Anda di halaman 1dari 7


Breaking News Magnesium Sulphate link to prevention of cerebral palsy. Under the Microscope With Australias leading CP researchers Then and Now Supporting research can change lives Festive Fundraising Band Together 2010 Purchase a carol for a cause

Donation Hotline 1300 551 137


Welcome to the last edition of Breakthrough for 2010, and what a year it has been. Firstly, I would like to welcome our newest Governor to the Cerebral Palsy Foundation, Mr James Warburton. As we head towards the final months of 2010, its interesting to reflect on where our journey started, and how far we have progressed. There has been significant progress made since the Foundation was established in 2005. At that time, there were few research projects focused on the prevention and cure of cerebral palsy. Researchers interested in the area were also few and far between. Our vision of a future without CP was brave and far-sighted. This year has seen many steps forward. The new Macquarie Group

Foundation Chair of Cerebral Palsy, Professor Nadia Badawi has publicly stated that she believes one day there will be a prevention and a cure for cerebral palsy. Professor Badawi will lead the research agenda, and has just returned from her first trip overseas in her new capacity as Chair. On the research front, we will be announcing the 2010 successful grant recipients shortly. To date, we have supported 34 research projects in Australia and overseas, and each year the calibre of applications increases. We now have more projects we wish to fund than funds available. We also welcomed back Professor Cioni from Pisa who came to Sydney to continue training Australian health professionals in the early identification of babies with cerebral palsy through his video surveillance techniques. Early identification will ensure early intervention. I also know Professor Badawi is excited about the new guideline regarding magnesium sulphate

that has the potential to reduce the incidence of cerebral palsy in babies born before 30 weeks gestation. Fundraising continues and a novel initiative for our corporate supporters is Band Together 2010. This video eCard is an alternative to Christmas Cards, and is an environmentally friendly way to get into the spirit of Christmas and at the same time help our cause. Our Ambassadors, Jimmy Barnes and his daughter Elly-May who has cerebral palsy, led the Christmas choir of children with cerebral palsy. Read more on page six. The number of projects we can support is directly related to the funds available. I would like to thank our generous supporters for having faith in us to make a difference. I would also like to thank our honorary Governors and the researchers we support for taking up the challenge and working so tirelessly to help make our vision a reality. Bill Bartlett Chairman, Cerebral Palsy Foundation


beST mIndS
has shown that around two thirds (60%) of babies born with cerebral palsy are actually born at term. This begs the question why?

With the support of the Cerebral Palsy Foundation, Research Fellow Sarah Mcintyre is conducting cutting edge research to understand risk factors and causal pathways to cerebral palsy.
The complexity of cerebral palsy can make researching its causes a challenging process; a process which hopefully can be accelerated by developing research careers and providing more funding into the field. One research career that is being supported by the Cerebral Palsy Foundation is that of Sarah McIntyre, a Research Fellow at the Cerebral Palsy Institute. She is currently carrying out a PhD focusing on mapping the complex patterns of events, known as causal pathways, which lead to the development of cerebral palsy for infants born at full term (around 40 weeks). Sarah is being supervised by two giants of the field, Professor Eve Blair from the Telethon Institute for Child Health and Professor Nadia Badawi from The Childrens Hospital at Westmead and Macquarie Group Foundation Chair of Cerebral Palsy. Sarahs PhD forms a significant part of the Creating a Road Map for Prevention of Cerebral Palsy Program. This will be the largest study of cerebral palsy in term infants in the world due to the dedication of all those who work with the Western Australian Cerebral Palsy Register. Over the last decade, research has shown that a number of previously held beliefs about cerebral palsy are incorrect. This has opened up exciting new possibilities for research. One common assumption is that most people with cerebral palsy were born prematurely. Research

Research has shown that around two thirds (60%) of babies born with cerebral palsy are actually born at term. This begs the question why?
Sarah says, Prematurity is the largest risk factor for cerebral palsy and has rightly received a lot of research and public attention. However, since 90% of all births are at term, the majority of children with cerebral palsy are born at term. Other assumptions are disproved by research. The first is that cerebral palsy is associated with problems during labour. In fact problems usually start during pregnancy or even before, and may actually cause a difficult labour rather than the other way around ( and many mothers dont have a difficult labour at all). Secondly, that cerebral palsy is caused by one single factor. Since there isnt one simple cause which, when identified, will prevent cerebral palsy, its important to start the complex work of mapping all the various possible causal pathways before progress in preventing cerebral palsy can be achieved. Sarahs research is part of mapping this process for infants born at term, and with this she hopes to help create a road map for prevention of cerebral palsy. This is a first step in a long process and requires funders with long term vision. We are delighted that through initial support from The Corio Foundation, and a further substantial donation from the projects major sponsor Star Scientific Foundation, this work will take us one step closer to our aim of prevention and cure of cerebral palsy.


