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VO LU M E 1 8 N U M B E R 1 W I N T E R 2 0 07

Personalized medicine:

Attacking cancer one patient at a time

Breaking through the blood brain barrier Islet cell research program backed by national foundation

Leadership Messages



The far-reaching impact of our research

Patients treated at City of Hope may impact hope and healing for people around the world more than they realize. Patients who participate in the hundreds of clinical trials that continually take place at City of Hope lead our physicians and scientists to new clues about the mysteries of cancer and other devastating diseases. Such trials and innovative treatments that take place here enable advances in cancer care to progress ever more rapidly and safely. Treating a cancer patient often requires a team of caregivers from varied fields of study. When physician-researchers work together to treat one patient, lessons learned may yield more effective treatments for others, with fewer side effects, propelling medical science continually forward. City of Hopes collaborative research environment, internally and with other research facilities, increases possibilities for scientific breakthroughs, the development of better drugs and new therapies. As you will learn in this issue of City News, we are beginning an era where cancer treatments can be tailored to individual patients based upon their DNA or the DNA of their tumors a remarkable step that can be attributed to great scientific minds coming together in shared missions. The institutions new strategic plan, highlighted on page 12, will enable even greater growth and development at City of Hope. The board and I are proud to provide guidance and leadership that supports City of Hopes focused progress as the institutions clinicians and researchers spend their days at patients bedsides and at laboratory tables providing hope, healing and progress toward cures. Your support completes the picture. Philip L. Engel
Chair, City of Hope Board of Directors

Fostering continued success and growth

2006 was a year of tremendous success at City of Hope. Success breeds growth, and we are growing at an unprecedented pace. Never have so many surgeons performed so many healing procedures in our operating rooms; never have we had so many nationally recognized scientists among our ranks. And we have never seen so many donors confidently invest their dollars in our clinics and labs. We stand on the verge of a great era. But success also brings tremendous responsibility. As we look forward to our 100th anniversary in 2013, we also accept that we must plan our growth carefully to maximize our vast potential and be good stewards of our gains. That is why City of Hope recently unveiled its 2007-2013 strategic plan, a roadmap developed with the input of leaders, the board and staff members across the organization. The plan supports our key mission: to shorten the time from initial research observations to effective, new treatments. Each element builds on the urgency of this mission, and the plans priorities which draw from our core expertise in cancer provide us with ways to measure progress. Our goals are ambitious: We aspire to become the leading cancer center in Southern California and one of the top 20 cancer centers in the nation. We will get there by focusing on our strengths in basic, translational and clinical research, establishing centers of excellence in a variety of areas with great impact. We will tailor our capital investments to support our goals, which means putting a high priority on new infrastructure for emerging therapies and technologies. Your support ensured our previous successes, and as we set out on this exciting mission, we invite you to come with us. Michael A. Friedman, M.D.
President and Chief Executive Officer


Personalized medicine: Attacking cancer one patient at a time

Exploring a map of a patients DNA will yield more effective ways to diagnose, treat and even prevent cancer ways that are specifically tuned to each individual. City of Hopes Developmental Cancer Therapeutics Program is positioned to lead the charge into this frontier of research.

Breaking through a protective barrier

Although the blood-brain barrier poses one of the biggest hurdles to physicians who treat brain cancer patients, researchers are helping to find ways around it.


Poison with a purpose

A synthetic form of scorpion venom shows great promise as a potential treatment against brain cancer.


Less to fear, more help to fight

Older adults facing cancer are offered renewed hope through a gentler form of radiation therapy.


An ambitious vision, a new look

A comprehensive strategic plan and a strong new branding initiative support compassionate care and scientific innovation as City of Hope charges toward its second century.

City of Hope, an innovative biomedical research, treatment and educational institution, is dedicated to the prevention and cure of cancer and other lifethreatening diseases, guided by a compassionate patient-centered philosophy, and supported by a national foundation of humanitarian philanthropy.
City of Hope

City News is published quarterly for donors, volunteers and friends of City of Hope.

BRENDA MACEO Senior Vice President, Communications KEVIN KOGA Associate Vice President, Communications

STEVE KIRK Publications Manager KIM HOSOZAWA Associate Director, Creative Services




Chapters: A special section for our dedicated volunteer supporters


Americas Top Doctors For Cancer list includes 16 City of Hope physicians


Renowned hematologist, HIV/AIDS researcher named chief medical officer


Islet cell research program backed by national foundation



By Shawn Le

The black background of the image appears blank, a slate seemingly devoid of detail. However, it is far from empty. Upon closer inspection, the rectangular computer image contains hundreds of thousands of tiny colored specks representing genes that turn human bodily functions on and off, helping the body process, mend and grow. Genes show up as faint points of red, yellow and green scattered in a seemingly random jumble. But order does reassuringly exist: The points line up along a grid pattern, an abstract, modern masterpiece of genetics that is actually one of the most accurate portraits of cancer now available to researchers.



An individuals
DNA is like the blueprint for the human body, guiding how genes create proteins, which are the building blocks of cells.


The image shows a cancer patients gene expression patterns, determined through analysis of a DNA microarray: a collection of microscopic segments of DNA that are attached to a sheet of glass or plastic or a silicon chip. When tested against tissue samples, the individual gene segments respond, producing colors indicating how the genes react and how they express proteins. The grid of colors paints a portrait of the patient and the cancer that lays the foundation for the promise of personalized medicine. Within these enigmatic blips and points lie the very map for how a patients particular cancer grows, defends itself and spreads. City of Hope researchers believe that exploring this map will yield more effective ways to diagnose, treat and even prevent cancer ways that are specifically tuned to each patient. The institution created the Developmental Cancer

Therapeutics Program to lead the charge into this frontier of research, where the promise is high and steadfast scientists pursue discoveries with urgency. An individuals DNA is like the blueprint for the human body, guiding how genes create proteins, which are the building blocks of cells. Over the course of a lifetime, we accumulate mutations to our DNA, whether its the natural effects of aging or environmental effects such as sun exposure or toxic chemicals, said Richard Jove, Ph.D., deputy director of the Comprehensive Cancer Center, chair of the Division of Molecular Medicine and co-director of Developmental Cancer Therapeutics. Mutations in DNA lead to changes in the proteins created by genes, and this change in gene expression is called a molecular signature or profile, he added. Microarray analysis not only identifies signatures, it also identifies possible targets for cancer drugs. Comparing a gene profile of healthy breast tissue to that of breast tumor tissue offers insight. If the breast cancer depends on hormones to grow, then one gene in particular in that profile will glow red instead of green, for example. That gene expresses proteins differently in tumors than in healthy tissue, or perhaps even malfunctions entirely. For each gene like this, the evidence sets up a cascade of research. Is the gene crucial to the tumors growth or survival? What happens if researchers can modify the genes expression? Is there a chemical, molecule or compound that can turn the gene on or off? Would it be safe for patient use? Researchers in the Developmental Cancer Therapeutics Program and their colleagues nationwide are changing todays

standard approach to treating most cancers, one that looks beyond simple chemotherapy.

A better way?
Chemotherapy remains the most successful treatment for many cancers, but its benefits sometimes come at a price. Each variety of chemotherapy comes with its own indicated uses and side effects. But all share one thing in common: They kill cells. Specifically, they target fastgrowing cells, taking many healthy cells along with the cancerous ones they are meant to destroy. That can lead to damage in vulnerable tissue, causing complications such as nausea, infection and bloodclotting problems. In breast cancer, physicians believed for years that chemotherapy represented the best approach to treating all patients, despite its side effects. A study by the National Surgical Adjuvant Breast and Bowel Project in 2004, though, challenged that conviction. In the study, chemotherapy benefited breast cancer patients with estrogensensitive tumors deemed at high risk of recurrence, reducing the chance that their cancer would return by 28 percent. But patients who were unlikely to suffer a relapse got little, if any, benefit from chemotherapy. In this case, chemotherapy seemed to pose more complications than benefits. The key to choosing the best treatment was identifying genetic characteristics of the breast cancer in each individual patient that determined whether it was likely to return Not all cancers are the same, and not all patients are the same. The more we learn about how cancers work, the greater the role we see genetic profiles playing in deciding the optimal care and

treatment of the patient, said Jove. We are working toward designing targeted therapies to match the patients genetic profiles for the most effective treatments with the fewest side effects. Medical oncologist, cell biologist and pathologist Yun Yen, M.D., Ph.D., leads the Developmental Cancer Therapeutics Program along with Jove. The enthusiastic pair has charted a creative approach toward drug development, including researchers from seemingly unrelated areas such as molecular biology, proteomics, gene therapy, computational biology, organic chemistry, clinical pharmacology and cancer medicine. All are bound by one central mission: to hunt down genetic cancer culprits and create tools to fight them, fast. City of Hopes Developmental Cancer Therapeutics Program is unique among cancer centers, said Yen, director of the Department of Clinical & Molecular Pharmacology and Cancer Center associate director of Translational Research. While many cancer centers are doing work in different aspects of drug development, very few are working the entire range. We have everyone we need at the different stages of development who can apply their expertise toward rapidly turning scientific discoveries into cancer therapies. Jove and Yens battle plan has six phases to speed them toward discoveries: target identification, target validation, lead compounds, drug development, preclinical studies and early phase clinical trials.

genetic targets for study. Hitting these targets may cripple cancer growth, cause outright tumor death or even prevent cancer from ever developing. While many targets play a role in cancer development, researchers must figure out which targets are most critical to tumor growth and spread. We are accumulating a database of genetic profiles that not only help us to identify specific genes that may be tied to specific cancers, but also aid us in determining if patients with particular genetic traits can benefit from specific therapies, said Wu. Patients who come to City of Hope today for treatment are donating tissue and other samples for research that will help those who may face cancer in the future.

A litmus test
Validating a target is a painstaking, stepby-step process within the realm of basic and clinical sciences. Lawrence Weiss, M.D., chair of the Division of Pathology, and Hua Yu, Ph.D., professor in the Division of Cancer Immunotherapeutics & Tumor Immunology, study targets to verify whether seeming defects in genetic sequences actually correspond to tumor development and whether they are tied to a specific cancer type. For example, Jove and Yu have shown that a family of proteins called STAT is linked to cancer development. These studies demonstrate that tumors activate one particular family member, STAT3, which helps the cancer grow and shuts down an immune response to the cancer cells, Yu explained. Over the past decade, we have shown how STAT3 has played a crucial role in at least seven different cancer types, Yu added. And our studies into STAT3

The hunt for targets

Xiwei Wu, M.D., Ph.D., makes sure the search starts in the right direction. Wu, who directs the Affymetrix Core, analyzes gene microarrays and identifies



continue at City of Hope, so that we may understand cancer development better, which will lead us to design more effective and safer medicines.

Picking the winner

Once researchers know their target, the search is on for a compound that will act on it. With many hundreds of thousands of compounds to choose from, the task might seem daunting; but scientists use their expertise and advanced equipment to narrow down the list. Researchers like Nagarajan Vaidehi, Ph.D., professor in the Division of Immunology, and M.L. Richard Yip, Ph.D., director of the High Throughput Screening (HTS) Core, focus on hunting down natural and synthetic compounds that might fit the bill. Vaidehi enlists the aid of a high-performance computing cluster at City of Hope that she helped design to conduct screenings of compounds virtually, with computers simulating how compounds react on a structural level. City of Hopes computing cluster allows us to visualize the molecular structure of a target and identify reactive areas that lead compounds can attach to so they can do their work. Its like finding the correctly shaped blocks that fit into holes with the same shape, said Vaidehi. Through computer simulations, we can quickly cut down the number of compounds to test based on structure and shape, which helps speed the development process. Yate-Ching Yuan, Ph.D., associate research scientist in the Biomedical Informatics Core, takes complementary approaches to screening drugs with the aid of computers. The computational studies of Vaidehi and Yuan will help Yip to identify the most promising drug

candidates from screening tens of thousands of real chemical compounds using high throughput robotics. We also gain a more fundamental understanding of how proteins work, which can lead us to designing drugs that more exactly fit what we need, says Vaidehi.

