Main use: Epilepsy Active ingredient: Sodium valproate Manufacturer: Sanofi Aventis
Warning!
Epilim enteric-coated tablets should be swallowed whole and not chewed, broken or crushed. This medicine may cause drowsiness, especially if it is taken with other antiepileptic medicines, or with benzodiazepines such as lorazepam. This may affect your ability to drive or operate machinary. This medicine can cause some people to put on weight. Talk to your doctor about this before you start treatment so that you can discuss strategies, such as diet and exercise, for minimising any weight gain. This medicine may on rare occasions affect your liver, pancreas or blood cells. You should haveblood tests to monitor your liver function, blood cells and blood clotting time before you start treatment. Your liver function should be monitored for the first six months of treatment, and your blood cell count should be checked before any surgery. Tell your doctor immediately if you, or a child taking this medicine, experience any of the following symptoms during treatment, particularly if they come on suddenly or occur in the first six months of taking the medicine: lack of appetite and energy, weakness, feeling generally unwell, drowsiness, nausea, vomiting, severe
abdominal pain, swelling of ankles, yellowing of the skin or whites of the eyes (jaundice), or unusual bruising or bleeding. This medicine may cause skin reactions. You should let your doctor know if you develop a rash, skin peeling, itching, or other unexplained skin reaction while taking this medicine. There may be a small increased risk of suicidal thoughts and behaviour in people taking antiepileptic medicines such as valproate for any condition. For this reason, it is very important to seek medical advice if you, or someone else taking this medicine, experience any changes in mood, distressing thoughts, or feelings about suicide or selfharm at any point while taking this medicine. For more information speak to your doctor or pharmacist. People with diabetes should be aware that Epilim syrup contains sucrose, and that sodium valproate may cause false positive results in urine tests for ketones, ie the test may say that ketones are present in the urine even if they are not. If you have epilepsy it is important to take your medication regularly, as directed by your doctor, because missing doses can trigger seizures in some people. If you have trouble remembering to take your medicine you should ask your pharmacist for advice. You may find a pill reminder box helpful. You should not suddenly stop taking this medicine unless your doctor tells you otherwise, as suddenly stopping treatment is likely to make your symptoms return. If this medicine is stopped, it should normally be done gradually, under the supervision of your specialist. Wherever possible, it is recommended that people with epilepsy always receive the same brandof their antiepileptic medicine. This is because different brands of these medicines may differ in the way they are absorbed into the body, which could either reduce the effect of the medicine and increase the risk of seizures, or increase the effect of the medicine and hence increase the risk of side effects. You should make sure you know what brand of valproate you normally take and check with your pharmacist if you are ever dispensed a different brand.
Not to be used in
Active liver disease. Personal or family history of severely decreased liver function, particularly if due to a medicine. Hereditary blood disorders called porphyrias.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Women who continue to take valproate during a pregnancy should, wherever possible, be prescribed valproate on its own, in the lowest effective dose, in doses that are split over the day, and if possible as a prolonged release brand. These measures can help minimise the risk to the baby. Specialist medical advice must be sought. Valproate passes into breast milk in small amounts, but there have been no reports of harmful effects from this on nursing infants. Seek further medical advice from your doctor.
Label warnings
Enteric-coated sodium valproate tablets should be swallowed whole and not chewed, broken or crushed. Do not stop taking this medication except on your doctor's advice.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect. Disturbances of the gut such as diarrhoea, nausea, vomiting or abdominal pain. Increased appetite and weight gain. Decrease in the number of platelets in the blood (thrombocytopenia). Temporary hair loss - regrowth may be curly. Increased alertness. Aggression. Hyperactivity. Shaky movements and unsteady walk (ataxia). Tremor. Inflammation of blood vessels (vasculitis). Drowsiness. Confusion. Liver disorders. Irregular or stopping of menstrual periods. Skin rashes. Decreased numbers of white blood cells in the blood (leucopenia). Anaemia. Acne. Increased hair growth (hirsutism). Inflammation of the pancreas (pancreatitis).
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
phenobarbital phenytoin (phenytoin blood levels should be monitored if taken with sodium valproate) primidone tricyclic antidepressants such as amitriptyline and nortriptyline zidovudine.
There may be increased drowsiness and sedation if sodium valproate is taken with benzodiazepines, eg diazepam. There may be an increased risk of side effects on the liver if sodium valproate is taken with phenytoin or carbamazepine. There may be an increased chance of side effects such as dizziness, tiredness, blurred vision and vomiting if sodium valproate is taken with carbamazepine. The following medicines may increase the blood level of sodium valproate: cimetidine felbamate large repeated doses of aspirin.
The following medicines may decrease the blood level of sodium valproate: carbamazepine phenytoin phenobarbital primidone.
Colestyramine may reduce the absorption of sodium valproate from the gut. This can be minimised by separating doses of these medicines by at least three hours. It is recommended that people who are taking any antiepileptic medicines should avoid taking the herbal remedy St John's wort (Hypericum perforatum). This is because St John's wort may affect the level of antiepileptic medicines in the blood and could increase the risk of seizures. There may be an increased risk of a drop in white blood cell count if olanzapine is taken sodium valproate. If you are taking olanzapine in combination with sodium valproate it is important to tell your doctor if you experience any of the following symptoms: sore throat, mouth ulcers, high temperature (fever), or general illness or infection. Your doctor may want to take a blood test to check your blood cells.
Epilim chronosphere
Episenta
Epival CR
Orlept
Sodium valproate crushable tablets, enteric-coated tablets and oral solution are also available without a brand name, ie as the generic medicine.