through research, and research costs money. Five years ago, less than $1 million was being spent by the government on research, and no-one was privately raising funds either. My hope for the Foundation is that through funding research, a number of incremental breakthroughs can be achieved; weve already notched up one with the recent discovery of a link between magnesium sulphate and the prevention of cerebral palsy. Im particularly interested in the research being done regarding viruses as a possible cause to cerebral palsy. With no medical rationale, my gut instinct tells me research in this area may help answer many questions we have about the causes of cerebral palsy. While the Cerebral Palsy Foundations research is looking at discovering the causes of cerebral palsy, it is possible that this research could also lead to a cure. I would imagine families raising a child with cerebral palsy wouldnt want to see any other family face the challenges they face. It is the hope of everyone involved in the Foundation that one day cerebral palsy will be cured. We hope this wider community will support us in this quest.

Anne Keating
Ive been involved with the Cerebral Palsy Foundation since shortly after it launched in 2005. Prior to joining the Council of Governors, I knew a little about cerebral palsy, but had no idea about the prevalence of the condition. I was also shocked to learn that despite medical advances, the statistics about the incidence of cerebral palsy have not improved. The Cerebral Palsy Foundation appealed to me because I realised a breakthrough would only come

If you would like to support our researchers, phone 1300 551 137 or visit

Rob White ,CEO of the Cerebral Palsy Foundation, Pamela Horvath, CEO Star Scientific Foundation and Jen Wight, Trusts and Foundations Manager for the Cerebral Palsy Foundation


With the support of donors like you, cerebral palsy researchers have discovered one way to prevent cerebral palsy from developing in babies born pre-term.
One of the most exciting cerebral palsy (CP) research breakthroughs is the recent confirmation of a link between magnesium sulphate and the prevention of CP. Magnesium sulphate therapy involves giving magnesium sulphate to pregnant women via injection within 24 hours prior to birth. For babies born prematurely before 30 weeks gestation, researchers have found magnesium sulphate can prevent cerebral palsy in 1 in 63 cases. Every 15 hours an Australian child is born with cerebral palsy, and approximately 30% of these children are born before 30 weeks gestation. Professor Nadia Badawi, Macquarie Group Foundation Chair of Cerebral Palsy says the impact of this finding on the future of cerebral palsy research is huge. This is the first time we have scientific evidence that tells us that if magnesium sulphate is used throughout Australia, we can prevent 30-90 infants born pre-term each year from dying or developing cerebral palsy. Professor Caroline Crowther, Director of the University of Adelaides Research Centre for Health of Women and Babies is promoting the implementation of magnesium sulphate therapy within hospitals throughout the country. Earlier this year, Professor Crowther chaired a multidisciplinary panel,

including consumers, midwives, doctors and policy makers as well as Sarah McIntyre from the Cerebral Palsy Institute that released the worlds first clinical practice guidelines recommending that women at risk of early pre-term birth use magnesium sulphate to increase the chances of their babies surviving free of cerebral palsy. These guidelines were based on overwhelming evidence accumulated over the past 14 years that magnesium sulphate is effective in protecting the fetus against dying or developing cerebral palsy. Professor Badawi believes these findings are a great example of research possibilities when the community gets behind a cause. Community support can make a huge difference to research outcomes just look at childhood cancer whose survival rates have increased from less than 5% back in the 1960s to more than 70% today thanks to the financial support of the community. The widespread implementation of these guidelines into clinical practice will help improve the health outcomes of pre-term babies. Approximately 42% of all cases of cerebral palsy are associated with pre-term birth. Since these guidelines will be relevant to the work of health professionals who care for women at risk of pre-term birth and their babies and for policy makers in maternity care, there is a great opportunity to reduce the risk of cerebral palsy in babies born pre-term, says Professor Crowther. Although these findings show a link between magnesium sulphate and a reduced risk of death and cerebral palsy, researchers are still trying to understand why it works.