Designing drugs
Even when scientists find an effective compound, it still has a tough road to travel before it becomes a product that is both safe for patients and an effective cancerfighter. David Horne, Ph.D., professor and director of the Synthetic Chemistry Core, though, takes these lead compounds and makes them better. He examines compounds and attempts to engineer improved laboratory-made molecules that work longer, cause fewer side effects or fit better into their molecular keyholes. For example, we identified an interesting compound that is derived from a marine animal called a sea squirt. It has shown a strong effect against solid tumors and promising results against prostate cancer, said Horne, associate chair of the Division of Molecular Medicine. It would be impractical to harvest the compound from living sea squirts to meet current research needs and possible future treatment needs. Instead, we built a synthetic version, which not only shows stronger activity than the natural compound, but can also be manufactured on a large scale for testing.

Will it break down too fast in the bloodstream and never reach the tumor? Will it react poorly with other proteins or compounds in the body? Is it toxic to the system? It is the job of researchers like Timothy Synold, Pharm.D., associate professor in the Division of Medical Oncology & Therapeutics Research, and Edward Newman, Ph.D., associate professor in the Division of Molecular Medicine, to find out. They test what are called the pharmacokinetics of a drug compound to ensure drugs are safe before speeding them to human clinical trials. Preclinical studies help to establish how viable a drug may be for patients. Before a new molecule can be tested in patients, we first need to determine how it behaves in a living system, what the predicted effective dose in humans is and how toxic it may be, said Synold. We often find surprising reactions or unique breakdown products, also called metabolites, that were not anticipated, which then take us back to the drawing board and allow additional refinement of the lead compound to give us an even better result.

compounds against a molecular target and work our way methodically through the long process of drug development, shedding research that dead-ends and compounds that fail along the way, said Yen. Of those drug candidates that make it to early phase clinical trials, only 10 percent are successful enough to move on to phase II trials. And overall, only about 1 percent of the compounds we started off with in development make it past phase II testing. Its all about striving to find that one drug that can benefit patients. City of Hopes atmosphere of open communication and multidisciplinary interaction not only facilitates bringing these drug discoveries rapidly to patients, but also ensures a commitment to patient safety. The Developmental Cancer Therapeutics Program currently is investigating several targets. They include these proteins: I Ribonucleotide reductase A drug that inhibits this enzyme, which is critical to DNA replication, may overcome cancer cells that develop resistance to chemotherapy. I STAT3 A drug that inhibits activation of this protein will have far-reaching benefits, since STAT3 is active in major cancers including breast, prostate and lung cancer. I Aromatase A drug that inhibits this enzyme may help women with estrogendependent breast cancers, which account for a majority of breast cancer cases. I Leptin A drug that inhibits this growth-factor protein may help patients with prostate cancer who no longer respond to hormone treatment. I FXR A drug that targets this nuclearreceptor protein may have wide-ranging

benefits for treating colon cancer and controlling glucose levels in those with diabetes. I SIRT1, SUMO, FEN1, HMGA2 Drugs against these newly-identified molecular targets may provide therapeutic benefits to various cancers. It is well established that cancer is a genetic disease, and personalized medicine targets specific defects. We are now poised to develop therapies that are targeted to the genetic profile of a cancer patient, providing them with improved treatment with fewer side effects, said Jove. There is no one cure for cancer, but the research and testing were conducting at City of Hope will help those facing cancer in the future to receive the cure or therapy that is best matched to their condition. I I I

For the people

After grueling research and study, the most promising drug compounds finally make it to human testing. Yen oversees the early phase clinical trials of drugs in development at City of Hope. These small, early trials examine the safety and efficacy of the drug compounds in humans. So-called phase I trials seek to establish the safest drug dose for patients. Phase II trials identify the specific diseases a drug compound treats most effectively. We start out with hundreds of lead

Out of the dish

At this stage, drugs are ready to move out of the petri dish and into testing in living systems. Just because a compound fights tumor tissue and cancer cells in a lab does not mean it will work the same in a live model, researchers say.

A compound derived from a marine animal called a sea squirt has shown a strong effect against solid tumors and promising results against prostate cancer.



By Alicia Di Rado

Imagine squeezing a watermelon through a chain-link fence. Sound difficult? That is how hard it can be for some chemotherapy drugs to reach the brain.


A network of microscopic pores dot the walls of tiny blood vessels that course through the brain and more often than not, big drug molecules in the blood cannot seep through these gaps to reach the brain tissues they are meant to heal. Called the blood-brain barrier, this fence between the circulatory system and central nervous system poses one of the biggest hurdles to physicians who treat brain cancer patients, because it blocks 98 percent of drugs from reaching brain tissues. Fortunately, though, physicians such as Jana Portnow, M.D., medical oncologist at City of Hope, are helping to find ways around it. Compared to other types of cancers, it often takes longer to get new

drugs into brain tumor clinical trials, explains Portnow, assistant professor in medical oncology and therapeutics research. One reason is that we first need to determine if a new chemotherapy agent can cross the blood-brain barrier and achieve therapeutic levels in the brain. Portnow now leads a clinical trial that tests whether a catheter threaded into the brain can detect and measure levels of chemotherapy drugs. If it works, it could be used to evaluate promising cancer-fighting drugs and may speed new therapies to brain cancer patients. Slimmer than a piece of spaghetti, the flexible catheter has a semipermeable membrane at its tip and can measure levels of various substances in

the brain. Such catheters already form part of the tool kit of neurosurgeons, who use them to measure glucose and other substances in the brain tissue of head-trauma patients. In her study, Portnow will assess how much of a common chemotherapy drug reaches brain tissue. Patients with primary brain tumors (gliomas) or brain metastases may be eligible to participate. Neurosurgeon Behnam Badie, M.D., director of the Brain Tumor Program and associate professor of surgical research, collaborates with Portnow. If Badie can resect a study patients brain tumor, he inserts the catheter into the brain tissue surrounding the cavity left by the tumor. If the tumor is unresectable, he inserts the catheter directly into the tumor tissue. The catheter stays in place for about 48 hours

while the patient remains hospitalized. After surgery, patients receive a dose of chemotherapy. At the same time, a pump gently pushes drops of artificial cerebrospinal fluid through the catheter. Fluid seeps back into the catheter and is collected to test how much of the drug has reached tissues. As Portnow explains, Once we show our microdialysis technique works that we can detect levels in the brain of a drug that we already know crosses the blood-brain barrier then we can apply this technique to screen new drugs for their ability to get into the brain. This process would likely speed such drugs to future brain tumor patients. The General Clinical Research Center at City of Hope and National Cancer Institute support the study. I I I


Microdialysis catheters used in the clinical trial are as thin as spaghetti.





Breaking through the

blood brain barrier


By Pat Kramer

With a whip of its tail, a scorpion unleashes a sting that can stun, paralyze or even kill its unlucky victim. Now physicians are unleashing that powerful sting on cancer.
City of Hope researchers finished their first experimental trial of a synthetic form of scorpion venom as a potential treatment against brain cancer, and results were so encouraging that they have opened a phase II trial of the drug. Scientists hope that the substance, known as TM-601, will offer a natural delivery mechanism for radiation in treating glioma, an often-deadly form of brain cancer. In the phase I study, surgeons first removed patients brain tumors and then injected TM-601 into the cavities left by the tumors. During treatment, the drug acts as a sort of natural glue, binding radioactive iodine to the treatment area to focus radiation directly on the site. Called iodine-131-TM-601 therapy, the drug combines the synthetic version of a peptide (chlorotoxin) from the venom of the giant yellow Israeli scorpion Leiurus quinquestriatus with the cell-killing power of radioactive iodine. The chlorotoxin contains protein sequences that bind to a receptor found on cancer cells, but not on normal cells. Behnam Badie, M.D., director of both the Brain Tumor Program and the Division of Surgerys Department of Neurosurgery, said the drug was well-tolerated among the 18 patients in the phase I trial. Moreover, two study participants survived for 148 and 156 weeks, respectively, far longer than the typical 24 to 77 weeks seen among patients with recurrent


glioma. Since the drug caused no substantial adverse side effects and successfully carried radiation to its targets, Badie believes it could benefit many other types of treatment, as well. Now Badie is the principal investigator of City of Hopes phase II high-grade glioma study. City of Hope is part of a national consortium of 13 medical facilities evaluating TM-601 and is one of only two California centers participating in the study. He also has personal experience with brain cancer: His father was diagnosed with a brain tumor two years ago. Unfortunately, like many others with glioma, he succumbed to the disease. Badie recently dedicated a neurosurgical textbook, which he edited, to his father. About 36,000 people are diagnosed with primary brain tumors in the United States each year, said Badie. Of those, about half have high-grade glioma. Life expectancy is one year for about 50 percent of that group, while the rest survive up to two years. A small percentage do make it past two years, but usually suffer from treatment-related toxicity. Badie hopes TM-601 will join the treatment arsenal for brain cancer. It is simple to deliver and is well-tolerated, and appears safe for repeated injections, he said. However, what we have yet to determine is whether increased doses of radiation are safe. Thats what we are looking at in the phase II trials. Researchers from City of Hope, Cedars Sinai Medical Center, the University of Alabama at Birmingham, St. Louis University and TransMolecular Inc. (the drugs developer) collaborated in the phase I trial. Study results appeared in the Aug. 1, 2006, issue of the Journal of Clinical Behnam Badie Oncology. I I I









Less to fear, more help to fight

By Alicia Di Rado

Hematopoietic cell transplants have saved the lives of thousands of young and middle-aged adults with blood cancers; for children and seniors with certain cancers, though, the treatment is simply too grueling or poses too many side effects.
But City of Hope researchers increasingly are finding new ways to bring transplantation and renewed hope to these patients. Through a pilot trial available only at City of Hope, a senior with acute myelogenous leukemia recently received a gentler form of radiation therapy as part of the conditioning regimen for an allogeneic hematopoietic cell transplant, bringing the procedure to a man who otherwise may not have been appropriate for transplant. The procedure was the worlds first total marrow and lymphoid irradiation treatment (TMLI) using TomoTherapy, a highly targeted and customized radiation technology. The TomoTherapy HI-ART system allowed radiation oncologists to target radiation beams specifically to bone marrow, lymph nodes and the spleen while limiting radiation exposure to the rest of the body. In contrast, traditional radiation therapy used in conditioning regimens called total body irradiation, or TBI exposes every part of the body to the energy beams. Radiation therapy aims to destroy any remaining cancer cells and suppress the immune system to accept new, transplanted blood stem cells. Its too early to tell if this will replace total body irradiation, said Jeffrey Wong, M.D., chair of the Division of Radiation Oncology. But we feel this may be an appropriate way to administer radiation therapy to those who might not stand up to the rigor of TBI. Wong is an investigator in the phase I trial, which is led by principal investigator Joseph Rosenthal, M.D., director of the Department of Pediatric Hematopoietic Cell Transplantation. We hope that this combination of chemotherapy and TMLI may result in fewer side effects, especially among children, who often have serious longterm effects from bone marrow transplantation, said Rosenthal. At the same time, we want to reduce the risk of their leukemia returning. And tolerable treatments for older people with blood cancers are greatly needed, as well. The prevalence of acute myelogenous leukemia, for one, rises dramatically after age 59, and the disease is most common in the seventh, eighth and ninth decades of life. Researchers hope that gentler therapy will help bring hematopoietic cell transplantation to more of these patients. Hematopoietic cell transplantation begins with a conditioning regimen, in

According to Jeffrey Wong, chair of the Division of Radiation Oncology (right), patients undergoing TomoTherapy receive highly customized treatments.

which chemotherapy is used with or without radiation therapy to kill many of the cancerous cells riddling the body. After finishing the regimen, patients receive infusions of replacement hematopoietic (blood) stem cells, either from the patients themselves (called autologous transplants) or from matched donors (allogeneic transplants). These new cells give rise to the patients new immune system. As Wong explained, todays TBI requires patients to stand up while a machine administers radiation from head to toe. Patients receive radiation about three times a day over four days, resulting in approximately a dozen treatments. The radiation exposure may cause side effects such as sore throat, fatigue, nausea, vomiting and diarrhea. But the new investigational therapy requires only eight treatments with doses given twice a day for four days and patients undergo treatment lying down. At the same time, patients receive two chemotherapy drugs believed to be more tolerable than other similar medications. Wong and colleagues hope the combination of focused radiation and milder chemotherapy will make treatment easier for children and patients over age 55, both vulnerable groups. With TomoTherapy, the radiation dose to normal tissues is substantially reduced, which we believe may reduce side effects, he said. Researchers hope to open another trial soon, with Anthony Stein, M.D., as principal investigator, evaluating a more intensive treatment regimen for younger adult patients with acute myelogenous leukemia. Wong said City of Hope is the first to evaluate TMLI because it was one of the first centers to acquire and use TomoTherapy. We worked with TomoTherapy to develop the concept before we even acquired the machine, Wong said. In addition, we have a large bone marrow transplant program and a strong track record with clinical trials. I I I

