply an excessive stimulation of some other sense such as touch or temperature But instead is related to tissue damage at a cellular level This is why physiologists replace pain with noxious & pain receptors with nociceptors Pain stimulants products of tissue damage
Nociceptors
Touch & temperature receptors are well defined Pain receptors (nociceptors) respond to painful stimuli Nociceptor is a term used to describe a nerve ending that responds to stimuli that actually or potentially produce tissue damage Nociceptors may respond to very gross mechanical stimuli Other stimuli may result in painful sensation when level of stimulus is increased A single noxious heat stimulus is sensed as painful Repetitive stimulation of temperature receptors with less powerful stimuli may inhibit the passage of pain
A or C fibers
Information originating in nociceptors travels over small diameter afferent nerves (A or C fibers group) Double nature of pain
A faster producing stinging pain (sharp of high intensity initial pain) C slower - producing agonizing intolerable diffuse second pain
A fibers
Myelinated (2.5 m) Conducting at 12-30 m/s 12High threshold Transmit information from nociceptors or mechanoreceptors Activated by intense mechanical stimulation Involved with 1st pain
C fibers
Transmit a number of different stimuli though they are thought to be purely nociceptive in human Excited by intense mechanical, thermal & mechanical Diffuse & dull that follows 1st pain May arise independently
Pain neuron
Neuron
Pain neuron
Primary neuron
Cell bodies in
In the cranial area; all primary neurons conduct pain from pain receptor nerve endings to the Spinal Nucleus of Trigeminal nerve irrespective of the cranial nerve of origin From SN-CN5 to thalamus SNThalamus to cerebral cortex
Secondary neuron
Tertiary neuron
Stimulation of other sensory receptors at the same time as the nociceptors can prevent the perception of pain gate control theory If the impulses in the nociceptive nerves could proceed up to the cortex, pain would be perceived the pain gate would be opened Explains why pressing on a painful area or clenching on a painful tooth relieves the pain Can explain acupuncture treatment
Lowering threshold
Psychological factors Fear & worry Excitement & relaxation Soothing music
Elevating threshold
Nerve Physiology
The conduction of a nerve impulse Nerve cell axon Intracellular Fluid Extracellular Fluid Na and K ions Na and K channels Difference in polarity of interior and exterior of axon
Nerve Physiology
A result of the relative distribution of Na and K ions across the axon membrane Intracellularly
[K+] is high, [Na+] is low [Na+] is high, [K+] is low The interior of the axon is -ve relative to the exterior Potential difference of about 60 - 90 mV The natural tendency of Na influx is prevented by Na pump, a process that needs energy
Extracellularly
Depolarisation
Rapid fall in membrane potential from 70 to +20+20-30 mV Nerve impulse (action potential) propagates along the axon and when it reaches the resting segment of the axon it creates an electrical stimulus which increases the permeability of the diffusion barrier to Na and K ions by opening voltage gated ion channels
Depolarization
Na+ ions move into cell while K+ ions move out along concentration gradient Intracellular charge is +ve relative to extracellular This segment of the axon has undergone depolarisation and is in a state of action potential As depolarisation progresses along the axon the action potential is propagated and the nerve stimulus continues down the length of the axon
Repolarisation
The axon returns to its original state with initial concentrations of Na and K ions restored and the interior once again -ve relative to the exterior This is achieved by the Na and K channels The axon is ready to undergo depolarisation again to propagate a nerve impulse Active process that takes up energy
Blocking of the Na ion pumps in the cell membrane wall This results in an inability for Na ions influx when the action potential arrives at a given segment of the nerve No effect on resting potential