The exact mechanism as to how magnesium sulphate works in protecting the developing brain is not certain, says Professor Crowther. However, magnesium is vital for normal cell function, and may protect against destructive molecules that harm cells, and in some circumstances improves blood flow. Were still unsure of the role these factors play in preventing cerebral palsy. For many years, doctors had been using magnesium sulphate to reduce the risks to the mother of high blood pressure in pregnancy. However, it was only in 1992, when American doctors first observed a possible connection between the use of magnesium sulphate and a reduced risk of cerebral palsy in children born before 30 weeks gestation. Doctors suspected the potential role of magnesium sulphate as a neonatal neuroprotection agent because they had already seen its effect in preventing brain haemorrhages in babies (a bleed in the brain). Since they knew that many cases of cerebral palsy were preceded by a

bleed in the brain, doctors began to investigate the theory that if they could protect the brains in pre-term infants by preventing a brain bleed/ injury from occurring, perhaps they could also decrease the risk of that child developing cerebral palsy. However, since babies who experience a brain bleed dont always develop cerebral palsy, doctors wanted to see if there was any merit to their theory. To do this, they compared the incidence of cerebral palsy between two groups of pre-term infants; babies born less than 1,500g who had cerebral palsy against a control group of babies born at the same weight who did not develop cerebral palsy. During their observations, doctors noticed that of the group who did not develop cerebral palsy, 85% had received magnesium sulphate. Since this was just an observational study, better quality scientific evidence was required. This need led to five randomised controlled trials into the prevention of cerebral palsy (with a total of more than 6,000 participants) being conducted in different countries Australia and

New Zealand, two in the USA, France and the UK. Each trial had a slightly different focus. The best quality evidence from these trials comes from collectively pooling their results. What the researchers found when they did this was ground-breaking. They discovered that if magnesium sulphate was used to protect the brain of the fetus prior to very pre-term birth, they could stop one baby out of 63 born prematurely from developing cerebral palsy. In the context of Australian statistics, Professor Badawi says these figures are amazing. Each year, around 3,000 babies are born prematurely, so by using magnesium sulphate therapy, we know that we can stop nearly 60 of them from developing cerebral palsy that is a hugely positive result.

... if magnesium sulphate is used throughout australia, we can prevent 30-90 infants born pre-term each year from developing cerebral palsy or dying.
Professor Nadia Badawi

Professor nadia badawi is supported by the Cerebral Palsy Foundation. To make a donation visit or phone marisa Chilcott on (02) 9479 7286.


In August the Cerebral Palsy Foundation welcomed the return of Professor Giovanni Cioni and Dr Andrea Guzzett to Sydney to run the General Movements course. The course instructed 44 Australian health professionals in the Prechtls Method. There is compelling evidence available that qualitative assessment of general movements is the best predictor for cerebral palsy. This method has become an important supplement to traditional kinds of neurological examination. The course included studying the normal and abnormal general movements of a baby from birth to 20 weeks post term. A number of promising early interventions are on the horizon, and it is going to be even more important to identify those most at risk, so they can participate in future trials.

THen And nOw

By supporting cerebral palsy researchers, you can help people with severe cerebral palsy participate in daily activities more than ever before.
palsy including botox, baclofen pumps and surgical procedures such as selective dorsal rhizotomy either emerged or were greatly improved. Simultaneously, advances in general consumer electronics (computers etc) resulted in a plethora of assistive technology devices for use around the home, at work and for leisure. Today, thanks to a range of specialised equipment and technology, Jessika can communicate, attend school, be cared for at home, go on holiday (including skiing) and has a posse of girlfriends. Her list of equipment includes an aluminium lightweight rather than a heavy steel wheelchair, a sip and puff switch that allows her to use a computer, a modified car which enables her to travel with her mum in her wheelchair and an electric height adjustable sleep positioning system which makes bedtime more comfortable. Rather than struggling with a shower chair, Jayne can now bathe Jessika lying down in a shower bed. Jess can also join the family at the dinner table or play with her dog on the floor by using a height adjustable supportive chair. Most of this equipment which didnt even exist 10 years ago is not only improving the quality of life of people with cerebral palsy, but also the lives of their carers. For more information about supporting the work of cerebral palsy researchers, phone 1300 551 137 or visit