City of Hope

By Alicia Di Rado


City of Hope became the first institution in the world in 2006 to have two TomoTherapy machines available for targeted radiotherapy for patients, doubling the institutions capacity to administer the technologys highly precise treatments. City of Hope oncologists use the innovative system to treat everything from cancers in the brain to those in the pancreas. And because they were among the first in the nation to work with TomoTherapy, City of Hope physicians also are among the countrys most-consulted experts on the technology. The new helical TomoTherapy system means that we can offer highly precise and effective radiotherapy using CT guidance to even more patients, said Jeffrey Wong, M.D., chair of the Division of Radiation Oncology. Were excited to be at the leading edge of many new applications for this technology. The TomoTherapy machines symbolize the first step in a marked expansion planned for City of Hopes Division of Radiation Oncology in the next three years. The division will be housed in the Center for Targeted Therapy, a 28,000-square-foot area of the Medical Center scheduled for refurbishment and build-out. The future center will include not only two TomoTherapy units, but also a positron emission tomography/ computed tomography (PET/CT) simulation unit, two modern linear accelerators for image-guided radiation therapy and stereotactic radiosurgery, a dedicated magnetic resonance imaging unit for radiation planning, a CT simulator, high-dose rate brachytherapy suite and spacious lobby.

The two TomoTherapy systems mean physicians can perform more focused radiotherapy procedures than ever before. It also allows physicians to increase radiosurgery options for lung and brain cancers. Radiosurgery is different from radiotherapy: It focuses tightly conformed beams of radiation directly onto a tumor. Because little healthy tissue is exposed to radiation, oncologists can use high doses of radiation in a drive to destroy a tumor entirely. Radiosurgery may be a curative alternative that is especially appropriate for elderly patients and patients whose diminished health or complications make them poor candidates for traditional surgery. TomoTherapy marries two technologies: spiral CT scanning and spiral intensity modulated radiation therapy. As with a CT scanner, the patient moves through the unit. But instead of using X-rays for imaging, the TomoTherapy unit delivers high-energy therapeutic X-rays spirally around the patient, producing a sculpted dose of radiation at the tumor site. This leads to more effective and potentially more curative doses delivered to the cancer, while reducing radiation doses to healthy tissue. The image guidance involved in TomoTherapy means physicians can carefully map radiation doses to each patients tumors in advance and adjust doses as needed. City of Hope oncologists have developed such deep expertise that physicians around the globe, from Thailand to Taiwan, have invited them to lecture on TomoTherapy. Said Wong: Its a reflection of our hands-on work, and its gratifying to be able to influence how patients are treated worldwide.




An ambitious

A new look
By Kevin Koga

City of Hope has touched countless lives through the research and treatment efforts of its scientists and clinicians since its inception nearly a century ago. Today, more people are benefiting from the institutions breakthroughs, more nationally renowned scientists are joining its ranks, and more donors are supporting its mission than ever before.

To guide the organization as it moves into its second century, City of Hopes leaders have created strategic and master plans for 2007 to 2013. These plans are designed to advance the institutions mission of compassionate care and scientific innovation in coming decades. The strategic plan details City of Hopes future goals and identifies research and clinical priorities targeted for expansion, while the master plan determines the facilities and technologies necessary to support the institutions growth. After introducing the strategic plan, institutional leaders launched a branding campaign to more accurately reflect the organizations history and future. I am extremely optimistic about our potential as an organization, said Philip Engel, City of Hope board chair. We aspire to become the leading cancer center in Southern California and a top 20 cancer center nationally by 2013. City of Hope President and Chief Executive Officer Michael A. Friedman, M.D., expressed confidence in the plans goals as well, and the institutions capability to achieve them. We have been fortunate to enjoy the success and

growth weve experienced over the past few years. We must continue to be good stewards of those gains and manage our future growth strategically, he said. The organization will build around its core expertise in cancer, shortening the time from initial scientific idea to new treatment by conducting innovative basic research, providing excellent clinical care and significantly strengthening its infrastructure. As we move our organization forward, we will continue to build on our long-standing values of compassion and innovation, Friedman continued. We also will work to develop a unique attribute for our organization: fostering speed, safety and effectiveness across all of our research and treatment programs. As one of only a handful of freestanding academic medical centers, he added, City of Hope has a distinct ability to more quickly bring new treatments to patients.

uses the bodys own immune system; stem cell and developmental biology; developmental therapeutics; cancer biology; and population sciences, which combines cancer prevention research with outreach activities to reduce cancer-related deaths. Our leadership in leukemia and lymphoma provides an outstanding example of how clinical and research programs can come together to benefit patients, as well as contribute significant knowledge to the field on a national and international level, Friedman said. We will work to build upon this stature with several of our other programs, including breast, genitourinary/prostate, thoracic/lung, gastrointestinal/liver, pediatric, gynecological, musculoskeletal, brain and diabetes. City of Hope bolstered its educational capacities recently by bringing together all academic and training programs under a new Center for Graduate and Professional Studies. (See story on page 24.) City of Hope also will upgrade its technology and facilities to support burgeoning programs. This process began with opening of the Center for

Biomedicine & Genetics in 2001 and, more recently, Helford Clinical Research Hospital at City of Hope facilities that provide the organization with unique environments to manufacture biologics and conduct clinical trials. In the coming years, we must invest in even more new and upgraded facilities that will enable us to expand our research program and produce new, effective treatments, Friedman added. Prominent projects on the list include the Arnold and Mabel Beckman Center for Cancer Immunotherapeutics and Tumor Immunology, a Radiation Oncology facility, the Michael Amini Transfusion Medicine Center, and a recently completed Population Sciences building.

materials and training programs, creates a more cohesive overall image of the institution, according to Brenda Maceo, senior vice president, communications. All interactions people have with City of Hope help them to form an impression about the institution. The more we can unify our messages, the more prominent and compelling the brand becomes. A consistent and accurate brand makes it easier for us to strengthen our presence among our peers, and ultimately enhances our ability to fundraise. A new logo serves as the cornerstone of City of Hopes visual identity. The identity communicates a union of the science and compassion that make City of Hope unique. Drawing from the Spirit of Life fountain, the new logo represents hope, optimism and unity, while the contemporary font expresses innovation. The blue hue of the new logo crisp and energetic reinforces modernity. Because a brand is only as strong as those who articulate it, I ask that you embrace and champion this effort in your role as a City of Hope supporter, Friedman said. Its success depends upon our communicating it in a consistent and compelling way. I I I

A new visual identity

Coinciding with the adoption of the new strategic plan, City of Hope is launching a new visual identity this year. City of Hopes updated brand, reflected in written and verbal communications, signs, marketing

Boldly moving forward

Under the plan, City of Hope will work to develop leading research programs in a number of areas: immunotherapeutics and immunology, cancer treatment that









Real-time results
By Alicia Di Rado


Annual National Convention and groundbreaking events ring in new year

As 2007 begins to unfold, excitement is building at City of Hope. The upcoming year is filled with more opportunities to expand the institutions impact on millions of people worldwide. As part of our donor network, chapter support continues to fuel todays breakthroughs and tomorrows discoveries. To celebrate our success and recognize the dedicated volunteers who help fulfill City of Hopes vital mission, we have scheduled the National Convention for June 23 to 25 at The Beverly Hilton Hotel in Beverly Hills Calif. At this years event we will celebrate City of Hopes 94th anniversary, while welcoming chapter delegates from across the nation and recognizing outstanding fundraising achievements of the past three years. We also will share exciting news about the future. In the coming year, we expect to break ground on three important facilities that will bring us closer to our shared goal of ending the devastation of cancer and other life-threatening diseases. Foremost among these is the new Arnold and Mabel Beckman Center for Cancer Immunotherapeutics and Tumor Immunology, an innovative research center dedicated to immunotherapy, a treatment that uses the immune system to fight cancer and other diseases. Additionally, The Michael Amini Transfusion Medicine Center will house all aspects of blood collection and analysis that are critical to our programs at City of Hope. Also opening this summer is the Sheri & Les Biller Patient & Family Resource Center, a facility that will integrate and expand a wide range of patient support services, further strengthening our commitment to compassionate care. Although planning and early construction are under way for these facilities, we will count on your support as we work to make these dreams a reality. Further details about this years convention are outlined in a special question-and-answer feature with Alan Levey, senior vice president of Development, on page 18. Expect to receive more information as the event draws near. In the meantime, I hope you enjoy this issue of City News and wish you continued success in your fundraising efforts. Sincerely,

with PET to detect cancer. Todays commonly used isotope highlights tumors that metabolize glucose quickly, but some tumors, such as prostate cancers, do not do that. So, he hopes to explore other isotopes to spotlight hypoxia (oxygen deficiency), apoptosis (cellular suicide) and cellular proliferation, all important hallmarks of cancers. He also is interested in the use of various imaging technologies, such as magnetic resonance imaging, for radiation targeting. I I I

Harvey Schneider and his wife, Marilyn, at a special dedication ceremony held in recognition of their generous gift.



The key might lie with medical imaging. Nguyen is doggedly pursuing the potential of imaging during treatment to determine whether radiation therapy or systemic treatments, such as chemotherapy, are successfully killing off cancer cells. I want to know if there is a way to predict, early on, whether treatments are effective or not, and whether there is a benefit to the patient undergoing that treatment, Nguyen said. We may be able to gauge early treatment response using PET-CT. PET-CT draws on two imaging technologies, combining the power of positron emission tomography (PET) with the intricacy of computed tomography (CT). PET can show cancers activity, while CT displays the structures of a patients anatomy in detail. Over the last several years, researchers have begun exploring whether PET-CT can provide physicians never-before-seen information on treatment progress. The technique has potential for breast, esophageal, lung, rectal, anal and possibly pancreatic cancer. But much research is needed. We dont know how early we can start using 200 PETCT to see if treatment Khanh Nguyen is working, Nguyen

explained. Whats the optimal timing? We need to understand how it relates to characteristics of the patient and the type of tumor. Ideally, if a PET-CT scan shows that patients are responding to their ongoing treatment, physicians can continue patients therapy with confidence. But if the scan shows that the therapy is unlikely to help, physicians may recommend changing therapy early in the course of treatment without losing time or putting patients through unnecessary discomfort. He enthuses about PET-CTs potential, and he knows the technology well. He moved to City of Hope from the University of Tennessee Medical Center, where he worked with David Townsend, Ph.D., co-inventor of PET-CT dubbed the medical invention of the year 2000 by TIME magazine. Nguyen already has begun collaborating with other City of Hope physicians to include PET-CT in research protocols. Unfortunately, costs pose a challenge. The radioactive isotope for a single PET scan costs about $1,000, but Nguyen is committed to pursuing funds to advance the research. On the scientific side, Nguyen is seeking new markers that can be used

Kathleen Kane

Kathleen L. Kane, Executive Vice President of Development and External Affairs .......................................................................................................

