DRUGS CONTRAINDICATED IN PREGNANCY (part 1 of 2)

This chart represents information on select drugs that are contraindicated (Pregnancy category X) for women who are pregnant. This is not an inclusive list of products that carry that pregnancy category. Those drugs that are contraindicated at a certain phase of the pregnancy are listed next to the product name. For more information on specific drug monographs, see product entries or consult the manufacturer. Macrodantin (nitrofurantoin SSD (silver sulfadiazine) Late ALLERGIC DISORDERS macrocrystals) Pregnancy at term pregnancy Vistaril (hydroxyzine) Early pregnancy Rebetol (ribavirin) SSD AF (silver sulfadiazine) Late Rebetron (ribavirin/interferon alfa -2b) pregnancy CARDIOVASCULAR SYSTEM Septra (sulfamethoxazole/trimethoprim) Tazorac (tazarotene) Advicor (niacin ext-rel/lovastatin) Tilia Fe (norethindrone acetate/ethinyl 3rd trimester Aggrenox (dipyridamole/aspirin) 3rd Sulfadiazine Pregnancy at term estradiol) trimester Tri-Legest 21 (norethindrone acetate/ Tindamax (tinidazole) 1st trimester Altoprev (lovastatin) Urobiotic-250 (oxytetracycline HCl/ ethinyl estradiol) Bayer (aspirin) 3rd trimester sulfamethizole/phenazopyridine) Late Tri-Legest Fe (norethindrone acetate/ Caduet (amlodipine/atorvastatin) pregnancy ethinyl estradiol) Coumadin (warfarin sodium) Virazole (ribavirin) Tri-previfem (norgestimate/ethinyl Crestor (rosuvastatin) estradiol) METABOLIC DISORDERS Ecotrin (aspirin) 3rd trimester Tri-sprintec (norgestimate/ethinyl Juvisync (sitagliptin/simvastatin) estradiol) Zavesca (miglustat) Lescol (fluvastatin) Yaz (drospirenone/ethinyl estradiol) MUSCULOSKELETAL DISORDERS Lescol XL (fluvastatin) ENDOCRINE SYSTEM Letairis (ambrisentan) Advil (ibuprofen) 3rd trimester Lipitor (atorvastatin) Aleve (naproxen sodium) 3rd trimester Androderm (testosterone) Livalo (pitavastatin) Ansaid (flurbiprofen) Late pregnancy Androgel (testosterone) Mevacor (lovastatin) Arava (leflunomide) Android (methyltestosterone) Multaq (dronedarone) Arthrotec (diclofenac sodium/ Axiron (testosterone) Pravachol (pravastatin) misoprostol) Delatestryl (testosterone enanthate) Simcor (niacin ext-rel/simvastatin) Bayer (aspirin) 3rd trimester Depo-testosterone (testosterone Tracleer (bosentan) BC Arthritis Strength (aspirin/caffeine/ cypionate) Vytorin (ezetimibe/simvastatin) salicylamide) 3rd trimester Egrifta (tesamorelin) Zocor (simvastatin) Cataflam (diclofenac potassium) Late Fluoxymesterone pregnancy Fortesta (testosterone) CENTRAL NERVOUS SYSTEM Celebrex (celecoxib) 3rd trimester Juvisync (sitagliptin/simvastatin) Beyaz (drospirenone/ethinyl estradiol) Lupron (leuprolide acetate) Choline magnesium trisalicylate Dalmane (flurazepam HCl) Pregnancy at term Methitest (methyltestosterone) Doral (quazepam) Dantrium (dantrolene) Oxandrin (oxandrolone) Estazolam Daypro (oxaprozin) 3rd trimester Striant (testosterone) Halcion (triazolam) Diflunisal 3rd trimester Supprelin LA (histrelin acetate) Restoril (temazepam) Duexis (ibuprofen/famotidine) Late Synarel (nafarelin) Vistaril (hydroxyzine) Early pregnancy pregnancy (30wks) Testim (testosterone) Yaz (drospirenone/ethinyl estradiol) Ecotrin (aspirin) 3rd trimester Testred (methyltestosterone) Etodolac Late pregnancy Virilon (methyltestosterone) DERMATOLOGICAL DISORDERS Evista (raloxifene HCl) Amnesteem (isotretinoin) GASTROINTESTINAL TRACT Feldene (piroxicam) Late pregnancy Avage (tazarotene) Ketoprofen Late pregnancy Bellergal-S (phenobarbital/ergotamine Beyaz (drospirenone/ethinyl estradiol) Mobic (meloxicam) 3rd trimester tartrate) Carac (fluorouracil) Motrin (ibuprofen) 3rd trimester Cytotec (misoprostol) Claravis (isotretinoin) Nabumetone 3rd trimester Efudex (fluorouracil) Nalfon (fenoprofen calcium) 3rd INFECTIONS & INFESTATIONS Estrostep Fe (norethindrone acetate/ trimester Bactrim (sulfamethoxazole/ ethinyl estradiol) Naprelan (naproxen) 3rd trimester trimethoprim) 3rd trimester Fluoroplex (fluorouracil) Prevacid Naprapac (lansoprazole/ Loryna (drospirenone/ethinyl estradiol) Copegus (ribavirin) naproxen) 3rd trimester Flagyl (metronidazole) 1st trimester for Probenecid + Colchicine Ortho Tri-Cyclen 28 (norgestimate/ trichomoniasis ethinyl estradiol) Rheumatrex (methotrexate sodium) Furadantin (nitrofurantoin) Pregnancy at Salsalate 3rd trimester Propecia (finasteride) term Silvadene (silver sulfadiazine) Late Soma Compound w. Codeine Gantrisin (sulfisoxazole) 3rd trimester pregnancy (carisoprodol/aspirin/codeine) 3rd Grifulvin V (griseofulvin) Solage (mequinol/tretinoin) trimester Gris-Peg (griseofulvin) Solaraze (diclofenac sodium) 3rd Vimovo (naproxen/esomeprazole) Late Macrobid (nitrofurantoin as trimester pregnancy (30wks) macrocrystals and monohydrate) Soriatane (acitretin) Voltaren (diclofenac sodium) Late Pregnancy at term Sotret (isotretinoin) pregnancy
Not an inclusive list. (continued)