new name for Cerebral Palsy Foundation

In 2005, the Cerebral Palsy Foundation was established by The Spastic Centre to secure funds for research into the prevention and cure of cerebral palsy (CP). From 8 February, 2011, The Spastic Centre will be known as Cerebral Palsy Alliance. The Cerebral Palsy Foundation will be known as the Research Foundation of Cerebral Palsy Alliance. Cerebral Palsy Alliance reflects our many partnerships with children and adults with cerebral palsy and their families, donors, researchers, volunteers, small business, large corporate supporters and government to name a few. We are all working together with the single purpose of building futures for people with cerebral palsy. Our new name will help us achieve a stronger profile, clarity and an unambiguous focus on cerebral palsy, and will lead to greater support from the wider community over the coming years.

Festive Fundraising
Support cerebral palsy research by purchasing a Christmas carol as part of our new Band Together 2010 video eCard fundraising campaign.
Band Together 2010 is a fundraising campaign to raise vital funds for the Cerebral Palsy Foundation, which supports research into the cure and prevention of cerebral palsy. Companies can support the campaign by purchasing a Christmas video eCard to send to their clients, customers and employees in lieu of traditional Christmas cards and gifts. This year, companies can customise a choice of two video eCards with their logo and company name. Rock legend Jimmy Barnes, his daughter Elly-May and chart-topping soloist Ricki-Lee Coulter have lent their support by joining a group of children with cerebral palsy to perform unique versions of the classic Christmas carols, We Wish You A Merry Christmas and Jingle Bells. CEO of the Cerebral Palsy Foundation, Mr Rob White says Band Together 2010 represents the spirit of Christmas. The video eCard is a Christmas gift that will keep on giving. We are grateful for the helping hand given by Jimmy, Elly-May who has cerebral palsy, Ricki-Lee and all the children in the choir. Receiving this video eCard in your inbox in the lead up to Christmas is sure to be much more memorable and meaningful, than a paper card or traditional Christmas hamper! Band Together 2010 is supported by the 7 Network which produced the Christmas carols and Nova FM where Ricki-Lee is a breakfast cohost. Jimmy and Elly-May Barnes are both Ambassadors for the Cerebral Palsy Foundation. Today, people with cerebral palsy lead more functional lives, and in some cases experience less pain than people born with the condition only a decade before them. This is the result of research into ways we can improve the quality of life for people with cerebral palsy. Quality of life is a concept which considers how a person feels about their life, their sense of wellbeing (physical, social and emotional). Being able to participate in life situations is one of the things that will impact on a persons quality of life. For people with cerebral palsy, participation may be hampered by lack of access to community or technology, societal attitudes, policy as well as the persons physical limitations. Thanks to the support from donors
JessiKa aNd her frieNd aBBey

like you, children and adults with cerebral palsy will have greater opportunity to participate in daily activities. For Jessika who has the most severe form of cerebral palsy (level 5 on the GMFCS scale) the research developments of the past decade have been life changing. Jessika requires personal assistance for activities of daily living 24 hours a day. In 1998 when Jessika was born there was only a limited range of equipment for a child of her level of disability. The 1990s was a decade of great progress in cerebral palsy research. Had Jessika been born 10 years earlier, her level of participation in daily life would have been very different. During this time, medical interventions for treating cerebral

For more information visit, email or phone (02) 9479 7273.

under the microscope

One of the Cerebral Palsy Foundations major supporters, avant has put more than $600,000 behind the work of some our countrys leading cerebral palsy researchers as part of their $2 million pledge over four years.

the infection. Research has shown that inflammation caused by these infections is harmful to developing babies. Such inflammation before birth probably contributes to some children developing cerebral palsy after birth. Dr Tolcos research hopes to find a treatment for brain damage caused by inflammation during pregnancy.


