Lithotripsy is a non-invasive alternative to surgery for the treatment of kidney stones (urinary calculosis) and biliary calculi (stones in the gallbladder or in the liver) known as Lithotriptors. Lithotripsy was developed in the early 1980s in Germany by Dornier Medizintechnik GmbH (now known as Dornier MedTech Systems GmbH) and came into widespread use with the introduction of the HM-3 lithotriptor in 1983. It uses carefully focused, high-energy shock waves to disintegrate the kidney stones. Once the stone is disintegrated the sand-like fragments pass out of the body in the urine. Large stones may require more than one lithotripsy treatment.
Surgical Treatment
Some type of surgery may be needed to remove a kidney stone if the stone:
does not pass after a reasonable period of time and causes constant pain is too large to pass on its own blocks the urine flow causes ongoing urinary tract infection damages the kidney tissue or causes constant bleeding has grown larger (as seen on follow up x-ray studies).
Until recently, surgery to remove a stone was very painful and required a lengthy recovery time (four to six weeks). Today, treatment for these stones is greatly improved. Many options exist that do not require major surgery.
Occasionally, if the stone blocks the flow of urine (an obstructive calculus) the patient experiences severe pain (renal colic). This pain can be controlled by introducing a stent into the ureter. The stent is basically a tube which is placed in the ureter and allows the urine to drain past the obstruction. The stent may be left in after lithotripsy in case of obstruction due to fragments becoming lodged in the ureter A shock wave is characterized by a very rapid pressure increase in the transmission medium and is quite different from Ultrasound. The shock waves are transmitted through the patient's skin and pass harmlessly through the patient's soft tissue. The shock wave passes through the kidney and strikes the stone. At the stone boundary, energy is lost, and this causes small cracks to form on the
edge of the stone. The same effect occurs when the shock wave exits the stone. With successive shocks, the cracks open up, and in turn, smaller cracks form within the large cracks. Eventually, the stone is reduced to small particles, which are then flushed out of the kidneys or ureter naturally during urination. The process generally takes about 1 hour during which up to 8,000 shocks are administered. The patient will experience some discomfort during the treatment depending on the patient's pain tolerance. Analgesics may be administered to make the patient more comfortable.
Electrohydrolic Lithotripter (EHL) Pneumatic Lithotripters Ultrasonic Lithotripsy Cystolithalopaxy forceps percutaneous nephrolithotomy (PCNL) open surgery
These procedures are explained in more detail below. The type of treatment you have will depend on the size and location of your stones.
complications of ESWL include perinephric hematoma, bleeding, obstruction from stone fragments, and pain.
At the hospital, your nurse will check your heart rate and blood pressure, and test your urine.
Your doctor or radiographer will discuss with you what will happen before, during and after your procedure, and any pain you might have. This is your opportunity to understand what will happen, and you can help yourself by preparing questions to ask about the risks, benefits and any alternatives to the procedure. This will help you to be informed, so you can give your consent for the procedure to go ahead, which you may be asked to do by signing a consent form.
Side-effects These are the unwanted but mostly temporary effects of a successful treatment. Side-effects of lithotripsy include: pain and discomfort some blood and fragments of stone in urine for two or three days bruising or blistering of the skin of your tummy or groin
Complications This is when problems occur during or after the treatment. Most people are not affected. Your doctor will be experienced at performing lithotripsy but, even so, there is a chance it may not be successfully completed and may need to be repeated. Specific complications of lithotripsy are uncommon, but include: infection you may need antibiotics to treat this blockage of ureters you may need surgery to unblock the tubes kidney damage this can be permanent and affect your kidney function and blood pressure (this is very rare) The exact risks are specific to you and differ for every person, so we have not included statistics here. Ask your doctor to explain how these risks apply to you.
Laser lithotripsy
Laser lithotripsy is performed under general anesthesia. The light energy of the laser is transported through a flexible light guide to the stone. For ensuring a safe procedure the laser fiber is observed with an ureterorenoscope. The fiber tip must be in contact with the stone during the firing of the laser. The stone breaking mechanism of laser lithotripsy is a thermal one. The stone fragments when pulses of intense laser light from the Dornier Medilas H20 are applied. Based upon the principle that Holmium laser energy is strongly absorbed by water, the short laser pulses create a shockwave that causes fragmentation of both ureteral and intrarenal stones. Due to the flexibility and control of the system, different treatment techniques can be applied depending upon the location and shape of the stone. For example, smaller stones can be fragmented directly, whereas with larger concrements, holes are first made in the center, after which the edges can then be fragmented. Finally, the stone residues can be flushed out utilizing the endoscopes rinsing fluid. Lasers produce energy by exciting electrons that can then release the energy in the form of light. Most lasers function by turning this energy into a plasma bubble that produces a shockwave upon collapse. The most widely used laser lithotripter is the holmium:YAG laser and is available in 200, 365, 550, and 1000 micrometer fibers. The holmium:YAG laser has a pulse duration of 250-350 microseconds, functions at a wavelength of 2140 nm, and a depth of penetration of 0.5-1.0 mm. This particular laser works by causing stone vaporization through a photothermal mechanism, rather than by producing a shockwave. When performing laser lithotripsy, the fiber should be placed in contact with the stone and irrigation should be available as fragmentation may cause decreased visibility. The tip of the laser must be visible at all times while activated as it will fragment whatever is in front of it, including a wire or the ureteral wall. It is best to avoid drilling a hole through the stone. In general, the best technique is to start on the center of the stone and work outward, vaporizing the stone. By the end of the procedure, there should only be one fragment left that may
be removed with a basket. If being placed through a flexible instrument then a 200 or 365 mm fiber should be used. The procedure should begin with 0.6 joules and a pulse rate of 6 hertz. If need be, the pulse rate can be increased for quicker fragmentation.
