Lecture 6 Glucose Catabolism: Glycolysis

Glycolysis

Glycolysis is an essential pathway of energy metabolism

(Lippincotts page 94)

The three possible fates of pyruvate

Clicker
In muscle cells, when oxygen is in short supply, A.lactate dehydrogenase reduces pyruvate to lactate. B.alcohol dehydrogenase reduces pyruvate to ethanol. C.a lot of ATP is produced via oxidative phosphorylation.

Clicker
During strenuous exercise, muscle cells gain ATP molecules and NADH molecules for 1 Glucose molecule that is converted to 2 lactate molecules. A.2,2 B.0,2 C.2,0 D.1,1

Glycolysis is divided into two phases

First phase of glycolysis

Second phase of glycolysis

Clicker: Which reactions are considered substrate-level phosphorylations?

1

A. B. C. D.

1 and 3 1, 3 and 6 6,7 and 10 7 and 10

2 3 4 5 6 7 8 9 10

Clicker: Which reaction produces NADH?

1

A. B. C. D.

1 and 3 5 6 7 and 10

2 3 4 5 6 7 8 9 10

Clicker
How many isomerization reactions occur in glycolysis? A.1 B.2 C.3 D.4 E.5

Clicker
This intermediate is called: A. Glyceraldehyde-3-Phosphate B. 1,3-Bisphosphoglycerate C. 3-Phosphoglycerate