Thanks to your support, our researchers are able to play a big part on the world stage in shaping the future of cerebral palsy treatments.
Researchers from the Cerebral Palsy Institute, who receive their funding from the Cerebral Palsy Foundation, have co-ordinated the worlds first guidelines on the use of botulinum toxin (BOTOX) in treating cerebral palsy. Taking two years to develop, the Botulinum Toxin Consensus Statement is the first-ever comprehensive guide for medical practitioners and therapists around the world on how and when to use BOTOX, and importantly, how to effectively monitor patients following their treatment. BOTOX is one of the safest and most effective treatments for cerebral palsy. Dr Iona Novak, Head of Research at the Cerebral Palsy Institute, said the guidelines would change the way BOTOX was used to treat patients with cerebral palsy and other neurological conditions around the world. This is the first time that best practice for use of BOTOX, from assessment to treatment to safely monitoring, has ever been described in medical literature, Dr Novak said. Doctors, specialists and therapists now have an internationally agreed upon and uniform approach to treating patients with BOTOX.

Clinical Associate Professor Nick Evans

Head of the Department of Newborn Care, Royal Prince Alfred Hospital, Sydney & Clinical Associate Professor, Uni. of Sydney.

Severe Newborn Jaundice and Cerebral Palsy

Jaundice is a yellowing of the skin caused by raised levels of bilirubin in the blood. In almost all cases of juandice, it is benign. Some children who develop cerebral palsy have had severe jaundice at birth or soon after. In a small proportion of babies, bilirubin levels in the blood become dangerously high and can damage the brain and cause cerebral palsy. Clinical Associate Professor Nick Evans and Dr Angela McGillivray from the Royal Prince Alfred Hospital in Sydney are conducting the first nationwide survey of paediatricians through the Australian Paediatric Surveillance Unit (APSU) to ascertain if theres a link between severe jaundice and cerebral palsy. The study hopes to find out if there is an opportunity to prevent some children from developing cerebral palsy. Professor Evans research aims to determine the prevalence of, and causes of severe jaundice in Australian-born babies, and how often conditions such as cerebral palsy develop. Such severe jaundice can result from a range of conditions such as premature birth, infections, blood or liver conditions. Many of these conditions are treatable and so any resulting in cerebral palsy may be preventable. Clinical Associate Professor nick evans was a recipient of a Cerebral Palsy Foundation 2009 AVAnT Innovative research Grant of $33,000 over three years.

dr mary Tolcos was a recipient of a Cerebral Palsy Foundation 2009 AVAnT Innovative research Grant of $284,882 over 2 yrs.

Associate Professor David Walker

Department of Physiology, Monash University, Melbourne.

Dr Angela McGillivray
Royal Prince Alfred Hospital, Sydney.

Preventing brain damage to prevent cerebral palsy

Recent research suggests that a poor oxygen supply at times during pregnancy can lead to particular problems with the blood vessels in the babys developing brain. Associate Professor David Walker has conducted research with mice, showing that giving pregnant mice a dietary supplement called creatine can help prevent some of the damage to blood vessels in the brain caused by low oxygen. Creatine is an amino acid, found most commonly in our diet from red meat. Assoc. Professor Walker will now repeat his research on sheep because their brains are even more like humans than are the brains of mice. If his research is successful, it will be a step along the way towards preventing some forms of brain damage in children, which is very important in efforts to prevent cerebral palsy. david walker was a recipient of a Cerebral Palsy Foundation 2009 AVAnT Innovative research Grant of $137,040 over two years.

Professor Alastair MacLennan

Head of Obstetrics and Gynaecology, University of Adelaide and Head of the South Australian Cerebral Palsy Research Group

in the childs environment such as poor foetal growth and infections in the womb. Professor MacLennan and his colleagues research involved conducting genetic analyses of samples of saliva and comparing them against comprehensive medical records. The team hopes to make connections between the health of children with cerebral palsy and their genes.

Dr Mary Tolcos
Medical researcher, University of Melbourne.

Preventing brain damage to prevent cerebral palsy

Dr Mary Tolcos and colleagues from the University of Melbourne and Monash University are using animal models to study erythropoietin, or EPO, a naturally occurring hormone for its ability to reduce brain damage in babies caused by inflammation during pregnancy. Some pregnant women develop infections in the lining of the uterus, but not everyone becomes unwell from

Genes and Cerebral Palsy

Genes play an important role in human development, and Professor MacLennans research interest lies in the apparent links between faulty genes and factors Professor Alastair macLennan was a recipient of a Cerebral Palsy Foundation 2009 AVAnT Innovative research Grant of $145,900 over two years.





every 15 hours, an Australian child is born with cerebral palsy

I would like to make a difference to the lives of children and adults with cerebral palsy by making a gift of: $25 As a: Monthly gift $50 $100 One-off gift My choice $ ____________________________