A judges wise and reasoned investment in philanthropy

For more than 12 years, Los Angeles Superior Court System Judge Harvey Schneider relied upon his knowledge and wisdom of the law to rule on thousands of complex civil and criminal cases. But when it came to decide on the best way to honor his late parents, Sara and Harry Schneider, the retired judge didnt need time to deliberate. City of Hope was the only choice. Although his father served as president of the Arnold Alpert Chapter in the 1950s, the young man only occasionally crossed paths with City of Hope through his involvement with another national charity. In later years, however, he came to understand more about his fathers devotion to the institution. In 2001, during a tour of the Duarte campus where he met with Michael C. Jensen, M.D., associate chair of the Division for Cancer Immunotherapeutics & Tumor Immunology and director of Pediatric Neuro-oncology, Schneider heard a remark he could not forget. Dr. Jensen commented that the goal of mainstream medical research is to develop drugs for widespread use. Therefore, the development of drugs to treat diseases that affect fewer people was not pursued aggressively, he recalls. Dr. Jensen felt that this was something that set City of Hope apart, Schneider said. The goal here is to develop drugs to treat diseases that, while impacting fewer people, are just as important to those who need them. He said that City of Hope was one place where such research was conducted, and that left a very strong impression on me. When an opportunity arose to provide support, Schneider and his wife, Marilyn, seized it. The couples $100,000 gift is now recognized on the sixth floor of Helford Clinical Research Hospital at City of Hope in a patient room named in honor of Sara and Harry Schneider. Through this gift, I am honoring my parents strong sense of philanthropy, as well as supporting something that my wife and I wholeheartedly believe in. Its truly inspiring.

Cancer patients should not have to wait until treatment ends to find out if it has worked, says City of Hope radiation oncologist Khanh Nguyen, M.D. The way he sees it, the earlier physicians can determine whether cancer is responding to therapy, the earlier they can adjust treatment to benefit patients.



Stories by Pat Kramer, Associate Editor



Convention preview: A conversation with Alan Levey Florida supporter donates $100K
Alan Levey, senior vice president of CN: What activities are planned for Development, oversees activities surrounding delegates? Will there be any new features? the 2007 Annual National Convention. AL: We are planning a Day of Discovery at Recently, he shared his thoughts on what the Medical Center that will include general tours, patient speakers and a health fair for chapter delegates can expect at this years all delegates. To provide relevant gathering. information and activities, we have City News (CN): What changes can chapter incorporated flex time for delegates during delegates look forward to at this years their visit to the Medical Center so they can convention? focus their attention on their areas of Alan Levey (AL): An exciting and dynamic interest. three days are planned, with conventioneers areas of interest at the forefront of the agenda. CN: Will delegates have an opportunity for We also have added a new delegate twist this interaction with the medical staff? AL: Yes, there will be some great year. For the first time, each chapter opportunities for delegates to interact representative may bring an additional delegate of his or her choice to the convention. socially with staff and board members in a All that we ask is that this individual has had a casual setting. significant impact upon his or her chapters CN: These all sound like exciting changes. fundraising activities, and that the person they AL: They are. We want our chapter delegates choose has never attended a past convention. to have a wonderful time and a memorable CN: How will this move impact the convention? visit. We want all of the delegates to really AL: We welcome the opportunity to hear new understand how their efforts impact the mission at City of Hope and, at the same time, voices on how to maximize our fundraising let them know how much we appreciate them. efforts. The larger delegate group will bring fresh perspectives and diverse opinions to the Without the volunteer movement, City of Hope would not be where it is today. proceedings. .............................................................................

Philanthropists make the right connections

Michele Oken grew up home for his charity golf tournament, recalled Oken. surrounded by City of Hope Meeting and working with him during the past year supporters, so it is no has intensified my dream to find a cure for cancer. surprise that the dedicated He has been an incredible inspiration for me and all philanthropist founded and of the members of The now serves as president of Hope Connection. Spencer Shiffman (left) and event The Hope Connection, one On May 15, 2006, honorary chairman of Los Angeles newest and the inaugural Hope and PGA Tour Pro most vibrant chapters. Connection/Spencer Duffy Waldorf Her familys intergenerational Shiffman Charity Golf at the Hope Michele Oken connection to the institution Tournament and dinner Connection/Spencer Shiffman Charity dates back decades. Okens grandmother, Irene gala was held at El Golf Tournament Silverstein, belonged to The Merchants Club Caballero Country Club chapter. And her aunt, Sandy Hoffman, helped to in Tarzana, Calif. The well-received event found and still serves as the longtime president of attracted scores of celebrities, including film and the 500 Club, one of City of Hopes original television stars Joe Pesci, James Caan, Brad chapters. Her mother, Myrna Oken, and Micheles Garrett and Carlos Alazraqui, as well as Doors former husband, Bruce Moss, also have raised guitarist Robby Krieger. Renowned philanthropist funds. On a more personal note, since several and Los Angeles Sentinel publisher Danny family members were treated at City of Hope, the Bakewell Sr. also attended with his wife, Aline, institution stands as the familys charity of choice. and son, Danny Jr. The Hope Connection began in March 2005, This inaugural event, which raised more than when Oken helped found the group to complement $150,000, was a spectacular success, particularly support provided by the 500 Club. As she worked to since The Hope Connection is a new chapter, said establish her fledging chapter, Oken was introduced Rosalyn Phillips, associate vice president of to Spencer Shiffman, a three-time cancer survivor development. The group is a fine example of a and 2003 Spirit of Life recipient. family legacy of giving and unwavering support for City of Hope. At the time, Spencer was looking for a new .....................................................................................................

Laurie Tomchin

Can you identify the location and individuals in this photo from a fundraiser in the Los Angeles area in the 1950s? The first chapter member to provide information about the picture to archivist Susan Douglass Yates will be recognized in an upcoming issue.

From left, Southern California Artistic Tree Pruning Club members Fujio Kimura, Masao Morisaku and longtime El Camino Lions Club member Joseph Watari were part of a maintenance group visiting campus on Oct. 16, 2006.

Enthusiastic representatives from South Florida chapters gathered at the Diamantes Banquet Center last year to honor the regions Golter Society awardees. Sharon White, associate vice president of development, was on hand to celebrate the events fundraising total of more than $200,000, not including a generous $100,000 gift from longtime donor Laurie Tomchin, a member of both the Pembroke Pines and Kings Point chapters. Other Golter awardees who announced contributions of $5,000 or more at the event included Marilyn Stahl, Florida Golter chair Edith Susselman, Jaye and Roger Levy, Richard and Selma Ehrlich, Gerry and Tyby Klein, Rita Messner, Bernice Chernove and Sylvia Boklan.

You can help preserve City of Hopes illustrious past

Thousands of chapter members around the country have nurtured City of Hopes growth and development since the institution was founded in 1913. Now City of Hopes archival staff wants to document and preserve this important part of its history. If you or any of your chapter members possess any historical materials such as photographs or memorabilia that would be suitable to donate to City of Hopes archives, please contact archivist Susan Douglass Yates at or 626-256-4673, ext. 63482. Your participation will preserve City of Hopes rich heritage so that future generations may fully understand the contributions hundreds of chapters have made to the institution for nearly a century.

Japanese Garden has its roots in Lions Clubs

The tranquil Japanese Garden at City of Hope is one of the campus most visited meditative spots, and visitors have a local associate group to thank for the locales beauty. Although many Southern California Lions Clubs contributed to the project, the garden started and flourished largely through the efforts of one: the El Camino Lions Club. The story starts with the groups president, John Tsuruda, a friend of late Lions Club International President Koaru Jay Murakami. A committed horticulturalist, Murakami encouraged each Lion to plant one tree during his or her lifetime. When Murakami succumbed to cancer, the idea of planting an authentic Japanese garden at the Medical Center as a tribute to him took root. Tsuruda served as chair of City of Hopes Japanese Garden Committee, and the Lions Club helped enlist an architect, masons, horticulturalists and gardeners. Donors provided turtles and Japanese koi. The garden was dedicated in March 1991. Now, supporter Masao Morisaku, whose late wife Sachiko was a City of Hope patient, brings members of the Southern California Artistic Tree Pruning Club to campus once a year, ensuring the gardens beauty remains intact. The philanthropic Japanese gardening group prunes trees, weeds and hoes. Between the groups visits, City of Hope onsite gardeners tend to the garden.





City of Hope physicians named to


By Shannon Flaherty City of Hope doctors recognized in Americas Top Doctors for Cancer.

Regional Roundup Chapter news from around the country

From left, Rhoda Ehrlich, Southeast Council president and City of Hope National Board of Regents member, Toni Nathan, Spirit of Life honoree, Kevin Fererri, Ph.D., Ricky Paskow, Board of Regents member, and Henry Stevens, O.D., donor and award presenter, gather at the Miami Spirit of Life event.

SOUTHEAST: Miami More than $50,000 was raised when the Phyllis
Dropkin Chapter honored longtime chapter member and supporter Toni Nathan with The Spirit of Life Award at a special luncheon last year at the Westview Country Club. Kevin Fererri, Ph.D., assistant professor in the Department of Diabetes, Endocrinology & Metabolism at City of Hope, served as the events guest speaker.

SOUTHWEST: Torrance, Calif. The Angels of Hope chapter held its gala on Oct. 7, 2006, at the Torrance
Marriott to honor chapter members Max and Ana Negri, both M.D., with Spirit of Life Awards. Event chair Dolores Caffey-Fleming and chapter President Barry Tyson (pictured) welcomed more than 200 guests, who together raised $86,000. At the gala, Angels of Hope board member and cancer survivor Tim Scully, Ph.D., led a special tribute in which more than 45 cancer survivors and 100 family and friends participated. The Angels of Hope Chapter has raised more than $3 million since its inception four years ago. Numbering 119 families, including as charter members both the Helford and Cooper-Finkel families, the chapter is located in the South Bay. To learn more, visit

Sixteen City of Hope physicians are featured in the new book Americas Top Doctors for Cancer.
A guide to national cancer specialists, the book includes profiles of more than 2,000 doctors throughout the United States, within City of Hopes 49 commonly consulted cancer ...physicians specialties and subspecialties. Selection was based on continue nationwide surveys of more than 5,000 physicians, as well as to rank executives and administrators at major medical centers, specialty among the hospitals and teaching hospitals, nations and association and group members. The book includes best in biographies of physicians, cancer information on identifying and accessing clinical trials, and care. descriptions of many of the nations leading cancer centers. While City of Hope has Theodore many of the nations top physicians, the book highlighted Krontiris several individuals in various specialties (see listing at right). Every day I am impressed by the talent and commitment of our physicians, researchers and support staff who are focused on treating and curing patients, said Theodore Krontiris, M.D., Ph.D., executive vice president of Medical and Scientific Affairs. City of Hope is pleased to have our physicians continue to rank among the nations best in cancer care. Americas Top Doctors for Cancer is available at, and via publisher Castle Connolly Medical Ltd. at I I I

Division of Hematology & Hematopoietic Cell Transplantation

Stephen J. Forman, M.D., Francis and Kathleen McNamara Distinguished Chair in Hematology and Hematopoietic Cell Transplantation and division chair I David Snyder, M.D., division associate director

Division of Radiation Oncology

Richard D. Pezner, M.D., division associate chair I Jeffrey Wong, M.D., division chair

From left, Dan DeBrauwere of Bank of America, Rich Bosek of Wachovia Securities, Guy Fuchs of Wells Fargo Foothill and Scott Avila of Corporate Revitalization Partners enjoy a day of philanthropic golfing.

Rancho Palos Verdes, Calif. The Womens Council of Greater Los Angeles (WCGLA) held its Sixth Annual Golf Classic at the Trump National Golf Club in Rancho Palos Verdes, Calif. Honorary co-chairs Mark A. Sampson and Guy K. Fuchs led 136 golfers through the Donald J. Trump signature course, known as the most expensive golf course ever built. Thanks to Wells Fargo and Escreen, the events major sponsors, the fundraiser grossed more than $85,000 for City of Hope. WCGLA co-presidents Canise Arredondo and Nancy Brusegaard Johnson already are planning next years event. Palm Springs, Calif. Longtime Palm Springs Chapter member Dan Cohen again received a $5,000 Prudential CARES Volunteer Grant from the Prudential Foundation. Cohen has received the annual honor, which recognizes volunteer work, for more than a decade. Because Cohen designates City of Hope as his charity every year, the institution has received $25,000 in contributions from the Prudential Foundation. During his 35-year involvement with his chapter, the committed supporter has served as president and in other leadership roles.

Honoree Peggy Post (left) and event chair Mark Kingsdorf

Philadelphia Peggy Post, of the Emily Post Institute, received The Spirit of Life Award last year at Let Them Eat Cake, a fundraising event hosted by the Park Hyatt Philadelphia at the Bellevue hotel and chaired by supporter Mark Kingsdorf. Hundreds of brides-to-be and gourmet wedding cake enthusiasts each paid $25 to $35 to sample the citys best butter-cream confections. Twenty top wedding cake designers and four teams of student pastry chefs donated their talent to the wedding-cake showcase, raising more than $15,000. Post also signed copies of the Emily Post Institutes latest book, Wedding Etiquette.

