Characteristics of Sympathetics
Thoracolumber outflow : Spinal cord T1-L3 Ganglia : Either side of vertebral column Preganglionic fiber : short Postganglionic fiber : long Neurotransmitter in ganglia : Ach Receptor in ganglia : nicotinic Neurotransmitter in organ : norepinephrine Receptor in organ : alpha1, alpha2, beta1, beta2 Sweat gland ( organ ) : Ach, muscuranic
Characteristics of Parasympathetics
Craniosacral outflow : CN 3,7,9,10; Spinal cord S2S4 Ganglia : near the organ Preganglionic fiber : long Postganglionic fiber : short Neurotransmitter in ganglia : Ach Receptor in ganglia : nicotinic Neurotransmitter in organ : Ach Receptor in organ : muscuranic
Actions of Sympathetics
Heart : Increase rate, Increase conduction , Increase contractility ; beta 1 Bronchioles : Dilates ; beta 2 GIT : relaxes smooth muscle walls ; alpha 2 Bladder : contracts sphincters ; alpha 1 Eye : dilates pupil ; alpha 1 REFER : Costanzo
Actions of Parasympathetics
Heart : Decrease rate, Decrease conduction, Decrease contractility ; muscuranic Bronchioles : constricts ; muscuranic GIT : contracts smooth muscle walls ; muscuranic Bladder : relaxes sphincters ; muscuranic Eye : constricts pupil ; musuranic Refer : Costanzo
Mechanism of Action
Alpha 1 : IP3, Increase intracellular Ca++ Alpha 2 : Inhibition of adenyl cyclase, decrease cAMP Beta 1 : Stimulation of adenyl cyclase, increase cAMP Beta 2 : Stimulation of adenyl cyclase, increase cAMP Nicotinic : Opening of Na+ and K+ channels depolarization Muscuranic : IP3, Increase intrcellular Ca++
Nicotinic : Agonist : Carbachol ; Antagonist : Curare Muscuranic : Agonist : Carbachol ; Antagonist : Atropine Refer : Costanzo