CP Facts

Professors: eUaN waLLaCe aNd roBerT J. PaLisaNo

Method of payment: My cheque, made payable to the Cerebral Palsy Foundation is enclosed OR debit my Mastercard visa AMEX

You can share our vision of a future without cerebral palsy by leaving a bequest to the Cerebral Palsy Foundation.
Leaving a gift to the Cerebral Palsy Foundation in your will, regardless of the size will ensure cerebral palsy research can continue. Your decision could lead to vaccines, early intervention and new procedures that will change the lives of families affected by CP. It was impressive to see the incredible dedication and commitment of researchers ... I find it satisfying to know that my bequest will help continue their work. Sheila Fielding has an 12 year old grandson with cerebral palsy. In 2005, when the Cerebral Palsy Foundation was launched, it prompted her to amend her will and leave a bequest for research purposes into the cause, and ultimately, cure of cerebral palsy. In 2009, I was invited by the Cerebral Palsy Foundation to attend the 3rd International Cerebral Palsy Conference. It was impressive to see the incredible dedication and commitment of researchers from across the world. For more information about our Bequest program, please phone (02) 9479 7215 or email

Progress in the field of cerebral palsy research was recently showcased at the Cerebral Palsy Foundations bi-annual Research Briefing.
The Cerebral Palsy Foundation invited eminent researchers Professor Euan Wallace from the Ritchie Centre at Melbournes Monash Medical Centre, and Professor Robert J. Palisano from the USA, to discuss their work and its impact on the lives of people with cerebral palsy. Australian researchers, led by Professor Euan Wallace, are investigating the many causes of foetal brain injury in the hope of developing clinically useful treatments to reduce the incidence of CP. during childbirth, as the key cause of brain injury leading to cerebral palsy, Professor Wallace said. We now realise that most children with cerebral palsy actually sustained their brain injury during pregnancy rather than during labour. We have purposefully concentrated our research on pathways that are likely to be the major cause of injury leading to cerebral palsy in babies, such as foetal growth problems and infections during pregnancy. We are hopeful that our experimental work will lead to clinically useful treatments that will prevent brain injury happening in high risk pregnancies, long before the baby is born. The Research Briefing also included Professor Robert J. Palisano from the USA who discussed his work to identify innovative approaches to providing physical and occupational therapy to optimise the social participation of children with CP. Professor Palisanos research activities at CanChild have included the development of a system to classify gross motor function in children with cerebral palsy.

Cardholders Name ___________________________________________________________ Expiry Date __________________________________________________________________ Signed ______________________________________________________________________ Your details: Title _______ First Name _____________________________________________________ Last Name ___________________________________________________________________ Address _____________________________________________________________________ ____________________________________________ Postcode _______________________ Phone ______________________________________ Mobile _____________________________________ Email _______________________________________ Date of birth ________________________________ I would like to help in other ways: Im interested in making a gift in my Will My company is interested in the Cerebral Palsy Foundation Workplace Giving program Im interested in fundraising for the Cerebral Palsy Foundation

we now realise that most children with cerebral palsy actually sustained their brain injury during pregnancy rather than during labour.
His team is investigating the basic pathways by which the fragile developing brain is likely to be damaged, and when such damage is likely to occur. It has developed treatments that target those pathways, and is studying the effects of the treatments on brain structure and newborn function. For too long, attention has focused on sudden and abrupt shortages of oxygen, as can occur (rarely)

diary note 17 march 2011 - 10th Anniversary bulls & bears Trophy Charity Golf day, Lakes Golf Club. To book a place, contact marissa on (02) 9907 0000

Please detach and return this coupon to The Cerebral Palsy Foundation PO box 184 brookvale nSw 2100

Natasha Garrity, Cerebral Palsy foundation Ambassador



Thank You!
major supporters
Justin Gallagher

The Grevillea Group Trust

Tudor Foundation


media Supporters

Henry H. roth Charitable Foundation

Kim Sundell

Professor Henry J. Cowan The bulls & bears Charity Trophy Golf day The Greatorex Foundation The Corio Foundation

PLEaSE DONaTE NOW For further information or to make a donation: W: T: 1300 551 137 E: PO Box 184 Brookvale NSW 2100 ABN 82 582 833 857