Desert Communities Assistant Development Director Debbie Long and Dan Cohen display the big check.

MIDWEST: Columbus, Ohio The Golden Anniversary of the Columbus Chapter was acknowledged in grand style at the
Stargazer Style Show and Luncheon on Sept. 20, 2006. A hat competition at the event sponsored by Macys served to honor all chapter members as 2006 Women of the Year.
From left, Fran Luckoff, luncheon co-chair, Terry Johnson, co-chair, chapter President Joyce Nemeth and Kathleen Busche, co-chair.


Dolores Caffey-Fleming and Barry Tyson

Division of Surgery
James S. Anderson, M.D., director of the Department of Plastic & Reconstructive Surgery I Benham Badie, M.D., director of the Department of Neurosurgery I Joshua Ellenhorn, M.D., physician I Mark H. Kawachi, M.D., director of the Prostate Cancer Center I Kemp H. Kernstine, M.D., Ph.D., director of the Department of Thoracic Surgery I Lawrence D. Wagman, M.D., director of the Liver Tumor Program I Timothy G. Wilson, M.D., Pauline and Martin Collins Family Chair in Urology and director of the Department of Urology & Urologic Oncology

Division of Medical Oncology & Therapeutics Research

Robert A. Figlin, M.D., Arthur and Rosalie Kaplan Professor of Medical Oncology and division chair I Kim A. Margolin, M.D., division associate director for clinical research I Jeffrey N. Weitzel, director of the Department of Clinical Cancer Genetics I Yun Yen, M.D., Ph.D., director of the Department of Molecular & Clinical Pharmacology

Division of Pathology

Lawrence M. Weiss, M.D., division chair


By Barbara Romero

> National Cancer Institute grant

By Shawn Le

> Skirball Foundation advances research

of acute lymphoblastic leukemia The Skirball Foundation has awarded a two-year, $500,000 grant to support research on T-cell therapy for lymphoblastic leukemia. The project, which is led by Stephen J. Forman, M.D., the Francis and Kathleen McNamara Distinguished Chair in Hematology and Hematopoietic Cell Transplantation, and Michael C. Jensen, M.D., associate chair of the Division of Cancer Immunotherapeutics & Tumor Immunology, will focus on developing an immunotherapy-based treatment for patients with acute lymphoblastic leukemia.

> Susan E. Riley Foundation

grant to support pancreatic cancer research Joshua Ellenhorn, M.D., assistant professor of surgery and director of the Surgical Oncology Fellowship Program, received a two-year, $165,000 grant from the Susan E. Riley Foundation to support research targeting pancreatic cancer. Ellenhorn and his colleagues aim to develop a vaccine that will trigger a patients immune system to fight pancreatic cancer by targeting the Bcl-XL protein, which is found in 90 to 100 percent of pancreatic cancers. The team has significant expertise in this area, and already developed an investigational vaccine that targets another cancer protein known as p53. I I I

Alexandra M. Levine, M.D., has been named chief medical officer (CMO) of City of Hope.
An internationally known expert in lymphoma, Hodgkins disease and AIDS-related malignancies, Levine serves as the organizations chief clinician and oversees all clinical and hospital care programs at City of Hope. Levine was most recently distinguished professor of medicine, chair of the Division of Hematology at the Keck School of Medicine at the University of Southern California (USC), and medical director of USC/Kenneth Norris Jr. Cancer Hospital. As City of Hopes CMO, Levine develops and implements the institutions clinical strategy and program development. She serves as the primary liaison with the City of Hope Medical Group and its physician members to promote collaboration across disciplines and ensure effective staff recruitment and retention. Levine co-leads programs aimed at continually improving the standard of care at City of Hope, including quality of service, patient safety, clinical research, clinical information management and professional education. As chief clinician she serves as a role model and facilitator for all clinical staff. We are thrilled to have Alexandra Levine at City of Hope. She brings both her vast scientific expertise in hematology and HIV, and also her limitless compassion for patients facing cancer, said Michael A. Friedman, M.D., president and chief executive officer, City of Hope. Dr. Levine is a noted advocate of bringing more humanism into medicine and can address quality patient care from all angles, managing the needs of patients while also providing guidance for the physicians who treat them. Levine is a distinguished professor at Keck School of Medicine, and holds the Ronald H. Bloom Family Chair in Lymphoma. Her research interests include lymphoma, Hodgkins disease, and the treatment and prevention of HIV/AIDS among women. She worked with Jonas Salk, M.D., for eight years on the development and testing of an AIDS vaccine. Levine has served as principal investigator or co-investigator on more than 20 major research grants, most funded by the National Institutes of Health.

Levines scientific and clinical contributions have received national and international recognition. In 1995, President Clinton appointed her to the Presidential Advisory Council on HIV/AIDS. She also chaired the councils research committee. Levine has served as a member of the Board of Councilors of the National Cancer Institute and is currently a member of the Oncologic Drug Advisory Board of the Food and Drug Administration. In addition, she served as HIV/AIDS consultant to the health departments of Chile, Russia, India and China. I am delighted and honored to be given the opportunity to work with the City of Hope family. This institution has always distinguished itself by its commitment to quality in terms of patient care and research, and by the kindness and caring that has always been integral to its mission, said Levine. City of Hope is now poised to move to the next levels of expertise and national leadership, and I am most thankful to be given the chance to participate in this very exciting future. Levine is a member of the American Society of Hematology, the American Society of Clinical Oncology, the American College of Physicians and the International AIDS Society. She has published more than 300 articles and book chapters in noted medical journals such as the New England Journal of Medicine, Blood and the Journal of AIDS. In 1997, she received the Lymphoma Research Foundation of Americas Evelyn Hoffman Memorial Award in recognition of her achievements in lymphoma research and patient care. Levine received her medical degree from USC in 1971, and completed fellowships at Emory University and Los Angeles County+USC Medical Center. I I I Alexandra M. Levine

supports palliative care advancement A five-year, $1.5 million grant from the National Cancer Institute (NCI) will enable City of Hopes Department of Nursing Research & Education to educate social workers, psychologists and chaplains nationwide about palliative care for cancer patients. The program, the first that will focus on psychologists, social workers and spiritual care providers, is the latest in the departments series of seminal, national-level education programs, and aims to fundamentally advance quality of end-of-life care in the United States. Shirley Otis-Green, M.S.W., L.C.S.W., senior research specialist of City of Hopes Department of Nursing Research & Education, is principal investigator for the program, known as the ACE Project Advocating for Clinical Excellence: Transdisciplinary Palliative Care Education.

> Susan G. Komen Breast Cancer

Foundation supports breast cancer survivor research The Susan G. Komen Breast Cancer Foundation has awarded a three-year, $249,464 grant to study well-being among Asian-American breast cancer survivors, as well as their access to care. The grant funds the work of Kimlin Tan Ashing-Giwa, Ph.D. Breast cancer is the most prevalent cancer type among Asian-American women, yet few studies investigate the needs of these survivors, Ashing-Giwa says. Study findings will address the social support, psychological, functional and medical care needs of this group.

> American Cancer Society aids

cervical cancer survivors The American Cancer Society (ACS) has awarded a four-year, $1,548,000 grant to Kimlin Tan Ashing-Giwa, Ph.D., professor and director of the Center of Community Alliance for Research & Education (CCARE) in the Division of Population Sciences at City of Hope. Health professionals participating in the study will counsel women with cervical cancer in a way that is sensitive to their culture and language. According to Ashing-Giwa, the study is consistent with federal and state initiatives to increase nontherapeutic trials that may broadly benefit the population, particularly underserved communities.




chief medical officer


Internationally renowned hematologist and HIV/AIDS researcher named

City of Hope is a nationally recognized leader in biomedical research. The institution ranked in the top 5 percent among independent research institutes in total grants awarded by the National Institutes of Health in 2005. Following is a roundup of some notable grants recently awarded.


A melding of minds
By Shawn Le


A breast cancer survivor feels the need to

A new Center for Graduate and Professional Studies recently established at City of Hope will bring together all academic and training programs and foster a unified educational thrust.
Susan Kane, Ph.D., associate director of Beckman Research Institute, will lead the new center aims to coordinate City of Hopes educational strengths and create a cohesive academic campus. In the past, the Graduate School of Biological Sciences and the Office of Continuing Medical Education operated independently of each other. Departments created their own research or training programs, and postdoctoral fellows formed their own campus association. The new center will align such efforts, enabling the two entities to share valuable resources. Kane will lead the center in her new capacity as senior vice president of academics. Steven Novak, Ph.D., will oversee the administrative aspects of the center and work with external accrediting agencies. The mission of the Graduate School of Biological Sciences is to train students to be outstanding research scientists in chemical, molecular and cellular biology. The school has graduated more than 30 aspiring researchers since its inception in 1994. It will continue under the deanship of John J. Rossi, Ph.D., and the Office of

give back
In 2006, 48-year-old Beverly Austin celebrated her eighth year of remission after receiving treatment at City of Hope for early stage breast cancer. As a result of this experience, Beverly has a sense of gratitude for each day of her life and is a regular participant in the Walk for Hope to Cure Breast Cancer.
In July 1998, two months after my 40th birthday, my doctor called me at work to tell me that I had a malignant tumor in my breast. The news left me numb with despair. After moving beyond two unhappy marriages and trying to raise my young kids as a single mom, I thought, Why is this happening to me? Soon after, I met with an oncologist who recommended a lumpectomy followed by radiation and chemotherapy treatments. To make it through these challenges, I knew I would need a lot of emotional support, as well as a strong, positive mental attitude. After breaking the news to my family, I hesitated to tell my new boyfriend, thinking he would break up with me. Instead, he offered to take me to my surgical appointment. That was the day I fell in love with him. The lumpectomy went well but the radiation treatments proved challenging, as my doctor was located in Long Beach, Calif. a considerable distance from my San Gabriel Valley home. When a friend suggested that I transfer to City of Hope, it made perfect sense. I remember how impressed I was while visiting the campus as part of an on-site review team for my companys employee contribution committee for the United Way campaign.
Susan Kane leads efforts to unite City of Hopes education programs.

the new center. Kane explained that

Continuing Medical Education will operate with its current staff, with Jean Kagan as director. Kane said that both areas benefit from the centers centralized administration of registrar, recruitment and outreach, and outcomes research. The center also will house two newly created offices: the Office of Postdoctoral Studies and the Office of Clinical Research Training. The Office of Postdoctoral Studies will be the central point of contact for all incoming and current doctoral fellows. In the Office of Clinical Research Training, Jonathan Espenschied, M.D., will serve as clinical research training developer and Ann Geva as clinical research training coordinator. Espenschied and Geva will be responsible for

developing and implementing coordinated curricula and training activities for clinical researchers. There are tremendous synergies to be gained from taking a more integrated approach to these programs, Kane said. A number of outstanding clinical fellowship programs and world-class clinical researchers will benefit greatly in the didactic portion of their training as a result of this change. City of Hope also is organizing a faculty senate, which will advise the center once the senate is fully chartered and operational. We are entering into a new era at City of Hope and raising the visibility of educational activities on campus, she added. The Center for Graduate and Professional Studies will provide a more efficient and collaborative approach to sustaining our educational programs for students, fellows, staff and faculty alike. III

I was even more impressed with the care and support I received once I became a patient. Those at City of Hope treated me like family, preparing me every step of the way, for what I could expect when I received the radiation and chemotherapy treatments. As a patient, I learned about City of Hopes annual fundraiser: the Walk for Hope to Cure Breast Cancer. Seeing the value it provided to both survivors and the medical staff, I made the commitment to take part. That first Walk was a little rough because I was still undergoing treatment. But being among family, friends, and numerous survivors and supporters was an empowering experience. So, I have made a commitment to participate in the Walk, every year, and to make breast cancer awareness my mission for the rest of my life. Thanks to City of Hope, I am blessed to still be here. I hope that my involvement in the Walk and as a patient speaker gives other breast cancer survivors hope. I also wear a pink ribbon on my lapel to remind others to get regular mammograms and perform self-exams, because early detection truly is the key. I love the City of Hope credo: There is no profit in curing the body if, in the process, we destroy the soul. I carry that message in my heart every day. I I I