DRUGS CONTRAINDICATED IN PREGNANCY (part 2 of 2)

Flagyl (metronidazole) 1st trimester for trichomoniasis Follistim (follitropin beta) Ganirelex acetate Gonal-F (follitropin alfa) Lupron Depot (leuprolide acetate) Luveris (lutropin alfa) Menopur (menoptropins) Methergine (methylergonovine) Midol cramp (ibuprofen) 3rd trimester Midol menstrual (acetaminophen/ caffeine/pyrilamine) 3rd trimester Midol PMS (acetaminophen/ pamabrom/pyrilamine) 3rd trimester Midol teen (acetaminophen/pamabrom) 3rd trimester) Mifeprex (mifepristone) Motrin (ibuprofen) 3rd trimester) Naprelan (naproxen) 3rd trimester Ovidrel (choriogonadotropin alfa) NUTRITION Ponstel (mefenamic acid) Late Didrex (benzphetamine) pregnancy Fosteum (genistein/citrated zinc/ Repronex 75 IU (follicle-stimulating cholecalciferol) hormone/luteinizing hormone) Megace ES (megestrol acetate) Repronex 150 IU (follicle-stimulating Megace Suspension (megestrol acetate) hormone/luteinizing hormone) Xenical (orlistat) Serophene (clomiphene citrate) Synarel (nafarelin acetate) OB/GYN Tindamax (tinidazole) 1st trimester ALL ORAL CONTRACEPTIVES Zoladex (goserelin) ALL HORMONE REPLACEMENT PAIN & PYREXIA THERAPY Advil (ibuprofen) 3rd trimester Advil (ibuprofen) 3rd trimester Aleve (naproxen sodium) 3rd trimester Advil Migraine (ibuprofen) 3rd Aygestin (norethindrone acetate) trimester Betadine douche (povidone-iodine) Aleve (naproxen sodium) 3rd Bravelle (urofollitropin) trimester Cataflam (diclofenac potassium) Late Bayer (aspirin) 3rd trimester pregnancy BC Original Formula (aspirin/caffeine/ Celebrex (celecoxib) 3rd trimester salicylamide) 3rd trimester Cetrotide (cetrorelix) Cafergot (ergotamine tartrate/ Clomid (clomiphene citrate) caffeine) Depo-subQ provera Caldolor (ibuprofen) 3rd trimester (medroxyprogesterone acetate) Cataflam (diclofenac potassium) Late Endometrin (micronized progesterone) pregnancy Ectopic pregnancy Celebrex (celecoxib) 3rd trimester