Laser lithotripsy carries a slightly greater risk of complications than extracorporeal shock wave lithotripsy. However, lithotripsy using the holmium laser is characterized by a high success rate and low complication rate for all types of stones.
Benefits
Immediate relief of symptoms In most cases, you may go home the same day Faster recovery with fewer complications Works well on all types of stones A greater than 95% success rate with a single treatment
Risks
Laser Lithotripsy is generally safe. However, as with any medical procedure, complications can occur. Those related to lithotripsy include: Pieces of stone are left in the body. You may need more treatments. Bleeding around the kidney which, in rare cases, may require a blood transfusion. Blockage of urine flow from the kidney due to pieces of stone. If this causes severe pain or blockage of the kidney, a tube may be placed through your back and into the kidney to keep
the kidney drained until all the fragments pass out. Sometimes, a thin mesh tube called a stent is placed into the body (from the kidney to the bladder) before ESWL to prevent this from happening. A stent is usually put in the body after laser lithotripsy.
Electrohydraulic Lithotripsy
Electrohydraulic lithotripsy (EHL) is primarily used in the endoscopic fragmentation of difficult bile and pancreatic duct stones. It was originally used in the Soviet Union as an industrial tool for fragmentation of rocks. It was first used to treat bile duct stones in 1975 when it was performed through a T-tube tract using fluoroscopic guidance. Electrohydraulic lithotripsy (EHL) was the first form of contact lithotripsy developed. EHL can fragment urinary calculi of all compositions but it has the narrowest margin of safety. Injuries to structures surrounding a stone occur when the probe discharges too close to the tissues. An advantage of EHL compared with other methods for treating difficult stones is that it is portable rapid, efficient, and relatively inexpensive. EHL is typically used during peroral or percutaneous choledochoscopy or peroral pancreatoscopy. Because these techniques are not widely available, EHL is mostly used in tertiary centers with expertise in the endoscopic management of biliary tract disorders. The EHL uses an underwater spark discharge to generate a plasma channel that vaporizes the water near the electrode and produces a hydraulic shockwave. The hydraulic shockwave impacts and fragments the stone. If the shockwave misses the stone, it will release energy on whichever portion of the urothelium encountered and can cause ureteral or bladder perforation. Also, if the stones are loose, the shockwave can propel stones in a retrograde fashion. The probe should be placed >2 mm from the end of the endoscope and within 1 mm of the stone. The procedure should begin with 5060 volts in short or single bursts. The energy can be increased as need to effectively fragment the stone. If the insulation from the tip of the catheter loosens, a new probe should be used. EHL has also been used for treatment of urinary tract stones, a setting where it has largely been replaced by other methods to achieve stone fragmentation (particularly Holmium laser lithotripsy). Laser lithotripsy for bile duct stones has not been widely adopted in part because of the costs and limited availability of equipment , but Holmium laser lithotripsy has been used successfully at various endoscopy centers, including ours, for the management of biliary and pancreatic stones.
Electrohydraulic lithotripsy, the first technique used for intracorporeal stone fragmentation, utilizes a probe containing two electrodes separated by an area of insulation. While electric current is passed between two electrodes, a spark is created which vaporizes the water or other surrounding fluids at the end of the probe. This spark gap creates a cavitation bubble, which rapidly expands, creating a shock wave. Once the cavitation bubble collapses a secondary pressure wave is created which is then transmitted to the adjacent stone. At the stone-water interface, the difference in acoustic impedance causes energy to be released, resulting in stone fragmentation. This process is exactly similar to shock wave lithotripsy in generating a spark gap, however, the difference in EHL is that the shock wave is not focused, so the stone must be placed where the shock wave is generated.
Advantages of EHL
Widely available Inexpensive
Disadvantages of EHL
When utilized next to the ureteral wall it will likely perforate the ureteral wall. The risk for
perforation is proportional to the size of the cavitation bubble. The perforation rate is 17.6% in one series.
Probe deterioration with possible shedding pieces of insulation, and possible break off of
probe requiring retrieval of the device.
This device is not reusable. Multiple probes may be required during a single operation
increasing the cost of the procedure.
Pneumatic Lithotripsy
A pneumatic lithotripter works by essentially jackhammering the stone by direct contact. This mechanism is very effective in fragmenting stones and is also very safe, unless the lithotripter probe is moved off of the stone, potentially damaging whatever is in front of the probe. Success rates are 73%- 100%, with ureteral perforation rates up to 2.6%. However, given the mechanism of action, the chance of retrograde migration is greater than with other modalities. The probe is placed in direct contact with the stone, a clear visual is imperative, and the stone is pinned against the bladder, ureteral wall, or kidney prior to activating the probe. Again, the goal is to fragment the stone into multiple small fragments that can be removed or pass spontaneously Several pneumatic lithotriptors are in current use. In the Swiss Lithoclast compressed air repeatedly drives a metal bullet onto a metal rod creating a chisel and hammer effect that fragments the targeted stone. The Lithoclast and the Browne Pneumatic Impactor (BPI) are capable of fragmenting all stones, irrespective of their size or composition. Unlike laser and ultrasonic lithotriptors, there are no thermal sequelae.
Pneumatic lithotripsy utilizes compressed air forcing a metal projectile against a probe, which causes the probe to move back and forth very quickly, resulting in a "jackhammer" effect to fragment the stone.
1. 2. 3. 4. 5.
Simple to use No disposable parts Easy to maintain Relatively inexpensive Pneumatic lithotripsy comes in both rigid and flexible fibers and can be utilized in rigid and flexible ureteroscopy
Disadvantages
1. 2.
A tendency to propel the stone or fragmented stone toward the upper ureter Flexible fibers may have some decline in force compared to a standard rigid probes