Beverly Austin








By Fran Rizzi and Pat Kramer


Saying thank you through giving

When Sandy Sholkoff was diagnosed with leukemia five years ago, she initially sought treatment near her home in the San Fernando Valley area of Los Angeles. However, 13 months later, her cancer returned, and after a third treatment, it came back yet again. This time, the grandmother of three turned to City of Hope, where she met Stephen J. Forman, M.D., the Francis and Kathleen McNamara Distinguished Chair in Hematology and Hematopoietic Cell Sandy Sholkoff and her grandchildren (from left) Samuel, 14; Transplantation. Ronit, 6; and Avi, 9 Forman advised her to pursue a bone marrow transplant (BMT), and Sholkoff and her physicians began searching for a marrow donor. This treatment course posed a special problem for me, as I am an only child, Sholkoff said. Although my children were willing to help, none were an exact match for me. When a matching donor came forward seven weeks later, I was incredibly moved. Here was a complete stranger who was willing to make the effort to save someones life. The day of Sholkoffs bone marrow transplant June 23, 2004 is one she always will remember. She describes it as a life-affirming day, both physically and spiritually, due to the tremendous efforts made to save her life. After the first anniversary of her BMT, Sholkoff contacted her donor, a Michigan man who shared her eastern European roots. His first words were, How are you feeling? said Sholkoff. I said, Great, thanks to you. Fourteen months ago, you gave me a new life. In April 2006, the two met at City of Hopes 30th Annual Celebration of Life Bone Marrow Transplantation Reunion. Hes like the brother I never had, Sholkoff said. Because of his generosity, I can now spend time with my family, even travel with them. It truly was a miracle. Sholkoffs gratitude for the team that saved her life has inspired her to speak out for others. She made a generous donation that will benefit others facing similar diagnoses and also joined City of Hopes Patient Speakers Bureau. She hopes her story will inspire others to support the institutions urgent battle against cancer and other serious diseases. I I I

Maximizing two generous gifts through matching donations



Thousands of generous donors help advance science by ensuring that City of Hope remains at the forefront of biomedical research. Although their experiences with the institution may vary as patients, friends of a patient or longtime supporters all are committed to helping City of Hope fulfill its mission of preventing and curing cancer and other life-threatening diseases.

Throughout his high school and college years, Don Hoffman supported City of Hope, his familys charity of choice, by contributing to a myriad of fundraising activities. His parents set an example by being longstanding members of City of Hope chapters, and his father, Irving Hoffman, served as president of the Don and Lois Hoffman Merchants Club from 1962 to 1963. Don Hoffman now chairs the Think Tank of the Board of Governors, of which he is a member, and serves on City of Hopes board of directors and Ambassador Leadership Council, as well. Although Don Hoffman and his wife, Lois, contribute to City of Hope every year, they had not considered a long-term commitment until recently. In 2006, the Arnold and Mabel Beckman Foundation issued a challenge grant, matching donations up to $5 million, to support construction of the Arnold and Mabel Beckman Center for Cancer Immunotherapeutics and Tumor Immunology. It was the Beckman Challenge that really inspired us to sign a multiyear pledge agreement, Don Hoffman said. Recognizing the benefit of matching grants, the Hoffmans actions generated two significant pledges for the Arnold and Mabel Beckman Center. In the first, the Hoffmans personally pledged $75,000 over five years to support the project. And Don and Aubrey Grey, who serve as co-directors of the Lawrence P. Frank Foundation, pledged another $100,000 to the effort. The final result: A total of $350,000, including the matching grants. Construction on the Arnold and Mabel Beckman Center is scheduled to begin in 2007. The new facility will be an innovative research center dedicated to immunotherapy, a treatment that uses the immune system to fight cancer and other diseases. Aside from their dedication to supporting cancer research, the Hoffmans, married for 46 years, are avid square dancers and devotees of round dancing, a type of ballroom dancing. Each March, they volunteer and participate in the David Saul Heck Chapters Annual Square Dance fundraiser benefiting City of Hope, now in its 17th year. I I I

Sylvia Weisz (left) and Sophie Poster

Giving in memory of a lifelong friendship

Los Angeles resident Sylvia Weisz shared a special friendship with late City of Hope supporter Sophie Poster that endured for more than 50 years. Weisz hailed from an affluent family of entrepreneurs and great philanthropists, while Poster, known for her warmth, candor and generosity, emerged from a more modest background. The women first met while Poster was employed as the Weisz familys bookkeeper. And while the two were raised in very different ways, they developed a close bond that lasted a lifetime. While Poster never had children of her own, she informally raised many kids in her neighborhood, who she affectionately called the boys. Coming from widely varying ages and backgrounds, they were part of an extended family that included Weisz. In April of 2006, when Poster passed away at age 88, Weisz decided to honor the memory of her dear friend by pledging $100,000 to City of Hope. A beautiful granite plaque inscribed with Posters name has been placed on the walkway at the south side of the Platt Conference Center and serves as a testament to their lifelong friendship. Sophie was well known and well loved by many, many people, said Rodney Lucas, one of the friends in her group. She created very deep and meaningful relationships with others throughout her entire life and was an ardent supporter of City of Hope. Through the years, she purchased bricks in the Heritage Park, including one for Sylvia, to honor the people she loved. She also created several gift annuities as another way of giving. I I I




to eradicate disease. We thank all of the companies that support our lifesaving research and treatment efforts in cause-related marketing campaigns, and wish them continued success.

research program backed by

By Mark Wheeler

national foundation

By Brittany Hastings


The Juvenile Diabetes Research Foundation (JDRF) has designated City of Hope as an islet cell transplant center, making the institution one of only 14 in the United States and the only one in Southern California to receive this distinction. Focusing on type 1 diabetes, JDRF islet cell transplant centers provide scientists and clinicians opportunities to collaborate and drive new ideas from the research lab to the clinic. Complementing this designation, the JDRF recently awarded City of Hope a five-year, $3.3 million grant to optimize islet replacement therapies for patients with type 1 diabetes. The grant supports a phase I/II clinical trial scheduled to begin this year that will be the first to use certain growth factors to expand the number of islet cells before and after they are transplanted. Researchers hope this will result in a single islet infusion that can free patients from insulin dependence. To be recognized by the JDRF as an institution that is leading the way in islet transplantation is a testament to our researchers and clinicians, said Fouad R. Kandeel, M.D., Ph.D, who directs the Department of Diabetes, Endocrinology & Metabolism as well as the Southern California Islet Cell Consortium. The long-term effects of diabetes can be devastating and potentially life-threatening. We believe that combining City of Hopes expertise with the JDRF will lead to rapid advancement in treatment. Currently, the Edmonton protocol the established procedure for islet cell transplantation requires two to three infusions of islet cells. But under the new approach that expands the number of islet cells, researchers hope a single infusion can make the most of the limited number of available donor organs. Islet cell transplantation is considered one of the most promising methods for potentially curing diabetes. Islets are collections of cells in the pancreas that produce insulin; type 1 diabetes is an autoimmune disease that destroys the insulin-producing cells in these islets. For transplantation, islets are removed from a donor pancreas, purified and injected into the liver of the recipient. Transplanting donor islets can restore control of glucose levels and result in independence from insulin injections, while avoiding the invasive procedure of a whole pancreas transplant. Transplant recipients must take powerful medications to prevent their immune system from rejecting the islets.

City of Hopes new protocol will modify this drug regimen to eliminate medications that are toxic to islets or that interfere with the engraphment (growth) of the cells after transplantation. The institution has long been a leader in diabetes research. Pioneering work in the 1970s by Arthur Riggs, Ph.D., director of City of Hopes Beckman Research Institute, and colleagues led to recombinant DNA technology that was used to produce the first biotechnology product approved by the Food and Drug Administration. Called Humulin, this synthetic insulin is now used by millions of people with diabetes worldwide. Kandeel and his colleagues conduct research in the Leslie and Susan Gonda (Goldschmied) Diabetes and Genetic Research Center, a City of Hope building that, when opened in 1997, significantly expanded basic and clinical diabetes research on campus. Support from the Gonda Foundation has been pivotal in diabetes research and in developing City of Hopes islet cell transplant program. City of Hope is a National Institutes of Health Islet Cell Resource Center, one of only four out of an original 10 centers whose designation was recently renewed. In 2004 and 2005, the institution performed the largest number of islet transplants in North America, second only to the University of Edmonton in Alberta, Canada. The institution led the creation of the Southern California Islet Consortium, a group of academic and transplant institutions in Southern California that merge resources in islet Fouad R. Kandeel transplantation research. I I I

for future researchers. Albertsons supported the promotion through shelf diplays and donated ad space. Unilever and Albertsons are both longtime supporters of City of Hopes Southern California Food Industries Circle.

For a second year, Staples, one of the largest suppliers of office products nationwide, is featuring a unique campaign benefiting City of Hope. Customers who donate $1 receive a scratch card coupon redeemable during their next visit to the store, and manufacturers match the discount amount via a donation to City of Hope. With the help of consumers and participating manufacturers, the scratch-card campaign raised more than $800,000 in 2006. Look for Hope for Life signs at registers nationwide. To find a Staples location near you, visit

benefit City of Hopes breast cancer research, treatment and education efforts. The lightly powdered, latex-free vinyl pink gloves with embossed ribbon logos may be used in places such as spas, salons and hospitals, and are available in small and medium sizes. The gloves cost $9.99 for a box of 100. For each box sold between Sept. 1, 2006, and Aug. 31, 2007, $5.50 will be donated to City of Hope with a minimum guarantee of $50,000. (The per-box donation decreases for orders of more than 500 boxes, which results in a discounted price.) To find out more about the promotion, which represents just one of several successful programs supported by City of Hopes Professional Salon Industry, go to I I I

Albertsons consumers in California found specially designated Unilever products that supported City of Hope in the grocers stores from Sept. 20 through Oct. 6, 2006. Brands such as Lawrys, Bertolli, All, Sunsilk, I Cant Believe Its Not Butter and Country Crock contributed a total of $75,000 to fund City of Hopes scientific investigations, treatment and education


In addition to supporting and participating in the Los Angeles Walk for Hope to Cure Breast Cancer on Oct. 8, 2006, Grammy Award-winning entertainer Olivia Newton-John named City of Hope as the exclusive beneficiary from sales of the Olivia Breast Self-Exam Kit and a breast health dietary supplement, which is available at 4,500 Walgreens locations nationwide. From Nov. 1, 2006, to Feb. 28, 2007, 10 percent of sales from the kit and supplement will support City of Hopes breast cancer research, treatment and education efforts, with a minimum guarantee of $50,000. To find a Walgreens store near you, visit

Universal Companies, one of the nations largest suppliers of spa products, has created The Pink Glove promotional campaign to exclusively


C A U S E - R E L AT E D



Philanthropic companies align with City of Hope to save lives

Through cause-related marketing programs, City of Hopes dedicated corporate supporters have helped raise nearly $23 million since 1999. These programs generate national awareness and enhance community support for our mission



Industry groups raise tens of millions through annual campaigns


Each year, hundreds of fundraising events across the country raise millions of support vital research, treatment and programs at City of Hope. In this column, we highlight a few of the major fundraising activities that have taken place during the past few months. education

dollars to

More than 800 City of Hope supporters gathered in Greensboro, N.C., on Oct. 18 to honor Furniture/Today magazine publisher Joe Carroll (pictured at left) and Ashley Furniture President and CEO Todd Wanek (at right) with The Spirit of Life Award at the Home Furnishings Industrys annual gala dinner and American Furniture Idol talent contest. Held in conjunction with the High Point International Home Furnishings Market, the fun-filled evening raised nearly $1.5 million. In bigger news, through a series of fundraising events and generous individual donations, the industry raised $10 million for City of Hope throughout the year. Announcing the stellar campaign total were Michael Amini of AICO, Lynn Davis of Davis International, Todd Wanek and City of Hope President and CEO Michael A. Friedman, M.D. I I I

