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Exact cause is Idiopatic

Men-50 y/o above Diet Obesity DM Smoking

Ethinicity Hormonal fx Race Family Hx Alcohol Use

Estrogen

RISK FACTORS

Androgen

Become sensitive to growth stimulating hormone

Hyperplasia

Testosterone

Dihydrosterone Signals prostate cell to replicate

Binds to nuclear androgen receptors Late activation of cell growth Apoptosis

Signals growth factors

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