Immunology First Midterm Exam

1. If the patient is exposed to an antigen for the second time, then all the following are true EXCEPT : <c+> B cell receptor cant bind to a free antigen.

2. Which of the following stages of B cell development receptor editing takes place : <c+> immature B cell.

3. Which of the following mainly supports an immune response against intracellular viruses : <c+> good expression of class I MHC genes.

4. All of the following are properties of adaptive cell mediated immune response EXCEPT : <c+> mediated by activated macrophages.

5. All of the following are proposed to lead to tolerance EXCEPT : <c+> the use of an adjuvant.

6. Which of the following cells can induce very strong apoptotic signals in their targets ? <c+> T cytotoxic cell.

7. All of the following molecules are involved in lymphocytes homing and trafficking EXCEPT : <c+> CD80.

8. All of the following are true of B1 cells EXCEPT : <c+< they produce high specific antibodies compared to conventional cells.

9. IgE antibodies can be expressed on the surface of B cells only when : <c+> epsilon chain gene is selected following isotype switching of the heavy chain gene epsilon.

10. All of the following are true about IgG molecule treatment with pepsin EXCEPT : <c+> it can still bind J chain in IgA dimer.

11. All of the following are going to affect the diversity of antibody EXCEPT : <c+> constant light kappa chain.

12. Positive selection, what does it mean ? <c+> the process by which developing T cells that express a specific alpha beta T cell receptor able to interact appropriately with self MHC continue differentiation.

13. Which of the following cells has receptors for the Fc part of the IgE antibodies ? <c+> mast cells.

14. All of the following are true concerning oral tolerance EXCEPT :
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<c+> performed by lymphocytes in the paracortical area of the lymph nodes.

15. T cell development the double negative stage is most likely to be seen in : <c+> subcapsular area of the thymus gland.

16. All of the following can be present in B cell EXCEPT : <c+> the zeta chain of the coreceptor molecule.

17. Which of the following binds initially to the Lck during T cell signaling? <c+> tail of the CD4.

18. Which of the following steps will not take place in the activation of the phospholipase gamma C pathway when the drug tacrolimus is added? <c+> no increase in influx of calcium inside the cell.

19. Which of the following cytokines play a major role in the activation bone marrow in general to induce hematopoiesis ? <c+> IL-3.

20. Which of the following organs is going to be affected in deficiency in the autoimmune regulatory gene ? <c+> suprarenalglands.

21. Which of the following lymphokines is going to be affected the most when there is a mutation affecting the transcription factor Foxp 3 ? <c+> IL-10.
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22. Your classmate recently had his MHC analyzed and he found out that he is completely homozygous at class I and class II. How many different allelic forms in locus A you expect to find in the surface of macrophage? <c+> 1.

23. All of the following are true of NK cells EXCEPT : <c+> they undergo positive selection in the cortical area of the thymus.

24. All of the following genes can be involved in switching in process of isotype switching EXCEPT : <c+> Delta.

25. The effect of homozygous mutation introduced into the germline that eliminated expression of invariant chain will show : <c+> lack of MHC class II expression.

26. Alternative splicing in IgM and IgD is done at the level of : <c+> RNA splicing.

27. What is the main feature of malignant cells used in the monoclonal antibody production by somatic hybridization ? <c+> they die in specific selection medium.

28. Which of the following is true concerning lymph nodes ? <c+> large number of macrophages are present in the medulla.

29. Which of the following Ig is the most important in lactating mother breast feeding her baby ? <c+> IgA.

30. Allotypic differences between antibody molecules refer to : <c+> differences between antibodies of the same class or subclass between different individuals.

31. Which of the following structures D genes play a major role in their development ? <c+> variable region of the beta chain of the TCR.

32. All of the following are true of receptor editing EXCEPT : <c+> B cell variable light and variable heavy chains are involved is this process.

33. Which fraction of the serum protein electrophoresis contains most of the immunoglobulin ? <c+> gamma wave.

34. All of the following molecules contain ITAMS EXCEPT : <c+> the TCR beta chain.

35. All are true about T helper II cells EXCEPT : <c+> involved in intracellular immunity against intracellular bacteria.

36. All of the following are true o superantigen EXCEPT : <c+> induce immune response specific to the superantigen.

37. Which of the following can be detected using the technique of next lymphocyte culture : <c+> Allelic form in locus DR.

38. All of the following combination can be made by a single antibody secreting cell EXCEPT : <c+> Kappa an Lambda.

39. Which of the following statements regarding epitopes is false ? <c+> epitiope is never part of antibody.

40. Which of the following coreceptor marker is specific for B cells only ? <c+> Ig alpha.

41. When we detect syphilis serologically by dark field microscopy we use which libratory technique ? <c+> immunofluoresce.

42. The fact that only 1 of 4 is active in any single B lymphocyte the test will have either field combination of an unused this is due to mainly : <c+> Allelic exclusion.

43. All of the following types of diversity generation are used in antibodies EXCEPT : <c+> Allelic exclusion.

44. All of the following lead to SCIDD EXCEPT : <c+> defect in the Syk protein synthesis.

45. All of the following are true of gamma delta T cell types EXCEPT : <c+> They are mainly present in the GI tract.

46. Which disease has a very high relative risk with HLA-27 :
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<c+> Ankylosing sponidlitis.

47. Which of the following is not a specific antigen recognizing molecule? <c+> complement.

48. All of the following domains are parts of the Fab region of an antibody EXCEPT : <c+> the constant heavy 2.

49. When we count CD4 cells in a patient with AIDS we use which laboratory technique ? <c+> flow cytometry.

50. In which of the following TdT is used to add up more diversity of specificity of antibodies : <c+> junctional diversity.