NEOPLASMS

Bexxar (tositumomab) Casodex (bicalutamide) Delestrogen (estradiol valerate) Efudex (fluorouracil) Eligard (leuprolide acetate) Estrace (estradiol) Evista (raloxifene HCl) Firmagon (degarelix) Fluoxymesterone Menest (esterified estrogens) Revlimid (lenalidomide) Targretin (bexarotene) Thalomid (thalidomide) Trelstar (triptorelan pamoate) Trexall (methotrexate) Vantas (histrelin acetate) Zytiga (abiraterone acetate)

Choline magnesium trisalicylate Pregnancy at term Combunox (oxycodone/ibuprofen) 3rd trimester D.H.E. 45 (dihydroergotamine mesylate) Diflunisal 3rd trimester Etodolac Late pregnancy Excedrin Migraine (acetaminophen/ aspirin/ caffeine) 3rd trimester Fiorinal (butalbital/aspirin/caffeine) 3rd trimester Fiorinal w. Codeine (butalbital/aspirin/ caffeine/codeine phosphate) 3rd trimester Ibudone (hydrocodone bitartrate/ ibuprofen) 3rd trimester Ketorolac Late pregnancy Migranal (dihydroergotamine mesylate) Motrin Migraine Pain (ibuprofen) 3rd trimester Nalfon (fenoprofen calcium) 3rd trimester Naprelan (naproxen) 3rd trimester Percodan (oxycodone HCl/aspirin) 3rd trimester Ponstel (mefenamic acid) Late pregnancy Synalgos-DC (dihydrocodeine bitartrate/ aspirin/caffeine) 3rd trimester Vicoprofen (hydrocodone bitartrate/ ibuprofen) 3rd trimester

RESPIRATORY TRACT
None available

UROGENITAL SYSTEM
Avodart (dutasteride HCl) AVOID HANDLING CAPSULES Caverject (alprostadil) Edex (alprostadil) Jalyn (dutasteride/tamsulosin HCl) Lithostat (acetohydroxamic acid) Proscar (finasteride) AVOID HANDLING CRUSHED/BROKEN TABLETS

Not an inclusive list.

(Rev. 4/2012)

PREGNANCY CATEGORIES
When pregnancy appears as a contraindication or precaution to the use of a drug it is usually qualified by a category. Cat. A: Adequate studies in pregnant women have failed to show a risk to the fetus in the first trimester and there is no evidence of risk in later trimesters. Cat. B: Animal studies have failed to show a risk to the fetus but there are no adequate studies in pregnant women; or animal studies have shown an adverse effect but human studies have not shown a risk to the fetus in the first trimester and there is no evidence of risk in later trimesters. Cat. C: Animal studies have shown an adverse effect on the fetus but there are no adequate studies in humans, but the benefits may outweigh the risks; or there are no adequate human studies. Cat. D: Positive evidence of human fetal risk but the benefits may outweigh the risks. Cat. X: Animal or human studies have shown fetal abnormalities or toxicity and the risk outweighs the benefits.