Nearly 800 guests attended the Pacific Northwest Food Industries Circles (PNWFIC) 18th annual Harvest Celebration Ball, held October 28 in Seattle. At the favored fundraiser, where more than $1 million was raised, Associated Grocers Marketing and Sales Vice President and PNWFIC Craig Calton (pictured at right) presented the groups Lifetime Achievement Award to PNWFIC executive committee member and retired grocery industry executive Alan Jones (left). Also receiving a Lifetime Achievement Award at the gala was Jack Menashe, owner of Menashe Sales and Consulting and a past PNWFIC president (not pictured). I I I

Nearly 1,000 professionals from Chicagos real estate and construction industries celebrated the career and philanthropic achievements of Steven F. Stratton (pictured on the right), president of The Staubach Company, Midwest Region, at a gala and roast held in his honor on Nov. 2 in Chicago. At the evenings pinnacle, CBS 2 Chicago Chairman Joe Ahern (at left) presented The Spirit of Life Award to Stratton, his longtime friend. Stratton directed the groups 2006 fundraising campaign, which raised more than $500,000. I I I






City of Hope President and CEO Michael A. Friedman (pictured in center) presented longtime City of Hope supporter Willa Young Morehart (at left) with The Spirit of Life Award at the Southern California Food Industries Circles (SCFIC) 33rd Annual Harvest Ball and Silent Auction, held on Nov. 17 in Los Angeles. Joining the two was Moreharts companion, fellow longtime supporter and past SCFIC President Marty Maitino. More than 900 supporters turned out to acknowledge Morehart and to celebrate the groups annual fundraising campaign total of more than $3 million at the gala, themed Hot Salsa Nights. Represented by more than 1,000 leading retailers, manufacturers and brokers within the Southern California food industry, the SCFIC has raised more than $112 million since the circle's founding 33 years ago. I I I


From left, joining Markel Corporation President and Chief Operating Officer and 2006 Spirit of Life honoree Tony F. Markel on a recent campus tour were his wife, Sue, and Sullivan Group founder and fellow Spirit of Life honoree Jerry Sullivan. More than 400 supporters of the California Insurance Council for City of Hope gathered to honor Markel on Nov. 11, in Beverly Hills, Calif., and to acknowledge a record fundraising total of more than $625,000 for the group. I I I


Staples Executive Vice President Jay Baitler (pictured at left) presents his companys chairman and CEO, Ron Sargent, with The Spirit of Life Award at the National Office Products Industrys (NOPI) annual gala, held on Sept. 28 in Chicago. For 24 consecutive years, leading companies and executives within the office products industry have supported City of Hope through annual fundraising campaigns. Led by Sargent, NOPIs 2006 Give. Hope. campaign generated more than $6.2 million. The National Office Products Council, the groups executive advisory board, has determined that $5 million from NOPIs annual fundraising campaigns during the next several years will support the Arnold and Mabel Beckman Center for Cancer Immunotherapeutics and Tumor Immunology. Consequentially, $500,000 from NOPIs 2006 contributions will support the National Office Products Industry Cellular and Tumor Immunotherapies Center. I I I


Nearly 800 industry leaders and executives who gathered for the annual Apparel Industries Group Award of Hope Gala, held on June 10 in Beverly Hills, Calif., celebrated a fundraising total of nearly $1 million. Attendees also toasted the evenings two Spirit of Life honorees, Self Esteem President and CEO Richard Clareman (pictured at left) and Hana Financial President and CEO Sunnie S. Kim (right). Clareman was named the Fashion Industries Guilds Man of the Year in 2002. A 35-year financial industry veteran, Kim became the first woman in the Los Angeles Korean community to rank as executive vice president, chief credit officer and director (1998), and CEO (2003) in her industry. I I I


Richard A. Kornbluth, chief executive officer of Graham Webb International, was presented with The Spirit of Life Award at a black-tie gala held in Las Vegas in 2006. Kornbluth, who led a yearlong campaign to raise $1 million, was recognized for his tireless efforts in fundraising and his leadership in the beauty industry. More than 500 beauty industry members and salon professionals attended the annual event, held in conjunction with Cosmoprof North America 2006. I I I



Music industry mogul Charles Goldstuck honored with The Spirit of Life Award
By Andy Ishii


More than 1,300 music industry superstars and other supporters joined forces at the Music & Entertainment Industrys annual star-studded gala on Oct. 5 to honor Charles Goldstuck, president and chief operating officer of the Bertelsmann Music Group, U.S., with The Spirit of Life Award. The groups fundraising campaign total of more than $3 million also was announced at the event. Television celebrity Craig Ferguson emceed the gala, which was held in Los Angeles and included performances by headliners Velvet Revolver, Taylor Hicks, Maroon 5, Sarah MacLachlan and Josh Groban. I am honored to be the recipient of this years Spirit of Life Award and to continue my association with City of Hope, said Goldstuck. City of Hopes physicians and researchers are among the brightest minds in science today. Through their dedicated efforts, state-of-the-art facilities and exceptional technology, they are making scientific discoveries that will help improve medical treatment for people around the world who face a life-threatening disease.

The Music & Entertainment Industry chapter comprises nearly 100 executives who help raise funds for City of Hope through a number of events that have featured top talents such as Rod Stewart and Elton John. In its 32-year history, the group has raised more than $55 million for City of Hope. I I I

M From left, Richard Palmese, RCA Music Group executive vice president, promotions, Reprise Records recording artist Josh Groban, 2006 Spirit of Life honoree Charles Goldstuck, American Idol star Taylor Hicks, and Michael A. Friedman, City of Hope president and chief executive officer.


Cancer survivor speaks out for City of Hope
By Andy Ishii

Few can speak from the heart about the importance of cancer research and care like a cancer survivor. Fewer still are able to share their message with millions in the way a respected artist can.
When nine-time Grammy-winner and breast cancer survivor Sheryl Crow recorded three promotional spots for City of Hope in late 2006, her soothing voice provided a weighty reminder of the need to support quality research and treatment. Running during Premiere Radio Networks and Movie Tunes programming nationwide, the ads helped increase widespread awareness of City of Hope and its mission. Premiere Radio Networks Inc. syndicates 70 programs and services to more than 5,000 radio affiliations countrywide, while Movie Tunes provides music and audio messages in theaters coast-to-coast. City of Hope partnered with Zach Horowitz, Universal Music Group president and chief operating officer and member of the City of Hopes Music & Entertainment Industry chapter board, to capitalize on a rare opportunity to enter the recording studio with Crow. The spots began airing in October 2006 to coincide with Breast Cancer Awareness Month. With support from Alissa Pollack, senior vice president of Premiere Radio Networks, and David Forman, senior vice president of Movie Tunes, the spots were heard by more than 190 million radio listeners weekly and played in 16,500 movie theaters nationwide. As a highly recognized entertainer and breast cancer survivor, Sheryl Crow is an ideal celebrity to carry our message, said Maureen Carlson, associate vice president of development marketing. We are truly indebted to her as well as our


Singer, songwriter and breast cancer survivor Sheryl Crow.

Clive Davis and Stevie Wonder headline Music & Entertainment Industry gala
By Pat Kramer

Stevie Wonder and Clive Davis together at the gala.

M From left, Randy Jackson, Baby Face

and guest, Janet Jackson, Jermaine Dupri, Clive Davis and Gavin Degraw were among the entertainment luminaries supporting Songs of Hope IV.





Music legends Clive Davis, Stevie Wonder and Babyface were joined by popular recording artists Jermaine Dupri and Gavin DeGraw in headlining Songs of Hope IV, a Music & Entertainment Industry Group benefit held Nov. 1, 2006, in Beverly Hills, Calif. Hosted by the Esquire House 360, the evenings silent auction event raised more than $250,000 for City of Hope. Former Beatle Sir Paul McCartney, Sting, Paul Simon and B.B. King were among those who donated original lyrics, rare and one of a kind sheet music, and Oscar-nominated scores and songs for the silent auction. The evenings top bid was by Dupri, who purchased Wonders fingerprinted, framed sheet music for $30,000. Highlights of Songs for Hope IV included performances by Wonder and DeGraw and a starstudded awards show attended by Janet Jackson and legendary songwriter, Diane Warren, and emceed by Randy Jackson of American Idol fame. Recording industry pioneer Clive Davis presented Wonder with The Davis Legends in Songwriting award, while DeGraw and Dupri took home The Martin Bandier New Horizons award and The Songs of Hope Music Innovator award, respectively. We are pleased by the tremendous support of the songwriting, artist and music publishing community that went into making this event a

success, said David Renzer, Songs of Hope event chair and chairman/CEO of Universal Music Publishing Group. Since 2003, Songs of Hope has raised over $650,000 for lifesaving research, treatment and education programs at City of Hope. Songs of Hope IVs presenting sponsors were Universal Music Publishing Group, ASCAP, Peermusic, Warner Chappell, Famous Music, EMI Music Publishing, Harry Fox Agency and the National Association of Music Publishers. While affiliate sponsors included APM Music, BMG Music Publishing, Chrysalis Music, Interior Music, BMI, Windswept, and Sony/ATV Music Publishing. I I I


advocates at Premiere Radio Networks and Movie Tunes for this opportunity. Crow, a singer and songwriter whose spin on classic roots rock made her one of the nations most popular artists, performs with the A&M Records label. To hear the spots, go to I I I


headline inaugural American Express Celebrity Golf Invitational benefiting City of Hope
By Pat Kramer

Grammy Award-winning band Hootie & the Blowfish performed at the inaugural American Express Celebrity Golf Invitational benefiting City of Hope. Golfers and other supporters who attended the event, held from Oct. 8 to 10 at The Riviera Country Club in Pacific Palisades, Calif., were treated to expert golf instruction as well as first-rate entertainment, with a personalized golf clinic with renowned instructor Dave Pelz. Presented by the Hilton Family of hotels, a longtime City of Hope corporate sponsor, the event also included two days of golf and a reception at The Beverly Hilton Hotel in Beverly Hills, Calif. Other corporate supporters included American Airlines, Coca-Cola, Brown-Forman and In-N-Out Burger. To learn more about the event, visit I I I



These are just a few of the City of Hope


$1.6 million raised at Toast and Roast for former Board Chair Richard Ziman
By Steve Kirk

developments that have been making news across the country.

Oncology Center. Ziman co-founded Arden Realty Inc. in 1991. Under his leadership, Arden grew to be Southern Californias largest office landlord. Earlier this year, Arden was sold for $4.8 billion to a real estate affiliate of General Electric Co. Ziman is now chairman of American Value Partners Advisors, LLC, a diversified investment company headquartered in West Los Angeles. After receiving his undergraduate and law degrees from the University of Southern California, Ziman began his

Tim Nesvig Golf Classic raises more than $800,000 for lymphoma research
By Bryan Graves

Celebrities from the entertainment and sports worlds came out on Aug. 6 and 7 to support the 2006 City of Hope Golf Classic benefiting the Tim Nesvig Lymphoma

City of Hope President and CEO Michael A. Friedman (left) and former NFL quarterback Terry Bradshaw at the Golf Classic.

