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The Transportation of Blood Oxygen

Any one subunit receives an oxygen molecule will increase the oxygen-binding affinity of the others

O2

(R) relaxed state

Lung
When environmental [O2] increases, Hb binds oxygen efficiently

Artery

When environmental [O2] decreases, Hb releases oxygen to Mb

Muscle

Vein
Hemoglobin
(T) tense state

Myoglobin

Environmental Oxygen Effects Binding Affinity


Muscle in exercising Vein [O2] Relaxing muscle Myoglobin Artery [O2]

100
Percent O2 saturation 80 60 40 20 0 0 20 40 60 80 100 Partial pressure of oxygen (pO2, mmHg) 120 Hemoglobin

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