Fellowship and Research Fund, raising more than $800,000. The two-day event, held at the Fairmont Miramar Hotel in Santa Monica, Calif., and the Wilshire Country Club in Los Angeles, was a testament to the Nesvig familys commitment to City of Hope and the communitys support of its efforts. In 2005, the loss of Tim Nesvig to non-Hodgkins lymphoma at the age of 30 inspired the creation of the fund that bears his name. Under the direction of Stephen J. Forman, M.D., Francis and Kathleen McNamara Distinguished Chair in Hematology and Hematopoietic Cell Transplantation, Nesvigs friends and family members established the fund to further understanding of the underlying causes of lymphoma and to develop better



More than 850 leaders from many of Southern Californias real estate and construction enterprises and other supporters gathered on Sept. 14 to recognize Richard S. Ziman, former chairman and chief executive officer of Arden Realty Inc., at a special Toast and Roast gala. At the event, Ziman became the first individual to receive both City of Hopes Spirit of Life Award and the Presidents Award, a new honor that recognizes outstanding commitment to the advancement of science and the care of patients with cancer. City of Hope has been fortunate to have a wonderful association with Richard and his wife, Daphna Ziman, for decades, said Michael A. Friedman, president and CEO of City of Hope. City of Hopes special, effective cancer research and care would not be possible without the potent support

provided by the Zimans. The Los Angeles Real Estate & Construction Industries Council for City of Hope hosted the Toast and Roast at the Pacific Design Center in West Hollywood, Calif. Special guests included former California governor Gray Davis, American Idol celebrity judge Randy Jackson and other prominent roasters. The event raised more than $1.6 million for City of Hope. A celebrated humanitarian, Ziman is a past member of the national board of directors of City of Hope and served as its chair from 1989 to 1995. He is the recipient of the Gallery of Achievement Award, City of Hopes highest medical and scientific recognition. He and his wife, Daphna, are longtime supporters of City of Hope and have made numerous contributions to the institution, including endowing the Ziman Family Outpatient


(From left) City of Hope President and CEO Michael A. Friedman, M.D., event honoree Richard S. Ziman, and event master of ceremonies and ABM Industries Chairman Emeritus Martinn Mandles appear together at the gala.

career as a real estate attorney with the law firm of Loeb & Loeb, where he was a partner from 1971 to 1980. Utilizing his extensive real estate expertise, he went on to establish and manage Pacific Financial Group, which soon became a major private owner of office buildings in Southern California. For more than a decade, the Los Angeles Real Estate & Construction Industries Council for City of Hope has raised millions of dollars to support the institutions research, treatment and education programs. I I I

Singer and songwriter Olivia Newton-John was interviewed about her experience as a breast cancer survivor and her breast self-exam kits which benefit City of Hope on NBCs The Today Show, and CNNs American Morning and Larry King Live on Oct. 6. John J. Rossi, Ph.D., chair and professor of the Division of Molecular Biology, was quoted in the Nov. 29 issue of USA Today about the significance of RNAis ability to switch off genes that play a role in diseases. The December issue of Los Angeles Magazine included a list the publication deems as the 122 most influential people in Los Angeles. Executive Vice President of Medical & Scientific Affairs and City of Hope Comprehenseive Cancer Center Director Theodore Krontiris, M.D., Ph. D., was named as one of the five most influential individuals in the regions science sector. City of Hopes Walk for Hope to Cure Breast Cancer campaign received coverage in various outlets nationally, including: Los Angeles Magazine, L.A. Parent Magazine, Arroyo Monthly Magazine, Orange County Register, Pasadena Star-News, KTTV-TV (Fox), KCBS-TV, Los Angeles-area radio stations KRTH-FM, KMZT-FM and KTWV-FM; Chicago Sun-Times, Business Journal of Phoenix, East Valley Tribune (Phoenix),

Seattle Post-Intelligencer, KCPQ-TV (Fox/Seattle) and WPVI-TV (ABC/Philadelphia). The Nov. 27 issue of Forbes magazine included a profile on billionaire Ron Burkle. The story mentioned City of Hope as a charity he supports. On Oct. 3, announced musicians performing at City of Hopes Spirit of Life gala honoring Charles Goldstuck, BMG Entertainments U.S. president and chief operating officer. The event was also covered by on Oct. 5 and E! News and CNN Headline News on Oct. 6, as well as in the Hollywood Reporters Oct. 10-16 issue. On Dec. 12, the Associated Press ran a story on an agreement Sangamo Biosciences signed with City of Hope to develop a therapy to treat brain cancer, i.e., the killer T-cells therapy of Michael Jensen, M.D., associate chair of the Division for Cancer Immunotherapeutics & Tumor Immunology and director of Pediatric Neuro-oncology. The October issue of SELF magazine quoted Robert Morgan, M.D., about breast cancer screening options.

The October issue of Better Homes & Gardens listed City of Hope as a leading nonprofit organization in the fight against breast cancer. Golf for Womens September/ October issue featured Lawrence Wagman, M.D., in an article about the use of aromatase inhibitors to treat breast cancer. The Oct. 3 issue of Womans World highlighted City of Hopes study about mushrooms anticancer properties. The Teens Choice Celebrity Retreat was featured by the Los Angeles Times on Aug. 23 and Daily Variety and Boston Globe on Aug. 24. The articles cited celebrities donating their gift bags and signing auction items to benefit City of Hope. Investors Business Daily quoted Larry Couture, Ph.D., in a Sept. 29 story about the direction and future of stem cell research. Couture noted that stem cells might be used to help boost patients immune system after radiation therapy or chemotherapy. On Sept. 6, The Independent (UK) quoted John Rossi, Ph.D., in an article about how blood stem cells may be used to treat HIV/AIDS. The appointment of Robert Figlin, M.D., as chair of the Division of Medical Oncology

& Experimental Therapeutics, associate director for clinical research, and Arthur and Rosalie Kaplan Professor of medical oncology at City of Hope was announced by the San Gabriel Valley Tribune on Sept. 17, Los Angeles Business Journal on Sept. 18, and The Cancer Letter on Oct. 6.


On July 20, National Public Radios KCRW-FM mentioned City of Hope in a Which Way LA? segment about the state of Californias capacity to move science forward with current resources. I I I

treatments for patients. What started as a fellowship now has grown into a larger research fund to further science targeted at eradicating the disease. The fundraising event also included a dinner and silent auction. In only two years, the golf classic tournament has raised more than $1.5 million. This years event brought NFL Hall of Fame quarterback Terry Bradshaw, FOX Sports lead announcer Joe Buck, actor Ray Romano and many others to partake in the festivities and join in the support of Tim Nesvigs legacy. As momentum for the cause builds, the organizing committee has set a goal of $1 million for the 2007 event. To learn more about Nesvigs story, go to I I I






Patient and Family Advisory Council offers patients a way to help others
By Pat Kramer

Putting their best




(for patient referral inquiries) 800-826-4673


Whether they live in Duarte, Calif., or New York City, cancer survivors, their families and loved ones have one thing in common after receiving treatment: They want to give back.
Annette Mercurio, manager of Patient, Family and Community Education, has seen that throughout her time at City of Hope, and has been interested in drawing on patients and families personal experiences and knowledge to improve care for others. For some time, I had been interested in looking at ways we could have patients and families serve as our experts, Mercurio said. In our department, we have always utilized their input and expertise in all the materials we develop and the services we provide. I feel that services for patients and their families should also be driven by them.

Chicago Regional Headquarters


Philadelphia Regional Headquarters


San Francisco Regional Headquarters

Seattle Office


Florida Office (Fort Lauderdale)

Youthful two-legged supporters participate with their four-legged friend at Chicagos Walk.


Los Angeles Development Headquarters

Desert Communities Office (Cathedral City, Calif.)

Phoenix Office

San Diego Office

Last year, Mercurios wish came true with the convening of the 12-member Patient and Family Advisory Council. The council has helped select artwork for patients rooms in Helford Clinical Research Hospital at City of Hope, evaluated existing patient resources and identified gaps and strengths in programs, materials and services.


San Francisco walkers wait in anticipation at the starting line of their citys event.




To find out about events taking place across the country that support City of Hope, visit our Web site at For details about activities happening in your area, please contact your nearest City of Hope Regional Development Office.



Grammy Award winner and City of Hope supporter Olivia Newton-John joins fellow breast cancer survivors at the Los Angeles Walk.



When we were designing new facilities, patients and families helped select the furniture that would be most comfortable, Mercurio said. Some family members have spent a lot of nights with their loved ones and they know what is needed and what is missing. Linda Bergman, a chronic myelogenous leukemia patient now in remission, joined the council to help others. I believe that to work at City of Hope, you have to be a selfless, loving, caring and dedicated person, she said. I was so moved by the treatment I received that I vowed, when I got well, I would give back. The same is true for council member Bill Matteson, who underwent a bone marrow transplant (BMT) in 2002. After his BMT, Matteson wrote a guide for patients about the experience. I wanted to help send people into the process with a positive attitude, he said. Matteson believes the advisory council will let him use his experiences to help others. I believe that a positive attitude and proper medical care are a powerful combination, he said. Larry Kidd, R.N., M.N., vice president of patient care services and chief nurse executive, believes the council gives the hospital important input toward improving the quality of care and services. He and Mercurio are working to involve the council in issues such as parking, food waiting times, improving the flow of treatment and patient safety. Nationally, health organizations are encouraging more partnerships between patients and their caregivers so that patients can take a more active role in ensuring the safety of their care, Mercurio said. City of Hope leaders believe the council will identify improvements and make overall care more responsive to patients and families needs. I I I

feet forward
By Steve Kirk and Pat Kramer

In nine cities around the nation last year, more than 22,000 participants turned out in a concerted effort to eradicate the leading cancer among women through City of Hopes Walk for Hope to Cure Breast Cancer campaign.
With actress Andrea Evans again serving as the events national celebrity ambassador, organizers raised more than $2.5 million through burgeoning corporate sponsorships, increased team participation and continued support of thousands of dedicated volunteers. The top three Walks of 2006 were held in Los Angeles, Chicago and Phoenix. On Oct. 8, nearly 8,000 supporters generated more than $700,000 in Los Angeles and about 3,000 participants raised more than $330,000 in Chicago; and on Oct. 1, more than 3,500 contributors reaped more than $250,000 in Phoenix. Other 2006 Walks were held in San Diego; San Francisco; Edison, N.J.; Seattle; Philadelphia; Washington; D.C., and Fort Lauderdale, Fla. The team generating the most donations nationwide was Chicagos C is for Courage, S is for Strength, which garnered more than $61,000. One of the teams members, Chelli Fishman, also finished as the nations top individual fundraiser, generating contributions exceeding $24,000. For the sixth consecutive year, Wells Fargo served as a national sponsor of the event, submitting a $100,000 donation at the Los Angeles Walk. In addition, 625 Wells Fargo employees comprised the nations largest Walk team and raised more than $30,000. New cash sponsors in 2006 included Bamboo, Anne Michelle and Sebastian Body Double. 3M Post-It Sticky Notes, Hilton HHonors, Good Housekeeping magazine, Orbitz and Sandals/Beaches resorts rounded out the list of national sponsors. Sponsors created numerous offers and promotions to support the cause. Hilton HHonors offered all Walk participants raising $1,000 or more a free nights stay in one of their hotels, while the top individual fundraiser and top team captain received two nights of complimentary accommodations. Sebastian Body Double offered makeovers for breast cancer patients through the Positive Image Center located at the Medical Center and conducted fundraising at every salon carrying their products nationwide. In addition to providing promotional and financial support for City of Hope throughout the year, 3M provided Super Stickies for use on dedication walls located at each Walk. Grammy Award-winning recording singer, songwriter, actress and breast cancer survivor Olivia Newton-John lent her star power and cheered supporters as she participated in the Los Angeles Walk. Furthermore, Newton-John agreed to donate to City of Hope 10 percent of proceeds from sales of her breast cancer awareness product called the Olivia Breast Self-Exam Kit and a breast health dietary supplement, available at Walgreens. (See story on page 29.) Due to increased sponsor and team participation in 2006, we continued to increase the efficacy of our fundraising efforts, said Raymur Sweeney, director of national events for City of Hope. We are deeply grateful to everyone who helped to make this past season such an extraordinary success. Since its inception, the Walk for Hope program has raised more than $22 million for breast cancer research, treatment and education programs at City of Hope. III

Did you know that...

up to 65 cents of every dollar in your Individual Retirement Account (IRA) may go to taxes?
Individual IRA distributions can be subject to income tax as high as 35%. Additionally, if an heir inherits the IRA it may be subject to estate tax. By making an IRA Charitable Rollover directly from your IRA to City of Hope, BOTH OF THESE TAXES CAN BE AVOIDED. The new Pension Protection Act allows you to contribute part of your IRA to charity without paying federal income taxes on the withdrawal through December 31, 2007.*

Specifics and Benefits:

Must be age 70 1/2 or older. You can donate up to $100,000 per year in 2006 and 2007. Your donation may be counted toward the required minimal distribution for tax-deferred retirement accounts in the year the gift is made. The IRA Charitable Rollover applies to outright gifts only. A gift from your IRA will not generate federal taxable income or a tax deduction. Its easy Simply instruct your IRA custodian to transfer funds directly to City of Hope. For further information, please contact the Gift Planning Department at 800-232-3314.
*Confer with your advisor regarding your options as differing state tax laws may affect your plans.

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